New study digs into why some young adults get advanced colon cancer
NCT ID NCT07563166
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study looked back at medical records of 500 patients aged 50 or younger diagnosed with colorectal cancer or precancerous growths at a hospital in Shenzhen, China. Researchers compared those with early-stage disease to those with later-stage disease to identify factors linked to more advanced tumors. No treatments or extra tests were given—only existing data was analyzed. The goal is to improve early detection and risk assessment for younger patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors identify younger patients at higher risk for advanced colorectal cancer, leading to earlier detection and better outcomes.
- What could go wrong
- This is a retrospective observational study, so it can show associations but not prove cause and effect. The findings may not apply to other hospitals or populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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500 people
The number who actually took part.
- Started
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Jan 2026
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients aged ≤50 years with pathology-confirmed colorectal cancer (any T stage) or high-grade intraepithelial neoplasia (HGIN) diagnosed at Shenzhen Hospital, Southern Medical University between 2016-01-01 and 2025-09-30. This retrospective single-cohort study uses de-identified electronic medical records, endoscopy, imaging, and pathology reports to extract demographics, clinical presentation, lifestyle and family history, laboratory and tumor markers, endoscopic/imaging features, detailed pathology (location, size, differentiation, TNM/AJCC stage, LVI, molecular markers if available), treatments, and follow-up outcomes. No additional patient contact or study interventions; data handled under IRB approval/waiver with secure coding and restricted access.
- Ages
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18 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≤ 50 years * Pathologically confirmed colorectal neoplasia diagnosed at Shenzhen Hospital, Southern Medical University between 2016-01-01 and 2025-09-30, defined as colorectal cancer (any T stage) or high-grade intraepithelial neoplasia (HGIN). * Available source documentation: complete or retrievable clinical record, endoscopy report, and pathology report sufficient to determine diagnosis and stage. * De-identifiable data available for extraction (records can be coded and exported without direct identifiers). * No requirement for additional patient contact (retrospective use of existing records with IRB-approved consent waiver or documented consent per ethics approval). Exclusion Criteria: * Secondary/metastatic colorectal tumor (colorectal involvement proven to be metastasis from another primary site). * Prior history of other active malignancy within the last 5 years that could confound staging or outcomes, unless disease is in long-term remission and clearly documented. * Insufficient documentation to determine pathological diagnosis or T stage (key pathology report missing or illegible). * Critical data missing for primary outcome (e.g., pathology date or staging information) that cannot be resolved after source review. * Duplicate records or irreconcilable data (same patient with conflicting identifiers/records that cannot be reconciled). * Patients who received initial diagnostic or therapeutic care outside the study site with no accessible pathology or endoscopy reports at Shenzhen Hospital.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Shenzhen Hospital of Southern Medical University
Shenzhen, Guangdong, 518000, China
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