Which test is best for colon cancer screening in High-Risk families?
NCT ID NCT02738359
First seen Feb 28, 2026 · Last updated Jun 22, 2026 · Updated 16 times
Summary
This study looked at three screening methods—colonoscopy, colon capsule endoscopy, and a fecal immunochemical test (FIT)—to detect colorectal cancer or advanced growths in people aged 45 and older who have a first-degree relative with colorectal cancer. The goal was to see if the simpler tests (capsule or FIT) are as good as colonoscopy. The study enrolled 84 participants and compared how many cancers or advanced polyps each method found.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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CH d'Avignon
Avignon, Provence-Alpes-Côte d'Azur Region, 84000, France
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CHI de Créteil
Créteil, Île-de-France Region, 94000, France
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CHU de Besançon - Hôpital Minjoz
Besançon, Franche-Comté, 25030, France
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CHU de Bordeaux - Hôpital Haut-Lévêque
Pessac, Aquitaine, 33604, France
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CHU de Brest - Hôpital de la Cavale Blanche
Brest, Brittany Region, 29200, France
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CHU de Dijon
Dijon, Bourgogne-Franche-Comté, 21000, France
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CHU de Limoges - Hôpital Dupuytren
Limoges, Limousin, 87000, France
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CHU de Nantes - Hôpital de l'Hôtel-Dieu
Nantes, Pays de la Loire Region, 44000, France
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CHU de Nice - Hôpital Archet II
Nice, Provence-Alpes-Côte d'Azure, 06200, France
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CHU de Rouen - Hôpital Charles Nicolle
Rouen, Normandy, 16000, France
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CHU de Saint-Etienne - Hôpital nord
Saint-Priest-en-Jarez, Auvergne-Rhône-Alpes, 42270, France
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CHU de Toulouse
Toulouse, Midi-Pyrénées, 31059, France
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Hôpital Avicenne - AP-HP
Bobigny, Île-de-France Region, 93000, France
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Hôpital Cochin - AP-HP
Paris, Île-de-France Region, 75014, France
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Hôpital Edouard Herriot - Hospices civils de Lyon
Lyon, Auvergne-Rhône-Alpes, 69000, France
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Hôpital Saint-Antoine - Assistance publique-Hôpitaux de Paris
Paris, Île-de-France Region, 75012, France
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Hôpital de la Timone - AP-HM
Marseille, Provence-Alpes-Côte d'Azur Region, 13385, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could show that simpler, less invasive tests like colon capsule or fecal tests are as effective as colonoscopy for screening high-risk relatives.
What could go wrong
This is a small, completed study with only 84 participants, so results may not apply to larger populations. The non-inferiority margin is narrow, and differences between tests may still be uncertain.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.