New drug cocktail aims to shrink colon tumors before surgery
NCT ID NCT07156682
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests whether a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus chemotherapy can shrink tumors before surgery in people with stage III colon cancer that is microsatellite stable (pMMR/MSS). About 21 participants will receive four cycles of the drug combo, then undergo surgery. The main goal is to see if the cancer disappears completely after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- iparomlimab and tuvonralimab (QL1706) plus XELOX chemotherapy (oxaliplatin and capecitabine)
- What this could lead to
- If this works, it could lead to a new treatment option that shrinks tumors before surgery, potentially improving outcomes for people with hard-to-treat stage III colon cancer.
- What could go wrong
- This is a small, early-phase study with only 21 participants, so results may not apply to everyone. The combination therapy may cause significant side effects, and it is not yet known if it will improve long-term survival.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Qilu hospital of Shandong University
Jinan, Shandong, 250012, China
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Other studies related to the condition(s) this trial covers.
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- Can a chemo boost outsmart lingering colon cancer cells?