New device zaps lung tumors through a scope before surgery
NCT ID NCT06689488
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new device that uses microwave energy to destroy lung tumors during a bronchoscopy, before the patient has surgery to remove the tumor. The goal is to see if the device is safe and works well in 30 people with confirmed lung cancer who are already scheduled for surgery. The researchers will check for serious side effects and measure how well the device destroys the targeted tissue.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Microwave ablation device (MicroBlate™ Flex AB1)
- What this could lead to
- If it works, this could lead to a less invasive way to destroy lung tumors using a bronchoscope, potentially reducing the need for more extensive surgery.
- What could go wrong
- This is a very early, small trial with only 30 participants, so results may not apply to everyone. The procedure involves risks like bleeding or damage to nearby tissue, and the device may not work as expected.
Why investors are watching
Creo Medical is testing its AB1 electrosurgical system, which uses microwave ablation through a bronchoscope to destroy lung tumors before surgery. For a micro-cap company, this 30-patient safety and performance study is a key early read on whether the device works as intended and is safe enough to support future regulatory approval.
If it works: A positive result could show the device is safe and performs well, which may help Creo advance the product toward commercialization and attract partnership or licensing interest from larger medical device companies.
If it fails: The trial could fail to show adequate safety or performance, or the company could face delays in enrollment or data readout. Clinical trials often fail, and for a small company, a setback here could slow its development timeline and hurt its credibility with investors.
AI-written from the trial record. Speculative, and not investment advice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
General population going through lung cancer screening at investigative sites.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Patients who: 1. Have signed informed consent. 2. Subject is willing and able to comply with all aspects of the treatment and evaluation schedule. 3. Are ≥ 18 years old. 4. Have lung lesion(s)/nodule(s) which are histopathological-confirmed as cancer. 5. Have soft tissue lung lesion(s): * ≤ 30 mm in the largest dimension of the pulmonary window for Stage A. * ≤ 20 mm in the largest dimension of the pulmonary window for Stage B. 6. Are candidates for surgical resection as determined by a multi-disciplinary team (MDT) or tumour board. 7. Greater than 10 mm of tumour-free lung parenchyma between target tumour and pleura or fissure. 8. Subject is willing and able to comply with the study protocol requirements. 9. Are assigned an ASA (American Society of Anaesthesiologists) score of ≤ 3 or the patient is deemed fit for general anaesthesia. Exclusion Criteria: Patients who: 1. Have target nodule(s) within the International Association for the Study of Lung Cancer (IASLC) "Central Zone" (including bronchial tree, major vessels, heart, oesophagus, spinal cord, and phrenic \& laryngeal nerves). 2. Are pregnant or breast feeding, as determined by standard site practices. 3. Have participated in an investigational drug or device research study within 30 days of enrolment that would interfere with this study. 4. Have a physical or psychological condition that would impair study participation or jeopardise the safety or welfare of the subject. 5. Have an expected survival less than 12 months. 6. Have bleeding diathesis, uncorrectable coagulopathy, or platelet count ≤ 100 x 10\^9/L. 7. Have an implantable device, including pacemakers or other electronic implants. 8. Have known pulmonary hypertension (PASP \[pulmonary artery systolic pressure\] \>50mmHg). 9. Who are currently prescribed anticoagulants, clopidogrel or other platelet aggregation inhibitors which can´t be stopped or temporarily withheld. 10. Subject had a prior pneumonectomy. 11. Diagnosis of Small Cell Lung Cancer. 12. Any patient with clinically significant interstitial lung disease in the zone of planned ablation. 13. Subject had a therapeutic intervention (e.g., SBRT) within same lobe as the target lesion. 14. Subjects currently undergoing or underwent chemotherapy, systemic immunosuppressive treatment, or radiotherapy within 3 months of planned Study procedure.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Amsterdam University Medical Centres, Location AMC, Meibergdreef 9
RECRUITINGAmsterdam, The Netherlands, 1105 AZ, Netherlands
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