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Could a simple stool test replace colonoscopy for cancer surveillance?

NCT ID NCT06983639

Diagnosis Sponsor: Sorlandet Hospital HF Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two ways to monitor people who have had polyps removed from their colon: a fecal test that checks for blood in stool versus a standard colonoscopy. Researchers want to see if the simpler stool test is just as good at catching new cancers or high-risk polyps. About 4,000 participants will be followed over time to compare cancer rates and deaths between the two approaches.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Fecal occult blood test (FIT) and colonoscopy
What this could lead to
If successful, this could show that a simple stool test is as effective as colonoscopy for follow-up, reducing the need for invasive procedures.
What could go wrong
This is a large but early-stage comparison; the stool test may miss some cancers or polyps that colonoscopy would find, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 4,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jan 2050

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * High-quality baseline colonoscopy with adequat cleansing and cecal intubation * Remocval of at least one advanced adenoma * Clean colon (all polyps removed) * Signed informed consent Exclusion Criteria: * Colorectal cancer * History of surgical colon resection for any reason * Genetic cancer syndrome (adenomatous or serrated polyposis syndrome; Lynch or Lynch-like syndrome) * ≥ 10 adenomas at baseline colonoscopy (cumulative) * History of advanced serrated lesion, defined as SSL≥ 10mm or with dysplasia * Inflammatory bowel disease * On-going palliative care for any reason

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Conditions

The condition(s) this trial relates to.

colorectal adenoma colorectal neoplasm polyp

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colorectal neoplasms

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sørlandet sykehus HF

    RECRUITING

    Arendal, Agder, 4838, Norway

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