Subcutaneous tissue disorder

This Phase 3 trial tests garetosmab, an antibody that blocks activin A, in 18 children and teens with fibrodysplasia ossificans progressiva (FOP), a rare disease where muscle and tissue turn into bone. The study will check safety, side effects, and whether the drug reduces new ab…

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets…

This study tests whether a mobile app using artificial intelligence can help frontline health workers in sub-Saharan Africa better diagnose skin-related neglected tropical diseases, like leprosy and scabies. Researchers will collect images from dermatologists to train the AI, the…

This trial tests whether exercising in a pool or on land offers greater relief for women with lipedema, a condition causing painful fat buildup in the legs. Sixty women with moderate-to-severe lipedema will be split into three groups: supervised aquatic workouts, land-based train…

This study tests whether adding a personalized anti-inflammatory diet to standard physical therapy (compression, massage, and exercise) reduces leg swelling and improves quality of life in women with lipedema. 75 women aged 18-65 with stage I-III lipedema will be randomly assigne…

This study tests whether a non-invasive treatment called extracorporeal shock wave therapy (ESWT) can reduce pain and improve quality of life in people with lipedema, a chronic condition causing painful fat buildup. Participants receive six sessions over two weeks, with pain, fun…

This study will compare two types of supervised cycling exercise (high-intensity intervals or moderate continuous cycling) combined with compression therapy against compression plus a home walking program in 69 women with lipedema. The goal is to see which approach best reduces l…

This study tests whether adding shockwave therapy to standard care (like compression and massage) can reduce pain and swelling in women with lipedema. Fifty women aged 18-65 with early-stage lipedema will be randomly assigned to receive either standard care alone or standard care…

This study looks at whether women with lipedema, a condition that causes abnormal fat buildup in the legs and arms, are more likely to have osteoporosis, a condition that weakens bones. Researchers will measure bone density in the spine and hip of 120 postmenopausal women with li…

This study looks at whether magnesium levels in the blood are related to sleep quality, pain, and quality of life in women with lipedema, a condition that causes abnormal fat buildup in the legs. Researchers will compare women with good sleep versus poor sleep to see if magnesium…

This study looks at whether the 2-Minute Step Test—a quick, equipment-free exercise test—can reliably measure functional capacity in women with lipedema, a chronic fat tissue disorder that affects the legs and can limit mobility. Researchers will compare the step test results wit…

This study investigates whether a natural molecule called Maresin-1, which helps reduce inflammation, is linked to lipedema—a chronic condition causing painful fat buildup in women. Researchers will measure Maresin-1 levels in the blood of women with lipedema, women with obesity …

This study will test a specially trained AI model (like ChatGPT) to see if it can help doctors correctly diagnose and recommend treatments for lymphedema, lipedema, and venous insufficiency. Researchers will compare the AI's suggestions to current medical guidelines. The goal is …

This observational registry will follow over 6,000 people who have been prescribed the Jewel P-WCD, a wearable defibrillator that can detect and treat dangerous heart rhythms. The goal is to confirm the device continues to work safely and effectively in everyday life. No new trea…