Lung cancer

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This trial tests whether adding the experimental drug iadademstat to standard immunotherapy (atezolizumab or durvalumab) can help keep extensive-stage small cell lung cancer from growing. About 45 adults whose cancer responded to initial chemo-immunotherapy will receive the combi…

This Phase 3 trial will test whether a new drug called BL-M14D1 combined with atezolizumab works better than the current standard treatment for people with extensive-stage small cell lung cancer who have not had prior therapy. About 550 adults will be randomly assigned to receive…

This phase 3 trial is testing whether the immunotherapy drug durvalumab, given after surgery, can prevent early-stage non-small cell lung cancer from coming back. About 306 participants who have had their tumor completely removed will be randomly assigned to receive durvalumab or…

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This study tests whether taking special gut bacteria capsules (RMT) alongside standard chemotherapy and immunotherapy can help control advanced lung cancer. About 82 people with untreated non-small cell lung cancer will receive either RMT or a placebo. The goal is to see if the b…

This early-phase trial is testing a new oral drug called RMC-5127, alone or combined with other drugs, in adults with advanced solid tumors that have a specific KRAS G12V mutation. The study includes people with lung, colorectal, and pancreatic cancers who have already tried stan…

This study tests whether two common heart medications—atorvastatin (a statin) and lisinopril (an ACE inhibitor)—can prevent or reduce heart damage caused by radiation therapy for chest cancers like breast, lung, and esophageal cancer. About 60 adults receiving chest radiation wil…

This study tests whether using a chat-based mobile app (Zalo) can help people follow through with recommended tests after an abnormal chest X-ray read by AI. About 2,692 adults in Vietnam at risk for lung cancer or TB will be randomly assigned to receive either standard results o…

This study tests an experimental oral drug called S241656 (BDTX-4933) in people with advanced solid tumors that have certain genetic changes (KRAS, BRAF, or other RAS/MAPK mutations). The trial has two parts: first, finding a safe dose, then testing how well it works alone or wit…

This study tests the immunotherapy drug atezolizumab in 200 people with advanced solid tumors (breast, lung, GI, and others). Researchers use each person's tumor DNA to see if it predicts a response. Participants get the same dose every 3 weeks. The goal is to see if DNA analysis…

This early-phase trial is testing two drugs, osimertinib and tegavivint, as a first treatment for people with a specific type of advanced lung cancer (EGFR-mutant NSCLC that has spread). The goal is to find the best dose and see if the combination is safe and shrinks tumors. Abou…

This study tests a new drug called rezatapopt (PC14586) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The drug is designed to reactivate the p53 protein, which normally helps stop cancer growth. The trial will also test rezatapopt combined with th…

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

This study tests a new medicine called PF-08634404, given alone or with chemotherapy, for adults with early or locally advanced non-small cell lung cancer. The trial has three parts: before surgery, after surgery if cancer remains, or after chemoradiation. Researchers will check …

This study tests a new drug called BMS-986507, alone or with other cancer medicines, in adults with advanced lung or breast cancer that has spread. The goal is to check safety, side effects, and how well the drugs work. About 416 participants will receive different combinations t…

This Phase III trial is testing whether adding bevacizumab to the standard drug osimertinib can better control advanced EGFR-mutant non-small cell lung cancer. About 300 people with stage IIIB or IV disease will be randomly assigned to receive either the combination or osimertini…

This Phase 1 trial tests a new drug called BL-M07D1 in 280 adults with advanced HER2-positive cancers, including breast, lung, and stomach cancers. The study aims to find safe doses and check for early signs of tumor shrinkage. Participants must have tried at least two prior trea…

This early-stage study tests a new drug called BBO-10203 in people with advanced solid tumors (breast, lung, or colorectal cancer) that have not responded to standard treatments. The drug is designed to block two cancer-driving proteins (PI3K and RAS). Researchers will check safe…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard brain radiation can better control brain metastases that are at high risk of coming back. About 134 adults with certain cancers (like melanoma, lung, breast, or colorectal) that have spread to the br…

This clinical trial is testing a new drug called TQB6411 in people with advanced lung cancer. The study has two phases: first to find the best dose, then to see how well it works. About 465 participants will receive the drug every 21 days. Researchers will measure tumor shrinkage…

This phase 3 trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy after surgery can help prevent non-small cell lung cancer from coming back. About 1,210 people with stage II to IIIB lung cancer will receive either chemo plus pembrolizumab toge…

This study tests a new drug called AVZO-1418 in people with advanced solid tumors that have spread. The goal is to find a safe dose and see if it shrinks tumors. About 480 adults will take part, receiving the drug alone or with other treatments.

This study tests a combination of two targeted drugs—sotorasib and trastuzumab deruxtecan—in people with advanced non-small cell lung cancer that has a specific KRAS G12C mutation. The goal is to find the safest dose and see how well the combo works at shrinking tumors. About 37 …

This phase III trial compares adding chemotherapy to immunotherapy (pembrolizumab) versus immunotherapy alone in adults aged 70+ with advanced non-small cell lung cancer. The goal is to see if the combination improves survival. About 304 participants will be enrolled.

This phase II trial tests whether adding local treatments like surgery or radiation to the immunotherapy drug durvalumab can help control stage III non-small cell lung cancer that has progressed after chemoradiation and durvalumab. About 51 participants with 3 or more growing tum…

This trial tests whether adding electroacupuncture at a specific point below the knee, called Zusanli (ST36), to standard chemotherapy and immunotherapy can help shrink tumors in people with non-small cell lung cancer before surgery. The study includes 82 adults with this cancer …

This study tests a new targeted therapy called MK-1084, alone or combined with other drugs, in 190 people with advanced non-squamous non-small cell lung cancer that has a specific KRAS G12C mutation and has worsened after prior treatments. The main goals are to check safety and s…

This phase 2 trial is testing whether giving the immunotherapy drug pembrolizumab (Keytruda) along with chemotherapy before surgery can eliminate all signs of cancer in people with resectable stage II to IIIB non-small cell lung cancer. About 60 participants will receive the comb…

This phase 2 trial tests whether combining SX-682 (a drug that blocks certain immune-suppressing proteins) with atezolizumab (an immunotherapy) can shrink tumors in people with advanced non-small cell lung cancer that has worsened after chemotherapy and immunotherapy. About 32 ad…

This study looks at whether irreversible electroporation (IRE) can safely and effectively treat recurrent pelvic tumors in people who cannot have surgery, radiation, or other local treatments. IRE uses electrical pulses to destroy cancer cells without cutting or heating tissue. R…

This early-stage trial tests a new drug called DZD6008 in about 190 people with advanced non-small cell lung cancer that has a specific EGFR mutation. The main goals are to check the drug's safety and see if it can shrink tumors. Because this is the first time the drug is given t…

This early-stage trial tests a new drug called QXL138AM in about 100 people with advanced solid tumors (like ovarian, pancreatic, or lung cancer) or multiple myeloma. The drug is designed to help the immune system attack cancer cells. The main goal is to check safety and find the…

Researchers are studying whether a single-port robotic system can remove early-stage lung cancer through one small incision instead of several openings between the ribs. The approach aims to reduce pain and speed up recovery while keeping the same safety and cancer-fighting resul…

This phase 2 trial is testing a combination of three drugs—datopotamab deruxtecan, carboplatin, and pembrolizumab—in 46 people with non-small cell lung cancer that has spread to the brain and who have not had prior treatment for those brain tumors. The goal is to see how well the…

This study is testing two experimental drugs, BNT324 and BNT327, together in people with advanced lung cancer that has spread or come back. BNT324 targets and delivers a toxin to cancer cells, while BNT327 helps the immune system attack tumors and cuts off their blood supply. The…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors that have high levels of a protein called mesothelin, including mesothelioma. Participants' own immune cells are collected, modified in a lab to better attack cancer, and then gi…

This early-stage trial is testing a new type of immune cell therapy for people with advanced cancers that have a specific protein called KK-LC-1. The cancers being studied include stomach, breast, cervical, and lung cancer. Participants will receive chemotherapy followed by a sin…

This study looks at whether people with lung cancer who developed lung inflammation (pneumonitis) from immunotherapy can safely restart treatment with a different type of immunotherapy drug. Researchers will compare outcomes in patients who restart with a PD-L1 inhibitor, those w…

This study tests a personalized vaccine made from a patient's own tumor proteins, given alone or with the immunotherapy drug pembrolizumab. The goal is to see if the combination is safe and helps the immune system attack advanced solid tumors. About 132 people with various advanc…

This phase 3 trial is investigating whether adding an investigational drug called zoldonrasib to standard first-line treatment (pembrolizumab plus chemotherapy) can help people with metastatic non-squamous non-small cell lung cancer that has a specific genetic mutation (RAS G12D)…

This study tests an experimental oral drug called VMD-102 in people with advanced solid tumors, including liver, lung, kidney, skin (uveal melanoma), and colorectal cancers that have not responded to standard treatments. The drug works by blocking a specific protein (PKC epsilon)…

This study looks at whether giving radiation to the chest after surgery and chemo-immunotherapy can help people with stage III non-small cell lung cancer who still have signs of cancer after treatment. About 118 adults will be randomly assigned to receive or not receive radiation…

This study looks at whether non-small cell lung cancer patients who are less fit (performance status 2) can be treated just as effectively with a combination of chemotherapy and immunotherapy as those who are more fit (performance status 0-1). About 105 participants will receive …

This trial tests whether a personalized exercise program can safely help cancer survivors improve their physical fitness and quality of life. Participants who have finished curative treatment at least two months ago will receive a tailored plan based on heart, lung, and muscle as…

This trial tests whether a short course of exercise before lung cancer surgery can improve patients' fitness and post-operative outcomes. Participants with moderate-to-high surgical risk will be randomly assigned to either moderate-intensity continuous training or high-intensity …

This phase II trial tests a DNA vaccine called STEMVAC in 5 people with stage IV non-small cell lung cancer. The vaccine gives the body instructions to make parts of five proteins found on lung cancer cells, with the goal of activating immune cells to attack the tumor. Participan…

This trial tests whether a type of minimally invasive lung surgery that avoids inserting a breathing tube (non-intubated thoracoscopic surgery) can reduce complications in patients with impaired lung function. These patients often need ICU care after standard surgery because thei…

This study tests whether digital tools—text messages, a chatbot, an educational video, and patient navigation—can help more people in low-resource clinics get screened for lung cancer. Participants are current or former smokers aged 50–80 who speak English or Spanish and have a p…

This study compares two different schedules of stereotactic body radiotherapy (SBRT) for people with early-stage non-small-cell lung cancer. Patients are randomly assigned to receive radiation over 3 days or 5 days. The main goal is to see if one schedule causes fewer severe side…

This early-phase trial tests a new drug called TPD3310 in 112 people with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and check for early signs of tumor shrinkage. Participants receive weekly injections over 28-day cycl…

This study tests an experimental treatment called OBX-115 for people with advanced melanoma or non-small cell lung cancer that has spread or stopped responding to standard therapy. OBX-115 uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are modified in the…

This Phase 2 trial tests a drug called ivonescimab, either alone or with chemotherapy, in people with advanced non-small cell lung cancer that has certain genetic changes. The study aims to see if the treatment can shrink tumors and control the cancer. About 46 participants will …

This trial looks at whether surgically removing the primary lung tumor can help people with M1a stage lung cancer, where cancer cells are found in the chest lining during surgery. The study includes 66 adults aged 18–80 who have not had prior lung cancer treatment. Researchers wi…

This study tests a three-part program to increase the use of precision oncology—genetic testing that guides personalized treatment—for veterans with advanced lung or prostate cancer. The program includes a patient education video, feedback to doctors on their testing patterns, an…

This study tests a new drug called HS-20122 in combination with other cancer medicines for people with advanced non-small cell lung cancer. The trial includes three different drug combinations depending on the patient's tumor type. The main goals are to check safety, find the bes…

This trial investigates whether adding papaverine—a drug traditionally used as a muscle relaxant—to standard chemoradiation can improve treatment for people with stage II to III non-small cell lung cancer. Papaverine targets the energy factories inside cancer cells (mitochondria)…

This study tests a new device that uses microwave energy to destroy lung tumors during a bronchoscopy, before the patient has surgery to remove the tumor. The goal is to see if the device is safe and works well in 30 people with confirmed lung cancer who are already scheduled for…

This study looks at whether getting standard immunotherapy in the morning (before 11 am) or afternoon (after 12 pm) changes how well it fights advanced or metastatic solid tumors. Researchers think the body's internal clock (circadian rhythm) might affect immune activity. About 1…

This study tests a new treatment using a patient's own immune cells, called CAR T cells, that are specially designed to target and kill solid tumor cells while leaving healthy cells unharmed. It is for adults with certain advanced cancers, including lung, colon, pancreatic, ovari…

This phase 2 trial tests the drug avapritinib in 50 adults with advanced solid tumors that have mutations in the CKIT or PDGFRA genes. The drug blocks enzymes that help cancer cells grow. The main goal is to see how many patients' tumors shrink or disappear. Researchers will also…

This early-phase trial tests a new drug that delivers radiation directly to cancer cells carrying a specific protein called GRPR. The study includes 48 adults with advanced cancers like prostate, breast, lung, or colon cancer that have not responded to standard treatments. The ma…

This study tests whether lower doses of chemotherapy can effectively control lung cancer in patients aged 70+ or those with other health problems. About 280 participants will receive pre-set reduced chemo doses to see if tumors shrink while causing fewer side effects. The goal is…

This study is testing a precise type of radiation called stereotactic body proton therapy (SBPT) for people with early-stage non-small cell lung cancer who cannot have surgery or choose not to. About 65 participants will receive targeted proton beams in a few high-dose sessions. …

This study looks at whether adding Chinese herbal medicine to standard chemotherapy and immunotherapy can help prevent lung cancer from coming back after surgery. About 367 adults with a certain type of lung cancer (driver gene negative, stage Ib to IIIb) will take part. The goal…

This study is for adults with certain cancers (like breast, lung, or ovarian) that are in complete remission but have persistently low platelet counts from past chemotherapy. It tests whether adding a vitamin A derivative (ATRA) to a standard platelet-boosting drug works better t…

This study tests a new treatment for people with a specific type of advanced small cell lung cancer (SLFN-11 positive). The treatment combines low-dose radiation, chemotherapy, an immunotherapy drug (sugemalimab), and a targeted drug (olaparib). The goal is to see if this combina…

This study tests if axelopran, a drug used for opioid-induced constipation, can slow tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran daily for up to a year. Res…

This study tests a new surgical technique called septum-guided segmentectomy for people with small, early-stage lung cancer located deep in the lung. The goal is to remove the cancer completely while saving as much healthy lung tissue as possible, which may help preserve breathin…

This study tests whether adding ramucirumab to tepotinib works better than tepotinib alone for people with advanced non-small cell lung cancer that has a specific MET gene mutation. About 56 participants will be randomly assigned to one of two treatment groups. The goal is to see…

This study is testing a new way to give chemotherapy and immunotherapy for people with advanced lung or head and neck cancers. Instead of giving both treatments together every time, the plan alternates cycles of chemo plus immunotherapy with immunotherapy alone. The goal is to se…

This study tests whether the drug osimertinib can stop small, hazy spots (called GGNs) in the lungs from growing after surgery for a specific type of lung cancer. About 43 adults with early-stage lung cancer and an EGFR mutation will take a daily pill for one year. The goal is to…

This phase 2 trial tests a new radiation technique called lattice radiation therapy (LRT) combined with immunotherapy in 30 people with advanced solid tumors that have not responded to standard treatments. LRT delivers high doses of radiation to small spots inside the tumor while…

This study looks at whether giving early, tailored COPD treatment to people being evaluated for lung cancer can improve their breathing and overall health. About 280 participants will receive either standard care or extra COPD consultations focusing on medication, smoking cessati…

This study tests three new ways to deliver the chemotherapy drug cisplatin directly to tumors in the mouth or lungs. The goal is to kill cancer cells while reducing side effects on the rest of the body. About 40 adults with early-stage oral or lung cancer will receive the treatme…

This study tests whether giving a combination of drugs (IBI308, bevacizumab, pemetrexed, and carboplatin) before surgery can shrink stage III non-small cell lung cancer enough to allow surgical removal. The goal is to see how many people can then have surgery. The study includes …

This study tests a new device that uses microwave energy to heat and destroy lung tumors. 18 people with lung cancer who are already scheduled for surgery will receive this ablation first. The goal is to see if the device is safe and can effectively kill the tumor, which might on…

This study tests whether giving targeted drugs before surgery can help people with stage III lung cancer that has rare gene changes. About 120 adults who have not had treatment will receive a drug matched to their tumor's mutation, then doctors will check if the tumor becomes rem…

This phase II trial at Mayo Clinic is testing a special type of radiation called grid therapy combined with standard immunotherapy for people with stage IV non-small cell lung cancer that has stopped responding to treatment. Grid therapy delivers high doses of radiation to small …

This study compares two ways to destroy early-stage lung cancer tumors using heat (radiofrequency ablation) without surgery. One method goes through the chest wall, the other through the airways using a bronchoscope. Researchers will check which approach is safer and more effecti…

This study tests a flexible microwave ablation probe that can be guided through a bronchoscope to destroy small lung cancer nodules (up to 3 cm) before surgical removal. Ten people with stage I-II lung cancer will receive the ablation during a bronchoscopy, and the treated tissue…

This study is testing a new device called the FlexAblate Microwave Ablation System that uses heat from microwaves to destroy small lung cancer nodules. It is for people who cannot have surgery or choose not to. The trial will check if the device safely and completely treats the t…

This study looks at whether people with lung cancer that has spread to the brain can safely delay radiation therapy. Participants take alectinib, a targeted drug, either alone or with focused radiation. The goal is to see if starting with just the drug keeps the brain cancer unde…

This study tests a drug called osimertinib for people with a specific type of stage III lung cancer that cannot be removed by surgery. Participants take the drug before and after radiation therapy. The goal is to see if this approach helps control the cancer longer. The study is …

This phase 1 trial tests a personalized, accelerated radiation therapy for locally advanced lung cancer. The radiation dose is tailored to each patient's tumor size and location, aiming to deliver a higher dose in fewer sessions. The study will enroll 45 adults with non-small cel…

This study tests a combination of two targeted drugs (defactinib and avutometinib) plus an immunotherapy (nivolumab) in people with a specific type of advanced lung cancer (LKB1-mutant adenocarcinoma) that has stopped responding to standard treatment. The goal is to see if this t…

This early-phase trial tests a combination of two drugs, carfilzomib and sotorasib, in people with advanced or metastatic non-small cell lung cancer that has a specific KRAS G12C mutation. The study aims to find the safest dose and watch for side effects. About 15 participants wh…

This early-stage study is testing a new drug called DO-2 in people with advanced solid tumors (like lung cancer) that have a specific genetic change (MET mutation) and have run out of standard treatments. The main goal is to check the drug's safety and how the body processes it. …

This Phase 2 trial tests whether adding trilaciclib to the chemotherapy drug lurbinectedin can reduce severe neutropenia (a dangerous drop in white blood cells) in people with small cell lung cancer that has spread. About 30 participants will receive both drugs intravenously. The…

This early-stage trial tests a new drug called MRX-2843 combined with the standard targeted therapy osimertinib in people with advanced EGFR-mutant non-small cell lung cancer. The goal is to find the safest dose and see if the combination can stop tumor growth by blocking key enz…

This phase II trial is testing a new way to treat lung cancer that has spread to the brain. It combines a targeted cancer pill (osimertinib) with a special type of whole-brain radiation that tries to protect the memory center (hippocampus). The study will enroll 74 people with a …

This study tests a device that uses short electric pulses to destroy lung tumors before they are surgically removed. It involves 25 adults with suspected or confirmed lung cancer who are already scheduled for surgery. The goal is to see if the procedure is safe and can successful…

This early-phase trial tests CPO301, a drug designed to seek out and attack cancer cells that have a protein called EGFR on their surface. About 132 adults with advanced solid tumors (including lung, breast, and head & neck cancers) will receive the drug by IV every three weeks. …

This study tests a new drug, KESONOTIDE™, in people with advanced solid tumors like prostate, breast, lung, ovarian, brain, pancreas, or skin cancer. The trial has two phases: first, finding the safest dose, then testing that dose in a larger group. About 80 participants will be …

This study tests whether adding the immunotherapy drug tislelizumab after surgery can help prevent lung cancer from coming back in people with high-risk stage I non-small cell lung cancer. About 108 adults whose tumors are 2–4 cm and have certain high-risk features will receive e…

This early-stage study tests the safety of combining the drug talazoparib with low-dose chest radiation in people with extensive-stage small cell lung cancer that has not worsened after initial chemotherapy. About 24 participants will receive talazoparib pills daily during radiat…

This study is for people newly diagnosed with extensive-stage small cell lung cancer that has spread. Researchers want to see if adding a precise, high-dose radiation treatment (ablative radiation) to the standard combination of durvalumab (an immunotherapy) and chemotherapy (car…

This phase 2 study is testing stereotactic body radiation therapy (SBRT) for people with non-small cell lung cancer or other cancers that have spread to the lung. Instead of daily radiation for weeks, participants receive high doses in just 3 to 10 sessions over 1 to 2 weeks. The…

This early study tests whether injecting two cancer drugs (pemetrexed and bevacizumab) directly into the spinal fluid is safe for people with a specific type of lung cancer that has spread to the lining of the brain. The trial will enroll 19 adults whose cancer has worsened despi…

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to control advanced solid tumors like lung, pancreas, and colorectal cancers. The trial involves 54 adults whose current…

This study tests whether using a SPECT scan to map healthy, working lung tissue can help doctors aim radiation away from those areas during treatment for advanced lung cancer. The goal is to reduce lung damage and side effects like breathing problems. About 90 people with lung ca…

This phase II trial is testing whether giving a combination of two immunotherapy drugs (cemiplimab and fianlimab) before surgery can kill more tumor cells in people with stage IB to IIIB non-small cell lung cancer. About 60 participants will receive the drugs intravenously, then …

This early-phase study tests a new cell therapy called GK01 in 10 people with advanced lung or esophageal cancer that no longer responds to standard treatments. The main goal is to check safety and how the body handles the therapy. Researchers will also look for early signs of tu…

This study tests a new drug called MBRC-201 in people with advanced solid tumors (prostate, breast, colorectal, lung, or pancreatic cancer) that have not responded to standard treatments. The drug is an antibody-drug conjugate, designed to deliver a cancer-killing agent directly …

This study tests a new treatment called EBNK-001, made from donor immune cells (natural killer cells), in people with advanced solid tumors that have not responded to standard therapies. Participants receive the cells after chemotherapy to prepare the body, along with low-dose in…

This phase II trial tests whether adding diclofenac, a common anti-inflammatory painkiller, can help control advanced non-small cell lung cancer when immunotherapy alone starts to show signs of failing. About 20 adults whose cancer has progressed while on standard immunotherapy d…

This early-phase trial is testing a new drug called CLSP-1025 in about 90 adults with advanced solid tumors (like lung, colon, or breast cancer) that have a specific p53 mutation (R175H). The drug works by directing the body's immune cells to attack cancer cells carrying this mut…

This study tests whether adding a local treatment (like radiation or ablation) to the standard drug osimertinib can better control advanced EGFR-mutated lung cancer. About 64 adults with stable disease after 3-6 months on osimertinib and up to 3 remaining active spots will be ran…

This early-phase trial tests whether adding low-dose interleukin-2 (IL-2) to the immunotherapy drug pembrolizumab (Keytruda) can better activate the immune system against stage IV non-small cell lung cancer. The study will enroll 15 people who have not had prior treatment for the…

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to help the immune system attack cancer, followed by a…

This early-phase study tests a new drug called SH009 in people with advanced solid tumors (like liver, lung, breast, or stomach cancer) that have not responded to standard treatments. The main goals are to see if the drug shrinks tumors and to check its safety. About 150 adults w…

This early-phase study tests a new treatment for people with advanced lung cancer that has not responded to standard therapies. The treatment uses a patient's own immune cells (T cells) that are modified in a lab to better recognize and attack cancer cells. The main goal is to fi…

This early-stage trial tests a new drug called HC010 combined with chemotherapy in people with advanced lung cancer that has spread or come back. The main goal is to find a safe dose and check for side effects. About 328 adults will take part, and researchers will also see if the…

This phase 3 trial tests whether treating 1 to 10 metastatic tumors right away with precise radiation improves survival compared to waiting 3 months. It includes 800 adults with lung, colorectal, or prostate cancer that has spread to a few spots. Participants are randomly assigne…

This phase 3 trial is testing whether a personalized program of supplements (vitamin D, mushroom extract, fish oil, probiotics, and whey protein) plus lifestyle coaching can improve recovery and quality of life for people undergoing surgery for lung, stomach, or esophageal cancer…

This study tests whether ciprofol, a newer sedative, can reduce heart injury after lung surgery compared to the standard drug propofol. About 1,058 adults aged 45–80 having video-assisted lung surgery will be randomly assigned to receive one of the two drugs during anesthesia. Th…

This early-phase study tests a new treatment called PTC13, which uses specially engineered immune cells (CAR-T cells) to attack cancer cells that have a protein called CEA. The study includes 18 adults with advanced colorectal, stomach, pancreatic, or other solid tumors that have…

This study is testing an anti-PD-1 antibody (a type of immunotherapy) alone or combined with low-dose decitabine and/or standard chemotherapy in people whose cancers have come back or not responded to treatment. The trial includes patients with several cancer types, such as lymph…

This study tests a new drug called 3H-10000, which is an antibody-drug conjugate designed to target and kill cancer cells. It is for people with advanced lung or stomach cancer that cannot be removed by surgery or has spread. The trial will enroll 170 participants to find the saf…

This study is for people with a type of advanced lung cancer that cannot be removed by surgery. It tests a new approach that combines chemotherapy, radiation, and two types of immunotherapy to see if it can control the cancer longer. The trial involves 56 participants and aims to…

This early-phase trial tests an inhaled mRNA vaccine called BMD006 in 83 people with advanced lung cancer or solid tumors that have spread to the lungs. The vaccine is designed to train the immune system to attack tumor-associated antigens. The study will check safety, tolerabili…

This early-phase study tests a new treatment called GC203 TIL for people with advanced solid tumors (cancers in organs like the breast, lung, or gut) that have not responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to bet…

This study tests whether a low dose of radiation to the small intestine can help the immune system fight cancers that have stopped responding to immunotherapy. About 48 adults with advanced lung, esophageal, or other solid tumors will receive one radiation session followed by con…

This study tests a therapy using a patient's own tumor-infiltrating lymphocytes (TILs) to treat advanced non-small cell lung cancer. Doctors collect immune cells from a tumor, grow them in a lab, and infuse them back after mild chemotherapy. The goal is to see if this slows cance…

This study tests a drug called atezolizumab (Tecentriq) plus standard chemotherapy in 97 people with stage III non-small cell lung cancer. After initial treatment, some may have surgery, while others continue on atezolizumab. The goal is to see if this approach helps keep the can…

This study tests an inhaled treatment called KB707, a modified herpes virus designed to trigger the immune system against lung tumors. It is for adults with advanced solid tumors that have spread to the lungs and who have run out of standard options. The trial will test KB707 alo…

This study tests A2B395, a donor-derived CAR T-cell therapy designed to target cancer cells while sparing healthy ones. It is for adults with advanced solid tumors like colorectal, lung, or breast cancer that have lost a specific immune marker. The trial has two phases: first to …

This study tests whether doctors can deliver very high doses of radiation to tumors in the abdomen or chest using an MRI-guided machine, while limiting harm to nearby organs. About 60 people with abdominal or lung cancer will take part. The main goal is to see if the treatment ca…

Researchers are developing an artificial intelligence model that reads preoperative CT scans and clinical data to predict whether lung cancer associated with cystic airspaces has high-risk features. The study includes 600 patients with non-small cell lung cancer who had surgery a…

This study is testing a new blood test to find early-stage lung cancer in heavy smokers who have no symptoms. Researchers will collect blood samples from 350 current or former smokers aged 30-80, including those with and without lung cancer. The goal is to see if the test can det…

Researchers at Indiana University are testing an educational program called ED-LCS that teaches emergency department patients about lung cancer screening. The study enrolls adults aged 50 to 80 who have smoked at least 20 pack years and quit within the past 15 years, making them …

This trial investigates whether a femtosecond laser combined with an artificial intelligence model can diagnose lung cancer from fresh tissue samples as accurately as the standard frozen section method. About 294 adults scheduled for lung surgery will have their tumor specimens e…

This study looks at whether people with unexplained weight loss who are at high risk for lung cancer are more likely to develop the disease. Researchers will use low-dose CT scans and blood tests to screen 409 participants over one year. The goal is to see if adding weight loss t…

This study aims to see if a new blood test can accurately detect lung cancer by analyzing RNA from platelets. Researchers will collect blood samples from 240 adults with lung cancer or suspicious lung nodules. The goal is to validate whether this AI-powered test can distinguish b…

This trial compares two established biopsy methods for small lung nodules (≤2 cm): CT-guided percutaneous biopsy and shape-sensing robotic-assisted bronchoscopy with cone-beam CT. The goal is to see which approach is more effective at diagnosing cancer and which has fewer complic…

This study is testing a lung cancer screening program for smokers aged 45 to 74. It uses low-dose CT scans and metabolomics to find lung nodules and reduce false negatives. The goal is to improve early detection and help smokers quit. 1,000 participants will be followed in a publ…

This Phase 3 trial tests a fluorescent dye called abenacianine that makes lung cancer cells glow under a special camera during surgery. About 132 people having lung cancer surgery will receive the dye. The goal is to see if the dye helps surgeons find tumors that are hard to see …

This early-stage trial tests an experimental imaging agent called pemefolacianine in people with lung cancer who are scheduled for surgery. The agent is given as an injection before the operation, and researchers will check whether it safely makes cancer tissue glow under special…

This trial is testing whether a new radioactive tracer, called 68Ga-SorB, can help doctors see certain solid tumors on PET/CT scans. The tracer targets sortilin, a protein that is often found on cancer cells. About 50 adults with melanoma, liver, lung, breast, pancreatic, or ovar…

This study is testing a new device called a nitride-based Raman biochip that analyzes blood samples using light to detect molecular patterns linked to lung cancer. Researchers will compare results from 2,000 people with lung cancer and 1,000 without to see if the test can accurat…

This trial tests an artificial intelligence platform called NodeAI that analyzes ultrasound images in real time during a lung cancer staging procedure. The goal is to see if the AI can predict whether lymph nodes contain cancer more accurately than a surgeon's visual assessment. …

This study is testing whether a blood test that looks for specific chemical changes on DNA can help diagnose lung cancer. Researchers will collect blood samples from 750 adults, including those with lung cancer, precancerous conditions, and healthy volunteers, and analyze the DNA…

This study is testing a new test called FlowPath Lung that looks for signs of lung cancer in sputum (phlegm). It involves over 2,000 high-risk individuals aged 50-80 who have lung nodules found on CT scans. The goal is to see if this non-invasive test can accurately detect early-…

This study is testing a new blood test that looks for pieces of tumor DNA (EGFR mutations) to screen for lung cancer in healthy people aged 50-80 who are of East Asian, Southeast Asian, or Hispanic/Latinx background and do not currently smoke. The goal is to find lung cancer earl…

This study uses mobile low-dose CT scans to screen for lung cancer in people aged 40-54 who have a heavy smoking history (30 pack-years or more). Participants in North and South Carolina will get up to three scans over time. The goal is to see if screening younger high-risk smoke…

This study tests whether a special lung MRI, combined with a computer-generated CT-like image, can accurately detect lung cancer in heavy smokers. Participants are 55–74 years old with a solid lung nodule found on a prior scan. The goal is to see if this non-invasive method can r…

This study looks at whether community pharmacists can help more people get screened for lung cancer. It will enroll 300 adults aged 50-77 who are current or former heavy smokers. Participants can choose a simple blood test or a CT scan to check for early signs of lung cancer. The…

This study is testing whether low-dose CT scans can help find lung cancer early in people at high risk. About 20,000 adults aged 50-74 who are current or former heavy smokers will get a CT scan at the start, then again after 1 and 3 years. The goal is to see how many lung cancers…

This study is testing whether a simple blood test, combined with artificial intelligence (AI), can help find lung cancer early in people with COPD who are current or former smokers. About 1,000 participants will give a blood sample, and those flagged as high-risk by the AI will g…

The NIMBLE study is testing whether blood-based biomarkers can accurately distinguish between cancerous and non-cancerous lung nodules. Researchers will analyze blood samples from 1,800 patients referred with a lung nodule, looking at protein markers, epigenetic smoking markers, …

This study tests an FDA-approved AI software that analyzes CT scans of lung nodules to estimate cancer risk. 300 adults aged 35-89 with newly found lung nodules will be randomly assigned to have their doctors use the AI tool or not. The goal is to see if the AI helps doctors mana…

This study compares two ways to take tissue samples from small lung spots found during screening. One method uses standard forceps, the other uses a freezing probe (cryo biopsy) to get larger samples. The goal is to see if cryo biopsies give a clearer diagnosis with fewer complic…

This study is testing whether combining low-dose CT scans with blood-based biomarker tests can improve lung cancer screening in high-risk people. It will enroll 1,000 participants in Singapore, including both smokers and non-smokers. The goal is to see if this approach is practic…

This study tests an AI tool that looks at routine chest X-rays and medical records to find people at high risk for lung cancer. The AI alerts their doctor to discuss lung cancer screening. The goal is to see if this alert helps more high-risk people get a lung cancer screening CT…

This study is looking for biomarkers—clues in the body—that could help find lung cancer early. Over 3,600 participants, including people at high and low risk for lung cancer, will provide samples and undergo CT scans. The goal is to see if these biomarkers can spot tumors before …

This study is testing a device called Inflammacheck that measures chemicals in a person's breath to see if it can help tell the difference between lung cancer, other lung diseases, and healthy lungs. Researchers will collect breath samples from 140 adults and use AI to build a di…

This study is testing whether a minimally invasive procedure called EBUS-TBNA is more accurate than standard CT/PET scans for checking if lung cancer has spread to lymph nodes in the chest. The goal is to better select patients for a precise type of radiation therapy (SBRT). Abou…

This study is testing a new radioactive imaging agent that targets a protein called LRRC15, found on many cancer cells. Researchers will use PET scans to see if this agent can better detect and stage cancers like pancreatic, breast, lung, and others. The trial includes 26 healthy…

This study aims to see if analyzing DNA from fluid left over after a lung nodule biopsy can better detect cancer. About 60 adults with small lung nodules (20 mm or less) will have a standard bronchoscopy, and the leftover fluid will be tested for cancer-related DNA changes. If su…

This study looks at whether offering lung cancer screening through telehealth (phone or video visits) can help more high-risk people get tested. Researchers will identify eligible smokers aged 50-80, confirm their eligibility by phone, and schedule either an in-person or teleheal…

This study compares standard bronchoscopy (using a thin tube to look at the lungs) with and without an additional laser-based microscope called nCLE. The microscope helps doctors see if the sampling needle is in the right spot before taking tissue. About 208 adults with suspiciou…

This study is testing whether an artificial intelligence (AI) blood test and risk model can help find lung cancer early in people at high risk. Researchers will enroll 400 adults aged 50-80 who smoke or recently quit. Some will get the AI blood test, others an AI analysis of thei…

This early-stage trial is testing a new radioactive tracer called 68Ga-FXX489 (NNS309) for PET/CT scans. The goal is to see if it can safely and accurately detect tumors and their spread in 30 adults with suspected cancer. Researchers will measure how the tracer moves through the…

This study aims to see if a special MRI scan called CEST can accurately tell apart radiation damage from tumor growth in people with lung cancer that has spread to the brain. About 60 adults who have had radiation therapy for brain metastases and show new changes on follow-up MRI…

This study tests whether adding a freezing biopsy (cryobiopsy) to the standard needle biopsy improves diagnosis of lung cancer that has spread to the chest. About 240 adults with suspicious chest lymph nodes will get both procedures. The goal is to see if the combo finds cancer m…

This study is testing whether an artificial intelligence program can help detect lung cancer early in non-smokers aged 50 to 75 who have a close family member with lung cancer. About 3,000 participants will get a low-dose CT scan of their chest, and the AI will analyze the images…

This study is testing whether an artificial intelligence (AI) system can accurately identify different types of lung cancer by analyzing PET/CT scans and patient information like age, smoking history, and tumor markers. Researchers aim to improve how doctors distinguish between s…

This study is testing whether measuring telomeres (parts of your DNA) in a blood sample can help doctors diagnose lung cancer. Researchers will collect blood from 1,200 people, including those with lung cancer and healthy volunteers, to build a predictive algorithm. The goal is t…

This early-phase study is testing a new imaging agent called [68Ga]CBP8 to see if it can safely and accurately detect collagen buildup (scarring) in the lungs. Researchers will compare scans from healthy volunteers, lung cancer patients, and people with pulmonary fibrosis. The go…

This early-phase study is testing a new radioactive tracer for PET scans that may better detect non-small cell lung cancer that has spread to the brain. About 20 adults with this type of lung cancer and brain metastases will receive the tracer and undergo imaging. The goal is to …

This study tests a special PET probe called [68Ga]CBP8 to see if it can detect tissue damage caused by radiation therapy in people with lung or pancreatic cancer. About 72 participants will get a PET scan before and 3-6 months after radiation. The goal is to find early signs of r…

This study is testing two new diagnostic kits that use blood samples or tumor tissue to predict if early-stage lung cancer will come back after surgery. Researchers will enroll 236 people with stage IA to IIIA lung cancer who have had their tumor fully removed. The goal is to see…

This study looks at whether doctors need to change the needle between taking samples from different lymph nodes when staging lung cancer. About 30 people with suspected or confirmed lung cancer will have two rounds of staging—one with a needle change and one without. The goal is …

This study looks at whether a quick swallowing test done by a physical therapist can reliably detect vocal cord paralysis after major lung cancer surgery, compared to the standard scope exam. About 72 adults having lung surgery will take a swallowing test and a scope test right a…

This study tests a new robotic technology (ssRAB) to take tissue samples from lung nodules. Current methods work only about 70% of the time; the robot aims to be more accurate and safer. About 100 adults with lung nodules will undergo the procedure under anesthesia and be followe…

This study is testing whether a breath test can detect lung cancer early in people at high risk. Researchers will collect breath samples from 3,200 current or former smokers aged 55-74 and compare the results to standard low-dose CT scans. If the breath test works well, it could …

This study tests a special dye, panitumumab-IRDye800, that attaches to lung cancer cells and makes them glow under a special camera during surgery. The goal is to help surgeons see and remove all cancer tissue more accurately. About 30 adults with lung cancer or lung metastases w…

This study is testing a new blood test that looks at tiny pieces of DNA (cfDNA) to find out if lung nodules seen on CT scans are cancer or not. Researchers will study 240 adults with small lung nodules to see how accurate the test is. The goal is to avoid unnecessary biopsies or …

This study is testing a new way to detect cancer by looking at certain enzymes in the blood. Researchers will collect blood samples from 220 people—120 with breast, lung, or pancreatic cancer and 100 without cancer. They want to see if the enzyme levels are different between the …

This study is testing a new blood test that uses NMR technology to spot lung inflammation caused by immunotherapy drugs. The goal is to catch this serious side effect early, so doctors can treat it quickly. The study will include 60 people with lung cancer who are on immunotherap…

This study is testing a new way to screen for early lung cancer using a combination of breath analysis, blood tests, and CT scans. Researchers aim to reduce the high rate of false positives from CT scans alone. They will enroll 1,800 participants, including people with lung cance…

This study is testing whether a blood test (liquid biopsy) can be used as a first step to screen for lung cancer in high-risk people, before deciding if they need a low-dose CT scan. The goal is to reduce unnecessary scans, radiation exposure, and healthcare costs. The study will…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before it shows up on scans. The …

This study is testing a new AI-powered blood test that looks at platelets and immune cells to find early signs of eight different cancers, including lung, breast, and pancreatic cancer. Researchers will collect blood samples from 6,000 adults aged 40 and older, both with and with…

This study will give yearly low-dose CT scans to 1,000 people in Mexico who are at high risk for lung cancer—including heavy smokers, former smokers, and those exposed to wood smoke. The goal is to see if regular screening can find lung cancer at an earlier, more treatable stage.…

This pilot study is testing whether it's practical to add an abdominal CT scan to the standard lung cancer screening for people aged 55-70 who have smoked. The goal is to see if this extra scan can detect kidney cancer, abdominal aortic aneurysms, and kidney stones without slowin…

This study will give low-dose CT scans to over 6,600 people in Taiwan who are at high risk for lung cancer due to heavy smoking, family history, or environmental exposures like air pollution. The goal is to see how many people agree to screening and how many lung cancers are foun…

This study tests whether giving people a personalized report about their cancer risk and screening options helps them complete recommended cancer tests. Adults aged 45 to 74 who are at high risk for lung, breast, colorectal, upper gastrointestinal, or liver cancer are invited to …

Researchers are testing whether giving targeted radiation to lung tumors before a lung transplant can create an immune response that helps the body fight cancer. The trial enrolls adults with end-stage lung disease and hard-to-treat lung cancer who need a transplant. The goal is …

This trial tests whether drinking 40 mL of extra-virgin olive oil four hours before lung cancer surgery can reduce the risk of chylothorax, a rare but serious complication where lymphatic fluid leaks into the chest. About 1,036 adults with resectable lung cancer will be randomly …

This trial tests whether a mobile app called Wellnuts can help healthy adults aged 25–65 in Hong Kong become more aware of their health risks and take action. Participants use the app to assess their risk for conditions like diabetes, heart disease, and certain cancers, and recei…

Lung cancer is the top cancer killer of Veterans, often found too late to cure. This trial tests whether giving doctors personalized prediction tools and dashboards can increase lung cancer screening rates among 23,520 high-risk Veterans. The goal is to catch cancer earlier and r…

This study tests a smartphone app designed to encourage mothers of children aged 4 and under to test their homes for radon, a radioactive gas that is the second leading cause of lung cancer. Participants receive a free radon test kit and use the app to learn about radon risks. Th…

This study tests whether combining electroacupuncture (a type of acupuncture with mild electric pulses) with a standard nausea drug can prevent vomiting after lung cancer surgery. The trial will include 204 high-risk patients undergoing thoracoscopic surgery. The main goal is to …

This phase 2 trial tests whether riluzole, a drug already approved for ALS, can prevent the cognitive problems (often called 'chemo brain') that many cancer patients face during chemotherapy. The study will enroll 24 adults with various cancers who are about to start chemotherapy…

This study tests a new centralized screening unit at Montefiore-Einstein to help more people in the Bronx get screened for lung cancer. The unit will identify eligible smokers, educate them, and guide them through the screening process. Researchers hope this will lead to earlier …

This study looks at whether smokers aged 50-74 are more likely to get a low-dose CT scan for lung cancer when their family doctor recommends it. Researchers will track how many people complete the scan within one year. The goal is to catch lung cancer early in high-risk smokers.

This trial tests whether a mobile van with a CT scanner can help more people get screened for lung cancer, especially those who are socially disadvantaged. Over 4,300 heavy smokers aged 50-74 will be randomly assigned to either the mobile unit or a hospital. The goal is to see if…

Researchers are testing whether an AI-generated, personalized discharge plan improves the quality of discharge teaching and recovery for people who had lung cancer surgery. The trial enrolls 156 adults who had surgery for stage I to III lung cancer and are going home to recover. …

This study tests whether a nerve block given through a small port under the skin can help control chest pain in people with advanced lung cancer. The block delivers numbing medicine near the chest wall nerves. Researchers will compare pain levels and side effects in 180 patients …

Researchers are studying whether nutritional support helps people with advanced lung cancer maintain their weight, strength, and quality of life during chemotherapy. The trial enrolls 100 adults with high nutritional risk. Participants receive dietary advice or a structured nutri…

This study tests a flexible palliative care program for people with advanced heart failure or certain cancers. The program adds more team members—like a social worker or nurse—as symptoms get worse. The goal is to improve quality of life and match care to each person's changing n…

This study compares standard palliative radiation for lung tumors with a newer, more focused technique that delivers a higher dose while sparing the esophagus. The goal is to improve or maintain quality of life by better controlling symptoms and reducing side effects. About 141 a…

Cancer treatment often leaves patients with a deep, lasting tiredness that few treatments can fix. Researchers are testing whether guarana, a caffeine-rich Amazonian plant, can reduce that fatigue and improve daily life. The study gives 60 people with breast, lung, colorectal, ce…

This trial tests whether low-intensity endurance exercise can reduce cancer-related fatigue and improve quality of life in lung cancer patients. Participants will either do continuous exercise or interval exercise for 30 minutes a day, five days a week, for 12 weeks. Researchers …

This study tests whether a 20-minute exercise session on a stationary bike, done right before each radiotherapy treatment, is practical and safe for people with stage I-III non-small cell lung cancer. About 30 participants will try the program, and researchers will track how many…

This study tests two different ways to numb nerves around the chest to control pain after lung cancer surgery. Sixty adults having lung cancer surgery will be randomly assigned to one of two nerve block techniques. The goal is to see which method provides better pain relief durin…

This study compares two ultrasound-guided nerve blocks—rhomboid intercostal block and erector spinae plane block—for pain control after lung cancer surgery. Sixty adults undergoing thoracotomy will receive one of the two blocks with bupivacaine. Researchers will measure morphine …

This study tests if a painkiller called oliceridine can prevent long-term pain after lung surgery better than the usual drug, sufentanil. About 320 adults having keyhole lung surgery will receive one of the two drugs through a pump they control. The main goal is to see if fewer p…

This trial tests whether low-intensity endurance exercise can reduce cancer-related fatigue and improve sleep, stress, and quality of life in people with lung cancer. Researchers will compare two exercise styles: continuous and interval, both done for 30 minutes a day, five days …

This study tests a program called ICCAN that gives cancer patients extra help with social and economic needs, like finding resources and monthly check-ins. Researchers want to see if this support helps patients complete their cancer treatment and improves their quality of life, c…

This pilot trial tests a new approach to support cancer patients and their caregivers. The intervention combines social prescriptions—connecting people to community resources—with short online learning modules and regular symptom check-ins. The goal is to see if this package can …

This study tests whether N-acetyl cysteine (NAC) and a short course of steroids can reduce severe shortness of breath after lung radiation in people with both lung cancer and interstitial lung disease. About 98 participants will receive either NAC or placebo, plus either steroids…

This study tests whether doing breathing exercises at home can help reduce heart and lung side effects in people being treated for breast, head/neck, or lung cancer. The exercises are designed to strengthen breathing muscles and may be easier than regular aerobic exercise for pat…

This trial tests whether adding acupoint application—a herbal plaster placed on specific body points—to a standard anti-nausea drug can better control nausea and vomiting caused by chemotherapy in adults with lung cancer. Participants receiving first-line platinum-based chemother…

This study looks at whether 12 weeks of different exercise programs can help people with advanced lung cancer who are already receiving immunotherapy. The goal is to see if exercise is safe and doable, and if it can improve immune markers. About 30 adults with non-small cell lung…

This trial tests whether a newer ultrasound-guided nerve block, called retro-SCTLB, provides better pain relief after minimally invasive lung cancer surgery than the standard thoracic paravertebral block. Adults aged 18-80 scheduled for thoracoscopic lung cancer removal will be r…

This pilot study tests whether a personalized exercise program is practical for 20 adults with stage II or III non-small cell lung cancer who are about to start treatment. Participants will follow the Precise Exercise Regimen for Cancer Care (PERCC) program before and after their…

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This study is testing a stress management program designed for people with lung cancer who are waiting for routine scan results. The program includes a short orientation, self-guided web modules with stress management exercises, and coaching calls. Researchers want to see if the …

This study tests a navigation program for cancer patients starting immunotherapy. The program helps with essential needs like food, transportation, and housing, and tracks side effects. Researchers want to see if this support helps patients continue their treatment and improves t…

This study tests whether yoga and mindfulness programs can improve quality of life, reduce inflammation, and even affect gene activity in people who have survived lung, colon, or non-Hodgkin's lymphoma cancer. One hundred survivors, at least six months past treatment, will be ran…

This study tests a nurse-led support model (ICSM) for family caregivers of older adults newly diagnosed with advanced non-small cell lung cancer. The program includes education, counseling, symptom management, and a web-based resource platform. Researchers will measure whether it…

This study tests a home-based palliative care program called TIER-PC that adjusts the care team based on a patient's symptoms and ability to function. It includes 60 adults with advanced heart failure or certain cancers living in Manhattan. The program adds more specialists—like …

This study tests whether riluzole, a drug already used for ALS, can help cancer survivors who struggle with memory, focus, and mental clarity after treatment — a condition called cancer-related cognitive impairment. Researchers will measure changes in a brain protein called BDNF …

This study tests a new program called Open Door for Cancer (OD-C) designed to help older adults (65+) who have been diagnosed with breast, colorectal, lung, or prostate cancer and are feeling depressed. The program aims to make it easier for them to start mental health care. Rese…

This study tests whether a mobile app called THRIVE can help people with newly diagnosed advanced lung cancer feel better day-to-day. Researchers will compare quality of life, physical and emotional symptoms, and coping skills between app users and those receiving usual care. The…

This trial investigates whether a comprehensive geriatric assessment—a detailed evaluation of an older person's health, function, and social support—can help doctors make better treatment decisions for adults aged 60 and older with non-small cell lung cancer. Participants receive…

This study tests whether wearing a virtual reality (VR) headset during daily radiation therapy can help manage anxiety in people with prostate, breast, lung, or head and neck cancer. About 54 patients will use a Meta Quest 2 headset during their treatments, and researchers will t…

This study tests whether freezing certain nerves during minimally invasive lung surgery can help patients recover faster with less pain. 150 adults having lung surgery will either get standard pain management or standard care plus nerve freezing. The goal is to see if the freezin…

This study tests whether acupuncture at specific points before and after lung cancer surgery can improve sleep and reduce long-term pain. About 316 patients will receive either real or sham acupuncture alongside standard care. The goal is to see if this simple, low-risk treatment…

This study tests whether using a mobile app that gives visual feedback can help lung cancer patients do breathing exercises more effectively after having part of a lung removed. Forty patients will try both standard breathing training and app-guided training on the same day. Rese…

This study tests whether a telehealth education program, called Surgery School, helps people prepare for lung or major abdominal cancer surgery. Participants will watch videos and talk with a clinician online before their operation. The goal is to see if this reduces breathing pr…

This study tests a program to help long-term lung cancer survivors feel more socially connected and improve their quality of life. Thirty survivors will be randomly assigned to either the program or a comparison group. The program uses techniques from cognitive behavioral therapy…

This study tests whether a combination of two drugs, fosrolapitant and palonosetron, plus a steroid, can prevent nausea and vomiting caused by chemotherapy and immunotherapy in people with esophageal or lung cancer. About 120 participants will receive the drug before each chemo c…

This study tests a new way to plan radiation therapy for people with stage 3 lung cancer. The method uses CT ventilation imaging to identify and avoid the healthiest parts of the lungs during treatment. Researchers want to see if this approach helps patients maintain a better qua…

This study tests whether an artificial intelligence (AI) system can improve recovery after lung cancer surgery. About 868 patients from 20 hospitals will be randomly assigned to either standard care or standard care plus an AI tool that tracks symptoms, activity, and recovery pro…

This pilot study tests whether brodalumab, a drug used for autoimmune conditions like psoriasis, can safely reduce immune-related side effects caused by cancer immunotherapy. About 11 adults with advanced solid tumors who developed these side effects will receive brodalumab injec…

This study tests a brief program called Pathways, designed to help people with advanced lung cancer set personal goals and improve their mental health and quality of life during treatment. About 234 participants will be randomly assigned to receive either the Pathways program or …

This study tests whether a tablet-based video program can help rural cancer patients better understand their care and feel more coordinated. About 40 adults with early-stage breast, lung, or colon cancer living in rural Vermont will be randomly assigned to receive the videos righ…

This study explores whether a couple-based meditation program can improve quality of life for people with stage IV lung cancer and their romantic partners. Researchers will enroll 300 couples to attend meditation sessions and complete questionnaires about their health, mood, and …

This study looks at whether using a lower suction setting on a chest drainage device after lung cancer surgery can help the chest tube come out sooner. About 160 adults having part of a lung removed will be randomly assigned to either the standard suction or a gentler one. The go…

This study tests whether using an incentive spirometer—a device that encourages deep breathing—can lower the risk of lung inflammation (pneumonitis) in people with advanced lung cancer receiving chemotherapy and radiation. About 100 participants will use the device 10 times every…

This study compares two types of nerve blocks for pain relief after lung cancer surgery. One block is done before surgery near the spine, the other during surgery between the ribs. Researchers will measure pain scores and how much additional pain medication patients need. The goa…

This study is testing a jelly-based nutritional supplement in 52 people with head and neck, lung, or rectal cancer who are receiving standard cancer treatments like chemo or radiation. The supplement contains ingredients like arginine, omega-3, and olive oil, and is taken twice d…

This study tests a short, pre-surgery rehab program for people who smoke and have a lung nodule that may be cancer. About 20 participants will do breathing exercises and get help to stop smoking. The goal is to see if this program is practical and can improve fitness, reduce symp…

This study tests a telehealth program called ENGAGE for people with stage IV breast, prostate, lung, or colorectal cancer. The program helps manage symptoms like pain, fatigue, and distress that interfere with daily life. About 190 participants will be randomly assigned to ENGAGE…

This study tests whether regular phone support from a trained lay health worker can improve quality of life for veterans with lung cancer. 194 veterans will either receive usual care or weekly calls for 6 months. The goal is to see if this extra support helps with healthcare plan…

This study looks at whether a 6-month home exercise and nutrition program can improve thinking and physical abilities in cancer survivors aged 65 and older, along with their support person. About 1,500 participants will be assigned to either a virtually supervised or unsupervised…

This study tests two types of nerve blocks to see which one better prevents shoulder pain after lung surgery. 75 adults with lung cancer scheduled for open-lung surgery will receive either an interscalene block, an anterior suprascapular block, or standard epidural pain relief. T…

This study tests whether injecting a numbing medicine (bupivacaine) near the spine can reduce pain and the need for opioid painkillers after lung surgery. Researchers will track pain scores and medication use in 70 adults undergoing lung tumor removal. The goal is to find a safer…

This study tests a special program designed to help people living in rural areas who have had lung cancer. The program focuses on improving quality of life, reducing stigma, and helping survivors stay engaged with their healthcare. About 300 participants will be randomly assigned…

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

This study tests a six-week program of morning bright light exposure combined with moderate walking for people with lung or esophageal cancer. The goal is to see if it can improve sleep-wake rhythms, reduce physical and emotional symptoms, and boost quality of life. Two hundred p…

This study tests whether a smartphone app that lets cancer patients report their symptoms, combined with regular calls from a specially trained nurse, can help them better manage chemotherapy side effects and improve their quality of life. The study includes 414 adults with early…

This study tests whether a special imaging method (4DCT) can help doctors avoid giving too much radiation to healthy, working parts of the lung during radiotherapy for lung cancer. About 100 adults with lung cancer will receive standard radiation, but their treatment plan will be…

This study tests a program for older adults (65+) with cancer and mild memory issues, along with their spouse or caregiver. Over six video sessions, the pair learns strategies to manage challenges. The goal is to see if the program reduces distress and improves quality of life. A…

This study tests whether injecting a patient's own blood into the lung lining (a pleural blood patch) can prevent air leaks after thermal ablation for lung cancer. About 106 adults scheduled for lung ablation will be randomly assigned to receive the blood patch or not. The main g…

This study tests whether a special breathing exercise program can improve oxygen use, balance, and physical activity in people who have had lung cancer surgery. Forty adults aged 18-80 who are in remission will do breathing training with a device for 4 weeks, then add functional …

This study tests two different nerve blocks to control pain after lung cancer surgery. 70 adults will receive either a costotransverse foramen block or a thoracic paravertebral block, both using the numbing drug bupivacaine. The goal is to see which block reduces the need for mor…

This study tests whether a traditional Chinese medicine formula called modified Bufei Decoction can reduce cough, fatigue, and shortness of breath in elderly patients who have had lung cancer surgery. About 174 participants will receive either the herbal granules or a placebo twi…

This study tests whether adding intravenous vitamin C to standard chemotherapy can improve quality of life for people with advanced non-small cell lung cancer. About 90 adults with incurable lung cancer will receive either vitamin C or a placebo alongside their usual treatment. T…

This study tests whether a high dose of the steroid dexamethasone can reduce pain when coughing after lung surgery (VATS lobectomy or segmentectomy) in patients who score high on a pain-expectation scale. 80 adults will be randomly assigned to receive either a high dose (1 mg/kg)…

This study is testing a supervised exercise program for people with cancer. Participants will take part in group exercise classes twice a week for 8 to 12 weeks. The goal is to see if the program helps improve physical activity levels and manage cancer-related symptoms. The study…

This study tests whether adding daily cycling to standard physical therapy helps people recover faster after minimally invasive lung cancer surgery. 184 participants will be randomly assigned to either standard rehab or standard rehab plus 20 minutes of stationary cycling. The ma…

This study tests a decision-making support program based on restorative justice principles, designed specifically for Black adults who are at high risk for lung cancer. The goal is to see if this approach increases understanding, trust, and willingness to get screened. Forty-five…

Researchers are studying whether a next-generation radiation delivery system can run a complete treatment workflow while patients hold their breath. The trial enrolls about 20 adults with tumors in the chest or upper abdomen who are already scheduled for stereotactic body radiati…

This study is a registry that will follow 600 people with early-stage lung cancer who undergo a surgery called segmentectomy. Participants will fill out questionnaires about their health before surgery, shortly after, and six months later. The goal is to measure how long people l…

This observational study follows 50 adults with locally advanced or metastatic lung cancer who are starting chemotherapy or immunotherapy. Researchers want to see how cancer-related fatigue and daily physical activity change during treatment, and whether those changes are connect…

This study looks at how chemoradiation for locally advanced lung cancer affects the heart. Researchers will track 100 patients using heart tests, blood samples, and questionnaires. The goal is to see if tailoring treatment based on individual risk can reduce heart problems.

This study looks at whether getting immunotherapy infusions in the morning versus the afternoon changes outcomes for people with advanced lung cancer or head and neck cancer. About 238 participants will be randomly assigned to morning or afternoon infusions. Researchers will trac…

This study compares two types of minimally invasive lung cancer surgery: robotic-assisted (RATS) and video-assisted (VATS). It will follow 512 patients across Europe to see which technique leads to better quality of life and recovery. The goal is to help surgeons and patients mak…

This study looks at whether a structured program can help more high-risk smokers get a first lung cancer screening with a CT scan. About 500 people aged 50 to 74 who smoke or recently quit will join. The goal is to see if a dedicated network makes screening easier and more effect…

This study involves 3,400 people with advanced non-small cell lung cancer to see if a new test for a protein called TROP2 works consistently across different laboratories. The goal is to ensure that doctors can reliably use this test to guide treatment decisions. Participants pro…

This study aims to collect tumor, normal tissue, and blood samples from up to 1559 people with cancers of the lung, esophagus, or pleura. Researchers will analyze genetic and epigenetic changes to better understand these diseases and identify potential markers for future treatmen…

This study tests a new way to increase lung cancer screening in people at high risk. Researchers will use the emergency department to identify eligible patients and offer them extra help to get a low-dose CT scan. The goal is to see if this approach works better than standard car…

This observational study in Vietnam looks at archived tumor samples from patients with several solid cancers, including liver, colorectal, gastric, breast, lung, endometrial, melanoma, and pancreatic cancer. Researchers will measure the presence of two proteins, ENPP1/cGAS and FA…

This study screens adults with certain cancers (like melanoma, lung, or colorectal cancer) to see if they qualify for experimental treatments being tested by the NCI Surgery Branch. These treatments involve taking a patient's own immune cells, growing them in a lab, and giving th…

This study looks at 500 people with a rare type of lung cancer that has air-filled pockets (cysts). Researchers want to find the best way to measure these tumors to improve staging and predict outcomes. By reviewing past CT scans and health records, they hope to help doctors make…

This study will review health records of 60,000 adults with lung cancer in Alberta and Ontario to understand current treatments, survival rates, and healthcare costs. It aims to describe real-world patterns rather than test a new treatment. No direct benefit to participants, but …

This study tests whether a new type of adaptive radiotherapy can reduce radiation exposure to the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine, rectal, or cervical cancer. Using advanced imaging and an AI treatment planning system, resea…

This study will collect data from 2,000 patients in the Netherlands and France who are receiving standard, minimally invasive cancer treatments like tumor ablation or catheter-based therapies for liver, lung, kidney, or bone cancers. During these procedures, a special CT scanner …

This study aims to collect blood, urine, tumor samples, and health data from up to 1,000 people with malignant mesothelioma or other cancers that express a protein called mesothelin. Participants will be followed over time to track the course of their disease. The goal is to buil…

This study collects blood and other biospecimens from adults with cancer to analyze immune-suppressing cells and genetic changes. Up to 1,750 participants will provide samples before and after chemotherapy. The goal is to better understand how cancer affects the immune system, bu…

This study collects blood or cheek swab samples from 1,100 cancer patients at the National Cancer Institute to analyze genetic differences that may influence how their bodies process cancer treatments. The goal is to understand why some patients experience more side effects or le…

This study investigates whether certain inherited genetic mutations increase the risk of developing lung cancer. Researchers will collect blood or saliva samples and questionnaire data from 500 participants, including lung cancer patients and their family members. The goal is to …

This study investigates the types of fungi present in lung tissue from people with non-small cell lung cancer. Researchers will compare fungal communities across different tumor subtypes, stages, and patient outcomes to see if they relate to how the disease progresses. The goal i…

This study is testing whether a patient navigation program can increase the number of people who complete lung cancer screening. The study will enroll 675 Black or African-American adults who are at high risk for lung cancer due to smoking history. Participants will receive guida…

This study is testing whether a special MRI scan using an inhaled gas called hyperpolarized xenon-129 can help doctors identify and predict lung damage caused by radiation therapy in lung cancer patients. The gas is breathed in instead of being injected like a typical contrast dy…

This study tests a short, 10-15 minute health assessment called the Practical Geriatric Assessment (PGA) for adults aged 65 and older with early-stage non-small cell lung cancer who are about to receive radiation therapy. The goal is to see if using this quick checkup leads to mo…

This study tests whether community health workers can help more eligible people get screened for lung cancer and quit smoking. The workers will reach out to patients, help them make informed decisions, offer smoking cessation counseling, and navigate barriers to care. The study w…

This study follows 1,500 people recently diagnosed with lung cancer to see if their diet, lifestyle, and emotional well-being are linked to how the disease progresses. Researchers will collect blood, urine, stool, and tumor samples to analyze biological markers, including gut bac…

This study enrolls 7,000 people with various cancers who have had or will have treatment aimed at a cure. Researchers collect blood, tissue, urine, and saliva samples over time to look for tiny bits of cancer DNA left behind. The goal is to find any remaining cancer as early as p…

This study is looking at why some people with advanced cancer lose weight and muscle, a condition called cachexia. Researchers will follow 800 patients with advanced lung, pancreatic, or colorectal cancer to see if there are distinct subtypes of cachexia based on symptoms, biomar…

This study looks back at the medical records of 300 women diagnosed with lung cancer to identify common risk factors. Researchers will examine demographics, smoking history, environmental exposures, and other potential contributors. The goal is to better understand what may drive…

This study is building a large collection of blood, saliva, urine, stool, and tissue samples from people who are at increased risk of cancer, including those with genetic predispositions, survivors of childhood or adult cancer, or those with precancerous conditions. The goal is t…

This study looks at factors that might increase the risk of lung cancer in women aged 40 to 74 who have never smoked. Researchers will collect questionnaires and blood samples from 500 women—some with lung cancer and some without—to analyze genetic and exposure-related clues. The…

This observational study will follow about 2,000 patients in China who have early-stage lung cancer with a specific gene mutation (EGFR) and have received targeted therapy pills (EGFR-TKIs) after surgery. Researchers will track how long patients live and how long they stay cancer…

This early-phase trial will test a new PET imaging agent called 64Cu-DOTA-pembrolizumab in 6 people with stage IV non-small cell lung cancer who are already on the immunotherapy drug pembrolizumab. The goal is to see if the imaging agent can safely tell the difference between tum…

This study looks at whether genetic markers in tumor tissue, blood, and stool can predict how well lung cancer patients respond to immunotherapy. Researchers will analyze samples from 2,000 adults with lung cancer who are receiving immune checkpoint inhibitors, searching for patt…

This study looks at how PET/CT scans change during chemoimmunotherapy and radiation for stage IV non-small cell lung cancer. Researchers want to see if these scans can help predict how well the cancer responds to treatment. About 80 participants will undergo standard treatment al…

This study is collecting blood samples and health data from 15,000 symptom-free adults over 40 to understand what healthy aging looks like at the molecular level. By tracking participants over time, researchers hope to establish normal ranges for thousands of blood markers and id…

This study looks at the quality of life, symptom severity, and care needs of lung cancer patients who are receiving or have received immunotherapy. By analyzing questionnaires from 180 participants, researchers aim to identify factors that influence these needs, such as marital s…

This study looks at why some older adults with serious conditions like cancer or fractures become vulnerable or frail. Researchers will follow about 1500 patients to find out how common different causes of vulnerability are and how they affect outcomes like survival and quality o…

This trial asks whether five advanced AI models can match the treatment recommendations of expert tumor boards for cancer patients. Using 100 standardized synthetic cases across breast, lung, urological, digestive, and gynecological cancers, each AI and two independent tumor boar…

This study is testing whether regular heart and lung monitoring, along with blood samples, can predict side effects in people with lung cancer receiving radiation and immunotherapy. The goal is to find early warning signs of heart or lung damage before symptoms appear. The trial …

This study follows 142 adults having lung cancer surgery to see if measuring nutrition and muscle loss can help predict complications, hospital stay, and survival. Participants get blood tests, CT scans, and ultrasound before surgery. The goal is to create a better risk score to …

This study aims to safely collect health information like heart rate and activity levels from cancer patients using devices like smartphones and wearables. Researchers will use this data to learn more about how it relates to cancer diagnosis, treatment response, and risk factors.…

This study looks for biological markers in the blood that could help diagnose and predict the course of three serious lung conditions: COPD, idiopathic pulmonary fibrosis (IPF), and lung cancer. Researchers will analyze blood samples from 120 adults with these diseases to find li…

This study looks back at medical records of people in Colombia diagnosed with early-stage non-small cell lung cancer between 2017 and 2023. Researchers aim to understand how patients are diagnosed, how long it takes to start treatment, and what factors affect their care. By mappi…

This study tests whether having a specialist review genetic test results and guide treatment decisions can increase the use of targeted therapies for people with advanced solid tumors, including breast, lung, colorectal, and bladder cancers. Participants will have their tumor or …

This international registry collects data on patients diagnosed with thoracic cancers (including lung cancer) while pregnant or who become pregnant during or after cancer treatment. Because these cases are rare, there is little information to guide doctors. The registry aims to d…

This observational study looks at 300 people with early-stage lung cancer to understand why different types of the disease behave differently. Researchers will analyze genes, immune cells, and other markers from tumor samples. The goal is to find patterns that could lead to bette…

This study aims to collect health information from 12,000 adults with lung or other chest cancers. Researchers want to understand why some people respond better to treatment than others, even when their cancer stage is the same. By gathering data from routine care, they hope to i…

This study collects blood and tumor tissue samples from people with head and neck or lung cancers to find biological markers that indicate low oxygen levels within tumors. Low-oxygen tumors tend to be more aggressive and resistant to standard treatments like radiation and chemoth…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study tests whether combining 4D MRI and 4D CT scans can better track lung tumors and nearby organs as a person breathes during radiation therapy. Researchers will compare this new method to the current standard. The goal is to see if it improves targeting of the tumor while…

This study tests whether giving oxygen to the lung that is not being ventilated during lung cancer surgery can reduce inflammation and improve oxygen levels. Researchers will measure inflammatory markers in lung tissue and blood from 56 adult patients. The goal is to see if this …

This study watches for heart changes in 150 adults receiving chest radiation for lung, esophageal, breast, or thymus cancer. Researchers will check heart markers, electrical activity, and immune cells at the end of treatment and up to 3 months later. The goal is to find early sig…

This study is collecting tumor tissue and blood samples from 800 people with lung cancer to look for changes in a gene pathway called EGFR. The goal is to better understand the DNA mutations that drive the disease. No new treatment is being tested; instead, researchers hope to id…

This study is collecting detailed genetic and health information from 500 people with various cancers, including breast, lung, and leukemia. The goal is to create a shared database that helps researchers develop more personalized treatments. Participants provide samples and data,…

This study is looking at whether low-dose CT scans can find lung cancer early in people who have a parent, sibling, or child with lung cancer. The study includes 1,520 people aged 50 to 75, both smokers and non-smokers. Researchers want to see how many cases of lung cancer are fo…

This study tests whether an artificial intelligence (AI) model can help doctors make better treatment decisions for non-small cell lung cancer (NSCLC). About 300 patients will have their treatment plans created by both a standard team of doctors and the AI. Researchers will compa…

This study looks at how different lung cancer screening habits (like too much, too little, or just right) affect whether the cancer is caught early. About 5,390 newly diagnosed lung cancer patients will share their medical history and screening records. The goal is to find the be…

This study aims to collect and analyze tumor samples from 10,000 adults with advanced solid cancers (like breast, lung, or colon cancer) to create a province-wide gene database. The goal is to help doctors identify which targeted drugs or clinical trials might work best for each …

This study provides long-term follow-up for people who previously received gene therapy or other immunotherapy for cancers like prostate, liver, breast, colon, or lung cancer. Participants will have annual health check-ups or phone calls for up to 15 years to monitor for any long…

This study gathers information from the medical records of 75,000 adults treated for lung cancer at 38 French hospitals. Researchers will look at patient details, tumor types, and treatments given over time. The goal is to understand how care has evolved and what outcomes patient…

This study looks at whether lung ultrasound can detect emphysema (a type of lung damage) as well as CT scans do. About 1,600 people with or without emphysema will get both an ultrasound and a CT scan. The goal is to find patterns on ultrasound that match the damage seen on CT, wh…

This study is building a large collection of blood, tumor tissue, and fecal samples from 500 people with lung cancer. Researchers will track how patients respond to standard treatments and look for biological clues that predict success or failure. The goal is to better understand…

This study is testing a new technology that uses x-rays to track lung tumors during radiation therapy, without needing to implant markers in the lung. About 30 people with early-stage lung cancer or a few lung metastases will take part. The goal is to see if the markerless tracki…

This pilot study tests whether using CT ventilation imaging can more accurately predict lung function after lung cancer surgery compared to the standard method. Researchers will compare predictions from CT scans with actual lung function tests in 15 surgical candidates. If succes…

This study tests a new tool called TRTRM that predicts which older cancer patients are at high risk for severe side effects from treatment. Researchers will use the tool to adjust drug doses and monitoring for patients aged 65 and older with solid tumors. The goal is to see if th…

This study tests a new type of CT scan that pauses during irregular breathing to get clearer images for lung cancer radiation planning. It involves 30 adults with lung cancer who will receive one extra scan during their usual treatment simulation. The goal is to see if this metho…

Cancer patients face a higher risk of blood clots during chemotherapy, but it's hard to know who is most at risk. This study will measure clotting-related biomarkers in the blood of 380 patients with ovarian, lung, stomach, or pancreatic cancer at four points during their treatme…

This study tests a new way to predict how well your lungs will work after lung cancer surgery. Doctors will use 3D CT scans to create a virtual model of your lungs and simulate the surgery beforehand. The goal is to see if this method is more accurate than current techniques, hel…

This study is for people with advanced cancers who are taking long-term targeted treatments. Researchers want to learn about their experiences through interviews. The goal is to find better ways to support these patients. The study is currently recruiting 75 participants.

This study looks at whether a small sample taken from lung cancer patients during a routine biopsy (called EBUS-TBNA) can be used to analyze genes that predict how well treatments like chemotherapy or surgery might work. Researchers plan to enroll 400 adults with confirmed or sus…

This study is testing a new imaging method called 4D-MRI that creates 3D movies of the lungs and liver as a person breathes. The goal is to help doctors better track tumor movement during radiation therapy, making treatment more precise. Researchers will test this in healthy volu…

This study is investigating how common cannabis use is among lung cancer patients under 60 and whether it is linked to more aggressive tumors. Researchers will collect blood and hair samples from 150 participants across three French hospitals. The goal is to better understand if …

This study is testing whether a quick, non-invasive test that measures heart rate and breathing patterns before thoracic surgery can help predict which patients are more likely to have complications after the operation. Researchers will enroll 130 adults undergoing major chest su…

This study tests a new abdominal pressure device that helps limit breathing movement during radiation therapy for lung cancer. Researchers want to see if it safely reduces tumor motion, making treatment more accurate. About 50 adults with early-stage lung cancer will take part. T…

This study aims to develop a better way to image lung tumors using MRI and a natural, slightly modified sugar solution. Researchers will look at how tumors burn sugar for fuel by analyzing tumor samples after surgery. The goal is to understand the metabolic pathways of lung cance…

This study is testing whether tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. Researchers will follow 120 adults with various cancers who are receiving specific chemo drugs. Participants give blood samples and answer qu…

This study looks at how often lung cancer patients on immune checkpoint inhibitors develop blood clots (in veins or arteries) and what factors increase that risk. Researchers will follow 2,400 adults with lung cancer who are starting immunotherapy, comparing those who get clots w…

This study collects blood, urine, sputum, and lung tissue from 4,000 adults at high risk for lung cancer. Researchers analyze these samples to find DNA changes and other markers that could signal cancer early. The goal is to better understand how lung cancer develops and to find …

This study looks at how adults aged 70 and older with non-small cell lung cancer are treated in everyday medical practice. Researchers will track 500 participants to understand which treatments work best, how safe they are, and how they affect quality of life. The goal is to gath…

This study is creating a large database of 10,000 lung cancer patients who received radiation therapy. Researchers will collect information on tumor control, side effects, and quality of life to build models that predict outcomes. The goal is to use these models to select the bes…

This study is gathering information from 10,000 people with lung cancer or other chest tumors. Researchers want to learn more about the disease, how it is treated, and what affects a person's outlook. No new treatments are being tested—the goal is to collect data to help improve …

This study looks at whether DNA from blood, sputum, lung fluid, and breath can help find genetic changes in non-small cell lung cancer. Researchers will collect samples from 210 patients before and after surgery, then follow them for 24 months to check for cancer return. The goal…

This study looks at CT scans from 2,000 people to see if computer models can better predict how lung cancer will respond to treatment. Researchers will review past patient records and data from a national screening trial. The goal is to improve screening and treatment decisions f…

This study collects tumor samples from 150 lung cancer patients to grow miniature versions called organoids in the lab. Researchers will test how these organoids respond to chemotherapy and targeted drugs, and compare that to how the patient's actual tumor responds. They will als…

This study follows 110 adults with head and neck, lung, or rectal cancer to see how their nutrition and body composition change during standard cancer treatments. Researchers will measure food intake, muscle mass, and strength over time. The goal is to gather data that could late…

This study is watching how lung cancer patients do when they get the drug tislelizumab in normal doctor visits, not in a strict research setting. About 240 people with small cell or non-small cell lung cancer will take part. The goal is to see how long they live, how the drug aff…

This study tests whether a large language model (AI) can help junior doctors write more accurate and efficient cancer treatment reports. Forty doctors will be split into two groups: one using AI assistance, the other using traditional methods. The reports will be scored by expert…

This study tests a personalized 'open lung' breathing method during lung cancer surgery to see if it prevents low oxygen levels better than standard care. The method adjusts air pressure based on each patient's lung stiffness. 120 adults scheduled for lung cancer removal will be …

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study is collecting data from 180 lung cancer patients to understand their nutritional and metabolic status. Researchers will analyze factors like genetics and gut bacteria to create a model that can recommend personalized diets. The goal is to improve quality of life and ou…

This study tests whether advanced MRI scans can identify different immune types of non-small cell lung cancer (NSCLC) without needing a tissue biopsy. Researchers will scan 50 adults with early-stage lung cancer and compare MRI results to standard lab tests. If successful, this a…

This study is building a large collection of blood, urine, saliva, and other samples from 3000 people with lung nodules or lung cancer. Researchers hope to find biological markers that can help diagnose lung cancer earlier, predict how the disease will progress, and guide treatme…

This study is tracking 100 people with early-stage lung cancer who had surgery. Researchers will measure tumor cells and DNA in their blood to see if these markers can predict if the cancer comes back. The goal is to better understand how lung cancer spreads and improve long-term…

This trial compares conscious sedation versus general anesthesia for a lung biopsy procedure called pEBUS, used to diagnose lung nodules. About 306 adults with peripheral lung lesions will be randomly assigned to one of the two sedation methods. The goal is to see which approach …

This observational study tracks 500 lung cancer patients receiving a second round of high-dose radiation to the chest. Researchers will collect data on side effects and survival to find safer ways to deliver repeat radiation. The goal is to help doctors personalize treatment and …

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study looks at different types of neutrophils (a kind of immune cell) in the blood of people with lung cancer. Researchers want to see if certain neutrophil types are linked to tumor growth and resistance to immunotherapy. They will compare blood samples from 100 lung cancer…

This study follows 900 people having lung cancer surgery to learn why some develop blood clots in their legs (deep vein thrombosis) within 30 days after surgery. Researchers will collect medical data and use machine learning to build a tool that predicts each person's risk. The g…

This study is gathering information from 25 adults with breast, lung, ovarian, multiple myeloma, or acute myeloid leukemia who are on active treatment. Participants fill out a short online survey each week for at least 12 weeks to report how they are feeling. The goal is to build…

This study looks at whether tiny molecules in the blood, called microRNAs, can help predict how often and how severely cancer patients develop nerve damage from chemotherapy. Researchers will study 90 people receiving specific chemo drugs for lung or colon cancer. The goal is to …

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning earlier than standard scans. About 100 people with different solid tumors will give blood samples after treatment. The goal is to see if early detection can lead to better treatm…

This study looks at tumor samples from 500 adults with lung or other chest cancers to find out why some treatments stop working. Researchers will study genetic changes in the cancer cells. The goal is to learn how to better choose the next treatment for each person.

This study is testing whether a monthly blood test can predict dangerous blood clots in people with certain cancers (lung, pancreatic, stomach, or brain). Cancer patients are at high risk for clots, which can be deadly. Researchers will follow 200 participants for 12 months, taki…

This study is creating a risk prediction model for lung cancer in people who have never smoked. Researchers will enroll 10,000 participants aged 50-80 with a family history of lung cancer. They will collect data from questionnaires, blood tests for autoantibodies and genetic mark…

This study collects samples and health information from 2,000 people with lung nodules to find the best way to detect lung cancer early. Participants must have a nodule at least 5mm wide and plan to have a biopsy, PET scan, or follow-up within 7 months. The goal is to improve how…

This study compares two ways to take tissue samples from lung cancer patients: standard needle biopsy (EBUS-TBNA) and a newer freezing technique (cryobiopsy). The goal is to see which method provides enough tissue for genetic testing, which helps doctors choose the best treatment…

This study is testing a decision aid to help people decide whether to get screened for lung cancer. The tool is designed for patients in a safety-net healthcare system. Researchers will enroll 360 current or former smokers aged 50-80 to see if the aid is safe and helpful.

This study looks at how immune cells behave in people with lung cancer, sarcoidosis, and COPD. Researchers will collect blood and tissue samples from 425 participants to analyze immune function. No experimental treatments are given. The goal is to understand why some patients don…

This study looks at ways to encourage homeowners and renters in New Hampshire and Vermont to test their homes for radon, a radioactive gas that can cause lung cancer. In the first phase, participants join focus groups to share their views on radon testing. In the second phase, pa…

This study collects blood and tissue samples from 2,000 people being tested or treated for lung cancer. The samples are stored for future research into earlier detection, better treatments, and prevention strategies. No direct benefit is offered to participants, but the bank coul…

This trial compares two standard surgical techniques for early-stage lung cancer: tying off the pulmonary vein first versus the pulmonary artery first. Researchers want to see which method better reduces circulating tumor DNA (ctDNA) in the blood after surgery, as lower ctDNA may…

This study looks at how common severe fear of cancer recurrence is among people treated for breast or lung cancer. Researchers will survey 200 patients and interview 40 of them to understand their experiences and what kind of support they need. The goal is to find better ways to …

This study is collecting blood and tumor samples from 730 newly diagnosed lung cancer patients at Nantes University Hospital. Researchers will follow patients from diagnosis until death to understand how treatments work in real life, especially for patients often left out of clin…

This study is building a large collection of blood, tissue, and fluid samples from 7,000 people with lung cancer, other chest diseases, or lung transplants. The goal is to help researchers learn more about what causes these diseases, how to find them early, and how to treat them …

This study collects blood and leftover tissue samples from 9,600 people with various cancers, including breast, lung, and pancreatic cancer. Researchers will use these samples to improve tests that look for cancer DNA in the blood. The goal is to better detect if cancer returns o…

This study aims to develop a simple, non-invasive way to detect lung diseases like cancer, asthma, and COPD by analyzing DNA and proteins from cough samples. Researchers will collect cough specimens from 2000 adults, including smokers and non-smokers, and compare them to samples …

This study is observing 800 people with advanced lung, colorectal, or pancreatic cancer to understand why some lose weight and muscle (cachexia). Researchers hope to find distinct subtypes of cachexia, which could lead to better, more personalized treatments in the future. Partic…

This study tests whether special MRI scans with xenon gas can show which parts of the lung work best. Doctors then aim to aim radiation away from those healthy areas during lung cancer treatment. The goal is to learn if this approach reduces lung damage and helps breathing. About…

Researchers in Mexico are developing a questionnaire to measure how well lung cancer patients follow their respiratory rehabilitation program. The study will enroll 281 adults with lung cancer who are currently in rehab. Participants will fill out a 56-item scale, and the researc…

This study looks at how air pollution particles get into the bodies of non-smokers with lung cancer, COPD, or leukemia, and compares them to healthy volunteers. Researchers will use advanced microscopes and chemical tests to find these particles in blood and tissue samples. The g…

This study is collecting data from 200 people with advanced lung cancer to build computer models that could predict how well a treatment will work. Researchers will gather information from tumor biopsies, blood and urine samples, and patient questionnaires about quality of life a…

This study is testing a new tool called CANoPy that predicts whether a cancer patient will develop long-term nerve pain. Researchers will follow 625 adults with breast, gynecological, colorectal, or lung cancer as they undergo treatments like chemotherapy or surgery. By collectin…

This study aims to create a large collection of blood samples from 2,500 people with or at high risk for cancer. Researchers will use these samples to study liquid biopsies, which are blood tests that may help detect cancer, track treatment response, and spot recurrence. Particip…

This study looks at how the bacteria in your gut might influence diarrhea caused by cancer treatments. Researchers will follow 150 adults starting cancer therapy, collecting stool and blood samples to analyze gut microbiome changes. The goal is to better understand why some peopl…

This study is building a large database of blood samples, tumor samples, and scans from 4,000 people with lung cancer. Researchers will follow participants for up to 10 years to collect information that can help future studies. The goal is to better understand lung cancer and imp…

This study tracks 100 cancer survivors aged 18–74 to see how common muscle loss (sarcopenia) and cognitive problems ('chemo brain') are after treatment. Participants undergo physical and mental assessments. The goal is to better understand these long-term side effects and guide p…

This study tests whether a short educational video can encourage Hispanic current and former smokers to get screened for lung cancer. Researchers will enroll 2,000 people aged 50-80 who smoke or quit recently. Participants watch the video and answer surveys to identify barriers a…

This study looks at whether giving a paravertebral nerve block during chest surgery can lower the chance of problems like lung infections, collapsed lungs, or breathing failure. Researchers will follow 500 adults having keyhole or robotic lung surgery. The goal is to see if this …

This study looks at whether combining PET scan images with genetic testing can better predict how well non-small cell lung cancer patients will respond to treatment and how long they might survive. Researchers will analyze scans and tumor samples from 120 adults. The goal is to c…

This study looks at whether a quick ultrasound of the thigh muscle can detect muscle loss (sarcopenia) in people who have finished cancer treatment. Researchers will compare the ultrasound results with a standard whole-body scan (DEXA) in 55 adults aged 18-74 with certain cancers…

This observational study is gathering information from 1,000 people with advanced (stage IV) lung cancer in Italy. Researchers will look at patients' demographics, symptoms, imaging, and tumor samples to better understand the disease at the time of diagnosis. No new treatments or…

This study collects tumor samples from 50 lung cancer patients whose disease has worsened while on immunotherapy. The goal is to analyze the tissue for clues about why the treatment stopped working. No new drug is being tested; instead, researchers hope to better understand resis…