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Lipedema linked to flatter feet and loose joints, new study suggests

NCT ID NCT07294014

Knowledge-focused Sponsor: Marmara University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether women with lipedema have flatter feet and looser joints compared to women without the condition. Researchers will use foot X-rays and flexibility tests to measure these differences. The goal is to better understand how lipedema affects foot function and overall mobility.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better understand and manage foot problems in people with lipedema.
What could go wrong
This is a small, early observational study, so it cannot prove cause and effect. Results may not apply to all people with lipedema.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 32 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Female patients presenting to the Physical Medicine and Rehabilitation outpatient clinics at Marmara University Pendik Training and Research Hospital will be screened for eligibility. The study population will include women clinically diagnosed with lipedema according to established diagnostic criteria, as well as age- and BMI-matched female patients with nonspecific foot pain who will serve as the control group.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

General Inclusion Criteria (Apply to All Participants) * Female participants * Age 18 years or older * Able to read and write (literacy requirement) * Availability of bilateral lateral foot radiographs obtained within the past 1 year in the hospital PACS system * Willing and able to provide written and verbal informed consent Additional eligibility criteria for Lipedema Group \- Clinical diagnosis of lipedema according to Halk and Damstra criteria. Additional eligibility criteria for Control group: * Female patients presenting with nonspecific foot pain * Similar age and BMI range as the lipedema group * No clinical diagnosis or suspicion of lipedema Exclusion Criteria (Apply to all participants) * Pregnancy * Illiteracy * Inability or unwillingness to provide written and verbal informed consent * History of lower extremity fracture, trauma, or orthopedic surgery * Diagnosis of diabetes mellitus * Known rheumatologic disease * Known polyneuropathy or peripheral nerve injury affecting the lower extremities

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Conditions

The condition(s) this trial relates to.

flatfoot hypermobility spectrum disorder hypermobility syndrome Joint Instability Lipedema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypermobility syndrome (disorder) Joint hypermobility Lipedema Pes planus

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Marmara University Pendik Training and Research Hospital

    RECRUITING

    Istanbul, Turkey (Türkiye)

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