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Can a plasma beam stop colon polyps from coming back?

NCT ID NCT04015765

Prevention Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Sep 09, 2026 · Updated 2 times

Summary

This trial tests whether using a technique called hybrid argon plasma coagulation (h-APC) on the edges of the removal site can prevent colon polyps from growing back after endoscopic mucosal resection (EMR). EMR is a standard procedure for removing large polyps, but when polyps are removed in pieces, they can recur in 12-30% of cases. The study will include people with non-cancerous colon polyps of at least 20 mm. Half will receive standard EMR alone, and half will receive EMR plus h-APC ablation of the margins. The goal is to see if this extra step reduces recurrence to 5% or less.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Hybrid Argon Plasma Coagulation (h-APC) procedure
What this could lead to
If effective, this technique could significantly lower the chance of colon polyps returning after removal, potentially reducing the need for repeat procedures and lowering colorectal cancer risk.
What could go wrong
This is a single-center trial, and results may not apply broadly. The procedure carries risks like bleeding or perforation, and the recurrence reduction may not be as high as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

376 people

The number who actually took part.

Started

Aug 2019

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 89 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All Ethnicity and race * Patient referred for endoscopic resection of all colorectal polyps non-pedunculated equal or greater 20 mm * Written informed consent Exclusion Criteria: * Patients with known (biopsy proven) invasive carcinoma in a potential study polyp * Previous partial EMR * Pedunculated polyps (as defined by Paris Classification type Ip or Isp) * Patients with ulcerated depressed lesions (as defined by Paris Classification type III) * Patients with inflammatory bowel disease * Patients who are receiving an emergency colonoscopy * Poor general health (ASA class\>3) * Patients with coagulopathy with an elevated INR ≥1.5, or platelets \<50 * Poor bowel preparation (Boston bowel prep score ≤2) * Target sign or perforation during initial EMR * Need for ESD for complete resection prior to APC * Pregnancy and breast-feeding.

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Conditions

The condition(s) this trial relates to.

colorectal adenoma colorectal cancer colorectal neoplasm polyp of colon

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colorectal cancer Polyp of colon

Contacts and locations

Locations

  • Centre Hospitalier Universitaire de Montréal (CHUM)

    Montreal, Quebec, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.