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Freezing nerves during lung surgery may cut opioid use

NCT ID NCT06861387

Symptom relief Sponsor: St. Antonius Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether freezing certain nerves during minimally invasive lung surgery can help patients recover faster with less pain. 150 adults having lung surgery will either get standard pain management or standard care plus nerve freezing. The goal is to see if the freezing reduces pain, opioid use, and hospital stays.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cryotherapy (nerve freezing with a probe)
What this could lead to
If it works, this could offer a way to reduce pain and opioid use after lung surgery, leading to faster recovery and shorter hospital stays.
What could go wrong
This is a single-center trial with 150 participants, so results may not apply broadly. Risks include nerve damage, numbness, or bleeding at the treatment site.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients are at least 18 years or older. 2. Patients are electively scheduled to undergo minimally invasive (i.e., VATS or RATS) anatomical lung (i.e., pneumonectomy, (bi)lobectomy, or segmentectomy) resection for benign or malignant disease. 3. Proficient understanding of the consequences of enrolment by the patients. 4. Written informed consent by the patient. Exclusion Criteria: 1. Patients with reported intolerance or hypersensitivity to the anaesthetic drug used for ICNB. 2. Patients chronically using opioids for reasons not related to the operation (i.e., more than 3 months). 3. Patients with liver failure inhibiting the systematic use of acetaminophen (i.e., paracetamol) 4. Patients with connective tissue disease. 5. Patients with comorbidities or history contra-indicating ICCA. 6. Patients who are pregnant. 7. Participation in other clinical trial(s) that may interfere with the current trial.

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Conditions

The condition(s) this trial relates to.

agnosia lung cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cryo analgesia Intercostal nerve block Minimally invasive lung surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • St. Antonius Ziekenhuis

    RECRUITING

    Nieuwegein, Utrecht, Netherlands

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