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Gentler lung ventilation during surgery may tame tumor inflammation, early study hints

NCT ID NCT06230965

Knowledge-focused Sponsor: Affiliated Hospital of Nantong University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether a lung protective ventilation strategy (a gentler way of breathing during surgery) affects inflammation around tumors and certain blood markers in 60 colorectal cancer patients. Half received standard ventilation, half received the protective method. Researchers measured inflammatory substances in the blood at three time points and followed patients for up to a year to assess recovery and frailty. The goal is to see if this simple change during surgery could improve outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lung protective ventilation strategy
What this could lead to
If successful, this could show that a specific breathing method during surgery helps reduce inflammation around tumors, potentially improving recovery for colorectal cancer patients.
What could go wrong
This is a small, early-stage study with only 60 participants, so results may not apply to everyone. It looks at biological markers, not direct health outcomes, so benefits are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Jan 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

51 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. pathologic diagnosis of Colorectal Cancer 2. American society of Aneshesiologists（ASA）physical status classification system Grade Ⅱ-Ⅲ; 3. From 51-70 years old with no gender restrictions 4. Normal cardiopulmonary function before operation 5. Body Mass Index:18-30 Exclusion Criteria: 1. Preoperative anemia (hemoglobin\<10g/dl) 2. Patients with preoperative mechanical ventilation; 3. A history of pulmonary infection and pulmonary tuberculosis within 1 month before surgery; 4. Preoperative blood oxygen saturation (SpO₂) was less than 90% (SpO₂\<90%), or the oxygen partial pressure (PaO₂) was less than 90% (PaO₂\<60 mmHg), or PaO₂/fraction of inspired oxygen（FiO₂）ratio\<300 mmHg, or arterial blood carbon dioxide partial pressure (PaCO₂) was greater than 45 mmHg (PaCO₂\>45 mmHg); 5. Patients who take immunosuppressants, neoadjuvant chemotherapy and radiotherapy before surgery; 6. Preoperative abnormal coagulation function.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tumor microenvironment

Contacts and locations

Locations

  • The Affiliated hospital of Nantong University

    Nantong, Jiangsu, 226001, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.