Could a stem cell drug tame rare immune disease?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: All of the following inclusion criteria must be met for a subject to be enrolled in this study: * Clinical diagnosis of WHIMS and documented severe infection * Must be greater than or equal to 18 and less than or equal to 75 years of age * Willingness to interrupt medications to raise the white count (WBC) such as G-CSF or GM-CSF for at least 2 days before and while on the study drug * Must not be pregnant or breastfeeding * Must have a personal physician * Must be willing to provide blood, plasma, serum, and DNA samples for storage * Subjects must agree not to become pregnant or to impregnate a female. If of childbearing potential, must agree to consistently use two types of contraception throughout study participation. Acceptable forms of contraception include the following: 1. Condoms, male or female, with or without a spermicide 2. Diaphragm or cervical cap with spermicide 3. Intrauterine device 4. Contraceptive pills or patch, Norplant, Depo-Provera or other FDA-approved contraceptive method 5. Male partner has previously undergone a vasectomy for which there is documentation of aspermatogenic sterility EXCLUSION CRITERIA: If any of the following exclusion criteria are met, a subject will not be enrolled in this study: * Absence of a diagnosis of WHIMS * Patient is less than 18 years old * Absence of a documented history of severe infection * Neutropenia due to maturation defects in the myeloid lineage or that the PI feels is unlikely to benefit from this medication * Pregnant women or breastfeeding * History of serious cardiac arrhythmia or cardiac defects that make such more likely * Renal failure (calculated creatinine clearance \[CrCl\] \<15 mL/min or requiring dialysis) * Signs or symptoms of active microbial infection at the time of study entry. * Any condition that, in the investigator s opinion, places the patient at undue risk by participating in the study * Unwillingness to undergo testing or procedures associated with this protocol