COLORECTAL NEOPLASMS

This study looks at whether a simple stool test (FIT) is as good as colonoscopy for monitoring people who have had polyps removed from their colon. About 4,000 participants will be assigned to either regular FIT tests or colonoscopy to see if the stool test can catch new cancers …

This early-stage study tests a new drug, JNJ-95437446, in people with advanced solid tumors like lung, colorectal, or head and neck cancers that have not responded to other treatments. The main goals are to find safe doses and check for side effects. About 380 participants will t…

This study compares two drug combinations as first treatment for people with advanced left-sided colorectal cancer that cannot be removed by surgery. About 1,000 adults will receive either amivantamab plus chemotherapy or cetuximab plus chemotherapy. The goal is to see which comb…

This early-stage study tests an experimental drug called PF-08046050 in people with advanced solid tumors that have come back or not improved with standard treatments. The drug is designed to attach to cancer cells and kill them. The main goal is to check safety and find the righ…

This study looks at whether adjusting chemotherapy doses based on a patient's DPYD gene test can lower the risk of severe side effects. About 100 adults with certain cancers (like colorectal or breast) will get either a standard or a gene-guided lower dose. The goal is to see if …

This trial tests a new drug called UCB4594, an antibody that targets a protein (HLA-G) found on many cancer cells. The goal is to see if it helps the immune system attack tumors. It is for people with advanced solid tumors (like lung, breast, or colon cancer) that have not respon…

This study tests a new experimental drug (PF-07934040) in people with advanced solid tumors that have a KRAS gene mutation, including certain lung, colon, and pancreatic cancers. The drug is taken as a pill twice a day, either alone or with other anti-cancer medicines given by IV…

This study tests whether a combination of two targeted drugs (cetuximab beta and fruquintinib) with or without immunotherapy can control advanced colorectal cancer without traditional chemotherapy. About 70 adults with a specific genetic type (RAS/BRAF wild-type) will receive the…

This trial tests whether a combination of two drugs, vemurafenib and cobimetinib, can shrink or control rare cancers that have a specific BRAF V600 mutation. The drugs are already approved for melanoma, and researchers want to see if they help people with other cancer types, like…

This trial tests two drugs, trastuzumab and pertuzumab, already approved for breast cancer, in people with rare cancers that have a specific genetic change called HER2 amplification or mutation. About 30 adults and children with various rare cancers will receive the drug combinat…

This study tests a new medicine (PF-08634404) combined with standard chemotherapy against an approved drug (bevacizumab) plus chemotherapy for people with colorectal cancer that has spread. About 800 adults who have not had prior treatment for metastatic disease will be randomly …

This study tests a new drug, LY3537982, in people with advanced solid tumors that have a specific genetic change called KRAS G12C. The goal is to see if the drug is safe and shrinks tumors. About 540 adults with lung, colon, endometrial, ovarian, pancreatic, or bile duct cancers …

This study tests whether adding an immune-boosting drug (PDS01ADC) to standard liver-directed chemotherapy can help people with certain cancers that have spread to the liver. About 70 adults with colorectal, bile duct, or adrenal cancer will receive treatment through a pump place…

This study tests whether adding tucatinib and trastuzumab to standard chemotherapy helps people with HER2-positive colorectal cancer that has spread or can't be removed. About 400 participants will be randomly assigned to the new combo or standard treatment. The goal is to see if…

This study tests atezolizumab, a drug already approved for some cancers, in people with rare cancers that have high tumor mutational burden (TMB), high microsatellite instability (MSI), or a specific DNA repair defect (CMMRD). About 30 adults, teens, and children will receive the…

This early-phase study tests an experimental drug called JNJ-89402638 in people with advanced colorectal or stomach cancer that has spread and not responded to prior treatments. The study aims to find the safest dose and check if combining the drug with standard therapies like be…

This study tests whether adding the drug amivantamab to standard chemotherapy (FOLFIRI) helps people with a certain type of advanced colorectal cancer live longer without the disease getting worse. About 700 adults whose cancer has returned or spread and who have already had chem…

This early-phase study tests a new experimental drug called AZD9592, alone or with other cancer treatments, in people with advanced solid tumors (lung, head & neck, or colorectal cancers) that have not responded to standard therapy. The main goals are to check safety, find the ri…

This early-stage study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced breast, colorectal, prostate, or endometrial cancer that has spread. The goal is to find a safe dose and see if it s…

This early-phase study tests a new drug called DM002 in about 160 people with advanced solid tumors (ovarian, prostate, endometrial, colorectal, or other solid cancers). The study has two parts: first, finding a safe dose by giving small groups gradually higher doses; second, giv…

This study compares the immunotherapy drug pembrolizumab with standard chemotherapy in about 100 Chinese patients whose advanced colorectal cancer has a specific genetic feature (MSI-H or dMMR). The goal is to see if pembrolizumab can better delay cancer growth or improve surviva…

This early-phase trial tests a new drug called metarrestin in people with advanced solid tumors that have spread. The goal is to find a safe dose and see if it can shrink tumors or stop them from growing further. The study includes adults with pancreatic, breast, or other solid t…

This early-stage study tests a new drug called LY4337713 in people with advanced cancers (like pancreatic, breast, ovarian, or colorectal) that have high levels of a protein called FAP. The drug delivers radiation directly to cancer cells. The main goals are to check safety, find…

This study tests a new drug called LY4170156 in people with advanced solid tumors, such as ovarian, lung, and breast cancers. The drug is designed to target and kill cancer cells while sparing healthy ones. The trial has two parts: first to find the safest dose, then to see how w…

This study tests a new microwave-based device, called MiWEndo, during colonoscopy in 50 patients who already have a polyp in their rectum. The goal is to see if the device can find more polyps safely without changing the usual procedure. The device has been tested in earlier lab …

This study is developing a blood test to detect colorectal cancer in people under 50, a group where cases are rising. The test looks at tiny particles called exosomes and uses machine learning to find cancer signals. Researchers will test blood samples from 400 participants, incl…

This study tests whether using a computer-aided detection (CAD) system during screening colonoscopy can reduce the chance of developing advanced polyps or cancer within 3 years. About 592 adults who need a colonoscopy due to positive stool tests or personal/family history of colo…

This study tests a 12-week health program for people at high risk for colorectal cancer. The program includes workshops, online support, daily check-ins, and peer buddies to help improve diet, exercise, and reduce smoking or alcohol use. Researchers will measure changes in lifest…

This study tests whether adding dexmedetomidine to the standard anesthetic desflurane helps patients undergoing laparoscopic colectomy for colorectal cancer. The goal is to see if the combination reduces the amount of anesthetic needed, keeps heart rate and blood pressure more st…

This study tests whether a virtual hub offering personalized education, exercise, nutrition, and peer support before and after surgery can reduce complications within 30 days. About 564 adults in Australia having colorectal cancer surgery will be randomly assigned to the hub plus…

This study is a registry that collects information and tissue samples from 2,100 adults having surgery for colorectal cancer. Researchers will track survival and disease recurrence, and analyze genetic mutations and biomarkers. The goal is to better understand the disease, not to…

This study looks at the best time to start eating after a procedure called colorectal endoscopic submucosal dissection (ESD), which removes large polyps or early cancers from the colon. About 204 adults will be randomly assigned to start eating within 24 hours or wait longer. The…

This study collects tumor and normal tissue samples from people already scheduled for surgery or biopsy at the NIH Clinical Center. The goal is to provide researchers with biological material to discover new molecular targets for cancer therapies. Up to 1800 adults and children (…

This study looks at whether a simple blood test after surgery for colorectal cancer can better predict if the cancer will come back. About 1,600 patients will give blood samples to check for leftover tumor DNA. If successful, this test could help doctors decide who really needs c…

This study tracks 120 young adults (women under 40, men under 50) with early-onset colorectal cancer to see how chemotherapy and radiation affect their hormone levels, sexual health, and ability to have children. Researchers will measure changes in key hormones over time. The goa…

This study compares two ways to check for colon cancer in adults aged 65-82 who have had polyps before. About 9,000 participants will either get a yearly stool test (FIT) or a colonoscopy. Researchers will track which group finds more advanced polyps or cancer over up to 11 years…

This study takes tumor samples from people with breast, colorectal, or ovarian cancer and grows them in mice. Researchers then test different drugs on these mouse tumors to see which ones might work best for each person. The goal is to find personalized treatment options and lear…