Simple drugs may ease radiation breathing woes for lung patients

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Lung cancer or 1-2 oligometastatic pulmonary lesions planned for radical intent radiotherapy \[minimal Biologically Effective Does (BED) of 48 Gy10 (Gray) or biological equivalent\]. * Pathologically (histologically or cytologically) proven diagnosis of cancer is not required, but strongly recommended. * If the risk of biopsy is unacceptable, pathologic confirmation is not required providing there is growth over time on Computed Tomography (CT) imaging and/or Fluorodeoxyglucose (FDG) avidity that is strongly suggestive of malignancy. * Fibrotic Interstitial Lung Disease (ILD) of any subtype, as diagnosed by a respirologist and confirmed by central review * Eastern Cooperative Oncology Group (ECOG) performance status 0-3 * Age ≥ 18 * Life expectancy \> 6 months * Patients are allowed to receive anti-fibrotic agents used in the treatment of Idiopathic Pulmonary Fibrosis (IPF) or non-IPF fibrotic ILD (e.g. nintedanib, pirfenidone) and/or corticosteroids, if those are part of their current ILD treatment regimen. Other immunosuppressive drugs such as mycophenolate, azathioprine, cyclophosphamide, and rituximab must be stopped for 2 weeks prior and 2 weeks after Radiation Therapy (RT). * Concurrent standard chemotherapy is allowed where indicated. All other systemic therapies, including biologic targeted agents or immunotherapy, or any drugs with known radiosensitive effects, must be stopped for 2 weeks prior and 2 weeks after treatment. Exclusion Criteria: * Prior lung radiotherapy * Current use of oral or intravenous corticosteroids * Plans for the patient to receive other local therapy to the target lesion(s) while on this study, except at disease progression * Any medical condition that could, in the opinion of the investigator, preclude radiotherapy or prevent follow-up after radiotherapy * Pregnancy * If not pregnant, use of effective contraception methods for women of childbearing age is required which can include: * hormonal methods (e.g. oral, injected, implanted), * placement of an intrauterine device, * barrier methods (i.e. condoms), * sterilization of the partner (e.g. previous vasectomy) * abstinence * Women who become pregnant should stop taking NAC and/or dexamethasone and inform their study doctor. * Male participants should use adequate forms of birth control with their partners. * Currently breastfeeding * Current or recent use of NAC * Contraindications to dexamethasone or N-Acetyl Cysteine (NAC). These include: * Previous intolerance or allergy to dexamethasone or NAC * Scleroderma * Active infection * Glaucoma * Psychiatric disorder that could be exacerbated by dexamethasone * Cystinuria * Any other condition that the treating physician believes to be a contraindication to dexamethasone or NAC