New pain relief hope for lung cancer patients: nerve block via port

NCT ID NCT07396558

Symptom relief Sponsor: Hanoi Medical University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Sep 18, 2026 · Updated 3 times

Summary

This study tests whether a nerve block given through a small port under the skin can help control chest pain in people with advanced lung cancer. The block delivers numbing medicine near the chest wall nerves. Researchers will compare pain levels and side effects in 180 patients receiving this treatment against a historical control group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: local anesthetic (nerve block)
What this could lead to: If it works, this could offer a new way to manage severe cancer pain at home, reducing reliance on painkillers and their side effects.
What could go wrong: This is an early-stage study with no phase, so results are uncertain. The procedure carries risks like infection or nerve damage, and it may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 180 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Adult patients diagnosed with advanced-stage lung cancer who are currently receiving palliative care only. * Presence of chronic cancer-related chest pain lasting longer than 1 month, localized to the thoracic region due to chest wall invasion, pleural involvement, or bone metastases. * Performance status ≤ 3 according to the Eastern Cooperative Oncology Group (ECOG), allowing placement of a subcutaneous port and maintenance of local anesthetic administration. * Inadequate pain control with conventional analgesic therapies or clinical indication for the addition of regional analgesia. * Ability to understand the study procedures and provide written informed consent after receiving a full explanation of the intervention. Exclusion Criteria: * Chest pain with radiation to the upper extremities, neck, or shoulder, suggestive of non-localized thoracic pain. * Severe hepatic or renal dysfunction, or severe heart failure (New York Heart Association class III-IV). * Local infection at the injection or port placement site, or uncontrolled systemic infection. * Severe cachexia or insufficient subcutaneous tissue that does not allow safe coverage of the subcutaneous port. * Known allergy to amide-type local anesthetics or other contraindications to regional anesthesia. * Severe cognitive impairment, altered consciousness, or inability to cooperate with post-intervention monitoring. * Lack of adequate caregiver support for home-based follow-up after discharge or inability to coordinate follow-up with local healthcare facilities. * Severe coagulation disorders, defined as: * International normalized ratio (INR) \> 1.5 * Activated partial thromboplastin time (aPTT) \> 40 seconds * Fibrinogen \< 1.5 g/L * Platelet count \< 50 × 10⁹/L.

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Conditions

The condition(s) this trial relates to.

Cancer Pain lung cancer lung neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer pain Erector spinae plane block

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

New pain relief hope for lung cancer patients: nerve block via port

What the study statuses mean