Could antibiotics alone replace drains for diverticulitis abscesses? new pilot study aims to find out
NCT ID NCT07352605
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This pilot study tests whether antibiotics alone are as effective as antibiotics plus percutaneous drainage for treating diverticulitis with a large abscess (4-8 cm). Fifty adults with stable vital signs and no signs of peritonitis will be randomly assigned to one of two groups. The main goal is to see if hospitals can successfully enroll and follow patients, but the study will also compare how well each treatment resolves the infection within 30 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Antibiotics (piperacillin-tazobactam) and/or percutaneous drainage
- What this could lead to
- If successful, this pilot could pave the way for a larger trial that clarifies whether antibiotics alone are enough for diverticulitis abscesses, potentially avoiding invasive drainage procedures.
- What could go wrong
- This is a small pilot study (50 participants) focused on feasibility, not definitive results. The findings may not apply to all patients, and there are risks of infection, bleeding, or treatment failure with either approach.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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