New hope for Hard-to-Treat lung cancer: drug cocktail targets resistant tumors
NCT ID NCT06495125
First seen Apr 07, 2026 · Last updated Jun 17, 2026 · Updated 10 times
Summary
This study tests a combination of two targeted drugs (defactinib and avutometinib) plus an immunotherapy (nivolumab) in people with a specific type of advanced lung cancer (LKB1-mutant adenocarcinoma) that has stopped responding to standard treatment. The goal is to see if this triple therapy can shrink tumors or slow cancer growth. About 50 adults will take part.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Emory Saint Joseph's Hospital
RECRUITINGAtlanta, Georgia, 30342, United States
Contact Email: •••••@•••••
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Emory University Hospital Midtown
NOT_YET_RECRUITINGAtlanta, Georgia, 30308, United States
Contact Email: •••••@•••••
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Emory University Hospital/Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.