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Simple creams might fight aging inflammation

NCT ID NCT06750653

Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 15, 2026 · Updated 3 times

Summary

This pilot study tests whether applying over-the-counter moisturizers (CeraVe or Vaseline) daily for 4 weeks can reduce inflammation in adults aged 70 and older with dry skin. Researchers will measure skin barrier function, blood markers of inflammation, and skin microbes. The main goal is to see if a larger trial is possible.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CeraVe Moisturizing Cream or Vaseline petroleum jelly
What this could lead to
If successful, this could show that simple moisturizers help lower inflammation in older adults, pointing toward a low-cost way to improve health.
What could go wrong
This is a very small pilot study (32 people) focused on feasibility, not proof of benefit. Results may not apply broadly, and any anti-inflammatory effect may be minimal.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

32 people

The number who actually took part.

Started

Feb 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

70 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. Male or female ≥ 70 years of age at the baseline visit. 2. Diagnosis of xerosis cutis based on an Overall Dry skin (ODS) score of =\> 1 for any body site where patients will be asked to apply moisturizer (i.e. arms, legs, buttocks, front of trunk). 3. Written informed consent (and assent when applicable) obtained from subject or subject's legal representative 4. Ability for subject to comply with the requirements of the study. Exclusion Criteria 1. History of inflammatory skin disease (e.g. psoriasis, atopic dermatitis, or bullous pemphigoid) that has been active in the past 10 years. 2. History of contact dermatitis to moisturizers. 3. History of chronic inflammatory conditions (such as cancer, arthritis, inflammatory bowel disease, or coronary artery disease). Participants with a history of localized skin cancer will not be excluded. 4. Current infection. 5. Open skin wounds. 6. Physical limitations or lack of a caregiver preventing application of a moisturizer to skin on the trunk and extremities. 7. Current use of topical medications, oral systemic immunomodulatory treatments, or anti-microbial treatments. 8. Diagnosis of primary or acquired immunodeficiency. 9. Use of skin moisturizer less than 1 week prior to enrollment visit, with the exception that participants may use non-study moisturizer/sunscreen on face, if used consistently throughout study period. 10. Inability to give informed consent. 11. Presence of a condition or abnormality that, in the opinion of the Investigator, would compromise the safety of the patient or the quality of the data. 12. If the participant does not meet all the above criteria, he/she will not be eligible for study participation.

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Conditions

The condition(s) this trial relates to.

dermatitis Inflammation inflammatory disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Inflammation Skin inflammation

Contacts and locations

Locations

  • UCSF

    San Francisco, California, 94115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.