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New drug targets wasting syndrome in cancer patients

NCT ID NCT05546476

Symptom relief Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an investigational drug called ponsegromab in 187 adults with lung, pancreatic, or colorectal cancer who also had cachexia—a condition causing severe weight loss, loss of appetite, and fatigue. The goal was to see if ponsegromab could help patients gain weight and be more active compared to a placebo. The study was completed and used wearable sensors to track physical activity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

187 people

The number who actually took part.

Started

Nov 2022

Finished

Apr 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: * Documented active diagnosis of non-small cell lung, pancreatic, colorectal cancer * Cachexia defined by Fearon criteria of weight loss * Serum GDF-15 concentrations * Signed informed consent * ECOG PS ≤3 with life expectancy of at least 4 months to be able to complete Part A. Key Exclusion Criteria: * Receiving tube feedings or parenteral nutrition at the time of Screening or Randomization. * Current active reversible causes of decreased food intake. * Cachexia caused by other reasons. * History of allergic or anaphylactic reaction to any therapeutic or diagnostic monoclonal antibody. * inadequate liver function * renal disease requiring dialysis

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Conditions

The condition(s) this trial relates to.

Anorexia Cachexia colorectal cancer colorectal neoplasm Fatigue malignant pancreatic neoplasm neoplasm non-small cell lung carcinoma pancreatic neoplasm Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cachexia Colorectal cancer Fatigue Loss of appetite Non-small cell lung cancer Pancreatic cancer

Contacts and locations

Locations

  • Aichi Cancer Center Hospital

    Nagoya, Nagoya, Aichi, 464-8681, Japan

  • Bacs-Kiskun Varmegyei Oktatokorhaz

    Kecskemét, Bács-Kiskun county, 6000, Hungary

  • Beverly Hills Cancer Center

    Beverly Hills, California, 90211, United States

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana, 59715, United States

  • CARTI Cancer Center

    Little Rock, Arkansas, 72205, United States

  • CARTI Conway

    Conway, Arkansas, 72034, United States

  • CARTI North Little Rock

    North Little Rock, Arkansas, 72117, United States

  • CARTI Stuttgart

    Stuttgart, Arkansas, 72160, United States

  • CIUSSS- saguenay-Lac-Saint-Jean

    Chicoutimi, Quebec, G7H 5H6, Canada

  • Carta - Clinical Associates in Research Therapeutics of America, LLC

    San Antonio, Texas, 78212, United States

  • Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski

    Rimouski, Quebec, G5L 5T1, Canada

  • Centrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o.

    Krakow, Lesser Poland Voivodeship, 30-348, Poland

  • Chang Gung Medical Foundation-Linkou Branch

    Taoyuan, 333, Taiwan

  • Changzhou No.2 People's Hospital

    Changzhou, Jiangsu, 213003, China

  • Chi Mei Hospital - Liouying Branch

    Tainan, Tainan, 73657, Taiwan

  • China Medical University Hospital

    Taichung, 404332, Taiwan

  • Complex Oncology Center - Burgas

    Burgas, 8000, Bulgaria

  • Complex Oncology Center - Ruse EOOD

    Rousse, 7002, Bulgaria

  • Complex Oncology Center - Shumen

    Shumen, 9700, Bulgaria

  • Complex Oncology Center - Vratsa

    Vratsa, 3000, Bulgaria

  • Emad Ibrahim,MD,INC.

    Redlands, California, 92373, United States

  • Fakultna nemocnica Trnava

    Trnava, 917 75, Slovakia

  • Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica

    Banská Bystrica, 975 17, Slovakia

  • Fakultna nemocnica s poliklinikou Nove Zamky

    Nové Zámky, 940 34, Slovakia

  • Fundación Instituto Valenciano de Oncología

    Valencia, Valenciana, Comunitat, 46009, Spain

  • Henan Cancer Hospital

    Zhengzhou, Henan, 450008, China

  • Hospital Son Llàtzer

    Palma, Illes Balears [islas Baleares], 07198, Spain

  • Hospital Universitari General de Catalunya

    Sant Cugat del Vallès, Barcelona [barcelona], 08915, Spain

  • Hospital Universitari i Politecnic La Fe

    Valencia, 46026, Spain

  • Hospital Universitario HM Sanchinarro

    Madrid, 28050, Spain

  • Hyogo Cancer Center

    Akashi, Hyōgo, 673-8558, Japan

  • IU Health Arnett Cancer Center

    Lafayette, Indiana, 47904, United States

  • Institut Català d'Oncologia - L'Hospitalet

    L'Hospitalet de Llobregat, Catalunya [cataluña], 08908, Spain

  • Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház

    Szolnok, Jász-Nagykun-Szolnok, 5004, Hungary

  • Kanagawa cancer center

    Yokohama, Kanagawa, 241-8515, Japan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807, Taiwan

  • MHAT for Women's Health Nadezhda

    Sofia, 1330, Bulgaria

  • Multiprofile Hospital for Active Treatment Serdika EOOD

    Sofia, 1303, Bulgaria

  • NZOZ "Vegamed"

    Katowice, 40-060, Poland

  • Narodny onkologicky ustav, II. Onkologicka klinika LFUK a NOU

    Bratislava, 833 10, Slovakia

  • National Cancer Center Hospital East

    Kashiwa, Chiba, 277-8577, Japan

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • National Hospital Organization Shikoku Cancer Center

    Matsuyama, Ehime, 791-0280, Japan

  • Nemocnica na okraji mesta, n.o.

    Partizánske, 95801, Slovakia

  • Orange Hospital

    Orange, New South Wales, 2800, Australia

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Oregon Health and Science University: Center for Health and Healing 1

    Portland, Oregon, 97239, United States

  • Oregon Health and Science University: Center for Health and Healing 2

    Portland, Oregon, 97239, United States

  • Országos Korányi Pulmonológiai Intézet

    Budapest, 1121, Hungary

  • Pacific Cancer Medical Center INC

    Anaheim, California, 92801, United States

  • Peking University First Hospital

    Beijing, Beijing Municipality, 100034, China

  • Pennington Biomedical Research Center

    Baton Rouge, Louisiana, 70808, United States

  • Peter MacCallum Cancer Centre

    Melbourne, Victoria, 3000, Australia

  • Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2M9, Canada

  • Providence Medical Foundation

    Santa Rosa, California, 95403, United States

  • Qilu Hospital of Shandong University

    Jinan, Shandong, 250012, China

  • Regionalny Szpital Specjalistyczny im. Dr. Wladyslawa Bieganskiego

    Grudziądz, 86-300, Poland

  • Semmelweis Egyetem

    Budapest, 1083, Hungary

  • Shanghai Changhai Hospital

    Shanghai, Shanghai Municipality, 200433, China

  • Shanxi Provincial Cancer Hospital

    Taiyuan, Shanxi, 030013, China

  • Shizuoka Cancer Center

    Nagaizumi-cho, Shizuoka, 411-8777, Japan

  • Sir Run Run Shaw Hospital of Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310016, China

  • Specialized Hospital for Active Treatment of Oncology - Haskovo

    Haskovo, 6300, Bulgaria

  • Specjalistyczna Praktyka Lekarska Slawomir Mandziuk

    Lublin, 20-093, Poland

  • St Vincent's Hospital Sydney

    Darlinghurst, New South Wales, 2010, Australia

  • Tandem Clinical Research

    Marrero, Louisiana, 70072, United States

  • The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University

    Wenzhou, Zhejiang, 325035, China

  • The Cancer Institute Hospital of JFCR

    Tokyo, 135-8550, Japan

  • The First Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330006, China

  • The Ottawa Hospital - General Campus

    Ottawa, Ontario, K1H 8L6, Canada

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology

    Wuhan, Hubei, 430030, China

  • University Hospital,Kyoto Prefectural University of Medicine

    Kyoto, 602-8566, Japan

  • University Multiprofile Hospital for Active Treatment Sofiamed

    Sofia, 1797, Bulgaria

  • Univerzitna nemocnica Bratislava, Nemocnica Ruzinov

    Bratislava, 826 06, Slovakia

  • Virginia Mason Medical Center

    Seattle, Washington, 98101, United States

  • Wenatchee Valley Hospital

    Wenatchee, Washington, 98801, United States

  • Western Health-Sunshine & Footscray Hospitals

    St Albans, Victoria, 3021, Australia

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