Oxygen trick during lung surgery may cut inflammation

NCT ID NCT07393490

Knowledge-focused Sponsor: Osijek University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving oxygen to the lung that is not being ventilated during lung cancer surgery can reduce inflammation and improve oxygen levels. Researchers will measure inflammatory markers in lung tissue and blood from 56 adult patients. The goal is to see if this simple procedure could lead to better recovery after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Apneic oxygenation (a procedure where oxygen is given to the lung that is not being mechanically ventilated during surgery)
What this could lead to: If successful, this could lead to better oxygen management during lung cancer surgery, potentially reducing inflammation and improving recovery.
What could go wrong: This is a small, early-stage study (56 participants) looking at lab markers, not patient outcomes. The procedure may not show a meaningful benefit or could have unknown risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 56 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older * Patients scheduled to undergo surgical resection of a single lung segment for lung cancer * Written informed consent provided Exclusion Criteria: * Age younger than 18 years * Chronic corticosteroid therapy and/or other immunomodulatory treatments * Severe pulmonary diseases, including: Chronic obstructive pulmonary disease classified as GOLD stage 3-4 (Global Initiative for Chronic Obstructive Lung Disease). Severe asthma according to GINA classification (Global Initiative for Asthma), step 4. Severe interstitial lung disease defined by: Forced vital capacity (FVC) \< 50% predicted, diffusing capacity of the lung for carbon monoxide (DLCO) \< 40% predicted, presence of extensive pulmonary fibrosis on computed tomography (CT) * Surgical procedure expected to last less than 2 hours * Intraoperative hemodynamic instability, defined as: Mean arterial pressure \< 60 mmHg for more than 30 minutes despite adequate volume resuscitation, requirement for high-dose vasopressor support (norepinephrine \> 0.2 µg/kg/min) * New-onset intraoperative cardiac arrhythmias * Significant intraoperative blood loss, defined as the need for transfusion of more than two units of packed red blood cells * Intraoperative ventilatory instability, defined as: Severe hypoxemia (PaO₂ \< 60 mmHg or SpO₂ \< 85% with FiO₂ 1.0), hypercapnia (PaCO₂ \> 70 mmHg with pH \< 7.2), inability to achieve adequate ventilation.

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Conditions

The condition(s) this trial relates to.

disease lung cancer lung neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lung cancer (diagnosis)

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

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Oxygen trick during lung surgery may cut inflammation

What the study statuses mean