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Breathing in xenon: a new MRI method to map lung function

NCT ID NCT01280994

Knowledge-focused Sponsor: Bastiaan Driehuys Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a special MRI technique that uses a harmless xenon gas to create detailed images of lung function. Researchers will compare healthy volunteers and people with interstitial lung disease to see if the method can detect problems with air flow, lung structure, and gas exchange. The goal is to develop a safer, more informative way to assess lung health without radiation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Hyperpolarized 129Xenon Gas
What this could lead to
If successful, this could lead to a new, non-invasive way to assess lung function and diagnose lung diseases like fibrosis and emphysema more accurately.
What could go wrong
This is an early-phase study focused on developing the imaging technique, not on treating disease. It may not lead to a direct treatment or benefit for participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 445 people

The number the study aims to enrol. It can still change while the study runs.

Start date

Jan 2011

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion Criteria for Healthy Control Subjects 1. Subject has no diagnosed pulmonary conditions 2. Subject has not smoked in the previous 5 years. 3. Smoking history, if any, is less than or equal to 5 pack-years. Inclusion Criteria for Subjects with lung disease 1. Subject has a diagnosis of pulmonary dysfunction made by a physician 2. No acute worsening of pulmonary function in the past 30 days Exclusion Criteria: 1. Subject is less than 18 years old 2. MRI is contraindicated based on responses to MRI screening questionaire 3. Subject is pregnant or lactating 4. Respiratory illness of a bacterial or viral etiology within 30 days of MRI 5. Subject has received an investigational medicinal product (not including 129Xe) within 30 days of MRI 6. Subject has any form of known cardiac arrhythmia 7. Subject does not fit into 129Xe vest coil used for MRI 8. Subject cannot hold his/her breath for 15 seconds 9. Subject deemed unlikely to be able to comply with instructions during imaging

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Conditions

The condition(s) this trial relates to.

interstitial lung disease lung disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Interstitial lung disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Duke University Medical Center

    RECRUITING

    Durham, North Carolina, 27710, United States

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