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New registry shows promise for microwave ablation in liver cancer spread

NCT ID NCT03775980

Disease control Sponsor: Cardiovascular and Interventional Radiological Society of Europe Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This registry followed 500 adults with colorectal cancer that spread to the liver. All were treated with a microwave ablation device that uses heat to destroy tumors. The goal was to see how well the device controls tumors locally over 12 months and to track any side effects. The study is observational, meaning it simply recorded what happened in real-world use, without comparing to other treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Microwave ablation device
What this could lead to
If successful, this could confirm that microwave ablation is a safe and effective way to control liver tumors that have spread from colorectal cancer.
What could go wrong
This is an observational registry, not a controlled trial, so results may not prove the device is better than other treatments. Also, the procedure carries risks like bleeding or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

500 people

The number who actually took part.

Started

Sep 2019

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with colorectal adenocarcinoma and liver-only or liver-dominant metastatic disease

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years or older * Proven colorectal liver metastases either histologically proven or diagnosed by imaging in a patient with known colorectal cancer * Treated with the Emprint or Emprint HP Microwave ablation system * Patient referred to MWA by a multidisciplinary tumour board * Signed informed consent form * Intention to completely treat (ablation, resection, SBRT) all visible disease within 8 weeks * Maximum number of 9 total liver lesions * All liver lesions must be local treatment-naive * Maximum diameter of the largest liver lesion treated with MWA must not exceed 3cm * Maximum diameter of lesions treated surgically may exceed this limitation * Maximum number of 5 lung nodules eligible to be treated * Patients may receive simultaneous liver resection and microwave ablation * Patients may have received previous systemic therapy * Patients must not have received surgical resection or thermal ablation for other liver lesions in the last 3 months before inclusion * Patients treated with a liver-first approach may be included if treatment of the primary tumour is planned * If applicable: complete response of treated rectal tumour proven by imaging Exclusion Criteria: * Life expectancy less than 6 months (palliative treatment) * Extrahepatic metastases with the exception of a maximum of 5 lung nodules * Ongoing infection (viral/bacterial) * Patients receiving simultaneous bowel surgery and microwave ablation * Patients receiving simultaneous IRE, RFA, SBRT, Cryoablation, HIFU or other local treatment than resection * Pregnancy * Patients with liver metastases that cannot be completely and safely treated * Active cancers other than CRC * Non-resected primary colon cancer * Advanced liver disease or evidence of liver insufficiency

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Conditions

The condition(s) this trial relates to.

colonic neoplasm colorectal cancer colorectal neoplasm metastatic neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colorectal neoplasms malignant Neoplasm metastasis

Contacts and locations

Locations

  • Aarhus University Hospital

    Aarhus, 8200, Denmark

  • Amsterdam University Medical Center

    Amsterdam, 1105 AZ, Netherlands

  • Attikon University Athens

    Athens, 12462, Greece

  • CHU de Reims

    Reims, 51092, France

  • Centro Hospitalar Universitário de Lisboa Central

    Lisbon, 1169-050, Portugal

  • Charité - Universitätsmedizin Berlin

    Berlin, 10117, Germany

  • Città della Salute e della scienza Torino

    Torino, 10126, Italy

  • City General Hospital 8th September

    Skopje, 1000, North Macedonia

  • Cukurova University Medical School

    Adana, 01790, Turkey (Türkiye)

  • DRK Kliniken Berlin Westend

    Berlin, 14050, Germany

  • European Institute of Oncology

    Milan, 20141, Italy

  • Fondazione Poliambulanza Brescia

    Brescia, 25124, Italy

  • Hacettepe University Hospital

    Ankara, 06230, Turkey (Türkiye)

  • Hospital Universitari de Bellvitge

    Barcelona, 08907, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, 28034, Spain

  • IPO Porto

    Porto, 4200-072, Portugal

  • IRCCS Ospedale San Raffaele

    Milan, 20132, Italy

  • IRCCS San Giuseppe Multimedica

    Milan, 20123, Italy

  • Krankenhaus Barmherzige Brüder München

    Munich, 80639, Germany

  • Krankenhaus Nordwest

    Frankfurt, 60488, Germany

  • Leids Universitair Medisch Centrum

    Leiden, 2333, Netherlands

  • Les Hôpitaux Universitaires de Strasbourg

    Strasbourg, 67000, France

  • Medizinische Hochschule Hannover

    Hanover, 30625, Germany

  • Oslo University Hospital

    Oslo, 0372, Norway

  • Ospedale Santissima Annunziata

    Taranto, 74121, Italy

  • Ospedaliero Universitaria San Luigi Gonzaga di Orbassano

    Orbassano, 10043, Italy

  • SLK Kliniken Heilbronn

    Heilbronn, 74078, Germany

  • Städtisches Klinikum Braunschweig

    Braunschweig, 38126, Germany

  • Tübingen University Hospital

    Tübingen, 72076, Germany

  • Universitair Medisch Centrum Groningen

    Groningen, 9713, Netherlands

  • University Hospital Centre Sisters of Mercy

    Zagreb, 10000, Croatia

  • University Hospital of Nimes

    Nîmes, 30900, France

  • Universitätsklinikum Carl Gustav Carus Dresden

    Dresden, 01307, Germany

  • Universitätsklinikum Frankfurt

    Frankfurt, 60596, Germany

  • Universitätsklinikum Regensburg

    Regensburg, 93053, Germany

  • Vilnius University Hospital Santaros Klinikos

    Vilnius, 08406, Lithuania

  • Vivantes Klinikum Neukölln

    Berlin, 12351, Germany

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