Subcutaneous tissue disorder

This Phase 2 study tests an oral drug called RLY-2608 in adults and children with overgrowth conditions (like CLOVES or Klippel-Trenaunay syndrome) caused by PIK3CA gene mutations. The drug is designed to block the faulty protein driving abnormal tissue growth. The trial will enr…

This study looks at whether anti-inflammatory drugs (like anakinra or canakinumab) can reduce painful flare-ups and prevent extra bone growth in people with a rare genetic condition called fibrodysplasia ossificans progressiva (FOP). Eleven people with severe FOP will be tracked …

This Phase 3 trial tests an oral drug called KP-001 in 150 people aged 2 and older with venous malformations, lymphatic malformations, or KTS/CLOVES syndrome. Participants receive either KP-001 or a placebo for 24 weeks, then everyone gets the drug for another 28 weeks. The goal …

This Phase 2 trial tests an experimental drug called INCB000928 (zilurgisertib) in people with fibrodysplasia ossificans progressiva (FOP), a rare genetic condition where soft tissues turn into bone. About 98 participants aged 2 and older will receive either the drug or a placebo…

Researchers are testing whether the Turkish version of the Duke Activity Status Index, a 12-item questionnaire about everyday activities, reliably measures functional capacity in women with lipedema. The study will enroll 34 women with the condition and compare their questionnair…

This study uses special ultrasound techniques to find clear differences between lymphedema and lipedema, two chronic conditions that cause leg swelling and are often hard to tell apart. Researchers will compare 75 adults—those with lymphedema, those with lipedema, and healthy vol…

This trial tests two six-week physiotherapy programs in women with lipedema, a condition that causes painful fat buildup in the legs. One group receives manual lymphatic drainage from a therapist plus supervised aerobic exercise. The other group learns self-lymphatic drainage and…

This study tests two non-invasive treatments—ultrasound fat cavitation and pneumatic compression—to see which better reduces fat thickness in women with mild to moderate lipedema. Lipedema is a painful fat disorder affecting millions of women. The goal is to find a safe, surgery-…

This study is creating a registry of up to 1,000 people with rare lymphatic system disorders. Researchers will collect information from medical records and yearly surveys to understand how these diseases progress, what treatments are used, and how they affect quality of life. The…

This registry study follows about 100 people with FOP, a rare disease where soft tissue turns to bone. Some participants take palovarotene (an approved treatment), while others do not. Researchers will track side effects, flare-ups, and daily function over time to see how well th…

This study investigates how lipedema — a condition causing abnormal fat buildup in the legs — affects muscle structure and walking. Researchers will use ultrasound to measure leg muscle and tendon thickness in 45 women with lipedema and compare them to 45 healthy women. A foot-pr…

Lipedema is a chronic condition causing painful fat buildup in the legs, mostly in women. This study is testing whether a Turkish translation of the Rapprich Lipedema Symptomatic Assessment Questionnaire is a reliable and valid tool for measuring symptom severity. Researchers wil…

This study looks at whether vein problems are linked to pain, swelling, and daily function in women with lipedema. Researchers will use ultrasound to check leg veins and ask participants about their symptoms. The goal is to better understand how these conditions interact, which c…

This study will compare women with knee osteoarthritis who also have lipedema (a fat tissue disorder) to those without lipedema. Researchers will use ultrasound to measure knee cartilage thickness and questionnaires to assess pain and daily function. The goal is to understand if …

This global registry collects information from people with Fibrodysplasia Ossificans Progressiva (FOP), a rare condition where soft tissues turn into bone. Up to 800 patients worldwide can report their symptoms, flare-ups, and mobility changes through a secure online portal. The …

This study looks at how metabolic markers like insulin resistance and body measurements relate to pain and central sensitization in women with lipedema. Researchers will assess 59 women using questionnaires and physical measurements. The goal is to better understand these connect…

This study looks at whether women with lipedema have flatter feet and looser joints compared to women without the condition. Researchers will use foot X-rays and flexibility tests to measure these differences. The goal is to better understand how lipedema affects foot function an…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to study inflammation, blood clotting, and other biological pathways. The goal is to build a resource tha…

This study collects medical information and biological samples (like blood or tissue) from up to 12,000 people with leukodystrophies—rare disorders that damage the brain's white matter. Researchers will use this data to find new genetic causes, develop biomarkers for future trial…

This study examines whether women with lipedema have a condition called central sensitization, where the nervous system becomes overly sensitive to pain. Researchers will measure pain thresholds and use ultrasound in 50 participants, comparing them to healthy volunteers. The goal…