Integumentary system disorder

Researchers are comparing ceftobiprole, an intravenous antibiotic, with a standard combination of vancomycin plus aztreonam for treating acute bacterial skin and skin structure infections in hospitalized adults. The trial enrolls adults with serious skin infections such as cellul…

Scabies is a skin condition caused by mites that burrow into the skin and cause intense itching. This trial compares two creams used to treat it: sulfur 7% and permethrin 5%. Ninety adults with scabies were assigned to one cream or the other. Sulfur was applied each evening for t…

This trial compares the antibiotic tigecycline with two older antibiotics, ampicillin-sulbactam and amoxicillin-clavulanate, in adults with complicated skin or skin structure infections that need intravenous treatment. About 550 participants receive one of the treatments for 4 to…

Researchers are testing an inactivated enterovirus 71 (EV71) vaccine in healthy infants and children aged 2 months to 6 years. The trial aims to see if two shots of the vaccine can prevent hand, foot and mouth disease caused by EV71 and reduce severe complications like neurologic…

Researchers at Yale University are testing whether abrocitinib, an oral JAK1 inhibitor already approved for atopic dermatitis, can reduce inflammation in people with moderate to severe cutaneous sarcoidosis. The trial enrolls adults with a confirmed skin biopsy and a CSAMI activi…

This trial tests whether efgartigimod, an injected drug that blocks certain immune antibodies, can improve muscle strength and function in adults with active idiopathic inflammatory myopathy — a group of rare autoimmune diseases that cause muscle inflammation and weakness. About …

Researchers are testing a new oral drug called rintodestrant (G1T48) in women with advanced breast cancer that is estrogen receptor-positive and HER2-negative. The trial gives the drug alone or with palbociclib, a standard breast cancer medicine. The main goals are to find a safe…

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

Researchers are testing whether GNR-068, a ustekinumab biosimilar, works as well as the reference drug Stelara in adults with moderate to severe plaque psoriasis. About 422 participants receive either GNR-068 or Stelara as injections over several months, and everyone eventually r…

This early-stage trial tests a drug called PH-762, injected directly into skin tumors, for people with squamous cell carcinoma, melanoma, or Merkel cell carcinoma. Participants receive four weekly injections into one tumor, then have it surgically removed about two weeks later. T…

This study tests an experimental drug called rezpegaldesleukin in 94 adults with severe to very severe alopecia areata, a condition causing significant hair loss. Participants receive either the drug or a placebo for 36 weeks, with an optional extension. The main goal is to measu…

This trial tests whether an experimental antibody called 611, given as a shot alongside a topical corticosteroid, can improve moderate-to-severe atopic dermatitis (eczema) better than the steroid alone. Adults aged 18 to 75 with a history of inadequate response to topical treatme…

This early-phase trial tested two cancer drugs—imatinib mesylate and cyclophosphamide—given daily by mouth to 26 people with rare, advanced tumors that had no standard treatment. The main goal was to find the safest dose of imatinib when combined with a fixed dose of cyclophospha…

This early-phase study tested the safety of rituximab, a drug that targets faulty white blood cells, in 7 adults with rare immune diseases like pulmonary alveolar proteinosis and severe candidiasis. Participants received several doses over 6 months and were monitored for 18 month…

This phase 3 trial tests an oral drug called brepocitinib in 241 adults with dermatomyositis, a rare disease causing muscle weakness and skin rash. Participants receive either the drug or a placebo for 52 weeks to see if it improves symptoms. The study is active but no longer rec…

This study tested whether adding the antibiotic rifampicin to the standard antiseptic povidone-iodine could improve wound healing and prevent infection after hair transplantation. 65 adults were randomly assigned to receive either the combination or the standard antiseptic alone.…

Lentigo maligna is an early form of melanoma that appears on sun-exposed skin, often on the face. Doctors usually remove it with surgery, but it can be hard to decide how much tissue to take. This trial tests whether applying imiquimod cream for four weeks before surgery can shri…

Researchers are testing whether spironolactone, a drug usually used for high blood pressure, can treat moderate acne in adult women as effectively as doxycycline, a common antibiotic. The trial enrolls women with acne who have not recently used certain treatments. Participants re…

Researchers are testing an experimental ointment called IN-A002 for mild to moderate atopic dermatitis, a common skin condition that causes itchy, inflamed skin. The trial enrolls healthy adult men and adults with atopic dermatitis to see how safe and tolerable the ointment is wh…

Researchers are testing an experimental monoclonal antibody called OpSCF in adults with moderate to severe atopic dermatitis, also known as eczema. About 50 participants receive either OpSCF or a placebo injection every two weeks for 14 weeks. The main goal is to measure how much…

Dermatophytosis, a common fungal skin infection, often becomes chronic and resists standard treatment. Researchers are comparing three oral antifungal combinations: terbinafine plus fluconazole, terbinafine plus itraconazole, and terbinafine plus voriconazole. The trial enrolls 1…

This Phase 3 trial tested netakimab, a biologic drug given as a shot, against a placebo in 202 Chinese adults with moderate-to-severe plaque psoriasis. The main goal was to see if netakimab could improve skin symptoms by at least 75% (PASI75) or achieve clear/almost clear skin (s…

This phase 2 trial tested a combination of an injected drug (LTX-315) and an intravenous immunotherapy (pembrolizumab) in 23 people with advanced melanoma that no longer responded to standard PD-1/PD-L1 inhibitors. The goal was to see if the combination could shrink tumors or slo…

This study follows people with moderate-to-severe plaque psoriasis who have already taken deucravacitinib in earlier trials. It aims to check the drug's long-term safety and how well it controls psoriasis over time. A smaller group will also test how the drug affects immune respo…

Researchers are testing an experimental drug called sonelokimab in adults with active psoriatic arthritis, a condition that causes painful, swollen joints along with skin psoriasis. The trial compares sonelokimab injections with placebo injections, and also includes a third group…

This study tests whether boric acid vaginal inserts (600 mg) taken for 7 or 14 days can safely and effectively treat yeast infections. About 400 women aged 12 and older with active symptoms will participate. The goal is to see if all signs and symptoms disappear without needing m…

This study is testing whether combining platelet-rich plasma (PRP) with Botox injections works better than PRP alone for treating androgenetic alopecia (common pattern baldness). About 76 adults aged 18 to 60 with mild to moderate hair loss will receive either the combo treatment…

This study tests a drug called mogamulizumab in 23 Chinese adults with mycosis fungoides or Sézary syndrome, two types of skin lymphoma that have not responded to previous treatments. The drug is given as an IV infusion and aims to shrink or eliminate cancer in the skin, lymph no…

Researchers are testing a drug called sonelokimab in adults with moderate to severe hidradenitis suppurativa, a chronic skin condition that causes painful lumps and abscesses. The trial compares sonelokimab, given by injection, with a placebo and with adalimumab, an existing trea…

Researchers are testing a daily application of roflumilast cream 0.3% in people with chronic plaque psoriasis to see if it is safe and effective over 24 weeks. The study includes adults and children aged 2 and older, some who have used the cream before and some who have not. Part…

This phase 3 trial is testing the long-term safety of bimekizumab, a drug that targets inflammation, in 658 people with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition causing painful boils. Participants who completed a previous study will receive bimek…

This phase 2 trial tests whether adding triamcinolone 0.1% ointment to Valchlor gel reduces contact dermatitis, a common skin reaction, in people with early-stage cutaneous T-cell lymphoma. Participants apply Valchlor nightly, with or without the steroid up to three times daily, …

This Phase 2 trial tested whether oral cimetidine (Tagamet), a common heartburn drug, can reduce light sensitivity in people with erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP). These genetic conditions cause severe pain from sunlight exposure. The study en…

This Phase 3 trial tests an experimental injection called SHR-1819 in 652 adults with moderate to severe atopic dermatitis (eczema). Half get the drug, half get a placebo. The main goal is to see if it improves skin rash and itch after 16 weeks. If it works, it may offer a new wa…

This trial tests whether a shampoo with piroctone olamine can ease seborrheic dermatitis, a common cause of dandruff, in hijab-wearing women. Researchers compare it to a standard ketoconazole shampoo to see which better improves scalp symptoms and skin health. Participants use th…

This study tested a special nursing strategy to prevent pressure sores in patients with severe lung problems who need to lie face down (prone position). The trial included 160 adults in intensive care who were on breathing machines. The strategy involved protecting the eyes, tilt…

This trial tests whether injections of platelet-rich plasma from cord blood can ease vulvar lichen sclerosus, a chronic skin condition causing itching, burning, and pain. Researchers will compare CB-PRP against a placebo in 100 women, giving three treatments four weeks apart. The…

This trial tests an experimental drug called SNS-101, which targets a protein called VISTA that may help tumors evade the immune system. Researchers give SNS-101 alone or with another immunotherapy, cemiplimab, to adults with advanced solid tumors that have not responded to stand…

This trial tests whether adding a zinc-containing vaginal gel to the standard yeast infection pill can lower the chance of the infection returning. About 64 women with a current yeast infection will receive either the standard single dose of fluconazole alone or fluconazole follo…

This trial tests whether the probiotic Lactobacillus rhamnosus GG can ease atopic dermatitis, a chronic skin condition causing dry, itchy patches, in children aged 6 to 36 months. Half of the 100 participants receive the probiotic daily, while the other half get a placebo. Resear…

This study tests whether tiny particles from stem cells (exosomes) can safely help regrow hair in men with androgenic alopecia (male pattern baldness). The exosomes are delivered into the scalp using a microneedle device. The trial will enroll 18 men aged 18 to 60 with mild to mo…

This trial tests whether combining microneedling with a chemical peel improves atrophic acne scars more than microneedling alone. Sixty adults with these scars are randomly assigned to receive microneedling followed by a 35% glycolic acid peel, microneedling followed by a 15% tri…

This study tests whether taking dexamethasone pills twice a week for 3 months can stop active vitiligo from spreading in children aged 4 to 9. Researchers will also monitor side effects, especially on growth and bone health. The goal is to control the disease, not cure it.

This early-phase trial is testing whether combining two drugs—pembrolizumab (Keytruda) and ibrutinib (Imbruvica)—can safely treat advanced melanoma that cannot be removed by surgery. Pembrolizumab helps the immune system fight cancer, while ibrutinib blocks enzymes that help canc…

This study tests whether dietary nitrate from beetroot juice can disrupt the altered metabolism of breast cancer cells. Researchers will give a concentrated beetroot juice drink for five days to patients scheduled for breast cancer surgery. Using advanced MRI scans, they will mea…

This trial tests whether a generic ivermectin cream works as well as two brand-name versions for treating moderate to severe facial rosacea. Adults with the condition apply the cream once daily for 84 days. Researchers compare changes in inflammatory lesions and check safety agai…

This trial tests whether a topical medication called pentoxifylline, typically used to improve blood flow, can help restore skin color in people with stable vitiligo. It compares this approach to another topical drug, 5-fluorouracil, and to microneedling alone, with all patients …

This trial tests whether intradermal injections of exosomes—tiny particles that help cells communicate—can regrow hair in people with androgenetic alopecia (common pattern baldness) better than the standard topical minoxidil treatment. Forty participants will receive either exoso…

This trial compares two procedures for treating post-traumatic atrophic scars (depressed scars from injury or acne). One group receives a single session of subcision (breaking up scar tissue) plus insertion of poly-L-lactic acid (PLLA) threads, while the other gets subcision comb…

This study will follow about 1,000 adolescents and adults in China who are prescribed upadacitinib for moderate to severe atopic dermatitis (eczema). Researchers will track how patients use the medication, any dose changes, and how well they stick to their treatment over 12 month…

This pilot study looks at whether a daily low-dose iron supplement (27 mg for three months) can improve iron status, gut health, and endurance in young female elite football players. Researchers will track diet, blood markers like hemoglobin and ferritin, gut leakage indicators, …

This trial tests three ways to treat acanthosis nigricans, a skin condition causing dark, thick patches often linked to insulin resistance and obesity. About 54 people with the condition will receive either oral metformin, a topical metformin cream, or a glycolic acid chemical pe…

This trial tests whether using a fractional CO2 laser before hair transplant surgery can improve outcomes for people with permanent hair loss due to scars. The laser is thought to improve blood flow and tissue quality in scarred areas, potentially helping transplanted hair grafts…

This trial tests a drug called briquilimab for adults with chronic spontaneous urticaria (CSU) — long-lasting hives and itching that don't get better with standard antihistamines or omalizumab. The study has three parts, with some participants getting the drug and others a placeb…

This trial compares two ways of making the skin incision during upper eyelid surgery (blepharoplasty) to correct droopy or puffy eyelids. Each participant will have one eyelid cut with an electrocautery device and the other with a traditional scalpel, so the results can be compar…

This study tested a new medicine called rocatinlimab, given as an injection, for adults with moderate-to-severe eczema that wasn't well controlled with standard creams. About 746 participants received either the study drug or a placebo, along with topical treatments. The goal was…

This trial is testing whether an experimental oral drug called rilzabrutinib can reduce the itching and hives in adults with chronic spontaneous urticaria (CSU) — a condition where hives appear without a clear trigger — even when standard antihistamines haven't helped. Participan…

This study tests whether baricitinib, an oral anti-inflammatory drug, is safe and effective for children aged 2 to 17 with moderate to severe atopic dermatitis (eczema). About 516 participants will receive either baricitinib or a placebo, along with standard topical steroids. The…

This study tested three ways to treat warts: a topical acid solution, injections of candida antigen (a yeast extract), and a combination of both. 126 people with warts took part. The goal was to see which approach cleared warts best, including warts not directly treated, and how …

This phase II trial is testing whether an experimental drug called MG-K10 can reduce the severity of moderate-to-severe atopic dermatitis, a chronic inflammatory skin condition. About 60 adults who have not responded well to topical treatments will receive either MG-K10 or a plac…

This study tested two doses of bimekizumab, a drug that targets inflammation, in 41 adolescents aged 12 to 17 with moderate to severe plaque psoriasis. The main goals were to measure how the drug behaves in the body and to check its safety. Researchers also looked at how well it …

This study tested a drug called rocatinlimab in 187 teenagers aged 12 to 17 with moderate-to-severe eczema that didn't respond well to standard creams. The goal was to see if the drug is safe and tolerable over 52 weeks. Participants received regular injections, and researchers t…

This study tested a new medication called rocatinlimab for adults with moderate-to-severe eczema (atopic dermatitis). About 769 people took part to see if the drug can clear skin and reduce itching better than a placebo. The goal is to provide a new treatment option for those who…

This study tested a new medicine called amlitelimab, given as a shot under the skin, for people aged 12 and older with moderate-to-severe eczema that didn't get better with creams or other treatments. The goal was to see if it can clear or nearly clear the skin and reduce itching…

This trial tests whether applying the drug 5-fluorouracil through microneedling works better than standard injections of the same drug or corticosteroids for treating hypertrophic scars and keloids. About 60 adults with these raised scars will receive one of four treatments. Rese…

This study tests whether lebrikizumab, an injectable biologic, can improve skin symptoms in adults and adolescents (aged 12 and older) with moderate-to-severe atopic dermatitis, also known as eczema. Participants receive lebrikizumab for 24 weeks, and doctors measure changes in e…

This phase 3 trial investigates whether the antibiotic linezolid can cure yaws, a bacterial skin infection that causes ulcers, as effectively as the standard treatment azithromycin. The study involves 384 children aged 5 to 18 with confirmed yaws. Participants receive either line…

This trial tests a device called SELENE that gives surgeons a detailed view of the tissue removed during breast-conserving surgery. The goal is to see if using this imaging helps surgeons remove all cancer cells the first time, reducing the chance that a patient needs another ope…

This study tested whether cleaning the eyelids with wipes containing chlorhexidine can treat blepharitis caused by Demodex mites. 106 adults with the condition used the wipes twice daily for four weeks. Researchers measured mite counts and eyelash debris before and after treatmen…

This study tested an ointment called tirbanibulin (Klisyri®) on adults with actinic keratosis, a common precancerous skin condition caused by sun exposure. The trial included 280 participants and applied the ointment to larger skin areas (up to 100 cm²) on the face or balding sca…

This completed phase 2 trial tested whether adding alpha interferon to standard surgery helps prevent skin melanoma from returning. 278 participants with stage I-IV melanoma were assigned to one of six groups, including surgery alone, low or high dose interferon, chemotherapy, or…

This phase 3 study tested the drug bimekizumab in 133 Chinese adults with moderate to severe plaque psoriasis. Participants received either bimekizumab or a placebo for 16 weeks. The main goals were to see if bimekizumab could clear at least 90% of psoriasis (PASI90) and achieve …

This phase 3 study tested a drug called rocatinlimab in 726 adults with moderate-to-severe atopic dermatitis (eczema) that wasn't well controlled by creams. Participants received either the drug or a placebo as a shot under the skin for 24 weeks. The main goals were to see if the…

This study is testing how the drug guselkumab affects the immune system in people with two types of psoriasis: plaque and guttate. Twenty-five adults will receive guselkumab injections over 44 weeks. Researchers will measure changes in immune cells in the skin to understand how t…

This study tests whether a graft made from a patient's own or donor stem cells can repair the cornea's surface in people with limbal stem cell deficiency, a condition that causes pain, scarring, and vision loss. A small biopsy of limbal tissue is taken from a healthy eye or donor…

This study tested using cyanoacrylate glue to close off faulty veins that cause painful leg ulcers. 38 people with venous leg ulcers received the glue treatment. The goal was to see if the procedure is safe and helps ulcers heal faster.

This study tests whether using telemedicine (remote doctor visits) helps heal chronic wounds better than usual in-person care. Adults with long-lasting wounds in the Languedoc-Roussillon region of France are randomly assigned to telemedicine or standard treatment. The main goal i…

This phase 2 trial tested whether adding the oral drug baricitinib to phototherapy (light treatment) helps restore skin color in adults with progressive vitiligo. 49 participants received either baricitinib plus phototherapy or a placebo plus phototherapy for 36 weeks. The main g…

This Phase 3 study tested a topical solution called clascoterone in 703 men with mild to moderate male pattern baldness. Participants applied the solution or a placebo to their scalp twice daily for 6 months, and some continued for another 6 months. The goal was to see if clascot…

This study tested the drug bosentan in 18 adults with systemic sclerosis who had reduced blood flow in their hands and a history of digital ulcers. The goal was to see if bosentan could improve hand blood flow measured by laser imaging and how blood flow relates to ulcer severity…

This study tested a new gel-like wound dressing called MAP Wound Matrix (TT101) in 40 adults who had skin cancer removed with Mohs surgery. The dressing was applied right after surgery to see if it was safe and helped wounds heal compared to a standard hydrocolloid bandage. The m…

This study looked at how the drug abrocitinib affects the skin barrier in 20 adults with moderate to severe atopic dermatitis (eczema). Researchers measured water loss from the skin and changes in skin-related genes at 2 and 12 weeks. The goal was to see if the treatment helps re…

This study tested a surgical technique called a dermal roll flap to support the nostril base in 45 people who had a previous cleft lip repair. The flap uses extra skin from the lip to lift and stabilize the nostril on the cleft side. Researchers measured changes in nostril positi…

This study looked at 100 adults with cutaneous T-cell lymphoma (a rare type of skin cancer) who had already tried at least one other treatment. Researchers wanted to see how well the drug mogamulizumab works in everyday medical practice, not just in controlled trials. They measur…

This study tested the drug dupilumab (Dupixent) in 124 adolescents and adults with darker skin tones who have moderate-to-severe eczema. Participants received injections every two weeks for 24 weeks. The goal was to see if the drug safely improves skin symptoms and quality of lif…

This phase 2 trial tested whether adding methotrexate (a drug used for arthritis) to standard UVB light therapy works better than light therapy alone for adults with active, spreading vitiligo. Thirty-two participants were randomly assigned to receive either methotrexate pills pl…

This study followed 80 patients with pemphigus, a rare autoimmune disease that causes painful blisters on skin and mucous membranes. Researchers wanted to see how safe and effective rituximab (a drug that targets certain immune cells) is over the long term, compared to standard h…

This study looked at the long-term safety and effectiveness of lebrikizumab for adults and teens with moderate-to-severe atopic dermatitis (eczema). Participants who completed a previous year-long study could join this 2-year extension. The main goal was to see how many people st…

This study tested whether imatinib, a drug used for certain cancers, can reduce skin hardening in people with severe scleroderma. 28 adults received either imatinib or a placebo for 6 months. The main goal was to see if the drug improved skin thickness and quality of life.

This study followed 305 Canadian adults and children (ages 6+) with moderate-to-severe eczema who were prescribed Dupixent as part of their routine care. Researchers measured how many patients achieved at least a 75% reduction in eczema severity after 6, 12, and 18 months. The go…

This study tested an oral drug called GLPG3667 (Cadefrecitinib) in 40 adults with dermatomyositis, a rare disease causing muscle weakness and skin rash. Participants took the drug or a placebo daily for 24 weeks to see if it improves symptoms. The trial is complete, and results w…

This study tested whether sildenafil (the drug in Viagra) can help heal painful finger ulcers in people with scleroderma, a disease that damages blood vessels. 84 participants took either sildenafil or a placebo three times daily for 90 days. The main goal was to see if the ulcer…

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.

This study tested an oral tablet called JNJ-77242113 in 90 adults with moderate-to-severe plaque psoriasis. Participants were randomly assigned to receive the drug or a placebo for 16 weeks. The main goal was to see if the drug could improve psoriasis symptoms by at least 75% com…

This study tested a drug called bosentan in 16 adults with scleroderma who had a serious kidney complication called scleroderma renal crisis. The goal was to see if bosentan could help protect kidney function and improve survival over 6 months to a year. The drug works by blockin…

This completed phase 3 trial tested the drug guselkumab against a placebo in 338 adults with moderate plaque psoriasis covering only 2-15% of their body but including special sites like the scalp, face, or genitals. The goal was to see if guselkumab could clear or nearly clear ps…

This study tested whether nintedanib, a drug used for other lung diseases, can slow down lung damage in people who had severe COVID-19. It included 103 adults who still had lung problems more than 30 days after their COVID diagnosis. The main goal was to see if the drug helped ma…

This phase 2 trial tested a drug called lacutamab (IPH4102) in 170 people with advanced T-cell lymphoma, including Sezary syndrome and mycosis fungoides. The drug is an antibody that targets a protein on cancer cells. It was given alone or with chemotherapy to see if it could shr…

This study tested two ways to treat bullous pemphigoid, a severe blistering skin condition. One group used strong steroid creams for 9 months, while the other used steroids plus methotrexate for 4 weeks, then methotrexate alone for 8 months. The goal was to see if the combination…

This study looked at 781 adults with moderate-to-severe plaque psoriasis and metabolic syndrome (a cluster of conditions like high blood pressure and obesity). Researchers wanted to see if adding a lifestyle intervention (diet and exercise) to the drug Secukinumab (Cosentyx) impr…

This study tested whether taking two targeted drugs (dabrafenib and trametinib) for 12 months after melanoma surgery could keep the cancer from returning. It included 870 adults with high-risk stage III melanoma that had a specific BRAF V600 mutation. Results showed the drug comb…

This study tested a new drug called bimekizumab in 567 adults with moderate to severe plaque psoriasis. Participants received either bimekizumab, a placebo, or another active drug. The main goal was to see how well bimekizumab cleared skin lesions after 16 weeks. Results showed s…

This phase 3 study tested bimekizumab, a drug given by injection, against a placebo in 435 adults with moderate to severe plaque psoriasis. The main goal was to see how many people achieved at least 90% skin clearing after 16 weeks. The trial also looked at complete clearing and …

This study tested whether a single cycle of rituximab can control bullous pemphigoid, a severe blistering skin condition. Eighteen adults with steroid-dependent or relapsing disease were enrolled. Researchers checked disease control weekly for a month and then monthly for two yea…

This Phase 3 trial tested bimekizumab against secukinumab and placebo in 743 adults with moderate to severe plaque psoriasis. The main goal was to see how many patients achieved complete skin clearance (PASI100) at 16 weeks. Bimekizumab showed superior results compared to secukin…

This study tested a new medicine called bimekizumab against an existing drug (adalimumab) in 478 adults with moderate to severe plaque psoriasis. The goal was to see if bimekizumab could clear more skin at 16 weeks. Participants received either bimekizumab or adalimumab, and then…

This study tested whether adding placental tissue grafts to standard wound care helps close diabetic foot and venous leg ulcers faster. 292 adults with nonhealing ulcers received either standard care alone or standard care plus a graft. The main goal was to see if more ulcers clo…

This study followed 191 adults with chronic leg or foot ulcers that hadn't improved for at least 6 months. They received a gel called CACIPLIQ20 added to standard wound care. Researchers tracked how many wounds fully closed within 20 weeks and checked for side effects. The goal w…

This study tested whether a drug called ruxolitinib can reduce abnormal breast cells in people with high-risk or precancerous breast conditions like DCIS or atypical hyperplasia. Half of the 84 participants took ruxolitinib for about 15 days before surgery, and the other half too…

This Phase 2 trial tested whether Humira (adalimumab), a drug used for arthritis, can help people with Netherton syndrome, a rare genetic skin condition that causes severe inflammation, itching, and pain. Eleven patients received six injections over three months, followed by thre…

This study tested a drug called PF-06651600 in over 1,000 adults and teenagers with alopecia areata, a condition that causes patchy or complete hair loss. The goal was to see if the drug is safe and helps hair grow back over the long term. A smaller group also checked how well th…

This study tested the drug baricitinib in 606 adults with severe or very severe alopecia areata, a condition causing significant hair loss. Participants took either baricitinib or a placebo pill daily for up to 36 weeks. The main goal was to see if baricitinib could regrow enough…

This study tested a single dose of the oral drug acoziborole in 35 children aged 1 to 14 with sleeping sickness (g-HAT). The goal was to see how the drug works in the body and if it is safe and effective. This simpler treatment could help control the disease in remote areas where…

This study followed 48 people with hereditary angioedema (HAE) in Poland who were taking lanadelumab as part of a national drug program. Researchers tracked how many participants remained attack-free over 24 months, how many attacks still needed rescue treatment, and the severity…

This study tested a drug called alemtuzumab (Campath) as a first treatment for children with hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The goal was to see if it could help children survive until they could receive a stem cell transplan…

This early-phase study tested whether adding a TNF-blocking drug (infliximab or certolizumab) to standard immunotherapy (nivolumab and ipilimumab) is safe for people with advanced melanoma that has spread. The main goal was to find the best dose and check for serious side effects…

This study tested a new ovarian stimulation protocol using degarelix (a drug typically used for prostate cancer) to help breast cancer patients preserve their fertility before chemotherapy. The goal was to keep estrogen levels low while still collecting enough eggs for freezing. …

This Phase 3 trial tested whether low doses of interleukin-2 (IL2) can help people with severe alopecia areata, a condition causing patchy or total hair loss. 44 adults with at least 50% scalp hair loss who had not responded to other treatments received either IL2 injections or a…

This study tested whether the drug apremilast, taken as a pill twice daily, combined with narrowband UVB light therapy can help restore skin color in people with widespread vitiligo. 80 adults with stable or slowly progressing vitiligo covering at least 10% of their body took par…

This phase 2 trial tested avdoralimab, an antibody that blocks a specific immune signal, added to standard steroid cream for bullous pemphigoid—a severe blistering skin condition mostly affecting older adults. Fifteen participants received the combination to see if it leads to co…

This study compared two treatment strategies for people with early, severe scleroderma: a stem cell transplant using their own cells versus standard immunosuppressive drugs. The trial enrolled 60 adults with diffuse cutaneous systemic sclerosis. The goal was to see which approach…

This study tested a gel called Picato (ingenol mebutate) on 20 people with a very early form of melanoma on the face, called lentigo maligna. Participants applied the gel once a day for three days. The goal was to see if the gel could make the cancer disappear completely, offerin…

This study tested whether giving vitamin D based on a patient's deficiency level works better than a standard dose. 215 breast cancer patients on chemotherapy received either a fixed daily supplement or a tailored dose. The goal was to see which method normalizes vitamin D levels…

This study tested the drug lebrikizumab in 90 adults and teens with moderate-to-severe eczema who have skin of color. The goal was to see if the drug is safe and helps clear skin. Participants received injections over 24 weeks, and doctors measured improvement using a standard ec…

This observational study followed 331 adults with moderate-to-severe plaque psoriasis who were treated with tildrakizumab (Ilumetri) as part of their routine care. Researchers tracked how much the skin cleared and how quality of life improved over up to two years. The goal was to…

This study tested the drug upadacitinib in people with moderate to severe atopic dermatitis (eczema) who also have prurigo nodularis, a condition causing intense itching and hard bumps. The goal was to see if the drug reduces itching and improves skin. The study was observational…

This phase 3 trial tested a combination of two targeted drugs, LGX818 and MEK162, against standard treatments in 921 people with advanced melanoma that has a BRAF V600 mutation. The study compared the combo to vemurafenib alone or LGX818 alone to see which worked better at delayi…

This completed study tested whether painting metal roofs with a special heat-reflecting coating can lower indoor temperatures and improve health in Niue, a Pacific island nation facing record heat. Researchers enrolled 288 adults living in single-story homes with metal roofs. The…

This Phase 3 study tested ritlecitinib, an oral drug, in 607 adults and adolescents with nonsegmental vitiligo (a type of white patches on the skin). Participants took either the drug or a placebo daily for 52 weeks. The main goals were to see if the drug could improve skin color…

This study tested the drug risankizumab (Skyrizi) in 214 adults with moderate to severe genital or scalp psoriasis. Participants received either the drug or a placebo for 16 weeks, then all received the drug. The goal was to see if it could clear or nearly clear the skin in these…

This study tested a drug called lebrikizumab in 86 adults and teens with moderate-to-severe eczema who had already tried dupilumab. The goal was to see if lebrikizumab could safely improve their skin condition. Researchers measured how many participants achieved at least a 75% im…

This study tested a new oral medication, oteseconazole, to see if it can prevent recurrent yeast infections in women who have had at least three infections in the past year. Over 400 participants took either the study drug or a placebo for 12 weeks after an initial treatment, and…

This study tested a new oral medication, oteseconazole, to see if it can prevent recurrent yeast infections in women who have had at least three infections in the past year. Participants first received standard treatment for their current infection, then took either oteseconazole…

This phase 3 trial tested the drug povorcitinib in 608 people with moderate to severe hidradenitis suppurativa, a chronic skin condition causing painful lumps and abscesses. Participants received either the drug or a placebo for 12 weeks, followed by a 42-week extension where eve…

This study tested a drug called pegcetacoplan in 124 adults and teens with two rare kidney diseases (C3G and IC-MPGN). The goal was to see if the drug could reduce protein in the urine, a sign of kidney damage. Participants received either the drug or a placebo twice a week for 2…

This phase 2 study tested a new drug called SAR442970 in 86 adults with moderate to severe hidradenitis suppurativa, a chronic skin condition causing painful lumps. The drug is a Nanobody that targets two inflammatory proteins. Researchers compared it to a placebo to see if it co…

This study tested whether adding metformin, a common diabetes drug, to cyclosporine works better for psoriasis than cyclosporine alone. Thirty-two adults with moderate to severe psoriasis took part. Researchers measured skin improvement, body surface area affected, and quality of…

This study tested whether people with moderate-to-severe plaque psoriasis who achieve complete skin clearance after 20 weeks of guselkumab (Tremfya) can maintain that control with injections every 16 weeks instead of every 8 weeks. About 880 participants were enrolled, and the ma…

This study tested whether injecting a person's own concentrated platelets (PRP) into the scalp can improve hair growth in men with male pattern baldness. Two hundred one men received 3 to 5 sessions of PRP injections. The main goal was to see if hair loss grade improved based on …

This phase 3 trial tested an oral drug called povorcitinib in 619 adults with moderate to severe hidradenitis suppurativa, a chronic skin condition causing painful abscesses. Participants received either the drug or a placebo for 12 weeks, followed by a 42-week extension. The mai…

This Phase 2 trial tested an experimental oral drug called SCD-044 in 250 adults with moderate to severe atopic dermatitis (eczema). Participants received one of three doses of SCD-044 or a placebo for 16 weeks. The main goal was to see if the drug could reduce eczema severity by…

This study tested whether G-CSF (a drug that boosts white blood cells) can help heal toxic epidermal necrolysis, a rare but severe skin reaction. Ten patients were randomly assigned to receive G-CSF or a placebo for five days. Researchers measured how fast the skin healed and loo…

This Phase 3 trial tested a topical solution called clascoterone for male pattern hair loss. 762 men with mild to moderate balding applied the solution or a placebo twice daily for 6 months, followed by another 6 months for those who responded. The goal was to see if clascoterone…

This study looked at the long-term safety of a cream called roflumilast for people with mild to moderate eczema (atopic dermatitis). Over 1,200 participants, ages 2 and up, applied the cream once daily for up to 52 weeks. The main goal was to track any side effects, with secondar…

This study tested whether the drug everolimus can reduce new skin cancers in heart transplant patients who already had skin cancer. 175 participants received either everolimus or standard immunosuppressants. The goal was to see if everolimus lowers the number of new skin tumors n…

This study tested the safety and effectiveness of oral ivermectin for treating scabies in children weighing 5 to less than 15 kilograms. 240 children participated, receiving either ivermectin, a standard permethrin cream, or a placebo. The goal is to see if ivermectin can be a sa…

This completed Phase 2 trial tested oral ivermectin minitablets in 13 children aged 3 months and older weighing 5 to less than 15 kilograms who had scabies. The study aimed to check the safety, how the drug works in the body, and how well it treats the infection. Results will hel…

This small study tested whether a short course of HIV drugs (emtricitabine and tenofovir) could reduce inflammation in people with plaque psoriasis. Only 8 people took part, and the main goal was to see changes in certain markers in skin biopsies. The study is complete, but resul…

This completed study tested whether a shorter, more intense course of radiation (1 week) works as well as the standard 3-week course for women with early breast cancer after lumpectomy. Sixty women were split into two groups to compare side effects, cosmetic results, and cancer c…

This large study looked at whether taking daily vitamin D or fish oil supplements could lower the risk of developing autoimmune diseases (like rheumatoid arthritis), reduce signs of inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or …

This study compared two common antibiotics, doxycycline and TMP-SMX, for treating uncomplicated skin infections like boils and cellulitis. 269 people aged 9 to 85 took one of the drugs for 7 days. Researchers checked if the infection cleared up early, at the end of treatment, and…

This study looked at whether tildrakizumab, a drug already approved for psoriasis, can improve blood flow to the heart in people with moderate-to-severe psoriasis. 36 adults took the drug for 6 months, and researchers measured heart function using special scans. The goal was to s…

This study tested an oral medication called deucrictibant for quickly treating attacks of hereditary angioedema (HAE), a condition causing sudden, painful swelling. The trial involved 134 adolescents and adults with HAE types 1, 2, or 3. Participants took either the drug or a pla…

Researchers are testing whether a handheld device that shines a special light on the inside of the mouth can help clinicians spot suspicious areas that might be precancerous or cancerous. The study will have three dentists with different levels of experience examine 200 adults, i…

This study tests a special microscope that lets doctors check if all cancer cells have been removed during surgery for common skin cancers. About 42 adults with head, neck, or skin cancer will take part. The goal is to see if this quick method is as accurate as the standard lab t…

This trial tests whether indocyanine green, a dye injected before surgery, can find sentinel lymph nodes as reliably as the standard technetium-99 radioactive tracer. About 744 adults with various cancers will receive both agents, and surgeons will compare detection rates using a…

Researchers are testing whether a standard MRI scanner can be used to create detailed 3D maps of fat molecules in the breast. The idea is that changes in fat composition may appear before cancer develops, so this could help detect very early breast cancers. The study will compare…

This study follows people with a significantly elevated risk of pancreatic cancer—due to inherited gene mutations or strong family history—who choose to undergo early detection testing. Participants receive endoscopic ultrasound (EUS) and MRI scans on an alternating schedule ever…

This trial explores whether a standardized breakfast and a continuous glucose monitor can replace the traditional glucose drink test for diagnosing diabetes and prediabetes in people with Dunnigan's lipodystrophy, a rare genetic condition that causes severe insulin resistance. Th…

This trial tests whether a new hybrid tracer, ICG-99mTc-nanoscan, can replace the standard tracer for sentinel node biopsy in people with penile cancer, melanoma, or oral cancer. The hybrid tracer combines a fluorescent dye with a radioactive marker, potentially allowing surgeons…

This study is adapting and testing a French version of the Athletic Disordered Eating (ADE) scale, a 17-question screening tool designed specifically for athletes. Researchers will enroll 229 athletes aged 15 to 70 who exercise more than 6 hours per week. Participants complete th…

This study tested a non-invasive imaging device called dermal optical coherence tomography (D-OCT) to diagnose basal cell carcinoma (a common skin cancer) around the eye area. Researchers compared its accuracy to standard biopsy results in 210 adults with suspected lesions. The g…

This study tested a non-invasive device that uses light to classify skin lesions as healthy, actinic keratosis, or carcinoma. Researchers aimed to see if it could help doctors diagnose skin conditions more accurately without needing a biopsy. The study involved 142 adults with su…

This study tested whether a rapid point-of-care test (Xpert® Xpress MVP) helps doctors diagnose vaginal infections more accurately than usual methods. 351 women with symptoms like discharge or itching were randomly assigned to either usual care or the rapid test. Researchers then…

This study looked at whether whole body MRI can accurately diagnose inflammatory myopathies—a group of muscle diseases causing weakness and damage. Researchers compared MRI results with muscle biopsies in 139 people suspected of having these conditions. If MRI proves reliable, it…

This study tested whether an artificial intelligence tool called Legit Health Plus can help doctors track the severity of chronic skin conditions like acne, psoriasis, and eczema from a distance. 160 participants used a smartphone app for 6 months to take photos of their skin and…

This study tested whether an artificial intelligence (AI) system can help detect melanoma, a dangerous form of skin cancer. Researchers took photos of suspicious skin spots from 105 adults using a smartphone camera and let the AI analyze them. They compared the AI's results to di…

This completed study tested whether an AI device could help 16 doctors (10 general practitioners and 6 dermatologists) more accurately diagnose 13 different skin conditions, including melanoma, psoriasis, and acne. The doctors reviewed 29 medical images, first giving a diagnosis …

This study tested whether an artificial intelligence (AI) tool could help primary care doctors diagnose skin conditions more accurately. Nine doctors reviewed 30 images of various skin problems, first giving their own diagnosis and then a final diagnosis after seeing the AI's sug…

This study tested whether a painless, non-radiation ultrasound of the chest can find early signs of lung scarring in people with scleroderma. Thirty patients without known lung disease on CT scans underwent thoracic ultrasound. The goal was to see how often ultrasound detects hid…

This completed study tested a new rapid diagnostic tool to quickly identify antibiotic-resistant bacteria in wounded warriors and veterans. Over 2,200 participants provided samples from blood, lungs, or skin. The goal was to see if the test could accurately detect resistant bacte…

Researchers are testing whether low-dose tamoxifen or a 5:2 intermittent fasting diet can raise levels of a protein called sex hormone binding globulin (SHBG) in women at high risk of breast cancer. Higher SHBG levels have been linked to lower breast cancer risk. The trial enroll…

Researchers at Akdeniz University are testing Care-Up, a mobile-friendly web tool that gives family caregivers structured guidance on skin care, pressure-injury prevention, urinary-risk signs, nutrition, hydration, and when to call a professional. The trial enrolls 66 patient-car…

This trial tests whether a structured nursing care bundle can reduce pressure injuries caused by medical devices in critically ill patients. The bundle includes securing devices properly, frequent skin checks, repositioning, proper nutrition, and staff education. Researchers will…

This trial tests a workplace program designed to encourage local government organizations to adopt sun protection policies for outdoor workers. The program provides education and resources to managers and employees, aiming to increase the use of sun-safe practices. Researchers wi…

This trial tests whether giving azithromycin—a common antibiotic—twice a year to young children in Niger can reduce deaths. It compares giving the drug to all children aged 1-59 months versus only to infants 1-11 months, who are at highest risk. The study also checks how these ap…

This study looked at whether a powered alternating pressure air mattress can prevent pressure ulcers (bedsores) in patients at medium to high risk. 90 adults in nursing homes and long-term care used the mattress for up to 35 days. Researchers tracked how many developed at least a…

This study tested a mobile app designed to teach caregivers of bedridden patients how to prevent pressure injuries (bedsores). The app included educational modules, daily care tracking, and a way to ask a nurse questions. Researchers wanted to see if using the app for six months …

This small pilot study tested whether an ice plant cream could prevent hand-foot syndrome (pain, redness, peeling on hands and feet) in 15 breast cancer patients receiving doxorubicin or docetaxel chemotherapy. The main goal was to see if a larger study is possible, not to prove …

This study tested two different skin protection products to prevent incontinence-associated dermatitis (a type of diaper rash) in elderly nursing home residents. Researchers compared a film-forming protectant and a lipophilic (oil-based) protectant against no treatment in 220 par…

This study follows up on women who took a low dose of tamoxifen (5 mg daily) for three years to see if it continues to prevent breast cancer over the long term. The original trial found a 42% reduction in breast cancer events. Researchers will also combine data from three similar…

This study tested whether combining personal hygiene (using medicated washes and ointments) with household cleaning can prevent MRSA skin infections. Over 800 people from households with a recent MRSA infection took part. The goal was to see if this combined approach reduces the …

This study looked at whether teaching caregivers how to prevent pressure ulcers (bedsores) can lower the risk for patients receiving home care. The training covered skin care, repositioning, and pressure relief methods. Researchers measured patients' risk levels before and after …

Hailey-Hailey and Darier disease are rare inherited skin conditions that cause painful, itchy lesions in skin folds. Sweating makes them worse, and standard treatments often do not work well. Researchers are testing whether botulinum toxin injections into large skin folds can red…

Researchers are testing whether injections of botulinum toxin into the soles of the feet can reduce blistering in people with localized epidermolysis bullosa simplex, a rare skin condition that causes painful foot blisters. The trial enrolls 18 people with similar blisters on bot…

This study tested whether taking a cistanche supplement for 8 weeks, along with a supervised training program, improves anaerobic exercise performance and recovery in young men. 56 men aged 18-25, either elite or amateur athletes, were randomly assigned to receive cistanche extra…

Keloids are raised, itchy scars that grow beyond the original wound and often return after treatment. Researchers are testing dupilumab, an antibody that blocks two inflammation signals, in 20 adults with keloids. Participants receive the drug and doctors track scar appearance, i…

This study tests a special adhesive patch made with zinc oxide to hold catheters (thin tubes placed in veins) in place for hospitalized adults. The goal is to see if it reduces complications like the catheter moving, skin irritation, vein swelling, and pain. About 400 patients wh…

This Phase 3 trial tests a new gel (N-Acetyl-GED-0507-34-LEVO) applied once daily for 12 weeks to reduce acne lesions on the face and trunk. About 400 participants will be randomly assigned to receive either the active gel or a placebo. Researchers will measure changes in lesion …

This Phase 3 trial tests a new gel called N-Acetyl-GED-0507-34-LEVO for acne vulgaris. About 400 people will apply the gel or a placebo daily for 12 weeks. Researchers will count pimples and rate skin clarity to see if the gel works better than placebo.

This study tests whether a special silicone dressing (Neodyne embrace) can improve the appearance of abdominal scars in women who had breast reconstruction using tissue from their belly. Thirty women will have part of their incision treated with the dressing and the other part le…

This study tests whether using a virtual reality headset showing nature scenes with relaxing music can reduce pain and anxiety during dressing changes for pressure sores. Sixty-two adults with pressure sores will be randomly assigned to either receive VR during dressing or standa…

After Mohs surgery on the scalp, wounds are often left to heal on their own, which can take 8 weeks or more. This study tests whether a pinch graft—a thin piece of skin taken from the groin and placed in the wound—can help the wound heal faster. Researchers will compare healing t…

Researchers are testing whether an investigational eyelid emollient balm improves comfort and tolerance when used with tacrolimus 0.1% ointment in adults with atopic eyelid dermatitis. The study enrolls 33 people aged 18 to 65 with eczema on both eyelids. Each person applies the …

This Phase 3 trial tests whether dupilumab (Dupixent) can reduce severe itching in adults with lichen simplex chronicus, a skin condition causing intense itch. 142 participants will receive either dupilumab or placebo injections for 24 weeks. The main goal is to see if more peopl…

This Phase 3 trial tests whether dupilumab (Dupixent) injections can reduce severe itching in adults with lichen simplex chronicus, a skin condition causing intense, persistent itch. About 138 participants will receive either dupilumab or a placebo for 24 weeks. The main goal is …

This early-stage study tests a new drug called ATTO1310 to see if it is safe and how the body processes it. It includes healthy adults, people with atopic dermatitis (eczema), and those with long-term itching. Participants receive either the drug or a placebo and are monitored fo…

This early-stage study tests a new drug called ATTO-3712 in healthy adults and people with atopic dermatitis (eczema). The main goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo and are monitored with clinic visi…

Researchers at Tanta University are testing whether fractional CO2 laser can reduce skin amyloid deposits and itching in people with primary cutaneous amyloidosis. The trial enrolls 22 adults with confirmed disease who have not used other treatments for at least six months. Parti…

Researchers compare alpha hydroxy acids, both with and without nanocarriers, against a standard calcipotriol plus betamethasone ointment for plaque psoriasis. The trial enrolls 80 adults with mild to moderate psoriasis who have not used psoriasis therapy for two months. Participa…

Boys with hemophilia often miss out on games and activities because of concerns about bleeding and joint damage. Researchers developed a 12-week muscle-strengthening exercise programme with input from children, parents, and physiotherapists. The DOLPHIN-II trial compares this pro…

This study tests whether custom-made 3D-printed masks fit children better than standard commercial masks for non-invasive ventilation (NIV). Fifteen children aged 8-12 who already use NIV but have poor adherence will try a custom mask made from a 3D facial scan. Researchers will …

This study follows about 200 people aged 12 and older in Canada who are using a prescription gel containing clindamycin, adapalene, and benzoyl peroxide for acne. Researchers want to see how satisfied patients are, how well they stick to the treatment, and how it affects their qu…

Researchers are testing whether nicotinamide riboside, a form of vitamin B3 sold as a supplement, can reduce immune system activation in people with mild to moderate psoriasis. The trial enrolls adults aged 18 to 80 who are not on biologic therapy. Participants take either the su…

This trial tests a topical apple peptide complex for improving skin recovery after aesthetic procedures such as liposuction, breast augmentation, laser treatments, and microneedling. Women aged 45 to 65 who have had or are planning such procedures will apply the product to their …

This study tested whether a mobile application could help nurses and caregivers better manage pressure injuries (bedsores) in people receiving home care. Thirty participants were followed for 28 days, with caregivers using the app to track wound healing and receive reminders. The…

This study tests whether lightly sanding the skin edges during Mohs surgery (a type of skin cancer removal) can improve how scars look after healing. Thirty adults having facial or neck surgery will have half their scar treated with dermabrasion and the other half left as standar…

This study tests whether adding a nerve block (numbing medicine) before Mohs surgery for skin cancer on the face or scalp can lower pain and anxiety during the procedure. About 150 adults will be randomly assigned to receive either a real nerve block or a placebo (salt water) inj…

This trial tests whether injecting lidocaine under the skin at the shingles rash site can reduce pain and help prevent post-herpetic neuralgia, a long-lasting nerve pain that can follow shingles. Adults with acute shingles pain or established post-herpetic neuralgia will receive …

This study tests a new two-sided pad (Debrisoft Duo) for cleaning wounds by removing dead tissue. About 104 adults with various wound types (like diabetic ulcers or burns) will be randomly assigned to the new pad or the current one-sided pad. The main goal is to see if the new pa…

This Phase 3 trial tests whether wearing a hydrogel bandage on the skin of the head and neck during radiation therapy can reduce pain and skin irritation in people with head and neck cancer. About 130 participants will either wear the bandage for at least 5 hours a day during tre…

This study looks at whether a simple home exercise program can improve strength, endurance, and quality of life for people with hidradenitis suppurativa (HS), a painful skin condition. Researchers will have 86 adults with HS follow a video-guided exercise routine 3-4 days a week.…

This study tests whether a lower dose (6%) or a higher dose (8%) of sevoflurane gas works better and causes fewer side effects when putting children aged 1 to 6 years to sleep for minor eye surgery. The main goal is to see which dose leads to less agitation and confusion when the…

This trial compares two types of lasers—fractional carbon dioxide and long-pulsed Nd:YAG—to see which works better for keratosis pilaris, the rough bumps often called 'chicken skin.' People aged 13 and older with keratosis pilaris on both upper arms will receive each laser on a d…

This phase 2a trial tests whether an experimental oral drug called PORT-77 can lower levels of protoporphyrin IX (PPIX) in the blood of adults with erythropoietic protoporphyria (EPP). People with EPP experience severe pain and skin reactions after even brief sun exposure. The st…

This study tests whether a special antioxidant moisturizing serum can improve mild to moderate seborrheic dermatitis on the face. Researchers will apply the serum to one side of the face and a control product to the other side for 4 weeks in 13 adults. The goal is to see if the s…

This study tested a daily tablet called NatureU Histra Disslove in 19 adults with chronic hives. Participants took one tablet before a main meal for 28 days. The study measured how well the tablet controlled hives, reduced symptoms, and improved quality of life. Results showed ch…

This study investigates whether a low-energy ketogenic diet can reduce pain and improve quality of life in women with lipedema, a painful fat disorder affecting about 11% of women. Participants follow either a ketogenic or a non-ketogenic low-energy diet for 8 weeks. The goal is …

This study tested two ways of positioning patients with severe lung injury (ARDS) who are on ventilators and placed face-down (prone) to help breathing. The goal was to see if a 'swimmer' position—where the head is turned and one arm is bent—causes fewer severe pressure sores tha…

This study tested a new, standardized process for providing assistive devices (like special tools) to help people put on and take off compression stockings. 220 adults who need these stockings long-term took part. The goal was to see if the new method improves how often people us…

This study tested a drug called MT-7117 in 165 adults and adolescents (ages 12-75) with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP), conditions that cause severe pain from sunlight exposure. The goal was to see if the drug could delay the first symptoms o…

This early-phase study tested whether a drug used for lymphoma, brentuximab vedotin, is safe for people with a severe form of scleroderma (diffuse cutaneous systemic sclerosis). The drug targets overactive immune cells that may drive the disease. Only 17 people took part, and the…

This study tested a smartphone app called RENEW designed to help people with scleroderma manage fatigue and build resilience. Over 12 weeks, 43 participants used the app to set and track weekly healthy goals. The main goal was to see if people would actually use the app and compl…

This study tested a special cream made with ozonated oils and biotin for women with oily scalp. 66 women aged 18-40 used the cream or a placebo every night for 6 weeks. The active cream reduced scalp oil by 28%, compared to 10% for placebo, and was well-tolerated with only mild i…

This study tested a device called AVELI to safely reduce cellulite and fibrous tissue in 130 people undergoing body contouring surgery. Researchers measured safety, patient satisfaction, and appearance improvements over 9 months. The goal was to see if adding AVELI to standard li…

This study tested a new device called Flexitheralight against the usual light therapy for actinic keratosis, which are rough spots caused by sun damage. About 29 adults with at least 10 spots on their forehead or scalp took part. The goal was to see if the new device works just a…

This small study tested whether a special laser treatment can help veterans with leg amputations who have painful scars that make wearing their artificial limb hard. Ten veterans received the laser therapy, and researchers measured changes in pain, scar appearance, walking abilit…

This study tested a home-use light device and special mouth rinse to help people with oral lichen planus, a painful mouth condition. Thirteen participants used the device daily for a year alongside standard care. The goal was to see if it could reduce pain and inflammation better…

This study tested a special cream containing a butyrate releaser (a substance that helps the skin barrier) in 100 children aged 6-36 months with eczema. The cream was compared to a standard moisturizer over 12 weeks. The goal was to see if it could reduce eczema severity and impr…

This study tested whether caffeine helps elite weightlifters perform better in competition. Fourteen athletes took either caffeine or a placebo before a simulated weightlifting meet. The results suggest caffeine can provide a small performance boost, but the effect is modest and …

This study tested a pulsed dye laser to reduce red veins (telangiectasias) on the face and neck in 21 people with scleroderma. Participants received four laser sessions, and the researchers checked how many veins disappeared, how patients felt about the results, and any side effe…

This study tests whether biofield therapy, a type of energy healing or magnetism, can make common warts on hands and feet disappear. Sixty-two adults with warts for at least 3 months will be randomly assigned to receive either real biofield therapy from a recognized healer or fak…

This study looked at whether a larger trial on self-scar massage for women after childbirth is possible. 14 new mothers with healed episiotomy or perineal tears were asked to massage their scar tissue at home for 6 weeks. The goal was to see if women would stick with the routine …

This study looked at whether a diet low in salt and sugar can reduce common side effects of corticosteroid treatment, such as weight gain, high blood pressure, and diabetes. Fifty adults with autoimmune diseases or asthma who were starting high-dose corticosteroids were randomly …

This study tested two behavioral programs—coping skills training and general health education—to see which better improves well-being in people with ongoing pain after breast cancer surgery. About 316 participants who had surgery for breast cancer or precancerous conditions took …

This study tested whether adding a special antioxidant pill (GLISODIN) to standard UVB light therapy helps treat vitiligo better than light therapy alone. Fifty adults with non-segmental vitiligo covering more than 5% of their body took part. The main goal was to see if the combi…

This study tested a cream made from plant compounds (total coumarins) in 88 adults with mild-to-moderate psoriasis. Participants applied the cream or a placebo for several weeks. The goal was to see if the cream safely reduces skin redness, scaling, and thickness better than a pl…

This study tested a cream paste containing pleuran (a beta-glucan from oyster mushrooms) on 110 children with diaper rash, perioral dermatitis, or neonatal pustulosis. Participants applied the cream 2-3 times daily for up to 2 weeks without other treatments. Researchers measured …

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This study tested whether a personalized rehabilitation program could improve quality of life for people with systemic sclerosis, a disease that causes skin and joint stiffness. 220 adults with the condition were randomly assigned to either the rehab program or usual care. The pr…

This study tested whether eye drops made from a patient's own blood (autologous serum) can relieve severe dry eye better than standard artificial tears. 46 adults with severe dry eye tried both diluted (20%) and full-strength (100%) serum drops, as well as artificial tears. The m…

This study tested whether a measles vaccine could help control eczema (atopic dermatitis) in adults. Researchers gave 20 adults with moderate-to-severe eczema either the measles vaccine or a placebo and tracked their symptoms for 45 days. The goal was to see if the vaccine could …

This study tested a scalp moisturizer made with celastrol and chicory root extract in 23 adults with dry, flaky scalp or dandruff. Participants applied it every night for 4 weeks. Researchers used artificial intelligence to measure changes in scalp condition. The goal was to see …

This study tested whether breathing in lavender essential oil for 15 minutes before skin cancer surgery could reduce anxiety. Sixty-six adults with early-stage melanoma or other skin cancers took part. Researchers measured anxiety using questionnaires and vital signs like heart r…

This study tested an experimental drug called SCD-044 in 263 adults with moderate to severe plaque psoriasis. Participants received either the drug or a placebo to see if it could improve skin symptoms like redness and scaling. The main goal was to measure how many people achieve…

This pilot study tested an online program called THRIVE, based on Positive Affect Training, to help breast cancer survivors feel better about taking their anti-hormonal medication. The goal was to see if the program was acceptable and feasible for women who struggle with side eff…

This study tested whether adding a moisturizing cream with or without vitamin E (from palm oil) to a standard urea-based cream helps resolve hand-foot skin reactions caused by the chemotherapy drug capecitabine. 145 cancer patients with mild skin reactions took part. The goal was…

This study tested a cream made from andaliman fruit extract on 40 adults with seborrheic keratosis, harmless skin growths on the face. Participants applied the cream daily for 12 weeks, and researchers checked for changes in the growths using a special camera. The goal was to see…

This study tested a special dressing coated with a substance that binds bacteria (DACC-coated hydrogel) to treat skin burns caused by radiation therapy in 18 women with breast cancer. The goal was to see if it could reduce pain and help heal the skin. The study is already complet…

This pilot study tested whether gentle yoga and breathing exercises are feasible for people with scleroderma, a condition that can limit movement. Thirty participants learned chair-based yoga and breathing techniques, then practiced twice daily at home for 10 weeks. Researchers m…

This study tested whether gabapentin, a drug usually used for nerve pain, can reduce facial flushing and redness in people with rosacea. Fifty adults with rosacea took different doses of gabapentin or standard treatment for up to 12 weeks. Researchers measured changes in redness …

This study tested whether a selenium gel can help treat oral lichen planus, a chronic condition that causes painful sores in the mouth. Fifty adults with the condition used either selenium gel, a standard steroid cream, or an immunosuppressant cream. The goal was to see if seleni…

This Phase 3 trial tested a cream called ruxolitinib (also known as Opzelura) in 190 adults with prurigo nodularis, a skin condition causing intense itching and hard bumps. Participants applied the cream twice daily for 12 weeks. The main goal was to see if it could reduce itch b…

This study tested an oral medication called deucrictibant for quickly relieving swelling and pain attacks in people with hereditary angioedema (HAE) types I and II. 74 adults received either one of three doses of the drug or a placebo during an attack. The main goal was to see if…

This study tested whether listening to music during wound dressing changes can help reduce pain and anxiety in people with venous leg ulcers. 97 patients were split into three groups: one listened to Turkish instrumental music, one to Western music without lyrics, and one had no …

This study tested two oral medications, aprepitant and hydroxyzine, to see which better reduces severe itching triggered by water contact in people with myeloproliferative neoplasms (a type of blood cancer). 63 participants who had persistent itching rated 5 or higher on a 10-poi…

This study tested a behavioral therapy called EMD-U in 96 adults with atopic dermatitis or prurigo nodularis who had a strong urge to scratch. The therapy involves focusing on the itchy spot while moving the eyes, repeated until the urge fades. Researchers compared EMD-U plus usu…

Researchers are examining skin cancer among people whose jobs involve long hours in the sun. The study uses national administrative and medical records to describe who develops these cancers, including age, sex, region, cancer type, and disability outcomes. The goal is to underst…

Critically ill patients on hemofiltration face high odds of pressure injuries from immobility, medical devices, and long treatment hours. Researchers at one Turkish hospital observe 109 adults receiving hemofiltration in intensive care, tracking skin condition, consciousness, nut…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This completed study enrolled 377 individuals and families with a high risk of breast or ovarian cancer due to known or suspected genetic factors. Researchers collected medical records, questionnaires, and biological samples to better understand the disease's natural history and …

This study investigated whether environmental exposures during military service increase the risk of developing myositis, a rare autoimmune disease that attacks muscles. Researchers compared 37 military personnel with and without myositis using questionnaires and blood samples. N…

This completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…

Researchers are studying whether adults with Dunnigan lipodystrophy, a rare genetic condition that changes how the body stores fat, have higher levels of inflammation than people without it. The trial enrolls 64 non-diabetic adults on Reunion Island, including those with the cond…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This study looks at people who have severe allergic reactions (anaphylaxis), especially when the cause is unknown. Researchers will do blood tests and bone marrow biopsies to find genetic or molecular clues. The goal is to understand what goes wrong in the body, not to test a new…

This study looked at people with three rare genetic conditions—xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD)—that affect the body's ability to repair DNA. Researchers examined 709 participants to understand how these defects relate to cancer ri…

Researchers are studying whether a non-invasive skin imaging technique called reflectance confocal microscopy can predict how well people with moderate to severe atopic dermatitis respond to dupilumab. The trial enrolls 40 participants aged 6 months and older who are starting dup…

Researchers at Gazi University are studying whether Behçet's disease, which causes mouth sores and eye inflammation, is connected to gum disease. They compare 40 people with Behçet's plus gingivitis or periodontitis against 47 people with gum disease alone. The team measures infl…

This study follows people who have or had anthrax, those exposed, and healthy vaccinated volunteers to learn how the body fights the disease. Researchers will track symptoms, immune responses, and long-term health for up to 2 years. The goal is to better understand anthrax and im…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

This completed study followed 945 people, mostly children and young adults with severe eczema or related allergic conditions, along with their relatives. Researchers observed how these diseases progress over up to a year, using tests like allergy skin pricks, blood draws, and lun…

This study aims to find the best way to share research results with people who have scleroderma, a rare autoimmune disease. About 128 participants will be randomly assigned to receive either an infographic or a plain-language summary of a study. They will then rate how complete, …

This study looks at how oral isotretinoin, a common acne treatment, affects the surface of the eye and the meibomian glands, which produce the oily layer of tears. Researchers will measure tear film stability, gland structure, and dry eye symptoms in 60 acne patients before and a…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study looks at how a new medicine (PF-08049820) is processed by the body when taken alone or with another drug (rabeprazole). It involves 18 healthy Chinese adults aged 18-65. Participants take both medicines by mouth, and blood samples are collected to measure drug levels. …

This study aims to adapt the Menstrual Cycle Knowledge Questionnaire (MCKQ) into Turkish and check whether it is a valid and reliable tool for female athletes. Researchers will ask 120 women aged 16 to 35 who are licensed athletes to fill out the questionnaire, along with other s…

This study looks at how a new medicine called PF-08049820 changes the way birth control pills, a sedative, and a blood thinner move through the body. It involves 16 healthy adult women who will take the drugs alone and then with PF-08049820. The results will help plan future stud…

This study looked at 47 people with bullous pemphigoid, a blistering skin condition, who were treated with high-dose topical corticosteroids (clobetasol propionate) for 6 months. Researchers measured bone mineral density at the start, at 3 months, and at 6 months to see if the tr…

This early-stage study tests the safety of PF-08049820, a medicine being developed for eczema (atopic dermatitis), in about 71 healthy adults. Participants will take single or multiple doses of the drug or a placebo, and researchers will monitor how the body processes it and whet…

This observational study asks whether women with lipedema, a condition that causes abnormal fat buildup in the legs, are more likely to have joint hypermobility, or unusually loose joints, compared to healthy women of similar age and weight. Researchers will measure joint loosene…

This study looks at whether a common light treatment for vitiligo changes certain proteins in the skin. Researchers will measure two markers, CD63 and CD9, in skin samples from 20 people with vitiligo before and after three months of narrow-band ultraviolet B (NB-UVB) therapy. Th…

This study looks at how doctors currently diagnose lung and breast cancer using tissue samples. It will also test whether artificial intelligence (AI) can help analyze these samples faster and more accurately. Researchers will review records from 600 patients to measure diagnosis…

This trial tests two common warm-up techniques in amateur athletes aged 18 to 30. After a short cycling warm-up, participants either roll their hamstrings with a foam roller or perform PNF stretching. Researchers measure hamstring flexibility, leg strength, vertical jump, and pai…

This study looks at whether people with lipedema, a condition that causes painful swelling in the legs, also have sarcopenia, which is age-related loss of muscle mass and strength. Researchers will measure muscle thickness, grip strength, and walking speed in 102 adults with lipe…

This study looks at why some medications, like the antifungal voriconazole, can cause extreme sensitivity to sunlight, leading to severe sunburn-like reactions. Researchers will measure gene activity in skin samples from 62 participants, including healthy volunteers and patients …

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study is creating a large network of hospitals across Italy to improve the diagnosis and understanding of rare cerebrovascular diseases (rCVDs), such as CADASIL, Fabry disease, and Moyamoya. Researchers will collect medical information and blood samples from 500 patients to …

This study investigates whether compounds found in ultra-processed foods, like advanced glycation end products (AGEs), might play a role in childhood eczema, also known as atopic dermatitis. Researchers will compare the diets of 100 children aged 6 months to 10 years, half with e…

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This trial tests whether a 15-minute educational video and a list of suggested questions can improve understanding of immunotherapy among patients with advanced cancer and their caregivers. Participants are randomly assigned to receive the educational materials or usual care, and…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This study looks at how different doses of the antibiotic doxycycline affect antibiotic resistance in people with ocular rosacea, an inflammatory eye condition. Researchers will compare a low anti-inflammatory dose (40 mg daily) with a standard antibiotic dose (200 mg daily) and …

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This trial tests whether an online training course, called MelaMEd, can improve primary care doctors' ability to detect and manage melanoma, the most serious form of skin cancer. Participants—general practitioners, trainees, and pediatricians—answer questions and review skin lesi…

This study looks at how athletes who regularly lose and regain weight to meet competition categories experience changes in metabolism, body temperature, and body composition. Researchers will track 48 athletes through periods of weight maintenance, loss, and regain, using body te…

This observational study in children and adolescents with tinea capitis (a scalp fungal infection) investigates whether changes seen under a trichoscope—a special microscope for hair and scalp—can predict when the infection is cured. Participants receive the antifungal drug terbi…

This study reviews the medical records of 20 people treated for eyelid carcinomas at a hospital in eastern Morocco. Researchers are examining patient characteristics, tumor types, and surgical approaches to better understand how these cancers present and are managed in this regio…

This pilot study tests whether applying over-the-counter moisturizers (CeraVe or Vaseline) daily for 4 weeks can reduce inflammation in adults aged 70 and older with dry skin. Researchers will measure skin barrier function, blood markers of inflammation, and skin microbes. The ma…

This study enrolled 500 skin cancer patients in China and analyzed over 1.2 million of their social media posts using artificial intelligence. The goal was to see if AI could detect signs of psychological distress and suicidal thoughts. Researchers hope this approach could lead t…

This completed observational study followed 73 adults with mycosis fungoides or Sézary syndrome who were starting treatment with Poteligeo. Researchers tracked changes in symptoms like itching, skin pain, and fatigue, as well as quality of life for patients and their caregivers. …

This study looked at how the drug adalimumab affects gene activity in the skin of people with chronic plaque psoriasis. Researchers compared skin samples from normal, non-lesional, and lesional areas before and after treatment. The goal was to understand the immune changes that h…

This study examined 119 people with precancerous or early skin cancer lesions to understand how cells change as they become cancerous. Researchers took small skin samples and analyzed their metabolism and protein markers. The goal was to learn more about the transition from harml…

This study looked at whether adding strength training to regular cycling workouts helps competitive cyclists improve performance and muscle function. Twenty-four male cyclists either did strength training plus endurance training or just endurance training for 10 weeks. Researcher…

This study investigates people with oculocutaneous albinism who have no known genetic cause for their condition. Researchers use advanced DNA analysis techniques to search for new or hidden mutations. The goal is to improve diagnosis and understanding of this inherited condition.

This study followed 150 adults with systemic sclerosis (scleroderma) for two years to track their nutritional health. Researchers measured weight, diet, and disease severity every six months. If malnutrition was found, patients received dietary advice or supplements. The goal was…

This study looked at 20 adults with severe alopecia areata (hair loss) to see how the drug baricitinib changes certain immune markers in the blood. Researchers measured levels of two proteins, interleukin-15 and interferon gamma, before and after six months of treatment. The goal…

This study looked for a virus called HHV6 in the skin and blood of 37 adults with blood cancers who developed a rash during hospital stays. The goal was to see if the virus is linked to the rash, which could help doctors diagnose and treat the rash more effectively. The study is …

This completed study looked at scalp ringworm, a common fungal infection in children, across 11 French centers in 2023. Researchers collected 701 fungal samples to identify the species and test their sensitivity to common antifungal drugs. The goal was to understand which fungi c…

This study looked for a new gene that causes hereditary lipodystrophy, a rare disease where people lose body fat and often develop diabetes and heart problems. Researchers studied DNA and cells from 2 patients who had the disease but no known genetic cause. The goal was to find t…

This completed study created a biorepository of blood and tissue samples from 60 women with and without lipedema. The goal was to find molecular markers that can distinguish lipedema from obesity, which is often misdiagnosed. Researchers measured immune markers and physical funct…

This study looked at 271 hospital patients with incontinence to find out which factors most strongly predict a common skin problem called incontinence-associated dermatitis (IAD). Researchers tracked things like age, stool consistency, and mobility, checking patients' skin daily.…

This completed study examined 127 melanoma patients to understand how the IL4I1 enzyme influences disease progression and resistance to treatments like immunotherapy and targeted therapy. Researchers analyzed blood and tumor tissue samples before and after treatment. The goal was…

This study looked at 27 people with advanced basal cell skin cancer who were taking the drug vismodegib. The goal was to see if the amount of drug in their blood was linked to side effects like muscle cramps, hair loss, and taste changes. Researchers monitored patients for 6 mont…

This completed study looked at 126 people with different fat distribution patterns—including those with lipodystrophy (abnormal fat loss or distribution), obesity, and normal weight—to understand how fat tissue relates to insulin resistance and immune signals. Researchers measure…

This study looked at tiny particles called microparticles in the blood and urine of people with lupus or scleroderma. Researchers wanted to see if these particles could help explain how these diseases work and possibly lead to better diagnosis or treatment. Over 200 adults partic…

This study tested whether 40 sessions of hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) could improve aerobic and anaerobic fitness in healthy athletes. 59 participants, aged 18-25 or 40-50, underwent either real or sham treatment over two months. Rese…

This completed study from Israel examined 4,500 ICU patients to see if intermittent pneumatic compression (IPC) devices, which are used to prevent dangerous blood clots, might also cause pressure sores. The researchers focused on sores around the ankles and other bony areas. The …

This study looked at how blood vessel cells and immune cells talk to each other in people with systemic sclerosis, a rare autoimmune disease that causes skin hardening and organ damage. Researchers collected blood samples and skin biopsies from 350 participants to measure a speci…

This study tested whether a Spanish pressure injury risk scale, called EVARUCI, works well in Turkish intensive care units. Researchers translated it and checked its accuracy in 100 adult ICU patients without existing bedsores. The goal was to give nurses a reliable way to spot p…

This study looked at whether a food safety training program helps food service employees improve their knowledge, attitudes, and practices around safe food handling. About 200 adult workers took part, and the training covered personal hygiene and safe food preparation. The goal w…

This study looked at how skin changes from systemic sclerosis affect a person's feelings about their appearance. Researchers compared 170 patients with the disease to healthy people using surveys about body image and emotional distress. The goal was to understand the burden of th…

This study looked at whether specialized training for nurses on how to care for children with a rare, severe skin condition called epidermolysis bullosa (EB) can reduce their stress and anxiety. The study involved 19 nurses and nursing assistants at a hospital in France. Research…

This completed study looked at whether lichen planus, a chronic inflammatory condition, affects smell and taste. 88 adults (patients and healthy controls) took smell and taste tests and had oral and nasal exams. The goal was to see if mucosal involvement is linked to sensory chan…

This study looked at 100 adults with atopic dermatitis (eczema) who were prescribed tralokinumab. Researchers tracked how many developed eye problems like conjunctivitis within 4 months of starting the drug. The goal was to better understand these side effects in real-world use, …

This study looked at medical records of 500 adult ICU patients to see if computer algorithms could predict who might develop pressure injuries (bedsores). The researchers used data like lab results and nursing notes to test different prediction methods. No treatments or patient c…

This completed study looked at hand and wrist injuries in professional hockey players in the Swedish Hockey League over three seasons. Researchers analyzed injury data from about 2,300 games to understand what types of injuries happen, when they occur, and which players are most …

This pilot study tested a nurse-led educational program for people with psoriasis. Twenty-four participants received extra education sessions over six weeks, alongside standard care. The goal was to see if the program was feasible and could improve disease knowledge, self-managem…

This completed French survey of 300 hereditary angioedema (HAE) patients and their caregivers aimed to understand the challenges of using on-demand treatments for HAE attacks. Researchers collected data on attack frequency, severity, treatment delays, hospitalizations, and the fi…

This study looks at adults who received low-dose radiation to the brain as children for a non-cancerous skin growth. Researchers want to see if this radiation caused any long-term thinking or memory problems. About 150 participants will take memory and thinking tests to compare t…

This study tested whether holding a newborn skin-to-skin right after a C-section (within 5 minutes) or within the first hour helps with breastfeeding, reduces anxiety, and keeps mom and baby healthy. 92 mothers and their newborns took part. The results showed that early contact c…

This study involved 60 people with advanced melanoma who were already scheduled to receive immunotherapy drugs. Researchers collected blood samples and, when possible, tumor samples before and during treatment to look for biological markers that might predict whether the treatmen…

This completed study involved 775 women who had breast-conserving surgery and radiation for breast cancer. Researchers compared different surgery and radiation techniques to see which ones led to less breast hardening (fibrosis) and better cosmetic results. The goal was to find w…

This study looked at how fat cells grow in women with lipedema, a condition that causes painful fat buildup in the legs. Seventeen women drank heavy water so researchers could track new fat cell formation. The goal was to better understand what makes lipedema different from regul…

Cellulitis is a painful skin infection that often requires antibiotics, but the ideal treatment length is unknown. This study followed 230 adults hospitalized with cellulitis to identify factors that predict a good recovery, such as medical history and early response to treatment…

This study looked at 30 adults with scleroderma, an autoimmune disease that often causes hand stiffness and disability. Researchers measured how much movement was limited in each hand to compare the dominant and non-dominant sides. The goal was to better understand hand function …

This completed study surveyed 121 adults with autoimmune diseases like lupus, Sjögren's syndrome, or scleroderma. Participants filled out a questionnaire about their use of alternative medicines. The goal was to find out how common these practices are in this patient group.

This completed Italian study looked at over 1,300 people with scabies to see how often the first treatment cured them. Researchers also tracked how many scabies cases occurred over three years and analyzed patterns by age and ethnicity. The study did not test a new drug but colle…

This completed study looked at 52 adults with plaque psoriasis who had been on biologic drugs for at least one year. Researchers used questionnaires to measure treatment satisfaction, quality of life, depression, and personality type. The goal was to find out which clinical and p…

This study aimed to create a standard set of items, called an ICF core set, to describe the health and functioning of people with systemic sclerosis (scleroderma). Researchers gathered input from 100 patients and experts to identify the most important aspects of the disease. The …

This study explored whether the Epstein-Barr virus (EBV) contributes to inflammation in oral lichen planus, a chronic mouth condition that can be painful. Researchers measured levels of EBV genetic material in 13 adults with the atrophic or erosive form of the disease. The goal w…

This study tested a new questionnaire called DermCLCI-p to see if it accurately measures the long-term life impacts of moderate-to-severe psoriasis. 154 adults starting the medication risankizumab filled out the 30-question survey over 28 weeks. The goal was to validate the tool …

This study looked at how standing on a vibrating platform affects spinal reflexes in 15 healthy adults. Participants stood in different positions with or without vibration while researchers measured electrical signals from a leg muscle. The goal was to understand how vibration ch…

This completed study looked at the long-term safety of the drug sonidegib in 323 adults with a type of skin cancer called locally advanced basal cell carcinoma. Participants took a daily 200 mg pill, and researchers tracked side effects, serious events, and deaths. The goal was t…

This study followed 60 heart transplant patients for one year to see if levels of a harmless virus called TTV in the blood are linked to infections or organ rejection. Researchers took monthly blood samples alongside routine care. The goal is to find a new way to monitor transpla…

This study used advanced genetic sequencing to find new genes responsible for syndromic poikiloderma, a rare condition affecting skin and other organs. Researchers analyzed DNA from 39 patients to improve diagnosis, genetic counseling, and tumor risk monitoring. The goal is to he…

This study looked at the types of fungi living on the head and neck skin of 30 adults with eczema (atopic dermatitis) compared to healthy volunteers. The goal was to understand if differences in the fungal community are linked to eczema in these areas. Researchers used advanced l…

This study examined whether a specific change in the TLR7 gene is more common in people with alopecia areata, an autoimmune condition that causes hair loss. Researchers compared 120 participants (patients and healthy volunteers) to see if the gene variant is linked to the disease…

This study looked at whether a specific gene (NR3C1) that helps control inflammation is linked to alopecia areata, an autoimmune condition that causes hair loss. Researchers compared 120 people with and without the condition to see if gene variations affect disease risk or severi…

This completed study looked at 132 people with advanced melanoma to see if levels of a protein called interferon-gamma (IFN-γ) in their tumors or blood could predict how well they would respond to first-line immunotherapy drugs like pembrolizumab, nivolumab, or a combination. The…

This study looked at how skin cells from 30 people with recessive dystrophic epidermolysis bullosa (RDEB) grow and repair wounds. RDEB is a rare genetic condition that causes fragile skin and painful blisters. Researchers took small skin samples to study the cells in a lab, aimin…

This completed study tested two ways of dressing central venous catheters in 78 intensive care patients: one using gauze and tape, the other using a clear, medicated patch. The goal was to see which method leads to fewer medical device-related pressure injuries at the insertion s…

This completed study created a French national registry for people with rare overgrowth syndromes caused by PIK3CA gene mutations. Researchers collected medical and genetic information from 28 patients to better understand these conditions and estimate how many people are affecte…

This study tested whether an artificial intelligence (AI) tool could help doctors diagnose rare and tricky skin conditions like generalized pustular psoriasis (GPP). Fifteen doctors, including both general practitioners and dermatologists, looked at 100 skin images. They first ga…

This study looked at how a genetic test that checks 25 genes linked to hereditary cancers is used in clinics. Over 1,500 people with a personal or family history of cancer took part. Researchers collected blood samples and had participants fill out questionnaires over five years …

This study tested whether using a laser for oral biopsies causes less pain and heals better than the standard punch scalpel in people with oral lichen planus. 112 adults were randomly assigned to one of the two methods. Researchers measured wound healing and discomfort after the …

This study aimed to create and test a decision aid for people with psoriasis or psoriatic arthritis who are starting or switching treatments. Researchers worked with 37 patients and their doctors to design a tool that supports shared decision-making. The goal was to help patients…

This study followed over 2,300 adults with moderate to severe plaque psoriasis to see how safe and effective secukinumab is in everyday medical practice. Researchers recorded side effects and how well the drug cleared skin symptoms. The goal was to gather real-world evidence, not…

This study examined anxiety, depression, fatigue, and quality of life in 20 adults with Behçet's disease using questionnaires. Researchers aimed to understand the psychological symptoms that often accompany this rare inflammatory condition. The study was observational and did not…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study tested whether coaching sessions are practical for young people with rheumatic diseases moving from pediatric to adult care. 26 participants received up to 8 coaching sessions covering self-advocacy, medication management, and future planning. The main goal was to see …

This study looked at 82 intensive care patients to see how the time they spend in one position affects their risk of developing pressure injuries (bedsores). Researchers checked skin changes like redness, bruising, and moisture, and used a standard risk scale. The goal was to fin…

This study looked at 48 adults with pemphigus, a rare blistering skin disease, to understand what makes them feel vulnerable during their illness. Researchers used interviews and questionnaires to explore factors like misdiagnosis, differences in how patients and doctors see dise…

This study measured fluid retention in 30 people with bullous pemphigoid who were treated with a strong steroid cream (clobetasol propionate). Researchers used bioimpedance to track changes in body water over 30 days. The goal was to understand if the cream causes fluid buildup a…

This pilot study tested whether it is possible to collect and analyze small RNA molecules from a person's breath. Researchers took breath samples from 25 volunteers (healthy people and a few with lung disease) at rest and after intense exercise. They successfully extracted and se…

This study looked at gene activity in immune cells from 30 people with hereditary angioedema and healthy volunteers. The goal was to see if certain receptors on monocytes are linked to inflammation and blood vessel problems. No treatment was given; the study was purely observatio…

This study tested whether wearing special stroboscopic glasses during volleyball drills could improve how players' brains and bodies react. 42 female volleyball players aged 10-16, from beginners to elite, took part. They did 8 weeks of extra drills with or without the glasses. R…

This completed study looked at how well parents of infants with early eczema and parents of healthy infants could use a mobile-friendly platform called OneBiome. The platform gives reports on the baby's gut microbiome and eating patterns. Researchers wanted to see if parents foun…

This completed study tracked 132 children with obstructive sleep apnea who had their tonsils removed. Researchers recorded how many had breathing problems after surgery, especially those with other health issues. The goal was to create a simple flowchart to help doctors decide wh…

This completed study aimed to find out how many patients with a certain set of symptoms actually have acute hepatic porphyria (AHP), a rare metabolic disorder. Researchers enrolled 150 adults aged 18 to 60 who had severe abdominal pain along with neurological symptoms like limb w…

This completed study from Versailles Hospital looked back at 200 medical reports of adults with skin injuries like cuts, scrapes, burns, and leg ulcers. The goal was to see how well pain was controlled during treatment. Researchers also interviewed some patients and staff to chec…

This study tested an artificial intelligence algorithm designed to help primary care doctors decide whether a patient with a skin condition really needs to see a dermatologist. Researchers enrolled 200 adults with skin problems and had their doctors take photos of the affected ar…

This study involved 155 women with early breast cancer who had been taking hormone therapy for 2-3 years. Researchers wanted to understand how skin-related side effects from the treatment impact their quality of life. Participants filled out questionnaires about their skin sympto…

This study followed 88 people with hereditary angioedema (HAE) types I or II who already use icatibant for sudden attacks. Participants filled out diaries for 48 hours after each attack to report symptom changes, severity, and anxiety levels. The goal was to gather real-world inf…

This study looked at fatigue in 33 adults with psoriatic arthritis or psoriasis. Researchers used questionnaires to measure tiredness and see how it relates to disease severity and treatments. The goal was to better understand fatigue and its impact on quality of life.

This study looked at 43 adults with scleroderma or unexplained pulmonary arterial hypertension (PAH) to understand why the right side of the heart weakens. Researchers collected blood and tissue samples during routine procedures and measured heart function over 6 months. The goal…

This study looked at whether adding more legumes (like beans, lentils, and chickpeas) to a Mediterranean diet could improve hydration, heart rate balance, and swimming performance in competitive swimmers. Thirty-nine adolescent and young adult swimmers were split into groups base…

This pilot study gave 20 professional football players either a single high dose of vitamin D or a placebo before a match. Researchers measured how vitamin D levels changed in their blood. The goal was to see how exercise affects vitamin D metabolism, not to treat any disease.

This study looked at how staphylococcus bacteria on the skin affect inflammation and immune responses in people with moderate to severe atopic dermatitis (eczema). Researchers took skin biopsies and blood samples from 41 adults to measure bacterial toxins and immune cell activity…

This study used a very powerful 7 Tesla MRI to look at the hands of 50 people with systemic sclerosis (scleroderma), a rare autoimmune disease. The goal was to see bone, joint, and blood vessel problems in detail. Researchers hope this will help them understand how the disease af…

This study looked at how the body processes cortisol in people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2). The goal was to see if increased activity of a certain enzyme (11β-HSD1) contributes to the severe metabolic problems seen in this dis…

This study looked at immune cells in the blood of 15 adults with seborrheic dermatitis (a chronic, flaky skin condition) and 15 healthy people. Researchers measured different types of immune cells and chemicals to see if there are differences between the two groups. They also ask…

This study followed 150 children aged 2 to 12 who have a port wine stain on a leg. Researchers tracked how the stain changes as the child grows, and whether it leads to problems like blood vessel issues or bone growth differences. The goal was to learn more about the condition an…

This study looked at how often doctors increase the dose or give Xolair more frequently for people with chronic hives. Researchers followed 163 adults for 3 months to see how many needed a stronger treatment plan. The goal was to understand real-world use, not to test a new drug.

This study looked at whether people with systemic sclerosis (scleroderma) have higher levels of the hormone prolactin in their blood. Researchers measured prolactin in 71 patients and compared them to healthy volunteers. The goal was to understand if prolactin plays a role in the…

This study looked at whether placing a small compress under the plastic connector of a child's IV tube can prevent pressure sores. About 360 children from 1 month to 18 years old took part. Researchers compared the usual method (no compress) with the compress method to see which …

This study looked at how B cells, a type of immune cell, may contribute to scarring in people with systemic sclerosis (scleroderma). Researchers compared skin and blood samples from 71 participants, including patients and healthy volunteers. The goal was to understand the disease…

This completed study examined whether eosinophils, a type of white blood cell, contribute to fibrosis (scarring) in systemic sclerosis, an autoimmune disease. Researchers compared blood samples from 40 patients with systemic sclerosis and 30 healthy volunteers, with optional skin…

This study followed 56 adults with systemic sclerosis (scleroderma) who also had a serious lung complication called diffuse infiltrating pneumonia. Researchers measured lung function at 12 and 24 months to see how it changed and to identify factors that might predict faster decli…

This study looked at how skin blood flow and nerve sensitivity differ in psoriasis plaques compared to healthy skin. Twenty adults with psoriasis on their back received mild electrical currents to deliver vasodilators (acetylcholine, sodium nitroprussiate, or plain water) into bo…

This study tested whether a special laser technique called Raman spectroscopy can measure skin fibrosis (hardening) in people with systemic sclerosis, a rare autoimmune disease. Twenty-six adults with the condition had their skin scanned with the laser. The goal was to see if thi…

This study examined how the COVID-19 pandemic impacted skin allergy visits among healthcare workers. Researchers analyzed records from 341 healthcare workers who visited skin clinics before and after the pandemic. The goal was to understand if increased use of masks, gloves, and …

This study looked at how well the combination of dabrafenib and trametinib works in real-life settings for people with high-risk stage III melanoma that has been completely removed by surgery. It included 39 adults in Turkey whose melanoma had a specific genetic mutation (V600E).…

This study tested whether a smartphone app called MyDerm can help patients and doctors monitor chronic leg wounds from home. 25 adults with a single leg wound that had lasted more than 6 weeks took part. Patients used the app to take photos of their wound and answer questions abo…

This study tested a computer program called ACE that helps nurses decide which products to use for treating chronic wounds. Researchers compared outcomes when nurses used ACE versus their usual approach in 73 patients across 18 clinics. The goal was to see if the tool improves he…

This completed study involved 214 people with systemic sclerosis (scleroderma) to find out how often calcium deposits form in the hands and feet. Researchers used X-rays to detect these deposits and checked if they were linked to damage in organs like the lungs or heart. The goal…

This study looked at Netherton syndrome, a rare genetic skin condition, to better understand how it affects the body and immune system. Researchers studied 18 people with the disease, measuring immune markers in the blood and tracking skin changes. The goal was to find new target…

This study looked at how different music volumes affect balance in athletes. 48 healthy athletes listened to soft, medium, and loud music while standing on a virtual reality balance system. The goal was to see if sound intensity changes how well they can keep steady.

This completed study followed 127 adults with moderate to severe plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, or non-radiographic axial spondyloarthritis who were already taking or starting secukinumab. Researchers observed them for two years to see how long the…

This study looked at whether measuring circulating tumor cells (CTCs) in the blood can help doctors decide when to switch chemotherapy for women with metastatic breast cancer that has worsened after two prior treatments. The trial involved 265 women and compared standard care wit…