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Scientists uncover hidden electrical switch that fuels colorectal Cancer's spread

NCT ID NCT07650786

Knowledge-focused Sponsor: Ma Tianyi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates how differences in cell membrane voltage, caused by varying physical pressures inside a tumor, help colorectal cancer resist chemotherapy and evade the immune system. Using advanced lab models and tissue samples from 11 patients, researchers found that cells at the tumor's edge are electrically active and aggressive, while core cells are suppressed but stress-adapted. The work identifies a key immune checkpoint, PVR/CD96, that could be targeted to restore immune attack. This is a basic science study, not a treatment trial, but it may guide future drug development.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the findings hold, this could point toward new treatments that target membrane potential or the PVR/CD96 immune checkpoint to overcome drug resistance and improve immunotherapy in colorectal cancer.
What could go wrong
This is a very early, small study with only 4 participants and relies heavily on lab models. The results may not translate to real-world patients, and any potential therapies are years away from being tested in people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

4 people

The number who actually took part.

Started

Feb 2024

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

11

Ages

3 weeks and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

11

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colorectal cancer

Contacts and locations

Locations

  • Nanagngqu

    Harbin, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.