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Immunonutrition before surgery may cut complications and preserve muscle in colorectal cancer patients

NCT ID NCT07653737

Disease control Sponsor: Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial compares two types of oral nutritional supplements given to colorectal cancer patients before surgery. One group receives standard high-protein drinks, while the other gets immunonutrition drinks enriched with arginine, nucleotides, vitamin D, and omega-3 fatty acids. The goal is to see if the enriched supplements reduce post-surgical complications and help maintain muscle mass, as measured by CT scans. The study involves 56 adults scheduled for colorectal cancer surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Oral nutritional supplements with immunonutrition (arginine, nucleotides, vitamin D, omega-3 fatty acids)
What this could lead to
If it works, this could point toward a better way to prepare colorectal cancer patients for surgery, reducing complications and helping them maintain muscle strength.
What could go wrong
This is a small, early-stage study with only 56 participants, so results may not apply to everyone. The supplements may cause digestive discomfort or allergic reactions in some people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

56 people

The number who actually took part.

Started

Jan 2024

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients eligible for colorectal cancer surgery Exclusion Criteria: * Non-surgical colorectal cancer * End-stage liver o kidney disease * Emergency surgery * Previous nutritional supplements * Hypersensitivity to arginine, omega-3, or nucleotides * Inability for oral nutrition (dysphagia, esophageal/pyloric stenosis) * HIV infection * Pregnancy * Intestinal obstruction * Active uncontrolled infection * Dementia, advanced degenerative neurological disease.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colorectal cancer Nutrition aspect of cancer

Contacts and locations

Locations

  • Hospital Universitario Ramón y Cajal

    Madrid, Madrid, 28034, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.