Lung cancer (diagnosis)

This study looks at whether giving early, tailored COPD treatment to people being evaluated for lung cancer can improve their breathing and overall health. About 280 participants will receive either standard care or extra COPD consultations focusing on medication, smoking cessati…

This study tests a new treatment called EBNK-001, made from donor immune cells (natural killer cells), in people with advanced solid tumors that have not responded to standard therapies. Participants receive the cells after chemotherapy to prepare the body, along with low-dose in…

This trial compares two established biopsy methods for small lung nodules (≤2 cm): CT-guided percutaneous biopsy and shape-sensing robotic-assisted bronchoscopy with cone-beam CT. The goal is to see which approach is more effective at diagnosing cancer and which has fewer complic…

This study is testing a new device called a nitride-based Raman biochip that analyzes blood samples using light to detect molecular patterns linked to lung cancer. Researchers will compare results from 2,000 people with lung cancer and 1,000 without to see if the test can accurat…

This study is testing a new test called FlowPath Lung that looks for signs of lung cancer in sputum (phlegm). It involves over 2,000 high-risk individuals aged 50-80 who have lung nodules found on CT scans. The goal is to see if this non-invasive test can accurately detect early-…

This study is testing whether a simple blood test, combined with artificial intelligence (AI), can help find lung cancer early in people with COPD who are current or former smokers. About 1,000 participants will give a blood sample, and those flagged as high-risk by the AI will g…

The NIMBLE study is testing whether blood-based biomarkers can accurately distinguish between cancerous and non-cancerous lung nodules. Researchers will analyze blood samples from 1,800 patients referred with a lung nodule, looking at protein markers, epigenetic smoking markers, …

This study is testing a device called Inflammacheck that measures chemicals in a person's breath to see if it can help tell the difference between lung cancer, other lung diseases, and healthy lungs. Researchers will collect breath samples from 140 adults and use AI to build a di…

This study tests whether giving emergency department patients who are at high risk for lung cancer a direct referral to a screening program, plus text message reminders, increases the number who get screened. About 300 eligible adults will be randomly assigned to either basic inf…

This study is testing whether measuring telomeres (parts of your DNA) in a blood sample can help doctors diagnose lung cancer. Researchers will collect blood from 1,200 people, including those with lung cancer and healthy volunteers, to build a predictive algorithm. The goal is t…

This study looks at whether doctors need to change the needle between taking samples from different lymph nodes when staging lung cancer. About 30 people with suspected or confirmed lung cancer will have two rounds of staging—one with a needle change and one without. The goal is …

This study tests a new way to create detailed 3D images of lung and colorectal cancer tissue. Researchers will use a special preprocessing system and 3D imaging to get a clearer picture of tumors. The goal is to improve how doctors diagnose and plan treatment for these cancers. T…

This study is testing a new blood test that looks at tiny pieces of DNA (cfDNA) to find out if lung nodules seen on CT scans are cancer or not. Researchers will study 240 adults with small lung nodules to see how accurate the test is. The goal is to avoid unnecessary biopsies or …

This study tests three different ways of taking a lung tissue sample (needle biopsy) to see which one gives the best quality sample for diagnosing lung cancer. About 54 adults with suspected lung cancer will take part. The goal is to find the most accurate technique to help docto…

This study tests a community-based program to help underserved adults get screened for breast, lung, and prostate cancers. Researchers will work with local resource spots to offer screenings and follow-up care. The goal is to see if this approach increases screening rates and cat…

This study tests a smartphone app designed to encourage mothers of children aged 4 and under to test their homes for radon, a radioactive gas that is the second leading cause of lung cancer. Participants receive a free radon test kit and use the app to learn about radon risks. Th…

Researchers are testing whether an AI-generated, personalized discharge plan improves the quality of discharge teaching and recovery for people who had lung cancer surgery. The trial enrolls 156 adults who had surgery for stage I to III lung cancer and are going home to recover. …

This trial tests whether low-intensity endurance exercise can reduce cancer-related fatigue and improve quality of life in lung cancer patients. Participants will either do continuous exercise or interval exercise for 30 minutes a day, five days a week, for 12 weeks. Researchers …

This trial tests whether low-intensity endurance exercise can reduce cancer-related fatigue and improve sleep, stress, and quality of life in people with lung cancer. Researchers will compare two exercise styles: continuous and interval, both done for 30 minutes a day, five days …

This study tests whether acupressure can reduce coughing and related symptoms like shortness of breath and fatigue in lung cancer survivors. Eighty participants will either perform acupressure for 8 weeks or receive an educational booklet. Researchers will track changes in cough …

This study tests whether yoga and mindfulness programs can improve quality of life, reduce inflammation, and even affect gene activity in people who have survived lung, colon, or non-Hodgkin's lymphoma cancer. One hundred survivors, at least six months past treatment, will be ran…

This study tests whether an 8-week online yoga program can improve recovery in lung cancer patients who had lung surgery. Forty participants will either do live yoga sessions three times a week or receive standard care. The goal is to see if tele-yoga boosts exercise capacity, br…

This study looks at two different ways to reach out to lung cancer patients who may need help with anxiety or depression. The goal is to see which method gets more people to start a telehealth counseling program. About 30 adults being treated for lung cancer at Penn Medicine will…

This study tests whether a supplement made from the Antrodia cinnamomea mushroom can improve quality of life for people with lung cancer who are receiving platinum-based chemotherapy. About 40 participants will take either the supplement or a placebo for 3 months, and researchers…

Researchers are studying whether a next-generation radiation delivery system can run a complete treatment workflow while patients hold their breath. The trial enrolls about 20 adults with tumors in the chest or upper abdomen who are already scheduled for stereotactic body radiati…

This study will collect data from 2,000 patients in the Netherlands and France who are receiving standard, minimally invasive cancer treatments like tumor ablation or catheter-based therapies for liver, lung, kidney, or bone cancers. During these procedures, a special CT scanner …

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study tests whether giving oxygen to the lung that is not being ventilated during lung cancer surgery can reduce inflammation and improve oxygen levels. Researchers will measure inflammatory markers in lung tissue and blood from 56 adult patients. The goal is to see if this …

This study looks at how well a telehealth program called National TeleOncology works for veterans newly diagnosed with lung, colorectal, prostate, or breast cancer. Researchers will track how many veterans use telehealth visits and whether the program affects the quality of care …

This study is watching how lung cancer patients do when they get the drug tislelizumab in normal doctor visits, not in a strict research setting. About 240 people with small cell or non-small cell lung cancer will take part. The goal is to see how long they live, how the drug aff…

This study follows 900 people having lung cancer surgery to learn why some develop blood clots in their legs (deep vein thrombosis) within 30 days after surgery. Researchers will collect medical data and use machine learning to build a tool that predicts each person's risk. The g…

This study looks at how immune cells behave in people with lung cancer, sarcoidosis, and COPD. Researchers will collect blood and tissue samples from 425 participants to analyze immune function. No experimental treatments are given. The goal is to understand why some patients don…

This study is looking at genetic differences between the original lung cancer tumor and where it has spread in the body. Researchers will analyze DNA from stored tumor samples of 25 adults with non-small cell lung cancer. The goal is to better understand how lung cancer spreads, …

This study looks at whether giving a paravertebral nerve block during chest surgery can lower the chance of problems like lung infections, collapsed lungs, or breathing failure. Researchers will follow 500 adults having keyhole or robotic lung surgery. The goal is to see if this …