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Can a positive attitude help beat breast cancer recurrence? new study tests online training

NCT ID NCT06388304

Symptom relief Sponsor: Joanna Arch Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested an online program called THRIVE, based on Positive Affect Training, to help breast cancer survivors feel better about taking their anti-hormonal medication. The goal was to see if the program was acceptable and feasible for women who struggle with side effects or negative feelings about their daily pills. Thirty-nine survivors of hormone receptor-positive breast cancer participated after finishing primary treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
THRIVE Online Positive Affect Training (PAT) program
What this could lead to
If it works, this could offer a simple online tool to help breast cancer survivors stick with their anti-hormonal medication and feel less distressed about side effects.
What could go wrong
This is a very small pilot study with only 39 participants and no control group, so results may not apply widely. The program may not improve adherence or emotional well-being in larger, more diverse groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

39 people

The number who actually took part.

Started

Mar 2024

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * hormone receptor-positive breast cancer stages 0-3 * have finished primary treatment (chemotherapy/radiation/surgery) * are prescribed endocrine therapy (ET) currently or within the last two years * score above specified cut off (range, 0-10) on any of three questions: 1. How upset are you by having to take anti-hormonal therapy 2. How bothered are you by the side effects? 3. How difficult is it for you to take your anti-hormonal medication every day? * have internet access to complete online assessments and intervention components or agree to use and return a study wifi-activated iPad. Exclusion Criteria: * metastatic disease * Individuals who are unable to interact with the intervention as needed. This includes those who are extremely visually impaired to the degree that they cannot see the screen and interact as required and individuals who cannot read and/or write in English. This is due to the nature of the intervention itself. If a participant is unable to interact with THRIVE as required, they are unlikely to benefit from the intervention or offer insightful feedback that can be used in refining the program.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm ductal breast carcinoma in situ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast cancer DCIS

Contacts and locations

Locations

  • University of Colorado Boulder

    Boulder, Colorado, 80309, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.