Colorectal cancer

Researchers are testing whether adding fruquintinib to standard chemotherapy (mFOLFOX6 or FOLFIRI) helps people with metastatic colorectal cancer who have not yet received treatment for advanced disease. The trial enrolls adults up to age 75 with confirmed metastatic colorectal c…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This early-phase trial tests a new drug called AI-061, which combines two immune-boosting antibodies (anti-PD-1 and anti-CTLA-4) into one treatment. The study will enroll 18 adults with advanced solid tumors that have spread or cannot be removed. The main goals are to find a safe…

This early-stage trial is testing a new drug called tuvusertib, given together with either lartesertib or avelumab, in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see how the body pr…

This early-phase trial tested a new drug called vilastobart, alone or with another drug (atezolizumab), in 125 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looke…

This early-stage trial is testing whether a pill made from freeze-dried healthy donor stool (MTP-101P) is safe and can restore good bacteria in people having part of their colon removed. Forty adults aged 18-75 with colon polyps, early-stage cancer, or diverticulitis will take th…

This study looks at whether eating a high-fiber diet (over 21 grams per day) can change gut bacteria and improve the immune system's ability to fight solid tumors like colorectal cancer. About 25 adults with solid tumors will follow this diet to see if it is safe and helps with t…

This trial tests whether adding Lonsurf (trifluridine/tipiracil) to standard chemotherapy can help control metastatic colorectal cancer. Researchers will enroll about 97 adults in Taiwan whose cancer has progressed after prior treatments, including anti-VEGF therapy. Participants…

This trial tests whether combining the immunotherapy drug atezolizumab with precise, high-dose radiation (SABR) can better control metastatic cancers, including colorectal, lung, kidney, and sarcoma. The idea is that radiation may make tumors more visible to the immune system, wh…

This study looks at whether it's possible to increase fiber intake in people with colorectal cancer before they have surgery. Researchers will compare personalized digital dietary advice, a dried vegetable product, and usual diet in 54 participants. The goal is to see if fiber in…

This phase 1 trial tests an experimental drug called MRG003 in people with advanced solid tumors, including colorectal cancer, head and neck squamous cell carcinoma, and nasopharyngeal carcinoma. The study aims to find a safe dose and to see whether the drug can shrink tumors. Pa…

This study tests whether avatrombopag, a pill that boosts platelet production, can help people with gastrointestinal cancer who develop low platelets from chemotherapy. About 60 participants will receive either avatrombopag or a placebo. The goal is to see if the drug can raise p…

This study tested a special pump placed under the skin that sends chemotherapy directly to the liver through the hepatic artery. It was for people with colorectal cancer that had spread to the liver and who had already tried other chemotherapies. The goal was to see if this direc…

This phase 2 trial is testing two different sequences of the drugs panitumumab and regorafenib in 214 patients with advanced colorectal cancer that no longer responds to standard treatments. The goal is to see which order of these drugs helps patients live longer. Participants mu…

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could sh…

This trial investigates an experimental oral drug, LY3143921 hydrate, which blocks a protein called Cdc7 that cancer cells need to divide. It is being tested in adults with advanced solid tumours, including colorectal, ovarian, lung, and pancreatic cancers, that have not responde…

This early-phase trial tested whether giving patients their own natural killer (NK) cells, boosted by the drug bortezomib, is safe for treating advanced cancers like leukemia, lung, and pancreatic cancer. Thirty-five adults whose cancers had not responded to standard treatments r…

This phase II trial is investigating whether giving the drug bevacizumab directly into the liver's main artery, alongside standard chemotherapy, can shrink liver tumors in people with colorectal cancer that has spread only to the liver. The study enrolls patients whose cancer pro…

This early-phase study tested an experimental drug called COM902, alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, and colon cancer. The main goal was to check safety and find the right dose. Researchers also looked for early signs that the drug m…

This trial tests whether a simple clip-and-floss traction device can speed up the removal of large colon polyps using a technique called endoscopic submucosal dissection (ESD). About 280 people scheduled for ESD will be randomly assigned to receive either the traction device or s…

This trial asks whether adding the antibody drugs bevacizumab and/or cetuximab to standard chemotherapy can help people with metastatic colorectal cancer live longer. Participants receive one of several treatment combinations, and researchers compare overall survival and progress…

This phase II trial is testing whether a cancer vaccine called PolyPEPI1018, when combined with the immunotherapy drug atezolizumab, can help people with a specific type of metastatic colorectal cancer that has not responded to previous treatments. The study enrolls adults with m…

This study compares two bowel cleansing solutions, Golytely and SUPREP, for colon cancer screening in people with diabetes. Researchers want to see which one cleans the colon better and is easier to tolerate. About 80 participants will be randomly assigned to one of the two preps…

This trial tests an experimental virus-based therapy called JX-594 (Pexa-Vec) in people with advanced colorectal cancer that has not responded to standard treatments. The virus is designed to infect and kill cancer cells while also stimulating the immune system. It is given alone…

This study tests a new fluorescent clip that glows under special light to help surgeons locate colon tumors during minimally invasive surgery. About 110 adults with colon cancer will be randomly assigned to receive either the clip or a standard dye injection before surgery. The g…

This study tested an experimental drug called CTX-009 in 49 adults with metastatic colorectal cancer that had worsened after two or three prior treatments. The goal was to see if the drug could shrink tumors or stop them from growing. Results will help determine if further testin…

This trial tests whether giving the chemotherapy drugs raltitrexed and oxaliplatin every two weeks is as effective and less toxic than the standard every-three-week schedule in people with metastatic colorectal cancer who have not had prior chemotherapy. Some participants also re…

This phase 3 trial tested whether combining sotorasib (a pill) and panitumumab (an infusion) can slow tumor growth better than standard chemotherapy in 160 adults with metastatic colorectal cancer that has a specific KRAS G12C mutation. Participants were randomly assigned to rece…

This phase 2 trial tested a combination of three drugs—encorafenib, binimetinib, and cetuximab—in 95 patients with a specific type of advanced colorectal cancer (BRAF V600E mutation) who had not received prior treatment for their metastatic disease. The goal was to see how many p…

This early-stage trial tests a treatment called Anti-CEA CAR-T, which uses a patient's own immune cells modified to recognize and attack cancer cells that carry a protein called CEA. The study enrolls about 110 adults with advanced colorectal, gastric, or other solid tumors that …

This trial investigates a type of immunotherapy called CAR-T cells that are designed to recognize and attack cancer cells carrying a protein called CEA. The study includes adults with advanced gastric, colon, rectal, esophageal, or pancreatic cancer who have not responded to at l…

This early-stage trial tests a new type of cell therapy called CEA-targeted CAR-T for people with advanced colorectal, esophageal, stomach, or pancreatic cancers that have stopped responding to standard treatments. The therapy involves taking a patient's own immune cells, enginee…

This early-stage trial is testing a combination of two lab-made antibodies in people with advanced solid tumors that have not responded to standard treatments. One antibody (LDP) aims to reactivate the immune system against cancer, while the other (CDP1) blocks a growth signal on…

This study tests a new drug called CDP1, which is a biosimilar (a close copy) of the approved cancer drug cetuximab. The trial enrolls adults with advanced colorectal cancer or head and neck squamous cell carcinoma that has not responded to prior treatments. Researchers compare h…

This trial tests a temporary device called CG-100 that is placed inside the intestine during colorectal cancer surgery. The device is designed to protect the surgical connection while it heals, potentially reducing leaks and other complications. The study includes adults aged 22 …

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This phase 2 trial is testing whether a combination of chemotherapy (mFOLFOX6), a targeted therapy (bevacizumab), and an immunotherapy (PD-1 inhibitor) can help people with a specific type of locally advanced colorectal cancer called microsatellite stable (MSS). Unlike other colo…

This early-phase study tested the safety of combining two drugs—pembrolizumab (an immunotherapy) and AMG386 (which targets blood vessel growth)—in 62 people with advanced solid tumors like melanoma, ovarian, renal, or colorectal cancer. The main goals were to find the safest dose…

This pilot study tests whether a purified green tea extract called EGCG can help prevent colon cancer from coming back after surgery. 51 patients who had their colon cancer removed took either the extract or a placebo. Researchers are checking for changes in DNA methylation, a ma…

This trial investigates whether adding a dietary supplement called sodium nucleinate to standard FOLFOX chemotherapy helps people with metastatic colorectal cancer (cancer that has spread). Participants are randomly assigned to receive either the supplement or a placebo alongside…

This phase 2 trial tested a combination of two drugs—paclitaxel (given intravenously and directly into the abdomen) and oral nilotinib—in 21 adults with cancers that had spread to the lining of the abdomen and could not be surgically removed. The goal was to see if the treatment …

This trial compares two types of oral nutritional supplements given to colorectal cancer patients before surgery. One group receives standard high-protein drinks, while the other gets immunonutrition drinks enriched with arginine, nucleotides, vitamin D, and omega-3 fatty acids. …

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This trial tests whether a program of exercise, nutrition advice, and psychological support—started four weeks before surgery and continued afterward—can reduce complications in people having colon cancer surgery. Participants are adults over 40 with non-metastatic colon cancer w…

This early-phase study tested a personalized cancer vaccine (RO7198457) in 273 patients with advanced solid tumors like melanoma, lung, and breast cancer. The vaccine was given alone or with an immunotherapy drug (atezolizumab) to see if it was safe and how the body responded. Th…

This study tested whether a 20-minute arm cycling exercise, done twice daily for five days, could improve lung function and recovery in 60 elderly patients after colon cancer surgery. Participants also received standard physical therapy. The goal was to see if the arm exercise co…

This study tested whether adding the arthritis drug Celebrex to an experimental chemo drug called EPO906 could reduce severe diarrhea in people with advanced colorectal cancer. The trial enrolled 75 patients who had already tried other treatments. The first phase found the safest…

This Phase 3 trial tested a new drug combination called MK-4280A (favezelimab plus pembrolizumab) against standard treatments (regorafenib or TAS-102) in 441 people with advanced colorectal cancer that had stopped responding to prior therapy. The goal was to see if the new combin…

This study tested two different ways of stitching the belly wall closed after colorectal cancer surgery to see which one better prevents the wound from bursting open. Forty adults having open surgery were randomly assigned to either an interrupted 'figure-of-X' stitch or a contin…

This early-phase trial tested two drugs together—pembrolizumab (Keytruda) and XL888—in 47 people with advanced gastrointestinal cancers like colorectal and pancreatic cancer that had spread or could not be removed. The main goal was to find the safest dose and check for side effe…

This study tested whether adding bevacizumab to a powerful four-drug chemotherapy regimen (FOLFOXIRI) could shrink liver tumors in people with colorectal cancer that had spread only to the liver and could not be removed surgically. The goal was to see if more patients could then …

This study tested whether adding the anti-inflammatory drug celecoxib to standard FOLFOX chemotherapy helps prevent cancer from returning in people with stage III colon cancer after surgery. Over 2,500 participants were randomly assigned to receive either celecoxib or a placebo a…

This study tested whether injecting a special dye (ICG) during laparoscopic colorectal cancer surgery helps surgeons see blood flow and choose a safer spot to cut. Over 560 adults took part, with half getting the dye and half relying on the surgeon's usual judgment. The main goal…

This study tested a temporary device called Colovac 2 in 24 people undergoing colon cancer surgery. The device is placed inside the bowel to protect the surgical connection while it heals, potentially avoiding the need for a temporary stoma. Researchers checked if the device stay…

This registry followed 500 adults with colorectal cancer that spread to the liver. All were treated with a microwave ablation device that uses heat to destroy tumors. The goal was to see how well the device controls tumors locally over 12 months and to track any side effects. The…

This early-phase trial tested a combination of two drugs (MEK162 and mFOLFIRI) in 25 adults with advanced RAS-positive colorectal cancer that had stopped responding to standard treatment. The main goal was to find the safest dose and check for side effects. Researchers also looke…

This early-stage study tested a new antibody drug (similar to cetuximab) in 18 people with advanced colorectal cancer that had stopped responding to standard treatments. The main goal was to check safety and how the drug moves through the body. Participants received one of two do…

This early-stage study tested a custom-made yeast vaccine designed to train the immune system to recognize and attack leftover cancer cells. Five adults with various cancers (like colorectal, breast, or lung) who had completed initial treatment received the vaccine. The goal was …

This study tested whether a new drug called A140 works as well as the standard drug Erbitux for people with a certain type of advanced colorectal cancer (RAS wild-type). Both drugs were given together with chemotherapy. The trial involved 688 adults and measured how many patients…

This study looked at the long-term safety of the cancer drug vismodegib in 19 patients with ovarian cancer, basal cell carcinoma, or metastatic colorectal cancer. All participants had previously taken vismodegib in an earlier Genentech trial and were expected to benefit from cont…

This study tested a new way to reconnect the colon after removing a cancerous section using a robot. The technique uses a special double purse-string stitch and a single stapler. Thirty-nine patients with sigmoid colon cancer were included, and the study looked at how well the te…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced cancers like breast, ovarian, stomach, colorectal, brain, bile duct, or pancreatic cancer that had stopped responding to standard treatments. The goal was to see if the combo c…

This study tested a device called Colovac+ in 27 adults having surgery for colorectal cancer. The device is placed inside the bowel to protect the surgical connection and keep stool away while it heals. The goal was to see if it is safe and effective, and whether it could help pa…

This early-phase study tested the safety of combining the immunotherapy drug pembrolizumab with precise, high-dose radiation (SBRT) to the liver in 15 adults with colorectal cancer that had spread only to the liver. The goal was to see if this combination could prevent the cancer…

This study tested a new two-drug combination (encorafenib and cetuximab) against standard treatments in 107 Chinese patients with a specific genetic mutation (BRAF V600E) that makes colorectal cancer harder to treat. The goal was to see if the new combo could slow cancer growth b…

This phase 2 study tested the immunotherapy drug prolgolimab in 30 people with a specific type of colorectal cancer (MSI/dMMR) that had not spread. Participants received the drug for 6 months before planned surgery. The main goal was to see if the cancer completely disappeared in…

This early-phase study tested a combination of two drugs, cabozantinib and TAS-102, in 15 people with advanced colorectal cancer that had spread and stopped responding to standard treatments. The main goal was to find the safest dose and identify side effects. The study is comple…

This study tested whether a 3-year physical activity program could help prevent colon cancer from coming back in 889 patients who had surgery and chemotherapy for high-risk stage II or stage III colon cancer. Participants were randomly assigned to either the exercise program plus…

This phase II trial tested the immunotherapy drug nivolumab (Opdivo) in 35 adults with advanced colorectal cancer that has a specific marker (class II expression) and is microsatellite stable, a type that usually does not respond to immunotherapy. The goal was to see if the drug …

This early-phase trial tested a combination of three drugs—vemurafenib, cetuximab, and irinotecan—in 47 people with advanced solid tumors that have a specific BRAF V600 mutation and could not be removed by surgery or had spread. The main goal was to find the safest dose and under…

This study tested a drug called axitinib against a placebo in 52 people with advanced colorectal cancer that had spread to the liver and stopped responding to chemotherapy. The goal was to see if axitinib could help control the cancer and to test a special ultrasound technique th…

This study compared two ways to close skin after colorectal cancer surgery: a tissue adhesive (skin bond) and traditional skin stapling. Researchers looked at wound infection rates within 30 days, pain, and cost in 304 patients. The goal was to see if skin bond leads to fewer inf…

This study tested a new drug called TAK-676, alone and with pembrolizumab, in 248 adults with advanced solid tumors that had no standard treatment options. The main goal was to check safety and find the highest dose that causes few side effects. The study also looked at how well …

This phase 3 trial tested whether a surgical procedure called laparotomy plus heated chemotherapy (HIPEC) could improve outcomes for colorectal cancer patients at high risk of cancer spreading in the abdomen. 150 patients who had already undergone surgery and chemotherapy were ra…

This study tested an experimental drug called BMS-986016 (anti-LAG-3) alone or combined with nivolumab in people with advanced solid tumors that had spread or couldn't be removed by surgery. It included several cancer types like lung, stomach, liver, kidney, bladder, head and nec…

This early-phase study tested a new drug called gevokizumab alongside standard cancer treatments in 167 adults with advanced colorectal, stomach, or kidney cancer that had spread. The goal was to find a safe and active dose and see if the combination could help control the diseas…

This study looked at whether a high-protein drink with added arginine can reduce problems like infections and slow bowel movement after colorectal surgery. It included 44 adults who were malnourished or at risk of malnutrition before their operation. Participants received either …

This early-phase study tested a personalized immunotherapy (iNeo-Vac-P01) in 6 patients with stage III colorectal or non-small cell lung cancer who had already completed surgery and standard adjuvant therapy. The vaccine was designed to target unique neoantigens from each patient…

This study tested a new cancer drug called ERAS-007, given by mouth, together with other targeted therapies in 101 people with advanced colorectal or pancreatic cancers that have certain gene changes. The main goals were to check safety, find the best dose, and see how the drugs …

This study tested a drug called TAS-102 (Lonsurf) combined with a precise type of radiation (SBRT) in 52 people whose colorectal cancer had spread to the liver. The goal was to find the safest dose and see if the combination could control the liver tumors. The trial is complete, …

This study tested a combination of two drugs, palbociclib and cetuximab, in 24 people with a specific type of advanced colon cancer that had spread. The goal was to see if the combo could shrink tumors or stop them from growing. Participants took palbociclib pills and received ce…

This study tested a combination of two drugs—NT-I7 (efineptakin alfa) and pembrolizumab (Keytruda)—in 215 people with advanced solid tumors that had stopped responding to treatment. The goal was to check safety, find the right dose, and see if the combo could shrink tumors. The t…

This study tested a two-step approach for people with metastatic colorectal cancer that doesn't respond well to standard treatments. First, patients received a drug called temozolomide to make their tumors more genetically unstable. Then, they received the immunotherapy drug pemb…

This study tested a combination of two treatments (regorafenib and FOLFIRINOX) in 13 people with a type of advanced colorectal cancer that has a specific gene change (RAS mutation). The main goal was to see if the combination was safe and tolerable. The study also looked at how l…

This trial tested a new approach for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Doctors removed immune cells from patients' tumors, used CRISPR gene editing to disable a gene called CISH, and then infused the modified cells b…

This early-stage trial tested the safety and tolerability of a chemotherapy drug called raltitrexed when given as a heated solution directly into the abdomen (HIPEC) in 30 patients with colorectal cancer. The goal was to find the highest safe dose and understand how the drug beha…

This phase 2 trial tested whether adding the immunotherapy drug nivolumab to standard chemotherapy could help people with a specific type of metastatic colorectal cancer (MSS/pMMR). Eighty participants received either the combination or chemotherapy alone. The main goal was to se…

This study tested the drug tislelizumab given before surgery in 33 people with early-stage colorectal cancer that has specific genetic changes (MSI-H or dMMR). The goal was to see if the drug could shrink or eliminate tumors before surgical removal. The trial has completed, and r…

This early-phase study tested a combination of two drugs, regorafenib and nivolumab, in 52 people with advanced colorectal cancer that had stopped responding to other treatments. The goal was to find the safest dose and see if the combination could help control the cancer. The st…

This phase II trial tested a combination of three drugs—TAS-102, irinotecan, and bevacizumab—in 42 people with advanced colorectal cancer that had spread or couldn't be removed. The goal was to see if this mix could slow tumor growth better than standard treatments. Participants …

This study looked at whether taking daily aspirin and vitamin D, along with exercise and a low-fat diet, could help prevent colorectal cancer from returning in 16 patients who had no visible cancer but still had signs of cancer DNA in their blood. The goal was to see if these lif…

This phase II trial tested two different drug combinations in 240 people with advanced HER2-positive colorectal cancer that had spread and could not be removed by surgery. One group received the antibodies trastuzumab and pertuzumab, while the other received cetuximab (an antibod…

This phase 2 trial tested whether combining two drugs, sorafenib and irinotecan, works better than either drug alone in people with advanced colorectal cancer that has a KRAS mutation and has stopped responding to all standard treatments. The study enrolled 173 participants acros…

This study tested whether a Medtronic pump and Codman catheter can safely deliver chemotherapy directly to the liver in 35 people with colorectal cancer or bile duct cancer that spread to the liver. The main goal was to check safety, including liver side effects and need for sten…

This study tested a combination of the targeted drug cetuximab with a strong chemotherapy cocktail (FOLFIRINOX) as a first treatment for people whose colorectal cancer had spread and could not be removed by surgery. The goal was to see if this mix could shrink tumors better than …

This early-phase study tested a new drug called SHR-A1811 in 101 people with advanced stomach or colorectal cancers that have a specific protein called HER2. The main goals were to check the drug's safety, find the best dose, and see early signs of tumor shrinkage. Participants h…

This study tested a combination of two drugs, sorafenib and irinotecan, in 64 adults with metastatic colorectal cancer that has a K-RAS mutation and has progressed after prior treatment. The goal was to see if the combination could control the disease and to check for side effect…

This study tested whether more intense chemotherapy combinations could shrink liver tumors in people with colorectal cancer that cannot be fully removed by surgery. 124 participants received either standard two-drug chemo or one of three stronger regimens. The goal was to see if …

This early-phase trial tested a new drug called SNB-101 in 21 people with advanced solid tumors (like colorectal, breast, and lung cancers) that had stopped responding to standard treatments. SNB-101 is a nanoparticle version of SN-38, the active part of a common chemotherapy dru…

This phase 1 trial tested a combination of regorafenib (a targeted therapy) plus two immunotherapy drugs (nivolumab and ipilimumab) in 39 patients with advanced colorectal cancer that had spread and stopped responding to chemotherapy. The goal was to find the safest dose and chec…

This study tested a new immunotherapy drug, ezabenlimab, combined with other cancer medicines in 211 adults with advanced solid tumors that had spread. The goal was to see if the tumors shrank or disappeared. Participants received different drug combinations, and doctors monitore…

This study tested two experimental drugs (BI 754111 and BI 754091) that help the immune system attack cancer. It included 172 adults with advanced solid tumors, including non-small cell lung cancer that had returned after prior treatment. The first part found the safest dose, and…

This early-phase study tested a combination therapy in 15 people with colon cancer who had completed standard treatment but still had tiny amounts of cancer DNA in their blood (called minimal residual disease). The treatment used specially activated immune cells from donated umbi…

This study tested a combination of two drugs, sorafenib and bevacizumab, in 83 people with advanced colorectal cancer that had spread and was no longer responding to standard treatments. The goal was to see if this combination could stop or slow tumor growth. Participants receive…

This early-phase trial tested a new drug called CUE-102 in 42 adults with certain advanced cancers (colorectal, gastric, pancreatic, or ovarian) that had returned or spread despite prior treatments. The drug is designed to help the immune system attack cancer cells that carry a s…

This study tested a drug called trastuzumab deruxtecan (T-DXd) in 122 people with advanced colorectal cancer that has too much HER2 protein. The goal was to see if the drug could shrink tumors. About 45% of patients had their tumors shrink. This treatment is not a cure, but it ma…

This early-phase trial tested a new oral drug called JAB-21822, alone or with cetuximab, in 29 adults with advanced solid tumors (like lung or colorectal cancer) that have a specific KRAS G12C mutation. The main goals were to check safety and find the right dose. Participants had…

This early-phase trial tested a combination of three drugs—utomilumab, cetuximab, and irinotecan—in 34 patients with advanced colorectal cancer that had spread and stopped responding to standard treatment. The goal was to find the safest dose and check for side effects. While the…

This early-phase study tested a combination of two experimental drugs (BGB-283 and PD-0325901) in 91 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and see if the drugs could shrink tumors. The trial is no…

This early-stage trial tested an oral drug called JAB-3312 in 40 adults with advanced solid tumors (like lung, colon, or breast cancer) that had stopped responding to standard treatments. The main goals were to find a safe dose and check for side effects. Researchers also looked …

This study tested a new drug, TAK-981, combined with the immunotherapy pembrolizumab in 161 adults with advanced or metastatic solid tumors that could not be cured. The main goals were to check safety and see if the combination could shrink tumors. Participants received treatment…

This study tested whether adding the immunotherapy drug pembrolizumab to standard radiation or ablation could help people with metastatic colorectal cancer. The idea is that the combination might trigger a stronger immune response that also attacks tumors not directly treated. Th…

This study tested whether using an artificial intelligence system (GI GENIUS) together with a special cap (ENDOCUFF VISION) on the colonoscope helps doctors find more precancerous polyps during colonoscopy than using either tool alone. About 481 adults undergoing screening or fol…

This study tested a combination of nivolumab (Opdivo) and trametinib (Mekinist), with or without ipilimumab (Yervoy), in 325 people whose colorectal cancer had spread and had not responded to prior treatments. The main goals were to check safety and see if the drugs could shrink …

This early-stage study tested whether adding two drugs (romidepsin and 5-azacitidine) to an immunotherapy (MK-3475) could help shrink tumors in people with a type of advanced colorectal cancer that usually doesn't respond to immunotherapy. 27 adults with microsatellite stable (MS…

This phase 3 trial tests a new drug combination, MK-4280A (favezelimab plus pembrolizumab), against standard treatments (regorafenib or TAS-102) in 94 Chinese adults with advanced, PD-L1 positive colorectal cancer that has worsened after prior therapy. The main goal is to see if …

This study tested a cancer vaccine called ETBX-011 in 43 people with advanced colorectal, lung, breast, or prostate cancers that produce a protein called CEA. The vaccine uses a modified virus to teach the immune system to attack cancer cells making CEA. The main goals were to ch…

This early-stage trial tested a new drug called CFT1946, alone or with other drugs, in 89 adults with solid tumors that have a BRAF V600 mutation, including melanoma, lung, colon, and thyroid cancers. The main goals were to check safety and find the best dose. The study is comple…

This study looked at whether taking vitamin D supplements can help people with stage II or III colorectal cancer who are receiving chemotherapy. The researchers measured markers of cell death and inflammation in 44 patients before and after 6 months of vitamin D. The goal was to …

This study tested an oral drug called GFH925 in 334 people with advanced solid tumors that have a specific KRAS G12C mutation. The trial aimed to find the safest dose and check if the drug can shrink tumors in cancers like lung and colorectal cancer. Results will help decide if l…

This study tested whether giving the immunotherapy drug pembrolizumab (Keytruda) along with chemotherapy before surgery can help shrink colorectal tumors and improve immune response. Thirty-three patients with non-metastatic colorectal cancer received the drugs, then had surgery.…

This study tested giving the cancer drug nivolumab as a shot under the skin (instead of through an IV) to people with advanced cancers like lung, kidney, melanoma, liver, and colorectal cancer. The main goal was to see how the drug moves in the body and to check for side effects.…

This early-phase study tested an experimental drug called GDC-1971 combined with either osimertinib (for lung cancer) or cetuximab (for colorectal cancer) in 10 people with advanced cancers that had spread. The main goal was to check safety and find the right dose. Researchers al…

This study tested whether the immunotherapy drug nivolumab, alone or with other drugs, can shrink tumors in people with colon cancer that has returned or spread. It included 385 participants whose tumors had a specific genetic feature called MSI-H or were non-MSI-H. The goal was …

This study tested a combination of an oral bacterial product (VE800) and the immunotherapy drug nivolumab in 56 people with advanced or metastatic cancers like melanoma, stomach, and colorectal cancer. The goal was to see if the bacteria could help the immune system fight tumors …

This study tested a new drug called E7386 combined with the immunotherapy pembrolizumab (Keytruda) in 89 people with advanced melanoma, colorectal cancer, or liver cancer. The goal was to see if the combination is safe and can shrink tumors. Some participants with liver cancer al…

This completed Phase IIB trial tested an experimental immunotherapy called STIMVAX (AlloStim) in 29 adults with metastatic colorectal cancer that had not responded to two prior chemotherapy regimens. The treatment uses immune cells from healthy donors to try to fight the cancer. …

This study tested combinations of a new drug called etrumadenant (AB928) with other treatments in 227 people whose colorectal cancer had spread. The goal was to see if these combinations could shrink tumors or slow the cancer's growth. Participants received different drug mixes, …

This study tested whether adding the targeted drug panitumumab to standard chemotherapy (given through the liver artery and a vein) could help keep colorectal cancer from returning after liver metastases were surgically removed. It involved 75 adults with a specific gene type (wi…

This study tested an experimental drug called BMS-813160, given together with chemotherapy or the immunotherapy nivolumab (Opdivo), in 332 people with advanced colorectal or pancreatic cancer. The main goals were to check safety, side effects, and how the body processes the drug,…

This study tested a doctor-designed dose adjustment algorithm to prevent unplanned delays in FOLFOX chemotherapy for people with cancers of the colon, stomach, esophagus, and other digestive organs. 52 adults participated, and the goal was to see if the algorithm could keep treat…

This study tested a combination of three drugs (encorafenib, binimetinib, and cetuximab) given before surgery to people with a specific type of colorectal cancer that has a BRAF V600E mutation. Only 2 patients took part. The goal was to see how much the tumor shrank and to check …

This study tested whether taking a daily mix of dietary fiber and probiotics for 12 weeks could improve gut bacteria, immune function, and nutrition in 80 malnourished patients with advanced colorectal cancer. Participants received either the supplement or standard nutritional ad…

This study tested a new drug called SAR444245 combined with other cancer treatments in 138 adults with advanced gastrointestinal cancers, including esophageal, stomach, liver, and colorectal cancer. The goal was to see if the combination could shrink tumors. The study is complete…

This early-phase trial tested a combination of two drugs—copanlisib and nivolumab—in 48 adults with advanced solid tumors, specifically a type of colorectal cancer called MSS that usually doesn't respond to immunotherapy alone. The goal was to see if the combination could shrink …

This study tested a new drug called zanidatamab (ZW25) combined with standard chemotherapy in 74 people with advanced HER2-positive cancers of the stomach, bile duct, or colon. The goal was to see if the combination is safe and shrinks tumors. Results will help decide if larger s…

This early-phase study tested an experimental drug called TPST-1495, taken as a pill, either alone or combined with the immunotherapy Keytruda (pembrolizumab). The trial included 89 people with advanced solid tumors like colorectal, lung, head and neck, and endometrial cancers wh…

This early-phase trial tested an experimental immunotherapy called ELI-002 in 25 people with KRAS-mutated pancreatic, colorectal, lung, ovarian, or bile duct cancers who had signs of remaining disease after standard treatment. The therapy aims to train the immune system to attack…

This small, early-phase trial tested a combination of two drugs—cetuximab and capecitabine—as a maintenance treatment for people with a specific genetic type of advanced colorectal cancer (KRAS/BRAF wild-type). The main goals were to check safety, find the best dose, and see how …

This early-phase trial tested a new drug called PTX-100 in 25 people with advanced cancers like multiple myeloma, lymphoma, and certain solid tumors. The goal was to find safe doses and understand how the drug behaves in the body. Participants received the drug by IV for five day…

Researchers test a two-step PET scan to find colorectal cancer that has spread to the liver or other organs. The scan uses an antibody that sticks to a protein called CEA on cancer cells, then a radioactive peptide that lights up those cells. Adults with colorectal cancer that ma…

Researchers at Washington State University are testing whether tailored digital messages can increase colorectal cancer screening among American Indian and Alaska Native adults aged 50 to 75. The trial compares screening rates between people who receive the messages and those who…

This study looked at whether a new at-home stool DNA test (Cologuard) can help more Alaska Native people get screened for colorectal cancer, which is very common in this group. About 2,000 Alaska Native adults who were due for screening took part. The test was offered in differen…

This trial tests a blood-based test designed to detect multiple cancers early in people aged 40 to 74 who have no cancer symptoms. The study will enroll about 2,500 participants and will check how well the test identifies lung, colorectal, liver, gastric, and esophageal cancers. …

This trial tests how accurately an AI system, called GI Genius, can identify which polyps found during a colonoscopy are adenomas, the type that can become cancer. About 395 adults undergoing screening, diagnostic, or surveillance colonoscopy will receive the AI-assisted procedur…

This study investigates whether a protein called FGF19, normally found in the intestine and gallbladder, appears at higher levels in the blood of people with breast or colorectal cancer compared to healthy individuals. Researchers will measure FGF19 and related markers in fasting…

This pilot study tested whether ultrasound can detect nerve damage caused by the chemotherapy drug oxaliplatin in people with gastrointestinal cancer. Twenty participants who had or were receiving oxaliplatin and had symptoms of nerve damage underwent nerve ultrasounds, skin biop…

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This early-phase trial tested a radioactive tracer called 68Ga-NODAGA-SNA009 in 12 people with colorectal cancer. The tracer targets a protein (GPA33) found on cancer cells and is used with PET scans to see where the cancer is in the body. The main goals were to check safety and …

This study tested whether specially trained dogs can identify breast, lung, prostate, or colorectal cancer by sniffing breath samples collected on masks. Over 1,300 people provided breath samples before their regular cancer screening or biopsy. The dogs' results were compared to …

This pilot study compared two stool-based tests—Cologuard and the fecal immunochemical test (FIT)—for colorectal cancer screening in adults aged 45-49. Researchers mailed the tests to eligible participants and tracked how many completed screening, had abnormal results, and follow…

This study looked at three screening methods—colonoscopy, colon capsule endoscopy, and a fecal immunochemical test (FIT)—to detect colorectal cancer or advanced growths in people aged 45 and older who have a first-degree relative with colorectal cancer. The goal was to see if the…

This study looked at whether offering a blood test for colorectal cancer screening would be accepted by average-risk patients in Appalachian outpatient clinics. Over 200 participants were given the option of a standard screening method or a blood-based test called Shield. The goa…

This study tested a new radioactive tracer called [18F]FAPI-74 for PET scans in people with gastrointestinal cancers, including liver, bile duct, stomach, pancreatic, and colorectal cancers. The goal was to see if the tracer can accurately detect cancer cells by comparing scan re…

This study tested a new blood test designed to find colorectal cancer early in people at average risk. Nearly 49,000 adults aged 45-85 gave a blood sample before their routine colonoscopy. The goal was to see how well the blood test could detect cancer and advanced growths compar…

This study tested whether using a camera capsule (a pill you swallow) as a first test for bowel cancer screening could encourage more people to get screened and find more polyps or cancers. Over 2,000 people in Denmark took part. The goal was to see if this approach reduces the n…

Researchers are testing whether a supplement made from nine fungal extracts, called MICODIGEST 2.0, can reduce complications after surgery for colorectal cancer. The trial enrolls 48 adults scheduled for curative-intent surgery. Half receive the supplement and half receive a plac…

This trial tests whether using a technique called hybrid argon plasma coagulation (h-APC) on the edges of the removal site can prevent colon polyps from growing back after endoscopic mucosal resection (EMR). EMR is a standard procedure for removing large polyps, but when polyps a…

This study tested a program to increase colorectal cancer screening among adults aged 50-74 in 12 counties in Appalachian Kentucky and Ohio. The program included efforts targeting clinics, doctors, patients, and the community. Researchers measured screening rates using clinic rec…

This trial tests whether a structured education program can improve colorectal cancer knowledge, health beliefs, and screening uptake in adults aged 50-70. Participants are randomly assigned to receive the program—combining face-to-face teaching, a video, and a brochure—or to a c…

This trial tests whether sending a colorectal cancer screening kit directly to people's homes, along with the invitation letter, increases the number of people who get screened. It compares this approach to the standard practice of asking people to visit their doctor to receive t…

This study tested a community-based program to encourage colorectal cancer screening in rural China. Over 20,000 adults aged 45-70 took part. The goal was to increase the number of people who complete a colonoscopy after initial risk assessment and stool tests, since early detect…

This study tests whether a remotely-delivered patient navigation program helps more rural adults complete colonoscopy screening for colorectal cancer. Participants aged 45-75 who are due for a colonoscopy receive either navigation support from a trained lay navigator or an educat…

This study tests whether giving general practitioners a list of patients who have not completed colorectal cancer screening encourages those patients to get screened. Over 48,000 patients aged 50-74 are involved, and their doctors either receive the list or do not. The goal is to…

This study tested whether personalized reminders (like texts or emails) could encourage more people to return their at-home stool test kits for colon cancer screening. Over 2,100 adults aged 45 to 75 who had not yet returned their kit took part. The goal was to see if these gentl…

This study looked at whether a Mediterranean diet, weight loss, or both could lower colorectal cancer risk in 180 obese African Americans aged 45-75. Participants followed one of four plans for six months, and researchers measured changes in bile acids, gut bacteria, and cell act…

This study looked at whether mailing free stool tests (FIT kits) to people's homes could increase colorectal cancer screening rates. Over 4,300 adults aged 45-75 who were at average risk took part. The goal was to make screening easier for those who might otherwise skip it, espec…

This study looked at whether giving extra help and information to spouses of colorectal cancer patients could get them to complete a simple at-home screening test (FIT). About 60 people took part. The goal was to find out what stops them from screening and if a tailored approach …

This phase 3 trial compared colonoscopy with annual fecal occult blood tests for colorectal cancer screening in nearly 5,000 healthy adults aged 50-69. The goal was to see which method finds more early tumors and has a better balance of benefits and harms. Participants were rando…

This study tested whether taking magnesium supplements could reduce the risk of colorectal cancer in people with a specific genetic makeup. Researchers gave 250 participants either magnesium or a placebo for 12 weeks and measured changes in colon tissue markers linked to cancer d…

This study tested a smartphone-based program designed to help African American men get screened for colorectal cancer. 128 men who were not up-to-date on screening received either the new program (text messages with videos and quizzes) or standard educational texts. After 6 month…

This study tested whether omeprazole, a common heartburn medication, could prevent nerve damage caused by oxaliplatin chemotherapy in 46 adults with colorectal or pancreatic cancer. Participants took omeprazole before and during chemotherapy cycles. The goal was to see if it redu…

This study looked at two oral chemotherapy drugs, Xeloda and UFT with folinic acid, in 89 people with advanced or metastatic colorectal cancer. The main goal was to see which treatment patients preferred after trying both. The study also checked how safe each drug was. Results he…

Researchers are studying whether a stoma self-care app, accessed through the LINE messaging platform, can help people with an enterostomy improve their self-care and quality of life. The study enrolls 50 adults who have a colostomy and can use a smartphone. It combines two models…

Researchers at Jagiellonian University are studying whether a supplement made from freeze-dried black raspberries and strawberries affects inflammation in people over 65 receiving treatment for colorectal cancer. About 70 participants take the anthocyanin-rich supplement for 21 d…

This study tests an internet-based self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. About 48 people who finished treatment for early-stage breast or colorectal cancer will try the program. The goal i…

This study tests whether a conversation game called 'Hello' can help people with cancer and their loved ones discuss advance care planning—decisions about future medical care. Participants will play either the Hello game or a similar conversation game, complete questionnaires, an…

This study tests an online cognitive therapy program, guided by a therapist, to help colorectal cancer survivors who have finished treatment reduce their fear of the cancer returning. The program includes educational text, exercises, and videos. Researchers will compare it to sta…

This study tests a new traction device called SureTrac to help doctors remove large colorectal lesions (precancerous growths) more easily. The device pulls the lesion upward during a procedure called submucosal dissection, which may make the surgery faster, safer, and more likely…

This pilot study explores whether cancer patients are willing to complete a quick self-screening for insomnia during clinic visits, and whether a video-based cognitive behavioral therapy (CBT-I) could help them sleep better. The study involves adults with breast, colorectal, lung…

This trial tests a nurse-assisted eHealth program for patients with heart failure or colorectal cancer. After leaving the hospital, participants use a tablet with the MyDignio app to track vital signs and symptoms, and communicate with a nurse navigator. The goal is to see if thi…

This study tests whether a home-based telerehabilitation program can improve functional capacity and quality of life for patients recovering from colorectal cancer surgery. Fifty-four participants will either follow the digital program or receive a standard booklet. The goal is t…

This study tested a small, disposable device that gently stimulates nerves in the ear to see if it could reduce the amount of strong painkillers (opioids) needed after open abdominal or pelvic surgery. 286 adults who had surgery for cancer or a liver transplant took part. The goa…

This trial compares two approaches to a nerve block (TAP block) for pain after colorectal cancer surgery. One group receives the standard numbing drug bupivacaine, while the other gets bupivacaine plus dexmedetomidine, a drug that may extend pain relief. The study measures pain s…

This study tested a drug called M701, given directly into the belly, combined with standard cancer therapy, for people with malignant ascites (fluid buildup) from stomach, colon, or ovarian cancer. The goal was to see if M701 could delay the need for fluid drainage and improve su…

This study looked at whether placing a bridge device during loop ileostomy creation reduces complications like infections or stoma problems. 166 adults having elective colorectal surgery took part. The goal was to see if the device improves outcomes or just adds difficulty to car…

Many colorectal cancer survivors lose muscle mass and strength after chemotherapy. This study tested whether adding creatine supplements to a 10-week resistance training program could help. Twenty-seven survivors participated, comparing those who took creatine with those who only…

This study tested a web app called PrehabPal designed to help frail adults aged 65 and older prepare for colon cancer surgery. The app creates a personalized prehabilitation program and offers coaching. Researchers compared it to standard written instructions in 132 participants …

This study tested an investigational drug called ponsegromab in 187 adults with lung, pancreatic, or colorectal cancer who also had cachexia—a condition causing severe weight loss, loss of appetite, and fatigue. The goal was to see if ponsegromab could help patients gain weight a…

This study tested whether silkworm pupa tablets can improve nutrition and reduce frailty in people who had surgery for stomach, colorectal, esophageal, or pancreatic cancer. 120 participants took the tablets for 3 months. Researchers measured weight, frailty, muscle mass, and qua…

This study looked at whether doing special exercises before colorectal cancer surgery (called prehabilitation) helps patients recover better compared to standard care. Over 700 adults scheduled for surgery took part. The main goal was to see if the exercise group had better physi…

This study tested a web-based support program for people with colorectal cancer undergoing treatment. The program provided information and tips on physical, emotional, and daily-life challenges. Researchers measured whether it helped reduce symptoms and improve quality of life co…

This study looked at whether chewing gum after colorectal surgery can help reduce nausea, vomiting, and get the bowels working again sooner. 84 adults who had laparoscopic colorectal surgery took part. The idea is that chewing tricks the body into thinking it's eating, which may …

This phase II trial tested a concentrated plant dietary supplement (made from foods like taro, rice, and carrots) in 30 people with gastrointestinal cancers who had diarrhea from chemotherapy. Participants received the supplement alongside standard anti-diarrheal treatment. The g…

This study tested a stepped-care telehealth program for cancer survivors living in rural areas who experience anxiety, depression, or sleep problems. Participants received either low-intensity check-ins or high-intensity phone therapy with a licensed therapist, depending on sympt…

This study tested a personalized rehabilitation program for 150 adults who finished treatment for colorectal cancer. The program connects patients with specialists like physiotherapists, dietitians, and psychologists based on their individual needs. The goal was to improve qualit…

This study tested whether group-based cancer rehabilitation could work when done virtually instead of in person for people with advanced breast or colorectal cancer. 111 participants were offered either in-person or online sessions to see which was more practical and acceptable. …

This pilot study tested whether offering free, personalized legal services to people with advanced colorectal cancer could help reduce stress, financial worries, and improve quality of life. Twenty participants received help from a nonprofit legal organization for six months. Res…

This study tested whether taking N-Acetylcysteine before chemotherapy could reduce nerve damage in colorectal cancer patients receiving oxaliplatin. 46 participants received either N-Acetylcysteine or a placebo before each chemo session. The goal was to see if the supplement coul…

This completed trial tested a web-based remote monitoring platform called CONTINUUM+ CONNECT in 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Patients used the platform to report symptoms and receive alerts, aiming to improve their physical health and q…

This study tested whether an oral iron pill (ferric maltol) can improve anemia in 40 adults after colorectal cancer surgery, compared to standard care. The main goal was to see if a larger study is possible, while also checking blood iron levels. The approach is simple and aims t…

This study tested whether nursing interventions based on the Levine Conservation Model could help colorectal cancer patients cope with fatigue, nerve damage, and anxiety caused by chemotherapy. 68 patients receiving the FOLFOX regimen were taught to use sensory balls, progressive…

This study looked at whether adding acupuncture to standard recovery care helps colon cancer patients get their digestion back on track faster after surgery. 70 patients were split into two groups: one got standard care, the other got standard care plus acupuncture sessions. Thos…

This study tested whether a 20-minute education session before colorectal surgery helps patients recover faster. 88 adults with colorectal cancer took part. Half received the extra education based on ERAS guidelines, and half got the usual care. The main goal was to see if the ed…

This study looked at whether listening to music for a week before colon cancer surgery can lower anxiety. 116 adults scheduled for surgery were asked to listen to music three times a day. Their anxiety levels were compared to a group that did not have a music routine. The goal is…

This study tested a specially designed corset to help people with colorectal cancer feel more comfortable during continuous 5-FU chemotherapy. Forty patients were split into two groups: one used the corset, the other received standard care. Researchers measured discomfort, anxiet…

This study tested whether neurotropin, a drug that may protect nerves, can reduce the nerve damage caused by oxaliplatin chemotherapy in people with stage II or III colorectal cancer. The trial included 333 participants who had surgery and were about to start chemotherapy. Resear…

This study tested whether an online program combining nutrition counseling and resistance training could improve physical function in older adults (65+) who finished treatment for breast, colorectal, or prostate cancer. 75 participants received virtual sessions with dietitians an…

This study tested a 12-week nursing program based on the Roy Adaptation Model for adults who recently had a colostomy. It aimed to reduce anxiety and depression and improve quality of life compared to standard care. 115 participants were randomly assigned to either the special pr…

This early-stage study tested a new mind-body program designed to help female survivors of colorectal and anal cancer improve their sexual well-being. Six women who had finished initial cancer treatment took part in group sessions. The main goal was to see if the program was acce…

This study tested whether a nerve block called the erector spinae plane block (ESPB) can reduce pain and the need for opioids after robotic colorectal surgery. 70 patients with colorectal cancer were enrolled. The block is a simple ultrasound-guided injection near the spine. Rese…

This study looked at whether applying a topical diclofenac gel to the hands and feet could prevent or delay hand-foot syndrome in patients with colorectal or gastric cancer taking capecitabine. About 150 patients were observed at two cancer centers in Turkey. The goal was to see …

This completed study tested whether Reiki, a gentle touch therapy, can reduce pain, anxiety, and improve recovery in 64 patients who had colorectal cancer surgery. Patients received Reiki sessions after surgery, and researchers measured their pain, anxiety levels, and vital signs…

This study tested whether taking zinc supplements and applying a strong steroid cream (clobetasol) can prevent or reduce hand-foot skin reaction, a common and painful side effect of the cancer drug regorafenib. About 150 patients starting regorafenib were split into three groups:…

This study looked at whether early contact with a palliative care unit improves quality of life for people with advanced cancers of the upper gastrointestinal tract or colorectal cancer. 108 participants were randomly assigned to either early palliative care or standard care (con…

This completed phase 3 trial tested whether taking psyllium husk fiber capsules during pelvic radiation therapy could reduce gut inflammation and urgency symptoms. 354 adults with pelvic cancers (like rectal, prostate, or gynecological) took either fiber or placebo capsules daily…

This study tested a mobile app called PainPac designed to help people with colorectal cancer manage pain. The app provides coping strategies and tracks symptoms in real time. Researchers enrolled 62 adults with stage I-IV colorectal cancer to see if the app was easy to use and ac…

This study tested two types of nerve blocks—Quadratus Lumborum (QL) and Erector Spinae (ESP)—to see which provides better pain relief after abdominal surgery. 100 adults having surgery for colorectal, prostate, or kidney cancer, or gallbladder removal, received one of the blocks …

This study tested whether yoga-based breathing exercises can reduce pain, fatigue, and insomnia and improve self-efficacy in people recovering from colorectal cancer surgery. 80 patients were split into two groups: one did the breathing exercises twice daily for about 20 minutes,…

This study investigates whether the unique bacteria found inside digestive system tumors can help predict how well a patient will respond to neoadjuvant therapy (chemotherapy before surgery). Researchers will analyze tumor samples from 90 adults with pancreatic, gastric, colorect…

Researchers at Ghent University Hospital are studying whether MRI scans combined with computer models can measure the pressure inside tumors. High pressure in tumor tissue can block cancer drugs from reaching their target. The study enrolls 22 patients with pancreatic cancer or w…

Researchers are studying whether delays in follow-up colonoscopies after certain polyp findings raise the risk of advanced growths or colorectal cancer. The study looks at medical records of adults aged 45 to 80 who had serrated lesions or high-grade dysplasia found during a colo…

Researchers at Centre Oscar Lambret are studying how immune cells get inside breast and colon tumors. They will analyze stored tumor samples from about 70 patients treated between 2005 and 2007, looking at genes and proteins on blood vessel cells that may control this process. Th…

This study aims to identify which of four French-validated questionnaires is most suitable for assessing sexual function in women who have had surgery for rectal or recto-sigmoid cancer. Researchers will ask 50 women to complete all four questionnaires and rank their preferences.…

This study tests whether a novel MRI technique called Fast Field Cycling imaging and the bacteria in the mouth and bowel can predict how well rectal cancer responds to chemoradiotherapy given before surgery. Researchers will scan 15 patients three times and collect saliva and sto…

This study examines national data from Switzerland to understand trends in early-onset colorectal cancer, which affects people under 50. By analyzing surgical cases from 2003 to 2022, researchers aim to see how common this cancer is, where it occurs, and what short-term outcomes …

This study looks at whether obesity, measured by body mass index (BMI), affects the chances of a 'textbook outcome' after minimally invasive surgery for colorectal cancer. A textbook outcome means the surgery went smoothly with no major complications, a short hospital stay, and n…

This trial tests whether a 15-minute educational video and a list of suggested questions can improve understanding of immunotherapy among patients with advanced cancer and their caregivers. Participants are randomly assigned to receive the educational materials or usual care, and…

This study looks at whether changes in tumor DNA found in the blood (ctDNA) can predict if chemotherapy is working in people with advanced colorectal cancer that no longer responds to standard treatments. About 103 participants will give blood samples and have regular scans to tr…

This study investigates whether a protein called WT1 is present in colorectal cancer tissue and whether its presence relates to tumor characteristics like grade, spread, and invasion. Researchers will analyze tissue samples from 60 patients with colorectal adenocarcinoma using a …

This study looks at whether stopping certain blood pressure medications (ACE inhibitors or ARBs) before colorectal cancer surgery can reduce the risk of heart injury. Researchers will monitor 156 adults for signs of heart damage after surgery. The goal is to find the safest way t…

This trial is testing whether contrast-enhanced ultrasound (CEUS) can reliably measure tumor blood flow in people with metastatic cancers like GIST, breast, kidney, colon, rectal, or melanoma. Participants will have two ultrasound scans before starting anti-angiogenic treatment, …

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to one of these two methods or to standard care. The goal was to se…

This pilot study tested whether a mindfulness program could help reduce colorectal cancer risk factors in Black women aged 45-65 who live in high-crime Chicago neighborhoods and have had a colon polyp. Twenty-four women participated to see if the program was feasible and acceptab…

This study looks at whether having certain E. coli bacteria in the colon after colorectal cancer surgery is linked to anxiety or depression. Researchers will compare psychiatric symptoms and diagnoses between patients who carry the bacteria and those who do not. The goal is to be…

This study measures the carbon dioxide emissions produced during colonoscopy for colorectal cancer screening, including energy use, equipment, medications, and waste. Researchers will also compare different polypectomy techniques to see which are more eco-friendly. The goal is to…

This study looks at people who develop a leak after colorectal cancer surgery. Researchers will track which patients need emergency surgery, die within 90 days, or end up with a permanent stoma. The goal is to find factors that predict these outcomes and help guide future care.

This large Italian study investigates whether a composite measure called 'Textbook Outcome' can serve as a reliable indicator of quality in colorectal cancer surgery. Researchers will analyze data from over 6,000 patients to see if meeting six key criteria—including survival, com…

This study compares two catheters used during the mapping step before radioembolization for liver cancer. One is a standard microcatheter, the other is a pressure-enabled device (TriNav). The goal is to see if the pressure-enabled catheter delivers more radioactive tracer directl…

This study aims to create a simple model that uses routine clinical and lab data from the first day after colorectal cancer surgery to predict the risk of anastomotic leakage—a serious complication where the surgical connection leaks. Researchers reviewed records of 117 patients …

This study tests a computerized tool that collects patient information and generates personalized, guideline-based next steps for colorectal cancer screening. It focuses on a large, diverse population of under- and uninsured patients in Dallas. The goal is to improve screening ra…

This study aims to create a mindfulness program designed for couples where one partner has metastatic colorectal cancer. Researchers will interview patients, their partners, and clinicians to understand their needs and preferences for such a program. The goal is to design a progr…

This study tested a physical activity program called PACE for African American colorectal cancer survivors. Researchers wanted to see if the program was practical and could increase steps and exercise. Twenty-one participants used Fitbits and watched videos to track their activit…

This study investigates whether women who have completed breast cancer treatment have a higher chance of developing colorectal polyps or colon cancer. Researchers will perform screening colonoscopies in 216 asymptomatic breast cancer survivors and check for abnormal growths. The …

This study tested whether a weekly electronic survey could help identify cancer treatment delays and racial differences. About 100 adults with newly diagnosed breast or colorectal cancer who hadn't started treatment yet filled out a short survey each week for 8 weeks. The goal wa…

This study investigates how differences in cell membrane voltage, caused by varying physical pressures inside a tumor, help colorectal cancer resist chemotherapy and evade the immune system. Using advanced lab models and tissue samples from 11 patients, researchers found that cel…

This study looked at whether a new blood test called EPISPOT can predict how well chemotherapy works in people with metastatic colorectal cancer. Researchers measured circulating tumor cells in 168 patients before and during treatment. The goal was to see if early changes in thes…

This study looked at the safety of Bevacizumab-Pfizer Biosimilar, a drug used to treat colorectal cancer, by analyzing medical records from 1,000 patients in Japan. Researchers focused on side effects like bleeding, high blood pressure, and kidney problems. The goal was to unders…

This study tested whether a theory-based chatbot could increase colorectal cancer screening rates. 500 adults aged 50-75 in Hong Kong were randomly assigned to receive either standard text reminders or a chatbot that provided personalized risk information and screening guidance. …

This completed study looked at how nerve damage from the chemotherapy drug oxaliplatin affects hand function, grip strength, and quality of life in 103 colorectal cancer patients. Researchers measured hand and finger strength, dexterity, and daily living abilities using standard …

This study looked at whether a nerve block called the erector spinae plane block can protect kidney function during laparoscopic colorectal cancer surgery. Sixty adults having this surgery were divided into two groups: one received the nerve block plus standard anesthesia, the ot…

This study looked at 30 colorectal cancer patients to see if tumor deposits (small clusters of cancer cells found near the main tumor) can help predict survival and whether the cancer spreads to other organs. Researchers tracked overall survival and the appearance of new metastas…

This study looked at the best ways to encourage childhood cancer survivors who are at high risk for colorectal cancer to get screened at the recommended age. Researchers tested different methods to see which helped more people complete a colonoscopy or stool-based test. The goal …

This study looked for leftover cancer DNA in the blood of over 2,000 people who had surgery for stage II or III colorectal cancer. Participants did not receive any new treatment—they just gave blood samples over about 21 months. The goal was to find patients who might be eligible…

This study looked at 590 colorectal cancer patients to develop a risk tool that predicts postoperative delirium—a common complication causing confusion and slower recovery. Researchers combined blood test results (including the TyG index) with patient subtypes to create a scoring…

This study looked at whether an AI computer program could suggest cancer treatments that match what experts recommend. Researchers reviewed medical records of 30 people with stomach, colon, or pancreatic cancer. They entered key details into the AI and compared its suggestions to…

This study followed 159 people with metastatic colorectal, pancreatic, biliary, or esophageal cancers who were starting a new line of therapy. Researchers collected blood samples (tumor markers and liquid biopsies) and patient-reported quality-of-life data to see if these could p…

This study looked at 140 patients who had colon cancer surgery and chemotherapy at Rouen University Hospital. The goal was to see if living farther from the hospital caused a longer wait to start chemotherapy after surgery. The findings could help improve care for patients who li…

This completed study looked at how well young and middle-aged colorectal cancer survivors can identify and describe their specific emotions—a skill called emotional granularity—and whether that helps them build resilience. Researchers surveyed 242 survivors online and interviewed…

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study looked at 150 colorectal cancer patients to see if counting tumor buds in biopsy samples could predict whether cancer has spread to lymph nodes or other organs. Researchers used a special stain to find tumor buds and counted them in the densest area. They then used a c…

This study involved 132 adults with colorectal cancer who had standard surgery (low anterior resection) and a temporary ileostomy (a stoma to divert waste). The goal was to measure major complications after surgery and create a single safety endpoint. This will help doctors compa…

This study tested a new classification system for people whose colorectal cancer has spread only to the liver. Researchers looked at survival rates and compared different patient groups to see if the system helps predict outcomes. The goal is to better identify which patients mig…

This completed study looked at how often joint pain occurs in 71 people with ovarian, colorectal, or lung cancer who were taking the drug bevacizumab. Participants filled out a questionnaire about their joint pain over 6 months. The goal was to better understand this side effect.

This completed study looked back at medical records of 500 patients aged 50 or younger diagnosed with colorectal cancer or precancerous growths at a hospital in Shenzhen, China. Researchers compared those with early-stage disease to those with later-stage disease to identify fact…

This study looked at 26 adults having colorectal (bowel) cancer surgery while placed in a steep head-down position with legs raised in stirrups. Researchers measured blood flow and oxygen in the calf muscles during the operation to understand how a rare but serious leg injury cal…

This study looked at 200 older adults (65+) having planned surgery for colorectal cancer. Researchers used a frailty test before surgery to see if it could predict complications like infections or longer hospital stays. The goal is to help doctors better plan care and reduce risk…

This study tested whether a flexible, personalized exercise program is practical for cancer patients receiving chemotherapy. Twenty-one adults with breast, ovarian, or colorectal cancer took part. The main goal was to see if patients would join, attend, and stick with the exercis…

This study looked at how prostate and colorectal cancer affect mitochondria—the energy factories in cells—and whether a 4-week home exercise program could improve them. Fifteen men awaiting surgery did either resistance or high-intensity interval training at home. Researchers mea…

This study tested whether using an artificial intelligence system (ENDOAID) together with a small attachment on the colonoscope (Endocuff) helps doctors find more precancerous polyps (adenomas) than using AI alone. Over 1,700 adults aged 45-85 undergoing colonoscopy for screening…

This study looked at whether adding walnuts to your diet can change the bacteria in your gut and reduce signs of colon cancer risk. About 140 people at higher risk for colorectal cancer ate walnuts for a month. Researchers measured changes in gut bacteria, blood markers, and colo…

This study looked at whether using a standardized set of measurements, including patient-reported outcomes, can improve care for people with colorectal cancer. Researchers followed 133 patients over time, collecting data on their health and quality of life. The goal was to see if…

This study looked at 74 people with metastatic colorectal cancer starting their first chemotherapy. Researchers took blood samples early in treatment to measure three markers: CEA, circulating tumor DNA, and total cell-free DNA. The goal was to see if early changes in these marke…

This study followed 56 patients who had surgery for non-metastatic colon cancer to see if the number and type of immune cells in their tumors could predict whether the cancer would come back. Researchers analyzed both blood samples and tumor tissue for various immune markers. The…

This study looked at whether a genetic test called QMPSF can help predict if stage II or III colon cancer will come back after surgery. Researchers analyzed tumor tissue from 401 patients for specific DNA changes. The goal was to see if these genetic markers are linked to cancer …

This study looks at whether certain combinations of genetic variations, rather than a single gene, can increase the risk of colorectal cancer. Researchers will compare the DNA of 700 patients with strong family histories of the disease against 350 healthy controls. The goal is to…

This study looked at 846 people who had a positive stool test for colorectal cancer and needed a follow-up colonoscopy. Researchers wanted to understand how involved patients felt in making decisions about their care and how satisfied they were with the entire screening and treat…

This study looked back at the medical records of 500 people with colorectal cancer from two regions in China. Researchers collected information on patients' backgrounds, lifestyle, and treatments to find patterns that affect survival. The goal was to understand regional differenc…

This completed study looked at 29 patients with a hard-to-treat form of advanced colorectal cancer. The goal was to find new ways to group these patients based on the biology of their tumors. This could help doctors choose more effective treatments in the future. The study did no…

This study looked at 76 adults with advanced colorectal cancer to find genetic markers that might predict how well a combination of chemotherapy (FOLFOX) and the drug bevacizumab works. The goal was to understand which patients benefit most, not to test a new cure. Participants h…

This study tested whether starting a colonoscopy with the patient lying on their back (supine) or on their left side (left-lateral) makes a difference. Researchers measured how long it took to complete the procedure, how much pain patients felt, and how difficult the procedure wa…

This study looks at whether the drug T-DXd works better than standard treatments for people with several types of HER2-positive solid tumors. Researchers will compare data from previous T-DXd trials with real-world medical records of patients who received standard care. The goal …

This study looked at how two different diets affect gut bacteria and markers linked to colon cancer risk in 15 African American adults at higher risk. Participants ate a high-fat, animal-based diet and a low-fat, plant-based diet for three weeks each. Researchers measured changes…

This completed study from West China Hospital examined tumor tissue from 100 colorectal cancer patients who had already received immunotherapy. Researchers measured levels of a protein called PHGDH to see if it was linked to how well the patients responded to treatment and how lo…

This study gave educational materials about colorectal cancer and screening to 188 adults aged 45-75 in the Tampa Bay area. Researchers used surveys to measure changes in knowledge and screening intentions. The goal was to see if education encourages people to talk to their docto…

This study looked at whether using a special balloon-assisted scope (G-Eye) together with artificial intelligence (CAD-Eye) finds more polyps than a standard colonoscopy with AI alone. About 300 people aged 50-74 who had a positive stool test took part. The goal was to see if the…

This study looked at nearly 1,000 cancer survivors to find out which follow-up care model works best for their quality of life and satisfaction. Participants were breast, prostate, or colorectal cancer survivors who had finished active treatment. Researchers compared different ca…

This completed study looked at 101 adults having laparoscopic colorectal surgery under general anesthesia. Researchers tested different levels of positive end-expiratory pressure (PEEP) after a lung recruitment maneuver to see how long the benefits lasted and how it affected hear…

This study tested whether a lung protective ventilation strategy (a gentler way of breathing during surgery) affects inflammation around tumors and certain blood markers in 60 colorectal cancer patients. Half received standard ventilation, half received the protective method. Res…

This study tested how different social media messages influence people's plans to get screened for colorectal cancer. Over 2,000 participants completed a 15-minute survey after seeing one of several message types. The goal was to see which messages made people more likely to foll…

This study looked at 100 adults having laparoscopic surgery for colon cancer to see if the amount of oxygen delivered to tissues during the procedure affects the risk of a leak where the bowel is reconnected. Researchers measured oxygen delivery using a non-invasive monitor. The …

This pilot study looked at whether repeated FDG-PET/CT scans can help select patients and evaluate how well a special chemotherapy (PIPAC) works for cancer that has spread to the lining of the abdomen. 34 patients with various abdominal cancers were included. The goal was to see …

This completed study tested a blood test that looks for tiny cancer leftovers after surgery in 175 people with stage II or III colorectal cancer. The goal was to see if the test could identify who really needs chemotherapy. If it works, it could help personalize treatment and avo…

This study followed 704 adults with metastatic colorectal cancer who received regorafenib through a French compassionate-use program. Researchers measured how long patients lived after starting the drug and collected data on tumor characteristics and prior treatments. The goal wa…

This study looked at 598 people who had surgery to remove colorectal cancer with the goal of curing it. Researchers wanted to understand how often the cancer comes back after five years and where it returns. The goal is to use this information to create better follow-up care plan…

This study tested a digital chatbot (called CATALYST) to help cancer survivors learn about genetic testing for inherited cancer risk. Fifty adults who had certain cancers (like breast, ovarian, or prostate) used the chatbot or received usual care. The goal was to see if the chatb…

This study looks at data from 121 people with metastatic colorectal cancer who received two approved treatments—regorafenib and TAS (with or without bevacizumab)—in different orders. Researchers want to see which sequence works better and how long patients live. Since this is an …

This study reviewed the medical records of 255 adults who had colorectal polyps removed during a colonoscopy. The goal was to find out which factors, such as how the polyp was removed or its tissue type, make it more likely to come back. Researchers also tracked any complications…

This study tested an 11-step community program to help African Americans get screened for colorectal cancer. The program included education, risk assessment, and help with barriers like cost, transportation, and scheduling. 163 participants joined, and the study measured whether …

This pilot study tested whether training primary care doctors in shared decision-making could increase colorectal cancer screening rates. Doctors in quality circles received evidence summaries, decision aids, and stool test kits to help patients choose between colonoscopy and FIT…

This study looked at 143 people in China who had a second surgery after rectal cancer treatment because of a leak or tumor return. Researchers wanted to find out what factors help the surgery succeed and whether patients can regain the ability to poop normally. The goal is to bet…

This study looked at whether using a special dye (indocyanine green) during laparoscopic surgery for colon or rectal cancer can help surgeons see blood flow in real time and reduce the risk of a dangerous leak where the bowel is reconnected. Researchers compared 115 patients who …

This completed study with 297 participants examined if offering a blood-based screening test (Guardant Shield) encourages people who previously avoided stool tests or colonoscopy to get screened for colorectal cancer. Participants were adults aged 45-75 at average risk who had no…

This study looked at whether two simple frailty questionnaires (G8 and VES-13) can predict serious side effects from chemotherapy in people 65 and older with gastrointestinal cancers. Researchers followed 72 patients receiving standard chemotherapy and checked their frailty, nutr…

This study tested whether a program that uses computer algorithms to identify people who are overdue for colorectal cancer screening, combined with a patient navigator to help them schedule and complete the test, could increase screening rates. The study included 385 adults livin…

This study looked at 227 people with colorectal cancer that had spread to the lining of the belly. Researchers wanted to see if waiting longer between chemotherapy and surgery affected how long patients lived without the cancer coming back. The goal is to find the best timing for…

This study looked at how a digital care planning tool (eHNA) can help personalize care for people with colorectal cancer. Researchers interviewed 76 patients and clinicians to understand what works and what doesn't. The goal was to identify best practices for using digital tools …

This study looked at 3000 cancer patients to see which treatments work best for preventing dangerously low white blood cell counts after chemotherapy. It compared different approaches to see how well they prevent infections and improve quality of life. The goal is to give doctors…

This study tested whether a blood test can find tumor cells or substances released by intestinal polyps. Researchers compared blood samples from 120 people with and without polyps during a colonoscopy. The goal is to see if these markers could help predict or monitor cancer sprea…

This completed study analyzed tumor and blood samples from 160 people with esophageal or rectal cancer. Researchers looked for genetic markers in the EGFR signaling pathway that might predict how well a patient responds to chemoradiotherapy given before surgery. The goal is to be…

This study looked at whether eating certain fats (polyunsaturated fatty acids) is linked to colorectal cancer risk. Researchers measured fatty acids in fat tissue and blood samples from 551 people with and without colorectal cancer. The goal was to find reliable biomarkers that c…

This study tested whether offering a simple blood test instead of a colonoscopy or stool test would encourage more people to get screened for colorectal cancer. Researchers enrolled 297 adults aged 45-75 who had previously skipped or refused traditional screening. The goal was to…

This study looked at whether a nurse practitioner can safely monitor people with colorectal cancer who are getting intravenous chemotherapy, compared to a doctor. About 207 adults took part. The goal was to see if the number of serious side effects and quality of life were simila…

This study tested a step-by-step plan for patients who had high C-reactive protein (CRP) levels after surgery for colorectal cancer. High CRP can signal a serious complication called an anastomotic leak, where the surgical connection leaks. The goal was to see if a proactive mana…

This study looked at whether proteins in the blood can help screen for colorectal cancer. Researchers tested blood samples from 350 people aged 50 and older who were already scheduled for a colonoscopy. The goal was to see if certain protein markers could reliably detect advanced…

This study looked at how bevacizumab, a drug used to treat advanced colorectal cancer, affects the stiffness of arteries. Researchers measured artery stiffness in 13 patients before and after 4 months of treatment. The goal was to better understand the drug's cardiovascular side …

This study looked at 236 adults with breast, colorectal, or pancreatic cancer who sought a second opinion at the University of Colorado. Researchers reviewed medical records to see if patients stayed for treatment or went elsewhere. The goal was to understand what factors influen…

This study tested an educational program to help people in rural areas learn more about colorectal cancer screening. 205 adults aged 45-74 from specific counties in New Hampshire and Vermont took part. Researchers measured changes in knowledge and intentions to get screened befor…

This completed study collected blood and tumor tissue from 64 patients with advanced cancers (like melanoma, breast, lung, and kidney cancer) to study genetic changes and treatment resistance. The samples are stored for future research, including genomic analysis. No new treatmen…

This completed trial tested an interactive survivorship program for adolescent and young adult cancer survivors. The program included a mobile app, telehealth support, and printed materials to help survivors access healthcare resources, improve self-management skills, and reduce …

This study tested whether an educational session at a church could help Latino adults learn more about colorectal cancer and feel more willing to join cancer clinical trials. Sixty Spanish-speaking participants watched videos and completed surveys. The goal was to understand barr…

This study looked at 679 people with colorectal cancer that had spread to the liver. Researchers compared having surgery to remove both the colon and liver tumors at the same time versus having two separate surgeries. The goal was to see which approach led to better survival and …

This study tested a program called KanSurvive, which uses virtual education sessions and practice support to help rural primary care clinics improve follow-up care for cancer survivors. Researchers worked with 15 rural practices to see if they could better follow guidelines for m…

This study looked at why many cancer patients lose muscle and weight, a condition called cachexia. Researchers collected samples of muscle, fat, blood, and urine from 282 people during cancer surgery and compared them with samples from non-cancer patients. They also measured phys…

This study tested a program to increase colorectal cancer screening and follow-up in federally qualified health centers, which serve many low-income and uninsured people. The program included education for doctors and staff, patient reminders, and help navigating care. Researcher…

This study tested a decision aid to help adults aged 76-85 with low health literacy decide about colorectal cancer screening. 60 participants from community health centers used the tool to weigh the benefits and risks. The goal was to see if it helped them make more informed scre…

This study examined how the COVID-19 pandemic affected the diagnosis and treatment of colorectal cancer in Hungary. Researchers looked at 198 patients, including 43 newly diagnosed, to see if cancer was found at a later stage or if treatments were missed during different pandemic…

This study looked at the gut bacteria of 1,757 people who had colon polyps or colorectal cancer in the past. The goal was to see if certain bacteria patterns could help predict who is at high risk for new polyps or cancer. Researchers hope this will lead to a simple, non-invasive…

This study looked at whether giving extra nutrition through a vein in the arm (instead of a central line) helps people recover after colorectal surgery. 200 adults who had surgery for conditions like colorectal cancer or inflammatory bowel disease took part. The goal was to see i…

This study looked back at medical records of 274 people with a specific type of advanced colorectal cancer (BRAF V600E mutation) to see what treatments they received and how well they worked. The goal was to understand real-world treatment patterns and outcomes, since there is no…

This study compared two at-home colorectal cancer screening tests—FIT and Cologuard—in over 5,000 patients at community health centers. Participants were mailed a test kit and asked to complete it at home. The goal was to see which test had higher completion rates and was more pr…

This study looked at whether a protein called tissue factor (TF) in the blood can help predict how serious colorectal cancer is and if it might come back. Researchers measured TF levels in 26 adults before and after surgery to remove their tumors. The goal was to see if higher TF…

This study checked how common colorectal polyps and cancer are in endurance athletes aged 35 to 50 who run ultramarathons or multiple marathons. Researchers gave 94 participants a screening colonoscopy and compared their results to historical data from the general population. The…

This study looked at the bacteria in the mouth and gut of 126 people with and without serrated polyposis syndrome, a condition that raises the risk of colorectal cancer. Researchers compared the bacteria in people with the syndrome to those with other types of polyps or no polyps…

This study looked at why some people develop colorectal polyps (growths that can turn into cancer) and others do not. Researchers collected blood, urine, saliva, and tissue samples from over 8,000 adults getting a colonoscopy. They also gathered information about lifestyle and he…

This study tested whether wearable wristbands can help monitor recovery after colorectal cancer surgery. 192 patients wore a device that tracked heart rate, sleep, and steps for about a week after surgery. The goal was to see if early walking reduces complications and shortens ho…

This study tested a 12-week web-based diet program with text messages for 50 colorectal cancer survivors. The goal was to see if survivors would use the program and if it could help them eat healthier. The study did not test whether the diet changes actually prevent cancer from c…

This study looked at 143 people in China who had repeat surgery after their first colorectal cancer operation failed or the cancer came back. The goal was to find out what helps the second surgery succeed and whether patients can regain normal bowel function. Researchers analyzed…

This study tested whether special sensors could measure changes in urine chemicals to track how chemotherapy affects cancer growth. Researchers collected daily urine samples from 16 people with metastatic colorectal cancer before and after starting chemotherapy. The goal was to s…

This study looked at people with advanced solid tumors (like lung, bladder, or melanoma) who had been on immunotherapy for one year and whose disease was stable. Half stopped treatment and half continued. The goal was to see if stopping early affected how long until the cancer pr…

This study tested a smartphone app that uses quizzes and rewards to help people make informed choices about colorectal cancer screening. 248 adults in Italy were randomly assigned to use either the gamified app or a basic information app. The researchers measured whether particip…

This study tested whether using at-home monitoring devices (like a wristband pedometer, scale, and blood pressure cuff) can help improve care for cancer patients after they leave the hospital following surgery. 22 patients with various cancers participated. The goal was to see if…

This study tested a program for adults aged 65-90 who had breast, colorectal, or prostate cancer. A community health worker assessed their health and provided coaching to address issues often missed after cancer treatment. The goal was to see if the program was feasible and could…

This study looked at 698 people with metastatic colorectal cancer to see if chronic inflammation changes how well bevacizumab (a targeted therapy) plus chemotherapy works. Researchers measured inflammation markers in the blood and analyzed immune proteins to find clues about trea…

This completed study looked at 60 people with colorectal cancer to better understand the cells that help the cancer spread and resist chemotherapy. Researchers collected blood and tumor samples to identify and study these 'cancer stem cells' in the lab. The goal was to learn more…

This study tested whether special sensors could measure certain molecules in urine to track how cancer treatment is working. Researchers collected urine samples from 32 people with metastatic colorectal cancer and healthy volunteers over two days. The goal was to see if these mol…

This study looked at 103 colorectal cancer patients undergoing chemotherapy to see if anxiety and sleep problems together affect their immune cells and quality of life. Researchers measured immune markers like T-cells and asked patients about their well-being. The goal was to und…

This study looked at whether giving cancer patients a decision aid before their doctor visit (on a smartphone) or during the visit (on paper) helps them feel more involved in treatment decisions. 274 adults with breast or colorectal cancer took part. The goal was to see which for…

This completed observational study examined the real-world use of two approved drugs, regorafenib and TAS-102 (sometimes with bevacizumab), in 818 adults with metastatic colorectal cancer that had stopped responding to other treatments. Researchers analyzed electronic health reco…

This completed study examined tumor samples from 3820 people with advanced solid tumors to find how many have NTRK gene fusions. Researchers used genetic testing to identify these rare changes. The study did not test any treatment, but aims to guide future targeted therapy decisi…

This study looked at 216 people with stage II or III colorectal cancer who had surgery to remove their tumor. Researchers compared two blood tests—one that looks for tumor DNA and another that looks for tumor cells—to see which better predicts if the cancer will come back within …

This study looked at tissue samples from 32 people who had surgery for colorectal cancer. Researchers measured the activity of certain genes in the tumors to learn more about how the disease works. The goal was to gather information, not to test a new treatment.

This study tested a web-based app called STOMA Care to see if it is practical and helpful for bladder or colorectal cancer patients getting ostomy surgery and their family caregivers. Researchers measured how well the app worked by tracking recruitment, retention, and changes in …

This study looked at whether sending text message reminders could increase the number of people who take part in colorectal and breast cancer screening programs. Over 44,000 eligible adults were included, and researchers compared SMS reminders to standard letters or no reminder. …

This study worked with American Indian communities in New Mexico to find better ways to encourage screening for breast, colon, and cervical cancers. Over 500 adults took part in focus groups, surveys, and pilot programs. The goal was to understand barriers and test simple educati…

This completed study looked at 261 French cancer patients to understand why many do not exercise, despite evidence that physical activity improves survival and well-being. Researchers surveyed patients about their personality, motivation, anxiety, and social background. The goal …

This completed study looked at how closely eight hospitals in Rome followed Enhanced Recovery After Surgery (ERAS) protocols for 1,000 patients having colorectal surgery. ERAS is a set of steps designed to help patients recover faster after surgery. The researchers wanted to see …

This study looked at how drugs that interact with the endocannabinoid system (the body's natural cannabis-like system) affect the movement of colon muscle. Researchers took healthy tissue from 36 colorectal cancer patients during surgery and tested these drugs in the lab. The goa…

This study tested different methods to increase colorectal cancer screening among 673 adults aged 50-75 who were not up to date with screening. Participants received either in-clinic education with a test kit, a mailed kit with phone reminders, both, or usual care. The goal was t…

This study tested an AI system called EndoStyle that can change the style of colonoscopy images to look like they came from different video processors. 40 doctors with colonoscopy experience were shown sequences of real and AI-transformed images to see if they could tell the diff…