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Singapore study aims to catch lung cancer earlier with CT scans and blood tests

NCT ID NCT05724264

Diagnosis Sponsor: National Cancer Centre, Singapore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether combining low-dose CT scans with blood-based biomarker tests can improve lung cancer screening in high-risk people. It will enroll 1,000 participants in Singapore, including both smokers and non-smokers. The goal is to see if this approach is practical and accurate for detecting lung cancer early.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Low-dose CT scan and blood biomarker tests
What this could lead to
If successful, this could lead to better, more personalized lung cancer screening guidelines for both smokers and non-smokers in Singapore.
What could go wrong
This is an early feasibility study, not a treatment trial. It may not prove that screening improves survival, and false positives could cause unnecessary worry or procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2022

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Smoker: * Participant is willing and able to give informed consent for participation in the study * Male or female, aged 50-80 years of age * No prior history of cancer, or cancer free in the last 5 years and not currently on cancer treatment * ECOG 0/1 * Current or former smokers with at least 30 pack years of smoking history * Willing to comply with study follow-up schedule and tests * Willing to cover the costs of downstream standard of care management and investigations including doctor's fee, CT scan and biopsy etc. * A Singapore citizen/Permanent Resident of Singapore Non-Smoker: * Participant is willing and able to give informed consent for participation in the study * Male, or female, aged 50-80 years of age * No prior history of cancer, or cancer free in the last 5 years and not currently on cancer treatment * ECOG 0/1 * Never smoker, or has smoked less than 10 pack-years and has quit smoking for at least 15 years * Family history of lung cancer up to 2nd degree relatives * Willing to comply with study follow-up schedule and tests * Willing to cover the costs of downstream standard of care management and investigations including doctor's fee, CT scan and biopsy etc. * A Singapore citizen/Permanent Resident of Singapore Exclusion Criteria: * Uncontrolled medical comorbidity on enrolment * Previous diagnosis of cancer * Bleeding diathesis that will preclude blood sampling * Fear of blood draw or needles * Pregnancy

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lung cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    5 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Changi General Hospital, Singapore

    RECRUITING

    Singapore, 529889, Singapore

  • National Cancer Centre, Singapore

    RECRUITING

    Singapore, 168583, Singapore

  • National Heart Centre Singapore

    ACTIVE_NOT_RECRUITING

    Singapore, 169609, Singapore

  • Sengkang General Hospital, Singapore

    RECRUITING

    Singapore, 544886, Singapore

  • Singapore General Hospital

    RECRUITING

    Singapore, 169608, Singapore

  • Tan Tock Seng Hospital, Singapore

    RECRUITING

    Singapore, 308433, Singapore

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