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Gene combo clues could spot High-Risk colon cancer families

NCT ID NCT01057953

Knowledge-focused Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether certain combinations of genetic variations, rather than a single gene, can increase the risk of colorectal cancer. Researchers will compare the DNA of 700 patients with strong family histories of the disease against 350 healthy controls. The goal is to better understand non-Mendelian genetic risk and potentially improve screening recommendations for at-risk relatives.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify families at high genetic risk for colorectal cancer, leading to earlier and more targeted screening.
What could go wrong
This is an observational study, not a treatment trial. It may not find clear genetic patterns, and results may not change current screening practices.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,550 people

The number who actually took part.

Start date

Jan 2010

Finished

Jan 2013

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 61 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * colorectal cancer (CRC) in two first degree relatives, one being diagnosed before 61 years of age * CRC diagnosed before 51 years of age or advanced colorectal adenoma before 41 years of age * multiple primary CRCs in the same individual, the first being diagnosed before 61 years of age. Exclusion Criteria: * Lynch syndrome, * adenomatous polyposis defined by more than 10 adenomas histologically proved, * hamartomatous polyposis defined by one hamartoma histologically proved, * absence of informed consent.

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Conditions

The condition(s) this trial relates to.

cancer colonic neoplasm colorectal adenoma colorectal cancer neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer

Contacts and locations

Locations

  • CH de Niort

    Niort, France

  • CHRU de Lille

    Lille, France

  • CHU de Dijon

    Dijon, France

  • CHU de Grenoble

    Grenoble, France

  • CHU de Montpellier

    Montpellier, France

  • CHU de Rennes

    Rennes, France

  • CHU de Saint-Etienne

    Saint-Etienne, France

  • CHU de Toulouse

    Toulouse, France

  • CLCC Val d'Aurelle

    Montpellier, France

  • Centre Eugène Marquis

    Rennes, 35000, France

  • Centre François Baclesse

    Caen, 14000, France

  • Hôpital Européen Georges Pompidou

    Paris, France

  • Institut Claudius Regaud

    Toulouse, France

  • Institut Curie

    Paris, 75005, France

  • Institut Gustave Roussy

    Villejuif, 94800, France

  • UHRouen

    Rouen, 76031, France

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