COLORECTAL NEOPLASMS

This study tests a new treatment for people with colorectal cancer that has spread and not responded to at least two prior therapies. Participants receive targeted radiation to tumors in the lung or liver, followed by a combination of three drugs: an immunotherapy (sintilimab), a…

This trial tests whether two drugs already approved for certain skin and lung cancers can help people with rare cancers that have a specific gene change called BRAF V600. About 30 adults and children with various rare cancers will receive dabrafenib and trametinib. The goal is to…

This study tests whether an artificial intelligence system can help doctors spot more precancerous polyps and colorectal cancers during colonoscopy compared to standard procedures. Over 3,300 adults scheduled for screening or surveillance will be randomly assigned to AI-assisted …

This study tests a new ultrasound method to see if it can predict whether chemotherapy is working for colorectal cancer that has spread to the liver. Standard scans take about 2 months to show results, but this ultrasound looks at blood flow inside the tumor after just 1-2 chemo …

This study compares two ways to prevent colon cancer in people at very high risk. One group gets a colonoscopy every three years as usual. The other group does a simple stool test every year, and only gets a colonoscopy if the test is positive. The goal is to catch and remove dan…

This study tests whether artificial intelligence (AI) can help more high-risk adults aged 40 to 64 in China get a colonoscopy, the best way to find colorectal cancer early. About 400 participants will be split into two groups: one gets usual care, the other gets extra AI-assisted…

This study looks at whether electroacupuncture (a type of acupuncture with mild electrical pulses) can help the bowels start working again sooner after minimally invasive colorectal cancer surgery. About 240 adults having surgery for colorectal cancer will be randomly placed into…

This study tests a new health education program using a virtual 'metaverse' to help colorectal cancer survivors improve their quality of life and adopt healthier lifestyles. The program includes online lessons, immersive virtual interactions, and group support via WeChat. Researc…

This study compares two surgical methods for removing right-sided colon cancer: laparoscopic (small incisions with a camera) and open (larger incision). Researchers will look at blood loss, complications, hospital stay, and recovery in 22 adults. The goal is to see if the less in…

This study compares two ways to examine the colon in people with inflammatory bowel disease (IBD) who are at higher risk for colon cancer. One method uses a dye sprayed inside the colon, while the other uses advanced camera technology to enhance images without dye. About 480 adul…

This study looks at past and future patients to build a tool that predicts whether colorectal adenomas (precancerous polyps) will return after removal. Researchers will collect lifestyle information and blood samples from 1,280 adults aged 18-75. The goal is to improve follow-up …

This study will collect blood samples from 1,000 people with small colon growths to see if a liquid biopsy can tell which growths are cancerous and which are harmless. The goal is to find blood-based markers that predict whether the cancer has spread to lymph nodes, helping avoid…