New trial tests diet and therapy combo for painful lipedema legs
NCT ID NCT07667270
First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times
Summary
This study tests whether adding a personalized anti-inflammatory diet to standard physical therapy (compression, massage, and exercise) reduces leg swelling and improves quality of life in women with lipedema. 75 women aged 18-65 with stage I-III lipedema will be randomly assigned to one of two diet approaches. The trial is not yet recruiting and aims to find better symptom management, not a cure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Anti-inflammatory diet and physical therapy (compression garments, manual lymphatic drainage, pneumatic compression, exercise)
- What this could lead to
- If it works, this could point toward a better way to manage lipedema symptoms like leg swelling and discomfort.
- What could go wrong
- This is a small, early-stage trial with only 75 women, so results may not apply to everyone. The diet and therapy are supportive, not a cure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 75 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Female, aged 18 to 65 years. * Clinical and physical examination confirming Stage I, II, or III lipedema. * Body Mass Index (BMI) \< 45 kg/m\^2. * Ability to walk without restriction. Exclusion Criteria: * Presence of active malignancy. * Decompensated heart failure. * Significant lower extremity peripheral artery disease. * Acute deep vein thrombosis or active thromboembolism. * Pregnancy. * Significant sensory loss or severe neuropathy in the lower extremities. * History of lower extremity liposuction within the last 12 months. * Active severe infection (e.g., cellulitis). * Other severe systemic diseases deemed unsafe for the study by researchers. * Severe non-compliance with the study protocol (e.g., missing \>30% of planned sessions) or participant requesting withdrawal.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Balikesir University Faculty of Medicine Hospital
Balıkesir, 10145, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can loose joints worsen lipedema pain? researchers investigate
- Can a 12-Item quiz capture daily life with lipedema?
- Can a Self-Drainage routine match Therapist-Led care for lipedema?
- Lipedema and muscle loss: is there a hidden link?
- A blood test clue to unmask lipedema?
- Could lipedema weaken bones? a new study investigates