COLORECTAL NEOPLASMS

This study tested whether a chemotherapy drug called FTD/TPI could help prevent colorectal cancer from coming back in patients who had surgery to remove their tumors but still had cancer DNA in their blood. 243 adults with stage III colorectal cancer took either the drug or a pla…

This study tested a combination of liver-directed chemotherapy (FOLFOXIRI via hepatic artery infusion) and a targeted drug (fuquintinib) in 44 people with colorectal cancer that spread to the liver and had not responded to at least two prior treatments. The goal was to see how ma…

This study tested a new drug (E7386) combined with an immunotherapy (pembrolizumab) in 89 people with advanced melanoma, colorectal, or liver cancer who had already tried other treatments. The goal was to check safety and see if the combination shrinks tumors. Results help decide…

This study tested whether a combination of two drugs, lenvatinib and pembrolizumab, works better than standard treatments for people with advanced colorectal cancer that has spread to other parts of the body. The trial included 563 adults whose cancer had worsened after or who co…

This study tested whether using a special monitor (ClearSight) to track blood flow during colorectal surgery could lower the chance of complications. 160 adults having surgery for colon polyps, colorectal cancer, or Crohn's disease took part. The goal was to see if this approach …

This study tested a two-step treatment for advanced colorectal cancer that hasn't responded to standard therapies. First, some patients received a chemotherapy drug (temozolomide) to make their cancer cells more genetically unstable. Then, they received an immunotherapy drug (pem…

This study tested whether artificial intelligence (AI) systems can help doctors find precancerous polyps during colonoscopy. Over 334,000 veterans from VA medical centers across the U.S. took part. Some centers used AI devices, while others did not, and researchers compared how m…

This study tested three different colonoscopy techniques—narrow band imaging, indigo carmine staining, and acetic acid staining—to see which most accurately predicts whether colorectal growths are cancerous. 565 patients with at least one growth 6mm or larger took part. The resul…

This study tested an artificial intelligence (AI) system that helps doctors identify whether growths in the colon (polyps) are cancerous or harmless during a colonoscopy. 570 adults with at least one colon polyp took part. The AI analyzed live video from a special microscope to g…

This study tested an artificial intelligence system called EndoBRAIN that helps doctors diagnose colorectal polyps during a colonoscopy. 680 adults with colorectal lesions participated. The AI analyzes high-magnification images to tell if a polyp is cancerous or not, potentially …

This study tested an artificial intelligence system called CAD EYE to see if it could accurately predict whether colon polyps are cancerous during a colonoscopy. Researchers compared the AI's predictions to those of doctors, using tissue analysis as the gold standard. The study i…

This study tested a remote monitoring system called CONTINUUM+ CONNECT in 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Participants used the system (with or without home nursing) or received standard care. The goal was to see if the system improved phy…

This study tested whether using both an artificial intelligence system (ENDOAID) and a small attachment called Endocuff helps doctors find more polyps during colonoscopy compared to using AI alone. Over 1,700 adults aged 45-85 who needed a colonoscopy took part. The goal was to s…

This study looked at 216 people with stage II or III colorectal cancer who had surgery to remove their tumor. Researchers compared two blood tests—one that looks for tumor DNA and another that looks for tumor cells—to see which one better predicts if the cancer will come back wit…

This study looked at 500 adults aged 50 or younger who were diagnosed with colorectal cancer or a precancerous condition. Researchers reviewed medical records to find patterns and risk factors linked to more advanced cancer stages. The goal is to help doctors catch the disease ea…

This study looked at the gut bacteria of 1,757 people who had colon polyps or colorectal cancer in the past. The goal was to find bacterial markers that could predict who is at high risk for new polyps or cancer. Researchers hope this leads to a simple stool test that could repla…

This study looked at whether starting a colonoscopy with the patient lying on their back (supine) or on their left side (left-lateral) makes a difference. 198 adults having a colonoscopy were randomly assigned to one of the two positions. Researchers measured how long it took to …

This study aimed to identify and understand special cells in colon cancer that may help the cancer spread and resist chemotherapy. Researchers collected samples from 60 patients' tumors, blood, and metastases to study these cells in the lab. The goal was to learn more about how t…

This study tested a computer tool that helps doctors and cancer survivors discuss heart health during follow-up visits. About 645 survivors of breast, prostate, colorectal, endometrial, and lymphoma cancers took part. The goal was to see if the tool leads to more conversations ab…

This study looked at whether a short training session on specific visual features (called 'Blink') can improve how well medical students and non-specialist doctors detect cancer in images of colon polyps. 65 participants took an online test before and after training to see if the…