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New pain drug may stop chronic pain after lung surgery

NCT ID NCT07018375

Symptom relief Sponsor: Tianjin Medical University General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 02, 2026 · Updated 5 times

Summary

This study tests if a painkiller called oliceridine can prevent long-term pain after lung surgery better than the usual drug, sufentanil. About 320 adults having keyhole lung surgery will receive one of the two drugs through a pump they control. The main goal is to see if fewer people have chronic pain three months after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 320 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-75 years * ASA physical status I-III * BMI 18-35 kg/m² * Scheduled for unilateral video-assisted thoracoscopic surgery (VATS) lung resection, including wedge resection, segmentectomy, lobectomy, or radical resection for lung cancerresection for lung cancer * Preoperative Numeric Rating Scale (NRS) pain score of 0 * Ability to understand the study objectives and procedures, with voluntary informed consent obtained * Expected postoperative recovery in the general ward setting Exclusion Criteria: * History of chronic pain or long-term analgesic use prior to surgery * Previous ipsilateral thoracic surgery * Prior neoadjuvant radiotherapy or chemotherapy * Severe cardiovascular or cerebrovascular disease, or hepatic/renal dysfunction (ALT/AST \> 3 × upper limit of normal; eGFR \< 60 mL/min/1.73 m²) * Severe or unstable psychiatric disorders requiring psychoactive medication (e.g., schizophrenia, bipolar disorder), or cognitive impairment precluding reliable self-report * Other concurrent active malignancy or active infection * Known hypersensitivity to study medications (opioids, adjuvant analgesics, anesthetics, or antiemetics) * Pregnancy, lactation, or planned pregnancy during the study period * Participation in another interventional clinical trial within 3 months before enrolment * Any condition deemed unsuitable for study participation by the investigator

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Conditions

The condition(s) this trial relates to.

lung cancer Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic postsurgical pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    7 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Haibin People's Hospital of Tianjin Binhai New Area

    RECRUITING

    Tianjin, China

  • North China University of Science and Technology Affiliated Hospital

    RECRUITING

    Tangshan, Hebei, China

  • The No. 2 Hospital of Baoding

    RECRUITING

    Baoding, Hebei, China

  • The People's Hospital of Jizhou District, Tianjin

    RECRUITING

    Tianjin, China

  • The Second Hospital of Tianjin Medical University

    RECRUITING

    Tianjin, China

  • Tianjin Cancer Hospital Airport Hospital

    RECRUITING

    Tianjin, China

  • Tianjin Medical University General Hospital

    RECRUITING

    Tianjin, 300052, China

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