Colonic disorder

This phase 2 trial is testing whether giving two drugs—Zanzalintinib and Retifanlimab—before surgery can help patients with early-stage colon cancer. The study enrolls adults aged 18 to 80 with a type of colon cancer called pMMR that can be removed surgically. Participants receiv…

This early-stage trial tests an oral capsule containing a genetically modified probiotic yeast designed to neutralize toxins produced by C. diff bacteria. The study first evaluates safety in healthy adults, then in people at risk for recurrent C. diff infection. Participants take…

This study tests whether adding a combination of curcumin (from turmeric) and QingDai (a traditional Chinese herb) to standard vedolizumab treatment can help people with moderate to severe ulcerative colitis reach remission. About 160 adults will receive either the herbal combo o…

This study looks at whether immunotherapy can shrink certain gastrointestinal cancers (like colorectal or stomach cancer) enough that some patients may not need major surgery. People whose tumors have specific genetic features (MSI-H/dMMR or POLE mutation) and who respond well to…

This early-stage trial tests a drug called ACM-CpG, which is injected directly into the abdomen to stimulate the immune system against cancer. It includes 24 adults with colorectal or appendix cancer that has spread to the lining of the abdomen or caused fluid buildup. The main g…

This study tests an experimental tablet called Hemay005 in 360 Chinese adults with moderate to severe ulcerative colitis, a chronic gut condition. Participants will receive either the drug or a placebo to see if it can bring about remission and improve symptoms over 12 weeks, wit…

This study tests whether a supplement called palmitoylethanolamide (PEA) can help people with mild-to-moderate ulcerative colitis. Researchers will measure changes in disease activity, quality of life, and inflammation markers in 60 participants. The goal is to see if adding PEA …

This study tests whether adding an experimental immunotherapy drug (QL1706) to standard chemotherapy and radiation can shrink liver tumors from colon cancer enough to allow surgery. About 30 adults with colon cancer that has spread only to the liver will receive the combination b…

This study tests whether oral vancomycin, an antibiotic, can help children aged 6-15 with inflammatory bowel disease (IBD), especially types linked to liver problems. About 140 kids will either get vancomycin plus standard care or standard care alone for up to a year. Researchers…

This study tests an experimental drug called ATH-063 in 120 adults with moderate to severe ulcerative colitis who have not responded to or can no longer use biologic therapies. Participants will receive either the drug or a placebo for 12 weeks to see if it can reduce symptoms an…

This phase 3 trial tests whether a blood test that measures tumor DNA (ctDNA) can help doctors decide when to reduce or switch chemotherapy in people with metastatic colorectal cancer. About 408 participants will be randomly assigned to either standard treatment or a strategy whe…

This study observes 35 adults with moderate-to-severe Crohn's disease or ulcerative colitis to see how long they continue taking guselkumab in everyday medical practice. Researchers will track treatment persistence and early symptom relief, like reduced bowel urgency. No experime…

This study tests whether an intestinal or multivisceral transplant can help people with a rare abdominal cancer called pseudomyxoma peritonei (PMP) that cannot be removed by surgery. Twenty participants will receive the transplant and be followed for 12 months to see if they surv…

This study tests a treatment called extracorporeal photopheresis (ECP) for people with advanced melanoma who develop severe colitis or hepatitis from immunotherapy. ECP filters a patient's blood, treats it with a light-activated drug, and returns it to the body. The trial compare…

This phase II trial tests whether a stronger chemotherapy cocktail (cmFOLFOXIRI) plus an immunotherapy drug (PD-1 inhibitor) works better than standard chemotherapy (mFOLFOX6) when given before surgery for locally advanced colon cancer. About 138 patients with high-risk stage II …

This study tests whether treating children with uncomplicated appendicitis using antibiotics alone works as well as surgery. About 724 children aged 5 to 15 will be randomly assigned to receive either antibiotics or an operation. The goal is to see if the antibiotic approach lead…

This study tests a new drug combination for people with metastatic solid tumors that lack a gene called MTAP. The drugs, BMS-986504 and pemetrexed, aim to stop cancer cells from growing. The trial will check safety and how well the combo works in 72 participants.

This study will test whether a diet rich in protein and fiber can reduce harmful gas-producing bacteria in the gut of people with ulcerative colitis. Forty adults with mild to moderate disease will eat specially prepared frozen meals for two separate week-long periods. Researcher…

This study compares four different sequences of biologic drugs (infliximab, filgotinib, ustekinumab, and vedolizumab) in 240 adults with moderate to severe ulcerative colitis. The goal is to see which order of treatments works best to achieve and maintain remission without steroi…

This early-stage trial tests a technique called PIPAC, which turns a chemotherapy drug (mitomycin C) into a mist and sprays it directly onto cancer spread inside the abdomen. It is for people with advanced gastrointestinal cancers that cannot be removed by surgery. The main goal …

This study tests a new drug, BHB810, in adults with advanced stomach or gastroesophageal junction cancer that has not responded to standard treatments. The drug is given as an IV infusion every two weeks. The main goals are to check safety and find the best dose, while also seein…

This study tests whether two immunotherapy drugs, cemiplimab and fianlimab, can safely shrink colon tumors before surgery in people with stage II-III colon cancer that hasn't spread. Participants get two IV doses before surgery, then are followed for up to three years. The goal i…

This study tests whether frozen stool capsules (fecal transplants) can help children aged 8-17 with ulcerative colitis stay in remission after steroid treatment. Participants will receive either capsules or enemas containing healthy donor stool. The main goal is to see if the cap…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This trial compares a one-day course of antibiotics after appendix surgery to the standard five-day course in 200 children and adults with uncomplicated appendicitis. The goal is to see if the shorter course prevents infections just as well, while reducing side effects and costs.…

This phase 2 trial tests whether injecting an oncolytic virus (H101) directly into liver tumors, along with radiation, chemotherapy, targeted therapy, and immunotherapy, can shrink or control colorectal cancer that has spread to the liver and cannot be removed by surgery. The stu…

This study tests if adding a common heart medication (propranolol) to standard chemotherapy and immunotherapy before surgery can improve outcomes for people with a certain type of colon cancer. About 45 adults with stage II or III colon cancer that is mismatch repair proficient (…

This early-phase study tests a new treatment called ICG318 CAR-T for people with inflammatory bowel disease (IBD) that hasn't improved with standard therapies. The treatment uses a patient's own immune cells, modified in a lab to target and calm the overactive immune response cau…

This early-stage trial tests the safety of an experimental drug called LYNC-101 in 50 healthy adults. The drug is given by IV infusion, either as a single dose or multiple doses every 3 weeks. The goal is to see if it is safe and how the body processes it, before testing it in pe…

This study tests an experimental pill, IPG11406, in 144 adults with moderate to severe ulcerative colitis (UC), a chronic gut condition causing diarrhea and pain. The drug targets immune cells to reduce colon inflammation. Participants receive one of three doses or a placebo for …

This study looks at whether older adults (60+) with ulcerative colitis who are in long-term remission can safely stop taking thiopurines (azathioprine or 6-mercaptopurine) and rely only on high-dose mesalazine. Thiopurines carry increased risks of infection and cancer with age, s…

This study tests whether the oral medication upadacitinib can safely treat acute severe ulcerative colitis in hospitalized adults without using steroids. Fifty participants will take upadacitinib daily during their hospital stay and be monitored for up to a year. The goal is to s…

This phase 2 trial tests an oral drug called ibezapolstat in 20 people who have had three or more C. diff infections in the past year. The goal is to see if the drug can cure the current infection and reduce the chance of it coming back. Participants will take the drug twice a da…

This study tests a drug called fruquintinib in 88 adults with advanced colon cancer that has not responded to standard chemotherapies. The goal is to see if adding supportive care to manage side effects can help patients live longer without their cancer growing. Participants will…

This phase II trial tests a chemotherapy regimen called FULIRI, combined with either bevacizumab or cetuximab, as a first treatment for colorectal cancer that has spread to the liver. The goal is to shrink the liver tumors enough so they can be surgically removed. The study will …

This study tests a new drug called SSGJ-627 in 288 adults with moderate to severe ulcerative colitis, a chronic bowel disease. The goal is to see if it safely controls symptoms like bleeding and diarrhea. Participants must have tried other treatments without success.

This study will follow 95 adults with moderate-to-severe Crohn's disease or ulcerative colitis in Upper Egypt who are taking one of five biologic drugs: adalimumab, infliximab, ustekinumab, golimumab, or vedolizumab. After one year, researchers will measure how many patients avoi…

This early-phase study tests a new drug combination (PX plus nab-paclitaxel) given directly into the abdomen for people with a type of advanced cancer that has spread to the lining of the belly. The main goal is to find a safe dose and check for side effects. About 22 adults with…

This early study tests a new robotic surgical system (Revolve) in 3 adults with simple appendicitis who are already scheduled for appendix removal. The robot helps the surgeon work more precisely during minimally invasive surgery. The main goal is to see if the device can safely …

This study tests if xylitol, a common sweetener, can safely clear C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 99 adults with mild or inactive IBD will take either a low or high dose of xylitol or a placebo for four weeks. Researchers …

This study tests giving an immunotherapy drug (pembrolizumab) before surgery to people with a specific type of colon cancer (dMMR). The goal is to see if the drug can shrink or eliminate the tumor so some patients may avoid surgery and instead be closely monitored. About 152 adul…

This early-stage study tests a new cell therapy called CNK-UT009 in 40 people with severe inflammatory bowel disease (Crohn's or colitis) that hasn't improved with standard treatments. The main goal is to check safety and find the best dose, while also looking at how well it work…

This study compares giving chemotherapy before surgery versus standard surgery-first treatment for people with stage II or III colon cancer that has a high CEA level. About 100 adults aged 18-70 will be randomly assigned to one of two groups. The goal is to see if pre-surgery che…

This early-phase study tests a new cell therapy called KT032 in 24 adults with advanced solid tumors (ovarian, mesothelioma, colon cancer) that have spread to the abdomen and haven't responded to standard treatments. The main goal is to check safety and find the best dose, while …

This pilot study tests a new synbiotic formula (SGR11) in 50 adults with mild-to-moderate ulcerative colitis, a type of inflammatory bowel disease. Participants take the supplement daily for 8 weeks. Researchers will check if symptoms improve and if the supplement is safe, using …

This study tests whether using stool biomarkers (fecal calprotectin and fecal immunochemical test) to guide treatment adjustments can prevent relapses in people with ulcerative colitis. About 240 adults in remission will be randomly assigned to either biomarker-guided therapy or …

This study tests a blood-filtering device called Efferon LPS in 40 adults with Crohn's disease or ulcerative colitis during a flare-up. The device is designed to remove harmful substances from the blood to reduce inflammation. Participants will either receive standard care alone …

This study tests whether adding acupuncture to the standard drug mesalazine helps people with mild-to-moderate ulcerative colitis achieve and stay in remission. Eighty adults will receive either real acupuncture or sham patches alongside mesalazine for 12 weeks. The goal is to se…

This Phase 3 trial tests a personalized cancer vaccine called OncoVAX for people with Stage II colon cancer. After surgery to remove the tumor, the patient's own cancer cells are used to create a vaccine that trains the immune system to attack any remaining cancer cells. The goal…

This study tests whether a step-by-step plan to manage body temperature during a long surgery can lower the chance of postoperative delirium (sudden confusion). The surgery is for a rare abdominal tumor called pseudomyxoma peritonei and involves heated chemotherapy. The trial wil…

This study tests a new drug combination (HLX43 plus HLX07 or serplulimab) in people with advanced or metastatic colorectal cancer that has stopped responding to standard first-line treatment. About 126 participants will receive the experimental therapy to see if it can shrink tum…

This early-stage trial will test a new drug called cizutamig in 15 people with moderate to severe ulcerative colitis who haven't improved with other treatments. The main goal is to check if the drug is safe and tolerable. It is not yet recruiting and will be conducted at a single…

This pilot study tests whether antibiotics alone are as effective as antibiotics plus percutaneous drainage for treating diverticulitis with a large abscess (4-8 cm). Fifty adults with stable vital signs and no signs of peritonitis will be randomly assigned to one of two groups. …

This pilot study tests whether the antibiotic vancomycin can safely treat active ulcerative colitis in adults who also have primary sclerosing cholangitis, a liver condition. Fourteen participants will take vancomycin or a placebo for 4 weeks, with an optional 4-week extension. T…

This study tests whether a new drug called IP-001, injected into the liver after standard heat-based tumor destruction, can help prevent colorectal cancer from coming back. About 717 adults with colorectal cancer that has spread only to the liver will be randomly assigned to rece…

This early-phase study tests a new treatment called RD06-05, a universal CAR-T cell therapy, in 30 adults with moderate-to-severe ulcerative colitis or Crohn's disease who haven't responded to standard treatments. The therapy targets specific immune cells to reduce inflammation i…

This study looks at adults hospitalized with a severe flare of ulcerative colitis that didn't get better with IV steroids. It compares taking two drugs together (infliximab and tofacitinib) versus taking just one of them. The goal is to see if the combo leads to faster symptom re…

This pilot study tests whether xylitol, a common sugar alcohol, can safely clear C. difficile bacteria from the guts of people with inflammatory bowel disease (IBD). About 69 adults with mild or inactive IBD will take different doses of xylitol for up to 8 weeks. Researchers will…

This study will compare two methods of closing the skin after open appendix surgery: standard interrupted stitches versus a continuous stitch under the skin plus a small drain. The goal is to see which method leads to fewer wound infections and better healing. About 100 people ag…

This phase 3 trial tests a new method called PIPAC that delivers chemotherapy as a pressurized mist directly into the abdomen during a minimally invasive procedure. It compares this approach plus standard intravenous chemo (FOLFIRI) to standard chemo alone for people with appendi…

This study compares a new drain fixation method (extra-peritoneal tunneling) to the standard method after rectal cancer surgery. About 596 participants will be randomly assigned to one of the two groups. The goal is to see if the new method reduces drain movement and improves the…

This study tests whether adding a heat treatment (thermal ablation) to the standard procedure for removing large colon polyps can lower the chance they grow back. About 752 adults will be randomly assigned to receive either standard removal alone or standard removal plus burning …

This study tests a new, non-surgical treatment called ERAT for mild appendicitis. Instead of removing the appendix, doctors use a flexible tube through the colon to clear the blockage and infection. The trial will compare ERAT to standard laparoscopic surgery in 376 adults to see…

This study compares two antibiotics, fidaxomicin and vancomycin, to see which one is better at clearing C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 60 adults with IBD will take one of the two antibiotics for 10 days and be followed fo…

This study will follow 178 Chinese adults with Crohn's disease or ulcerative colitis who are starting treatment with IL-23 inhibitors (guselkumab or risankizumab). Researchers will track how well the drugs control symptoms and heal the gut over 52 weeks, as well as any side effec…

This study tests a steroid foam (budesonide) given rectally to children aged 5 to 17 with mild to moderate ulcerative colitis in the lower colon. The goal is to see if it can safely induce remission after 6 weeks of treatment. About 100 children will receive either a low dose, hi…

This Phase 3 trial will test two drugs, risankizumab and ustekinumab, in 260 adults with fibrostenotic Crohn's disease—a form where the bowel becomes scarred and narrow. The study compares how well each drug prevents further scarring over three years. Participants will receive ei…

This phase 2 trial is testing whether giving the drugs encorafenib and cetuximab again can help people with a specific type of advanced colorectal cancer (BRAF V600E-mutant) whose disease got worse after prior treatment with similar drugs. About 25 participants will receive the d…

This study tests a new surgical procedure called RISE that rebuilds the ileocecal valve during right colon cancer surgery. Normally, removing this valve can cause diarrhea and malnutrition. The trial will randomly assign 188 patients to either receive the valve reconstruction or …

This study tests a new type of day hospital for people with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. In one visit, patients get blood tests, a doctor checkup, education on managing their condition, and optional workshops on diet or fatigue. Th…

This study tests a device that uses both freezing and heating to destroy liver tumors in people with liver cancer or colorectal cancer that has spread to the liver. The goal is to see if this approach improves how long patients live without their cancer growing, and whether it ac…

This study tests whether a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus chemotherapy can shrink tumors before surgery in people with stage III colon cancer that is microsatellite stable (pMMR/MSS). About 21 participants will receive four cycles of th…

This study looks at whether a substance in urine, called PGE-MUM, can show if ulcerative colitis is active or in remission. Researchers will collect urine and blood samples from 114 adults with confirmed ulcerative colitis and compare the results with colonoscopy findings. If suc…

This study tests whether spraying a mix of acetic acid and indigo carmine dye during colonoscopy helps doctors find more precancerous polyps (called sessile serrated lesions) in the right side of the colon compared to standard white-light colonoscopy. About 2,689 adults aged 45-8…

This study tests a new device that flattens colon polyps before they are examined under a microscope. The goal is to help doctors better identify sessile serrated lesions, a type of polyp that can lead to colorectal cancer. About 1,156 adults having polyps removed during a colono…

This study tests whether a 3D computer model, made from a standard CT scan, helps surgeons better plan operations for locally advanced colon cancer. About 168 adults with stage cT3 or cT4 colon cancer will be randomly assigned to have surgery planned with or without the 3D model.…

This study tests a simple 10-item checklist that parents can use during a video call to help doctors figure out if a child's belly pain is appendicitis. About 1,500 children aged 3 to 16 with stomach pain will try the checklist with a medical student, then get standard care. The …

This study aims to see if measuring two proteins in the blood, Talin-1 and Cripto-1, can help diagnose colorectal cancer. Researchers will compare these levels in 70 newly diagnosed patients and healthy people. The goal is to find a simpler, more accurate way to detect the diseas…

This study aims to improve how doctors classify colon tumors by using artificial intelligence (AI) to analyze CT scans. The AI will be trained to tell early-stage tumors from advanced ones and to detect lymph node involvement, which is key for deciding on treatments like chemothe…

This study will check how well a non-invasive stool test (quantitative fecal immunochemical test, or qFIT) can detect colorectal cancer and precancerous lesions like adenomas and serrated polyps. Researchers will compare the test results with colonoscopy findings in 150 adults ag…

This study tests whether an artificial intelligence (AI) system can help doctors spot more precancerous polyps and colorectal cancers during colonoscopy compared to standard procedures. Over 3,300 adults scheduled for screening or surveillance will be randomly assigned to AI-assi…

This study tests whether an artificial intelligence (AI) tool can help doctors spot precancerous growths in the upper part of the colon during a colonoscopy. About 1,200 people with symptoms like belly pain, constipation, or black stools will take part. The goal is to see if usin…

This study tests a new platform called xDRIVE that combines drug sensitivity testing and AI to predict which treatments will work best for people with advanced colorectal cancer. The platform will not provide treatment itself but will give doctors a recommendation. The goal is to…

This study tests whether taking S-adenosylmethionine (SAMe), a natural supplement, can prevent liver injury caused by the chemotherapy drug oxaliplatin. About 30 adults with colorectal cancer that has spread to the liver will take SAMe pills daily for 3-6 months alongside their c…

This study tests different methods to help people get screened for colorectal cancer. About 2000 adults from community health clinics will receive reminders or extra support to schedule a colonoscopy or stool test. The goal is to see which approach works best to increase screenin…

This early-phase trial tests whether adding Ursodeoxycholic Acid (UDCA) to standard antibiotics can prevent Clostridioides difficile (C. diff) infection from returning. About 30 adults with C. diff and risk factors for recurrence will take UDCA three times daily for up to eight w…

This study compares three topical treatments—sesame oil, aloe vera gel, and nitroglycerin ointment—against no treatment for preventing phlebitis (vein inflammation) caused by chemotherapy. Researchers will enroll 190 adults with breast or colon cancer receiving specific chemo dru…

This study tests a culturally tailored educational program to help Syrian migrants in Turkey get screened for breast, cervical, and colorectal cancers. About 30 participants will take part in the program, which uses a questionnaire to measure their motivation and knowledge before…

This study tests whether taking oral vancomycin alongside other antibiotics can prevent Clostridioides difficile infection (C. diff) in people aged 65 and older. Participants are randomly assigned to receive either vancomycin or standard care. The goal is to see if the drug reduc…

This study tests whether spraying a protective medication (sucralfate) on the wound after removing colon polyps can prevent delayed bleeding better than the standard method of placing clips. The trial will include 160 patients who take blood thinners and have large polyps. Partic…

This study tests whether a probiotic supplement in oral drops can prevent diarrhea in children aged 0-12 who are taking common antibiotics like amoxicillin. One thousand children will receive either the probiotic or a placebo during their antibiotic course, and researchers will t…

This pilot study will test a 24-week digital self-management program designed to help people with inflammatory bowel disease (IBD) manage their symptoms and build long-term healthy habits. The program is accessed via web or mobile device and is used alongside standard care. The s…

This study compares two ways of adjusting the air cushion (cuff) on the breathing tube used during general anesthesia in children having laparoscopic appendectomy. One group uses the standard finger-palpation method, while the other uses a pressure sensor to keep the cuff within …

This study tests two online pain education programs for adults with Crohn's disease or ulcerative colitis who have chronic pain. Participants will complete a 2-hour online session and report their pain and quality of life weekly for 8 weeks. The goal is to see if these programs a…

This study tests a mobile app designed to help Black and Hispanic adults with inflammatory bowel disease (IBD) manage stress and improve their quality of life. The app teaches coping skills, mindfulness, and disease acceptance. Researchers want to see if the app is practical and …

This study looks at whether a prehabilitation program—including physical therapy, dietary advice, and emotional support—given before major cancer surgery can reduce deaths and serious complications within 30 days after the operation. About 180 adults with cancers of the pancreas,…

This study tests whether a short liquid diet followed by a low-sulfur eating plan is safe and helpful for people with mild to moderate ulcerative colitis. Researchers will check if this approach improves gut health, lowers inflammation, and eases symptoms. They will also use brea…

This trial tests whether people with mild diverticulitis can be safely treated at home with just pain medicines (ibuprofen and acetaminophen) instead of antibiotics. 556 participants will be randomly assigned to receive either pain medicines alone or pain medicines plus an antibi…

This study tests whether modafinil, a drug used for sleep disorders, can reduce severe fatigue in adults with inactive inflammatory bowel disease (IBD). Sixty participants will take either modafinil or a placebo for 8 weeks, starting at 100 mg daily with possible dose increases. …

This study tests whether a home-based exercise program can help people with gastrointestinal or lung cancer handle chemotherapy better. Up to 120 participants will be randomly assigned to either an aerobic and resistance exercise group or a stretching group. All activities are do…

This study tests whether an AI-enhanced virtual reality cognitive behavioral therapy (VR/AI CBT) program can reduce anxiety and improve quality of life in people with inflammatory bowel disease (IBD). Seventy-six adults with IBD and moderate-to-severe anxiety will be randomly ass…

This study tests whether a special liquid diet (elemental diet) can help adults with inflammatory bowel disease (IBD) feel better during a flare. The diet provides all nutrients in an easy-to-digest form. Researchers will track symptom changes and inflammation levels in 42 outpat…

This study tests whether a 14-day course of the antibiotic rifaximin can reduce bothersome bloating in adults with irritable bowel syndrome, functional constipation, or similar gut disorders. About 78 participants will receive either rifaximin or a placebo, and researchers will m…

This study tests whether a supervised exercise program, started two weeks before chemotherapy and continued for 16 weeks during treatment, can help adults aged 35 to 65 with breast, lung, or colon cancer tolerate chemotherapy better. The goal is to see if participants can receive…

This study explores whether physical activity and fitness can reduce inflammation and improve quality of life in children aged 6 to 17 with Crohn's disease or ulcerative colitis. Researchers will track 100 participants over time and test a 12-week supervised exercise program. The…

This study tests whether a 5-week heart rate variability biofeedback program can reduce symptoms in people with ulcerative colitis who are currently having a flare but show no active inflammation. Twenty-three adults will practice daily breathing exercises using a device and be f…

This study tests whether an 8-week mindfulness-based stress reduction (MBSR) program can lower stress and improve well-being in people with inflammatory bowel disease (IBD). Seventy adults with mild-to-moderate IBD will either take the MBSR course online or watch an educational s…

This study will test a one-day acceptance and commitment therapy (ACT) program for 50 veterans who have both inflammatory bowel disease (IBD) and a mental health condition like depression, anxiety, or PTSD. The goal is to see if this brief therapy can improve their quality of lif…

This study tests whether taking probiotic supplements can help reduce common chemotherapy side effects like nausea, diarrhea, and loss of appetite in people with stage III colon cancer. Forty adults will be randomly assigned to receive either probiotics or a placebo during their …

This study tests a new device called Medstrom that monitors pain, sedation, and muscle relaxation all in one during laparoscopic colon cancer surgery. Thirty patients will be randomly assigned to either the Medstrom device or standard monitoring. The goal is to see if the device …

This early study tests a new device that supports the colon wall during polyp removal. It involves 4 people who have a positive stool test and a polyp on the left side of the colon. The main goal is to see if the device can be placed successfully in one try.

This study tests whether modafinil, a drug used for narcolepsy, can reduce severe fatigue in people with Crohn's disease or ulcerative colitis. About 70 participants will receive either modafinil or a placebo for 12 weeks. The main goal is to see if a larger trial is possible, bu…

This study tests two special formulas—amino acid formula (AAF) and extensively hydrolyzed formula (eHF)—in 360 infants aged 0-6 months with suspected cow's milk protein allergy. Babies will receive one formula for at least 2 weeks, and doctors will check if symptoms like diarrhea…

This study tests whether remimazolam, a newer sedative, works as well as or better than midazolam for colonoscopy in 200 adults with inflammatory bowel disease (Crohn's or colitis). Participants get one of the two drugs plus fentanyl for pain, then rate their satisfaction and are…

This study looks at medical records from thousands of adults with Crohn's disease or ulcerative colitis treated in Dutch hospitals between 2018 and 2026. Researchers will analyze which treatments patients receive, how often they switch therapies, and how the disease affects other…

This study will follow 100 adults with Crohn's disease, ulcerative colitis, or other IBD, plus their healthy relatives, for up to 3 years. Researchers will collect blood, stool, tissue samples, and imaging to track how immune cells and genetics change over time. The goal is to fi…

This study will see if using a Garmin smartwatch to continuously track heart rate, breathing rate, and oxygen levels can help doctors spot early warning signs in hospitalized children in Ghana. About 250 children with traumatic injuries or after appendix surgery will wear the wat…

This study investigates whether the bacteria living in the gut influence the development of diverticular disease and acute diverticulitis. Researchers will compare the gut microbiota of people with and without these conditions to identify differences and risk factors. The goal is…

This study investigates whether acupuncture points become tender or more sensitive in people with inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis. Researchers will compare skin temperature, blood flow, and pain sensitivity at specific body points b…

This study looks at people who have had certain types of colon polyps (serrated lesions) removed. It aims to find out why some of them later develop new advanced growths in the colon. By tracking 750 adults over time, researchers hope to identify risk factors that could help doct…

This study explores whether changes in heart rate, sleep, and activity measured by a person's own smartwatch can predict flare-ups in inflammatory bowel disease (IBD). Six hundred adults with Crohn's disease or ulcerative colitis who already own a compatible device will participa…

This study explores whether combining artificial intelligence analysis of tumor tissue with special blood tests (liquid biopsy) can more accurately predict if colon cancer will return after surgery. Researchers will follow 400 adults with stage II or III colon cancer for up to fi…

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study looked at nearly 24,000 older adults (65+) with ulcerative colitis or Crohn's disease to see if certain advanced treatments lead to more infections. Researchers compared patients taking ENTYVIO, TNF-alpha inhibitors, or ustekinumab using Medicare claims data from 2016 …

This study looks at whether it's safe to skip mechanical bowel preparation (the drink that cleans out your colon) before colon surgery. Currently, the best practice combines that drink with antibiotics to prevent infections. The trial will compare two groups: one getting the drin…

This study will measure how much of the drug TREMFYA (guselkumab) passes into breast milk of 10 nursing women who are already taking it for conditions like psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn's disease. Researchers will collect milk samples to estimate th…

This pilot study looks at whether it is safe to stop giving antibiotics after surgery for a burst (perforated) appendix. About 100 adults will be randomly assigned to receive either antibiotics or no antibiotics after their operation. The main goal is to see if a larger study is …

This study tests whether watching a short video tailored to their specific type of inflammatory bowel disease (IBD) helps patients better prepare their bowel for a colonoscopy. About 600 adults with ulcerative colitis or Crohn's disease will be randomly assigned to receive either…

This observational study will collect detailed information from 150 adults undergoing emergency surgery for complicated diverticulitis. Researchers will analyze factors that influence surgeons' decisions to perform either a primary anastomosis (reconnecting the bowel) or a Hartma…

This study is testing whether a green dye called indocyanine green (ICG) can help surgeons see and remove lymph nodes that contain cancer during laparoscopic colon cancer surgery. About 25 adults with colon cancer will receive the dye injected around the tumor and into a vein. Th…

This study looks at where cancer spreads to lymph nodes in people with colon or rectal cancer. Researchers will examine tissue from 1200 patients who had surgery to remove their cancer. The goal is to find patterns that could help doctors better plan treatment in the future.

This study looks at how often polyps in the stomach or colon grow back after being removed during a scope procedure. Researchers will follow about 2,000 adults for up to three years to track recurrence and identify risk factors like polyp size, lifestyle, and health history. The …

This study will test a new way to create CT images for people with colon cancer. The method uses deep learning to make the images clearer. Researchers will compare the quality of these new images to standard ones. The goal is to see if this technique helps doctors see tumors bett…

This study will collect blood samples from 1,000 people with small colon growths to see if a liquid biopsy can accurately tell benign from malignant lesions and predict cancer spread to lymph nodes. Current methods often lead to unnecessary surgery. The goal is to create a bioban…

This study looks at how decision counseling affects people who get a positive result on the Shield blood test for colorectal cancer. Researchers want to see if counseling helps reduce confusion and increases the chance of getting a follow-up colonoscopy. About 350 adults aged 45-…

This study follows 75 adults with Crohn's disease or ulcerative colitis who are starting guselkumab, a drug used for inflammatory bowel disease. Researchers want to see if the drug also helps with joint pain and stiffness linked to spondyloarthritis. Participants will report symp…

This study looks at adults with severe constipation and an enlarged rectum (idiopathic megarectum) to see if the problem started in childhood. Researchers will compare 120 participants—some with the condition and some without—by asking about their early-life digestive health and …

This study will test whether an artificial intelligence (AI) system can help doctors identify inflammatory bowel disease (IBD) earlier and more accurately. Researchers will analyze medical records from 4,500 patients to see how well the AI's suggestions match actual diagnoses. Th…

This study looks at whether tumor DNA found in blood or peritoneal fluid can predict the spread of digestive cancers (stomach, colon, pancreas) to the lining of the abdomen. Researchers will follow 300 patients with early-stage tumors to see if those with positive DNA markers are…

This study looks at adults who had a C. diff infection and were treated with either a fecal transplant (FMT) or antibiotics alone. Researchers want to see if FMT leads to healthier gut bacteria and fewer health problems years later. Participants will give blood, stool, and urine …

This study looks at whether a special decision aid helps patients with a cancerous colon polyp choose between more surgery or careful monitoring. About 110 adults in Denmark will use the aid during their doctor visit. The goal is to see if it changes treatment choices and improve…

This study will give fecal transplants to 90 people with recurrent C. difficile infection, ulcerative colitis, or metabolic syndrome. Researchers will use advanced tests on stool and tissue samples to track how donor bacteria settle in the gut and interact with the host. The goal…

This study will test a new type of colonoscope called the Magnetic Flexible Endoscope (MFE) in 6 people with inflammatory bowel disease (IBD). The MFE uses a magnet at its tip, moved by an external robotic arm, to gently travel through the colon. The goal is to see if it can reac…

This study tests a new imaging system that uses a fluorescent dye and artificial intelligence during colonoscopy to measure how leaky the gut lining is in people with inflammatory bowel disease (IBD). It includes 70 adults (60 with IBD and 10 without) at three Canadian hospitals.…

This study follows 50 adults with ulcerative colitis who are already seeing a naturopathic doctor. Over 12 weeks, researchers track symptom changes using questionnaires. The goal is to gather early information on how naturopathic care may help, without changing anyone's usual tre…

This study will examine 100 patients with lower gut symptoms like chronic diarrhea, blood in stool, or abdominal pain who are having a colonoscopy. Researchers want to see which types of colon inflammation (colitis) are most common and how they appear during the procedure. The go…

This study looks at how anxiety, depression, and stress might cause advanced IBD treatments to stop working. Researchers will ask 450 people with IBD to fill out questionnaires about their mental health while they receive regular infusions. The goal is to understand if mental hea…

This study looks at whether certain bacteria in your stool can help predict if colon cancer will come back after surgery. Researchers will collect stool and blood samples from 107 adults before and after their surgery. They want to see if bacteria that break down collagen are lin…

This study is building a new questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will talk to 275 adults with Crohn's disease or ulcerative colitis to understand their self-care habits, then test the questionnaire to…

People with inflammatory bowel disease (IBD) have a higher risk of colon cancer and need regular colonoscopies. This study compares two advanced methods: one uses a dye spray to highlight abnormal areas, and the other uses built-in camera filters to enhance the view without dye. …

This study looks at how colorectal cancer grows when it spreads to the lining of the abdomen. Researchers want to see if the pattern of tumor growth can help doctors decide who will benefit most from surgery. The study will follow 30 adults who are already scheduled for surgery o…

This study looks at whether giving fish oil nutrition before colon surgery helps patients with constipation recover better. About 306 adults will either get fish oil before surgery or only after. Researchers will compare complication rates, recovery, and quality of life. The goal…

This study will collect data from 10,000 patients across Saudi Arabia who undergo emergency abdominal surgery (laparotomy). Researchers will track complications and deaths within 30 and 90 days after surgery. The goal is to understand current care quality, test international risk…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health after cancer treatment. The goal is to see if this program improves survivors' confidence and ability to handl…

This study looks at medical records of 51 patients aged 70 and older with metastatic colorectal cancer. Researchers want to see if using lower doses of chemotherapy along with full-dose targeted therapy can reduce serious side effects like low white blood cell counts and severe d…

This study will follow 83 adults with inflammatory bowel disease (IBD) at Assiut University Hospitals in Egypt to see if anemia can predict worse outcomes like hospitalizations. Anemia is common in IBD, but its role as a predictor is not well studied in this population. Researche…

This study tests a new device that takes detailed images of the lower gut during a standard colonoscopy. About 250 adults aged 45 to 75 will have the probe used during their procedure. The goal is to see if the device works well for real-time imaging.

This study will check if people with metastatic breast or colon cancer have antibodies that might also attack the heart. Researchers will collect blood samples and ECGs from 196 participants over 12 months. The goal is to see if these antibodies raise the risk of dangerous heart …

This pilot study will test whether a modified ultrasound technique can accurately measure disease activity in people with moderate-to-severe ulcerative colitis. Researchers will compare ultrasound results with standard colonoscopy findings in 25 patients starting a new treatment.…

This study compares two types of surgery for right-sided colon cancer: laparoscopic (keyhole) surgery and open surgery. The goal is to see which approach leads to less blood loss, fewer complications, and a shorter hospital stay. The study will include 22 adults with right colon …

This study tests whether fluorescent dyes attached to two IBD drugs (adalimumab and risankizumab) can show where the drugs go in the gut. 30 adults with ulcerative colitis or Crohn's disease will receive a low dose of the labelled drugs, then undergo a special camera procedure 2-…

This study looks at whether a simple intestinal ultrasound can accurately measure disease activity in people with active ulcerative colitis, compared to the standard colonoscopy. Researchers will enroll 200 adults with active UC to see if the ultrasound scores match the colonosco…

This study looks at whether measuring visceral fat (belly fat) using CT scans can predict how well ulcerative colitis patients respond to biologic therapy. Researchers will follow 200 adults with active ulcerative colitis for 6 months, tracking changes in fat volume and treatment…

This study tests whether a computer-aided detection system can help doctors find more polyps in the right side of the colon during a colonoscopy. About 686 adults aged 40-75 will have two colonoscopies in one session, with the AI system used in one of them. The goal is to see if …

This study will check how common Helicobacter pylori infection is in 100 adults with inflammatory bowel disease (Crohn's or colitis) at the Guadeloupe hospital. Researchers will take extra stomach biopsies during routine endoscopy to study the stomach's bacteria. The goal is to s…

This study looks at how a personalized strength training program affects people with different cancers, including lung, colon, breast, and blood cancers. 150 adults will either do supervised strength training plus home exercises, or just home exercises, for 12 weeks. Researchers …

This study will measure vitamin D levels in 100 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) to see if low vitamin D is linked to more active disease. Participants will have blood tests for vitamin D and inflammation markers. The goal is to better unders…

This study looks at the viruses (called bacteriophages) living in the guts of people with inflammatory bowel disease (IBD) and healthy people. Researchers want to understand how these viruses differ and whether they can be grown in a lab to create a new treatment. The study invol…

This study will follow 100 people who need a stoma (an opening in the belly to pass stool) after surgery. Some will have their stoma site marked and get education before surgery, while others will not. The goal is to see if these steps improve quality of life and reduce problems …

This study looks at why some people have ongoing loose stools after surgery for colon cancer. Researchers will use a new device to check for bile acid problems and bacterial overgrowth in the small intestine. The goal is to better understand these symptoms and how they affect qua…

This study compares a newer imaging method called TXI with standard dye-based imaging during colonoscopies in people with inflammatory bowel disease (IBD). The goal is to see which method better detects precancerous changes that can lead to bowel cancer. About 242 adults with IBD…

This study will use musculoskeletal ultrasound to look for hidden joint, muscle, and tendon inflammation in 81 people with inflammatory bowel disease (IBD) who have no known arthritis. The goal is to see how common these hidden problems are and to develop a standard ultrasound ch…

This study creates a registry of 500 cancer patients receiving immunotherapy to better understand and manage immune-related side effects (irAEs). Researchers will collect data on who gets these side effects, how they present, and what treatments work best. The goal is to improve …

This study will test whether robotic surgery can be used for emergency abdominal operations, such as for severe gallbladder infections or bowel blockages. The goal is to see if it's feasible and if it can lower complication rates and shorten hospital stays compared to traditional…

This study looks at whether taking a daily vitamin D supplement (2000 IU) for 12 months can improve the health and quality of life of people with Crohn's disease or ulcerative colitis. Researchers will track how well participants stick to the supplement and measure their vitamin …

This observational study will follow 4500 adults with Crohn's disease or ulcerative colitis to identify biological markers—such as gut bacteria patterns—that predict disease progression and complications. Researchers will collect blood, stool, saliva, and tissue samples during ro…

This study tests whether data from a wearable device and grocery loyalty cards can help detect disease flares in people with Crohn's disease or ulcerative colitis. Eighty adults will wear a smartwatch and use a store card to track their health and food purchases. The goal is to d…

This observational study will examine lymph nodes from the ileum mesentery in 406 people undergoing surgery for right-sided colon cancer. Researchers want to learn where cancer spreads in these nodes to help surgeons decide how much tissue to remove. Participants will be followed…

This study uses computer simulations to better understand how a subcutaneous (under-the-skin) form of the drug infliximab works in people with inflammatory bowel disease (IBD) and rheumatoid arthritis. Researchers will analyze data from previous trials to create a model that pred…

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…