New microwave probe aims to zap lung tumors without cutting
NCT ID NCT07291973
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing a new device called the FlexAblate Microwave Ablation System that uses heat from microwaves to destroy small lung cancer nodules. It is for people who cannot have surgery or choose not to. The trial will check if the device safely and completely treats the tumor, with follow-up scans and tests over one year.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Microwave ablation device (FlexAblate Microwave Transbronchial Ablation System)
- What this could lead to
- If successful, this could offer a less invasive treatment option for people with small lung cancer nodules who cannot have surgery.
- What could go wrong
- This is an early-stage study with only 43 participants, so results may not apply to everyone. The procedure carries risks like bleeding or infection, and it may not fully destroy the tumor.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 43 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2025
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult ≥ 18 years of age who has provided signed informed consent. * Subject is able and willing to comply with the planned clinical investigation follow-up schedule * Pathological confirmed malignant nodule in the lung either primary or metastatic disease. * Target nodule is ≤ 20mm in maximum diameter. * There is ≥ 5mm of nodule-free lung parenchyma between target nodule and pleura or fissure. * Subject is a candidate for an elective lung ablation procedure as determined by institutional multi-disciplinary board or equivalent. * Subject or the lesion is not suitable for surgery or patient refuses surgery. Exclusion Criteria: * Target nodule is abutting main or lobar stem bronchus, main pulmonary vasculature (vessel 5mm), heart, oesophagus and/or trachea. * Subjects who are extremely breathless or on home oxygen therapy. * Female subjects who are pregnant or nursing. * Subjects with uncorrectable coagulopathy or thrombocytopenia at time of screening. * Subjects with prior pneumonectomy. * Subjects who have had any radiation (i.e., SBRT or EBRT) to the intended ablation zone or lung ablation, surgical resection therapy, radiotherapy, or any other treating procedure within 30 days prior to the planned ablation procedure or those who plan to receive a lung ablation, surgical resection, or radiation therapy on the ablated lung side before completing the primary endpoint assessment (30 days post-ablation). * Subjects who have implantable electronic devices, including pacemakers or other electronic implants. * Known pulmonary hypertension (Pulmonary artery systolic pressure, PASP \>50mmHg). * Active active pulmonary infection at time of screening or the procedure. * Subjects medically unable to stop anticoagulant or anti-platelet therapy for relevant time period prior to and following the ablation procedure. * Participation in an investigational drug or device clinical investigation within 30 days of enrolment that would interfere with this clinical investigation. * The investigator determines that participation in this clinical investigation may jeopardise the safety or welfare of the subject.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
3 sites in 2 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
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Study contacts
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Contact
Email: •••••@•••••
Locations
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CMC Ambroise Paré - Hartmann
RECRUITINGParis, France
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St. Bartholomew's Hospital
RECRUITINGLondon, United Kingdom
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University College London Hospitals NHS Foundation Trust
RECRUITINGLondon, United Kingdom
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