INTERSTITIAL LUNG DISEASE

This study tests if abatacept can improve lung disease in people with common variable immunodeficiency (CVID). About 38 children and adults will receive either abatacept or a placebo for 6 months. The main goal is to see if the drug reduces lung damage on CT scans.

This study tests whether stem cells from donated fat tissue can help people with lung scarring caused by autoimmune diseases like lupus or scleroderma. Sixteen adults will receive infusions and be monitored for safety and breathing improvements over nearly a year. The goal is to …

This study tests an inhaled version of the drug pirfenidone (AP01) in 375 adults with progressive pulmonary fibrosis (PPF), a condition where lung scarring worsens over time. Participants receive either a high dose, low dose, or placebo twice daily for 52 weeks, alongside their u…

This study tests whether a once-daily inhaled medication called treprostinil palmitil can help adults with pulmonary hypertension (high blood pressure in the lungs) caused by interstitial lung disease (lung scarring) walk farther. About 344 participants will receive either the dr…

This study tests whether hydroxychloroquine, a drug used for malaria and autoimmune conditions, can improve breathing in children with a rare genetic lung disease. About 60 children under 18 with a confirmed genetic cause will be randomly assigned to receive the drug or not. Rese…

This study tests whether the drug telitacicept works better than the standard drug cyclophosphamide for lung scarring (interstitial lung disease) caused by lupus. About 100 adults with early lupus and lung changes on CT scans will take part. The main goal is to see if telitacicep…

This study tests whether an inhaled drug called treprostinil can slow the decline in lung function for people with progressive pulmonary fibrosis (PPF), a condition where lung scarring worsens over time. About 698 adults with PPF will receive either the drug or a placebo for 52 w…

This study tests whether adding the drug BIO 300 to standard chest radiation can prevent severe lung inflammation (pneumonitis) in people with early-stage non-small cell lung cancer who also have interstitial lung disease (lung scarring). About 25 participants will receive both t…

This study tests whether combining two drugs (nintedanib and tocilizumab) works better than standard treatments for lung scarring caused by scleroderma. About 86 adults will take the combination or standard therapy for 56 weeks. The main goal is to see if the combo better preserv…

This study tests an oral drug called H01 (hymecromone) in 37 adults with interstitial lung disease, a condition that causes lung scarring and often leads to death within 3-5 years. Participants take the drug twice daily for 12 weeks. The goal is to see if H01 can lower a marker o…

This study tests a stem cell transplant for people aged 8-24 with severe systemic sclerosis (scleroderma) that hasn't improved with standard treatments. The goal is to see if this approach is safer and still controls the disease. Participants receive high-dose therapy to reset th…

This study looks at whether a quick, safe, and cheap lung ultrasound can detect lung scarring (interstitial lung disease) in people with rheumatoid arthritis. About 280 adults with rheumatoid arthritis and risk factors for lung disease will get an ultrasound, and the results will…

This study is testing a special PET scan that uses a radioactive tracer to find collagen buildup in the lungs, which is an early sign of scarring. Researchers will compare scans from healthy relatives of people with pulmonary fibrosis and from patients with early lung abnormaliti…

This study tests whether two drugs, duloxetine and amitriptyline, can reduce coughing in people with interstitial lung disease (ILD). About 25 adults with a chronic cough for at least 3 months will receive either a low or high dose of one drug or a placebo. The main goal is to se…

This study tests whether drinking nitrate-rich beetroot juice helps people with fibrotic interstitial lung disease exercise longer. Fifteen participants will compare beetroot juice to a placebo juice during cycling tests. The goal is to see if this simple dietary addition can imp…

This study is testing whether a mobile app called SUPPORT-T can help people with progressive pulmonary fibrosis (a type of lung scarring) and their caregivers get easier access to palliative care — care that focuses on comfort and quality of life. About 170 patients and their car…

This small pilot study is testing whether semaglutide, a drug already approved for diabetes and weight loss, is safe and tolerable for people with advanced lung diseases like COPD or pulmonary fibrosis. Eight participants will take the drug for 12 weeks and be monitored for side …

This study tests whether two medicines—N-acetyl cysteine (a supplement) and dexamethasone (a steroid)—can reduce shortness of breath after radiation therapy for lung cancer in people who also have interstitial lung disease. About 98 participants will receive one or both drugs or …

This study looks at whether leg muscle issues contribute to shortness of breath and exercise problems in people with interstitial lung disease (ILD). Researchers will compare leg muscle structure and function in 40 ILD patients, and test if muscle fatigue limits exercise. They wi…

This study looks at 80 people with lung fibrosis who also develop a serious lung blood pressure condition. Researchers will test blood and urine before and during treatment to find chemical markers that show who benefits and who doesn't. The goal is to better understand how the t…

This study tests a new MRI technique that uses a special gas (129Xe) to take detailed pictures of lung function. It includes up to 445 healthy volunteers and people with interstitial lung disease. The goal is to see if this method can safely and clearly show how well the lungs mo…

This study looks at whether adding a simple microscope test of the tiny blood vessels at the base of the fingernails (capillaroscopy) can help doctors diagnose a type of lung disease linked to connective tissue disorders more quickly. About 48 adults newly diagnosed with intersti…

This study tests whether advanced MRI scans can detect low oxygen areas in the lungs of people with early-stage idiopathic pulmonary fibrosis (IPF), a rare scarring lung disease. Researchers will enroll 50 participants to see if MRI can identify patients whose disease might progr…

This study is testing a new MRI technique that uses a special gas called hyperpolarized xenon to take detailed pictures of lung function. It will include 260 healthy volunteers and people with various lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if thi…

This study looks at whether a type of artificial intelligence (AI) can help doctors better identify complications in people with rheumatoid arthritis (RA). Researchers will use AI to suggest possible complications from patient records and see if doctors agree with and use those s…

This study aims to see if automated computer tools can consistently measure the amount of lung damage caused by interstitial lung disease (ILD) on chest CT scans. Researchers will enroll 150 adults with ILD and repeat their CT scans to check how much the measurements vary between…

This study looks at whether adding breathing muscle training to standard rehab helps people with rheumatoid arthritis who also have lung disease. Researchers will check changes in exercise ability, breathlessness, and a specific gene (HOTAIR). About 39 adults will take part, and …

This study collects blood and tissue samples from 100 adults who have had a lung transplant in the last 10 years. Researchers will use these samples to study biomarkers and how infections affect outcomes. The goal is to improve care for people with advanced lung disease, not to t…

This study uses special PET and MRI scans to see how immunosuppressive drugs (like mycophenolate or prednisone) affect collagen buildup and tissue damage in the lungs of people with certain types of interstitial lung disease (ILD) that are not idiopathic pulmonary fibrosis. Resea…

This study aims to find better ways to detect lung scarring (interstitial lung disease) early in people with autoimmune connective tissue diseases. Researchers will analyze tiny particles in the blood and use AI to examine lung scans from 200 participants. The goal is to identify…

This study is a registry that will follow 900 adults who have both pulmonary hypertension (high blood pressure in the lungs) and interstitial lung disease (a type of lung scarring). The goal is to collect information on their health history and track how their condition changes o…

This study aims to develop a noninvasive way to detect blood vessel changes in the lungs of people with Group 3 pulmonary hypertension (PH) using a special MRI technique. Researchers will compare MRI scans with lung tissue from 30 patients awaiting lung transplants. The goal is t…

This study looks at 750 adults with rheumatoid arthritis (RA) who are at risk for interstitial lung disease (ILD). Researchers use CT scans and other tests to find early signs of lung damage and figure out who might get worse over time. The goal is to better understand the diseas…

This study is creating a collection of blood samples from people with interstitial lung diseases (ILD) and pneumonia, as well as healthy volunteers. The goal is to build a resource that scientists can use in future studies to find better ways to diagnose and treat these lung cond…

This study looks at whether giving extra oxygen during a 6-minute walk test helps people with chronic lung disease walk farther and feel better. About 114 adults with conditions like COPD or interstitial lung disease will do two walking tests—one with their usual oxygen and one w…

This study uses a special type of MRI (called 129Xe gas exchange MRI) to take detailed pictures of how the lungs and heart work together. Researchers want to see if these images can help measure lung function in people with conditions like lung scarring, blood clots in the lungs,…

This study aims to better understand the physical causes of certain patterns seen on lung ultrasound images in people with interstitial lung disease or COPD. Researchers will compare ultrasound findings with CT scans in 25 patients to link artifacts to specific lung changes. The …

This study follows 500 adults with non-IPF lung scarring (interstitial lung disease) for 24 months. Researchers collect health data, images, and samples to improve how progressive pulmonary fibrosis is classified and predicted. The goal is to better understand the disease, not to…

This study is creating a registry and biobank for people with interstitial lung diseases (ILD), including sarcoidosis and pulmonary fibrosis. Researchers will collect medical data and biological samples from up to 1,000 participants to support future studies. The goal is to bette…

This observational study aims to find early warning signs (biomarkers) that can predict when lung scarring (fibrosis) will get worse in people with various interstitial lung diseases. Researchers will follow 450 adults with conditions like idiopathic pulmonary fibrosis (IPF) or o…