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Breathing workouts may rewire genes in arthritis patients

NCT ID NCT07320846

Knowledge-focused Sponsor: Saglik Bilimleri Universitesi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether standard breathing exercises and extra muscle-strengthening breathing training can affect a specific gene (HOTAIR) in people with rheumatoid arthritis who also have lung disease. Researchers will compare two groups: one doing standard rehab and one adding inspiratory muscle training. They will measure changes in gene expression, breathing capacity, pain, and quality of life over 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pulmonary rehabilitation program and inspiratory muscle training
What this could lead to
If successful, this study could reveal how breathing exercises affect genes linked to inflammation, potentially guiding future treatments for rheumatoid arthritis-related lung disease.
What could go wrong
This is a small, early observational study (39 people) looking at genetic markers, not a treatment trial. Results may not lead to direct patient benefits or apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 39 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2024

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with RA according to the ACR/EULAR 2010 classification criteria * Duration of diagnosis greater than 2 years * Disease activity with a DAS28 score below 5.1 * Voluntary participation in the study * Presence of lung involvement Exclusion Criteria: * Having orthopedic deformities that may affect the treatment program * Pregnancy * Uncontrolled diabetes or heart disease * Participation in a rehabilitation program within the last 6 months * Body Mass Index (BMI) \> 30 * Patients with severe organ failure * Recent acute coronary syndrome * Presence of active infection

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Conditions

The condition(s) this trial relates to.

interstitial lung disease Motor Activity rheumatoid arthritis rheumatoid arthritis-associated interstitial lung disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Exercise Inspiratory muscle training Interstitial lung disease Long noncoding rna Pulmonary rehabilitation Rheumatoid arthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Health Sciences

    RECRUITING

    Istanbul, Turkey, Turkey (Türkiye)

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