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Scientists hunt for clues to stop cancer weight loss

NCT ID NCT03191955

Knowledge-focused Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at why many cancer patients lose muscle and weight, a condition called cachexia. Researchers collected samples of muscle, fat, blood, and urine from 282 people during cancer surgery and compared them with samples from non-cancer patients. They also measured physical function and quality of life before and after surgery. The goal was to find early signs of cachexia and identify possible targets for future treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

282 people

The number who actually took part.

Started

Nov 2015

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients referred to the NHS Lothian oesophagogastric, hepatobiliary, and colorectal MDT will be screened for eligibility. In addition, patients attending NHS Lothian outpatient clinics will be screened for eligibility.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients identified at multidisciplinary team meetings (MDT) as having oesophagogastric, hepatobiliary, and colorectal cancer suitable for resection * Patients over 18 years of age * Patients identified at surgical clinic as being planned for an abdominal operation for a non-cancer, non-inflammatory condition Exclusion Criteria: * Patients with inflammatory conditions or other condition other than cancer that might cause muscle wasting * Patients without the capacity to consent * Members of vulnerable groups * Patients not undergoing abdominal surgery * Patients undergoing totally minimally invasive (laparoscopic) surgery, with no open or hand-assisted component affording easy access to rectus muscle biopsy

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Conditions

The condition(s) this trial relates to.

Cachexia colorectal cancer esophageal cancer gastric cancer hepatobiliary neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cachexia

Contacts and locations

Locations

  • Royal Infirmary of Edinburgh

    Edinburgh, Lothian, EH16 4SA, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.