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New MRI-Guided radiation aims to hit tumors harder, spare healthy tissue

NCT ID NCT05903430

Disease control Sponsor: The Christie NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether doctors can deliver very high doses of radiation to tumors in the abdomen or chest using an MRI-guided machine, while limiting harm to nearby organs. About 60 people with abdominal or lung cancer will take part. The main goal is to see if the treatment can be completed successfully in most patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
MRI-guided stereotactic ablative radiotherapy (SABR) using a high-field MR-Linac
What this could lead to
If successful, this approach could enable more precise, high-dose radiation treatment for abdominal and lung cancers while reducing damage to nearby healthy organs.
What could go wrong
This is an early feasibility study with only 60 participants, so results may not apply broadly. The main goal is to see if the technique is practical, not yet to prove it works better than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Either patient with abdominal cancer or centrally located lung cancer eligible for SABR

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: 1. Have no MRI contra-indications. 2. Eligible for abdominal SABR in accordance with the NHSE SABR Consortium Guidelines or eligible for central lung SABR in accordance with RTOG Guidelines. 3. Be able to give informed consent. 4. Anticipated life-expectancy \> 6 months. 5. Not more than 3 oligmetastatic sites treated in total per patients. 6. Performance status ≤ 2. 7. Willing to attend follow-up and have details collected on prospective basis for a minimum of 1 year. Exclusion criteria: 1. Any contraindications to MRI identified after MRI safety screening including completion of an MRI Safety Screening Form. 2. Unable to tolerate MRI scans. 3. Any evidence of severe or uncontrolled systemic diseases which, in the view of the investigator make it undesirable for the patient to participate in the study. 4. Any evidence of significant clinical disorder or laboratory finding which, in the opinion of the investigator, make it undesirable for the patient to participate in the study. 5. Any patient known to have active hepatitis B, hepatitis C or human immunodeficiency virus (HIV).

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Conditions

The condition(s) this trial relates to.

digestive system cancer lung cancer lung neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Abdominal cancer Lung cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Christie NHS Foundation Trust

    RECRUITING

    Manchester, United Kingdom, M204BX, United Kingdom

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