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New trial tests diet and therapy combo for painful lipedema legs

NCT ID NCT07667270

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times

Summary

This study tests whether adding a personalized anti-inflammatory diet to standard physical therapy (compression, massage, and exercise) reduces leg swelling and improves quality of life in women with lipedema. 75 women aged 18-65 with stage I-III lipedema will be randomly assigned to one of two diet approaches. The trial is not yet recruiting and aims to find better symptom management, not a cure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Anti-inflammatory diet and physical therapy (compression garments, manual lymphatic drainage, pneumatic compression, exercise)
What this could lead to
If it works, this could point toward a better way to manage lipedema symptoms like leg swelling and discomfort.
What could go wrong
This is a small, early-stage trial with only 75 women, so results may not apply to everyone. The diet and therapy are supportive, not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 75 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female, aged 18 to 65 years. * Clinical and physical examination confirming Stage I, II, or III lipedema. * Body Mass Index (BMI) \< 45 kg/m\^2. * Ability to walk without restriction. Exclusion Criteria: * Presence of active malignancy. * Decompensated heart failure. * Significant lower extremity peripheral artery disease. * Acute deep vein thrombosis or active thromboembolism. * Pregnancy. * Significant sensory loss or severe neuropathy in the lower extremities. * History of lower extremity liposuction within the last 12 months. * Active severe infection (e.g., cellulitis). * Other severe systemic diseases deemed unsafe for the study by researchers. * Severe non-compliance with the study protocol (e.g., missing \>30% of planned sessions) or participant requesting withdrawal.

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Conditions

The condition(s) this trial relates to.

Lipedema Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Balikesir University Faculty of Medicine Hospital

    Balıkesir, 10145, Turkey (Türkiye)

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