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Timing of nerve block may ease pain after chest surgery

NCT ID NCT07532681

Symptom relief Sponsor: Erasme University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether giving a nerve block before or after video-assisted chest surgery (VATS) reduces pain better. 140 adults having VATS will receive two injections: one with a numbing drug (ropivacaine) and one with a placebo (saline). The timing of the active drug is swapped between groups. Researchers will measure pain scores and opioid use for 48 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ropivacaine 0.375%
What this could lead to
If successful, this could help doctors choose the best timing for nerve blocks to reduce pain and opioid use after chest surgery.
What could go wrong
This is a small, early-stage study (140 people) comparing two timings of a standard procedure. The difference may be small or not clinically meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Scheduled for single-port or two-port video-assisted thoracoscopic surgery (VATS). * ASA classification 1 to 3 * Able to understand the study, describe their pain and provide valid informed consent Exclusion Criteria: * Neurological or psychiatric conditions that compromise the reliable assessment of pain(dementia, cognitive impairment, severe communication disorders) * Chronic opioid use or regular use (\> 3 months) of strong analgesics for chronic pain * History of allergy or known hypersensitivity to local anaesthetics * Coagulopathy or anticoagulant therapy precluding the safe performance of an intercostal block * Local infection at the injection site or active systemic infection * Bilateral thoracic surgery or intraoperative conversion to thoracotomy * Second surgery at the same site. * Current pregnancy or breastfeeding * Inability to understand postoperative instructions or a language barrier preventing a validated assessment of pain * Simultaneous participation in another clinical trial involving analgesia or thoracic surgery * Refusal to participate or withdrawal of consent at any time

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intercostal nerve block Video assisted thoracic surgery (VATS)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • HUB Erasme

    Brussels, Belgium

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