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Blood test may boost colorectal cancer screening in reluctant patients

NCT ID NCT05536713

Knowledge-focused Sponsor: Milton S. Hershey Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether offering a simple blood test instead of a colonoscopy or stool test would encourage more people to get screened for colorectal cancer. Researchers enrolled 297 adults aged 45-75 who had previously skipped or refused traditional screening. The goal was to see if a blood-based test is more acceptable and improves screening rates, especially in underserved communities.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

297 people

The number who actually took part.

Started

Feb 2023

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients who are age-eligible for colorectal cancer screening based on the U.S. Preventive Service Task Force recommendation guidelines have an average risk for colorectal cancer.

Ages

45 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Between 45-75 years of age * Have an average risk for colorectal cancer * A patient at one of our partner FQHCs * Received a screening order (either using a stool-based test or colonoscopy) six months ago and failed or refused to complete the screening test * Able to comprehend and willing to give informed consent * Able and willing to provide a blood sample per protocol Exclusion Criteria: 1. Family history * One first-degree relative diagnosed with CRC or advanced adenoma at age \< 60 years * Two first-degree relatives diagnosed with CRC or advanced adenoma at any age * Known hereditary gastrointestinal cancer syndromes, such as Lynch Syndrome or Familial Adenomatous and Polyposis (FAP) 2. Personal History * History of CRC or adenoma * History of cancers * History of inflammatory bowel disease, including chronic ulcerative colitis and Crohn's disease * Have a recorded up-to-date CRC screening * Blood product transfusion in the past 120 days * A medical condition that, in the opinion of the patient's health provider, should preclude enrollment in the study

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colorectal cancer

Contacts and locations

Locations

  • PCC Community Wellness Center

    Chicago, Illinois, 60302, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.