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Which test is best for colon cancer screening in High-Risk families?

NCT ID NCT02738359

Diagnosis Sponsor: Hôpital Edouard Herriot Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at three screening methods—colonoscopy, colon capsule endoscopy, and a fecal immunochemical test (FIT)—to detect colorectal cancer or advanced growths in people aged 45 and older who have a first-degree relative with colorectal cancer. The goal was to see if the simpler tests (capsule or FIT) are as good as colonoscopy. The study enrolled 84 participants and compared how many cancers or advanced polyps each method found.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could show that simpler, less invasive tests like colon capsule or fecal tests are as effective as colonoscopy for screening high-risk relatives.
What could go wrong
This is a small, completed study with only 84 participants, so results may not apply to larger populations. The non-inferiority margin is narrow, and differences between tests may still be uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

84 people

The number who actually took part.

Started

Nov 2017

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients at high risk of colorectal cancer (first-degree relatives of patient with colorectal cancer) will be included prospectively in one of the 3 comparative arms.

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * History of colorectal cancers (any age) in first-degree relatives (parents, children, siblings including half-brothers and sisters) * Age \> or = 45 years * No previous colorectal cancer screening * Informed patient * Patient having signed the consent form * Patient affiliated to a social security system or recipient of such system Exclusion criteria: * Any previous colorectal cancer screening: * History of blood tests in the stool (hemoccult, fecal immunological test, ...) * History of colonic capsule screening * History of colonoscopy * Any known advanced neoplasia or colorectal cancer * Known genetic predisposition to colorectal cancer (very high risk group) * Adults protected by law (under guardianship or trusteeship) * Other metastatic cancers * Life-threatening diseases

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Conditions

The condition(s) this trial relates to.

colon carcinoma colonic neoplasm colorectal cancer rectal cancer rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colon cancer Rectum cancer

Contacts and locations

Locations

  • CH d'Avignon

    Avignon, Provence-Alpes-Côte d'Azur Region, 84000, France

  • CHI de Créteil

    Créteil, Île-de-France Region, 94000, France

  • CHU de Besançon - Hôpital Minjoz

    Besançon, Franche-Comté, 25030, France

  • CHU de Bordeaux - Hôpital Haut-Lévêque

    Pessac, Aquitaine, 33604, France

  • CHU de Brest - Hôpital de la Cavale Blanche

    Brest, Brittany Region, 29200, France

  • CHU de Dijon

    Dijon, Bourgogne-Franche-Comté, 21000, France

  • CHU de Limoges - Hôpital Dupuytren

    Limoges, Limousin, 87000, France

  • CHU de Nantes - Hôpital de l'Hôtel-Dieu

    Nantes, Pays de la Loire Region, 44000, France

  • CHU de Nice - Hôpital Archet II

    Nice, Provence-Alpes-Côte d'Azure, 06200, France

  • CHU de Rouen - Hôpital Charles Nicolle

    Rouen, Normandy, 16000, France

  • CHU de Saint-Etienne - Hôpital nord

    Saint-Priest-en-Jarez, Auvergne-Rhône-Alpes, 42270, France

  • CHU de Toulouse

    Toulouse, Midi-Pyrénées, 31059, France

  • Hôpital Avicenne - AP-HP

    Bobigny, Île-de-France Region, 93000, France

  • Hôpital Cochin - AP-HP

    Paris, Île-de-France Region, 75014, France

  • Hôpital Edouard Herriot - Hospices civils de Lyon

    Lyon, Auvergne-Rhône-Alpes, 69000, France

  • Hôpital Saint-Antoine - Assistance publique-Hôpitaux de Paris

    Paris, Île-de-France Region, 75012, France

  • Hôpital de la Timone - AP-HM

    Marseille, Provence-Alpes-Côte d'Azur Region, 13385, France

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