Gene study aims to boost kidney transplant success for african americans

NCT ID NCT03615235

Ongoing Knowledge-focused Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

The APOLLO study looks at how variations in the APOL1 gene, common in people of African ancestry, affect kidney transplant outcomes. Researchers are testing DNA from 5,000 kidney donors and recipients to see if certain gene variants lead to faster kidney failure or harm living donors. The goal is to make transplants safer and more successful for this group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors better match donors and recipients to improve kidney transplant survival and reduce risks for living donors.
What could go wrong: This is an observational study, not a treatment trial. It may not lead to immediate changes in care, and results depend on large-scale data collection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome kidney disorder kidney failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY DISEASE, CHRONIC KIDNEY DISEASES KIDNEY FAILURE

Contacts and locations

Locations

Cleveland Clinic

Cleveland, Ohio, 44106, United States
Columbia University Irving Medical Center

New York, New York, 10032, United States
Duke University

Durham, North Carolina, 27705, United States
Emory University School of Medicine

Atlanta, Georgia, 30322, United States
Ichan School of Medicine at Mount Sinai

New York, New York, 10029, United States
Johns Hopkins University

Baltimore, Maryland, 21205, United States
Joslin Diabetes Center / Harvard University

Boston, Massachusetts, 02215, United States
Saint Louis University Center for Transplantation

St Louis, Missouri, 63104, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
University of California San Francisco

San Francisco, California, 94143, United States
University of Maryland School of Medicine

Baltimore, Maryland, 21201, United States
University of Miami / Miami Transplant Institute

Miami, Florida, 33133, United States
University of Michigan Medicine

Ann Arbor, Michigan, 48109, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Wisconsin - Madison

Madison, Wisconsin, 53792, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Wake Forest School of Medicine

Winston-Salem, North Carolina, 27157, United States
Weill Cornell Medicine

New York, New York, 10065, United States

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