COLORECTAL NEOPLASMS

This study tested a drug called tisotumab vedotin, alone or with other cancer medicines, in 350 people with advanced colorectal, lung, pancreatic, or head and neck cancers that had stopped responding to standard treatments. The goal was to see if the drug could shrink tumors and …

This early-stage study tests an experimental drug called SGN-MesoC2 in people with advanced solid tumors (like lung, ovarian, or pancreatic cancer) that have not responded to standard treatments. The drug is designed to attach to cancer cells and kill them. The main goals are to …

This study tests a new drug called E7386 combined with other anticancer drugs in people with advanced solid tumors, including endometrial, liver, and colorectal cancers. The goal is to find safe and effective doses and see if the combination can shrink tumors. About 300 participa…

This study tests three drugs—durvalumab, olaparib, and cediranib—in different combinations for people with advanced solid tumors, including ovarian, breast, lung, prostate, and colorectal cancers. The goal is to see if these combinations can shrink or control tumors. Participants…

This early-phase study tests the safety and tolerability of a new drug called E7386 in 70 people with advanced solid tumors, including colorectal cancer. Participants have tumors that cannot be removed by surgery or have come back, and no standard treatments are available. The ma…

This study is for people with advanced solid tumors (like lung or colorectal cancer) that have a specific genetic change called KRAS G12C. It tests a new drug, JDQ443, combined with other treatments to see if they are safe and can shrink tumors. About 74 adults will take part. Th…

This early-stage study tests the safety of a new drug, PF-08046049/SGN-BB228, in people with advanced melanoma and other solid tumors that have spread or are hard to treat. The study involves 41 participants and will look at side effects and the right dose. It is not expected to …

This early-stage study tests a new oral medication, PF-07985045, alone or with other cancer drugs, in people with advanced solid tumors that have a KRAS gene mutation. The cancers studied include non-small cell lung, colorectal, and pancreatic cancers. The main goals are to check…

This study tests whether a software called ColoMaia II can help doctors find polyps (abnormal growths) in the colon during a colonoscopy. About 600 adults aged 40 to 80 having a routine colonoscopy will be randomly assigned to have the procedure with or without the software's ass…

This study looks at three different eating plans to help overweight people at risk for colorectal cancer eat healthier and lose weight. About 240 adults with a family or personal history of colorectal cancer or polyps will follow one of the plans for 12 months. The goal is to see…

This study tests whether taking two drugs (eflornithine and sulindac) together can prevent new high-risk growths or a second colon cancer in people who have already been treated for stage 0 to III colon or rectal cancer. About 354 participants will take the drug combination or a …

This study tests whether a personalized home exercise program can improve physical function and quality of life in people aged 75 and older with colorectal cancer who are having surgery. Participants receive weekly phone coaching on strength, balance, and breathing exercises from…

This study tests whether a specially designed physical activity program can help African American colorectal cancer survivors become more active. About 21 participants will use a Fitbit tracker and watch exercise videos to see if the program is practical and effective. The goal i…

This study looks at whether a plant-based Mediterranean diet can improve gut health in people who have had colon polyps removed. Researchers will check stool and blood samples over 8 weeks to see if the diet changes gut bacteria and lowers inflammation. The goal is to understand …

This study looks at 64 people with colorectal cancer that spread to the liver and was surgically removed. Researchers examined the immune cells around the tumors and how the tumors grow at the liver border. The goal is to see if these features are linked to how long patients live…

This study compares two ways of monitoring colorectal cancer patients after surgery: standard CT scans versus a new approach that also uses a blood test (ctDNA) to find cancer DNA. The goal is to see if the blood test helps detect cancer recurrence earlier and allows more patient…