Scientists probe gene activity in rare swelling disorder

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (patients): * Patient with inherited bradykinic angioedema due to quantitative or qualitative C1-inhibitor deficiencies, regardless of the frequency or severity of seizures and regardless of their background treatment, with the following diagnostic criteria: * C1-inhibitor rate \<50% of normal * Repeated episodes characteristic of bradykinic angioedema * Hereditary nature of the disease. * Person who read and understood the newsletter and signed the consent form * Person affiliated with a social security scheme * Effective contraception in women of childbearing age (negative pregnancy test). For postmenopausal women, a confirmatory diagnosis should be obtained (amenorrhea for at least 12 months before the inclusion visit). Inclusion Criteria (volunteers): * Person affiliated with a social security scheme * Person who read and understood the newsletter and signed the consent form * Effective contraception in women of childbearing age (negative pregnancy test). For postmenopausal women, a confirmation diagnosis should be obtained (amenorrhea for at least 12 months before the inclusion visit) Exclusion Criteria (patients): * Angioedema crisis less than 1 month old * Chronic inflammatory disease such as rheumatoid arthritis or Crohn's disease. * Acute infection in progress, with or without anti-infectious treatment * Contraindication to the use of trinitrin: * Hypersensitivity to nitrates or to any of the excipients * shock, severe hypotension, * obstructive cardiomyopathy, * inferior court inferior myocardial infarction with right ventricular extension, except in case of evidence of left ventricular failure, * intracranial hypertension, * patient treated with sildenafil * Pregnant or parturient or breastfeeding woman or lack of proven contraception * Person deprived of liberty by an administrative or judicial decision or person placed under the protection of justice / sub-tutorship or curatorship * Patient participating or having participated in another therapeutic trial within one week. Exclusion Criteria (volunteers) * Chronic inflammatory disease such as rheumatoid arthritis or Crohn's disease. * Acute infection in progress, with or without anti-infectious treatment * Contraindication to the use of trinitrin: * Hypersensitivity to nitrates or to any of the excipients * shock, severe hypotension, * obstructive cardiomyopathy, * inferior court inferior myocardial infarction with right ventricular extension, except in case of evidence of left ventricular failure, * intracranial hypertension, * patient treated with sildenafil * Pregnant or parturient or breastfeeding woman or lack of proven contraception * Person deprived of liberty by an administrative or judicial decision or person placed under the protection of justice / sub-tutorship or curatorship * Person participating or having participated in another therapeutic trial within one week.