Integumentary system disorder

Researchers compare two topical treatments for plantar warts: hydrogen peroxide 40% applied once weekly and salicylic acid 40% applied daily. The trial enrolls 70 people aged 12 and older with clinically diagnosed plantar warts. The main goal is to see how many participants achie…

Researchers test a one-time gene therapy infusion in children and adults with Sanfilippo syndrome (MPS IIIB), a rare inherited disease that damages the brain and body. The therapy delivers a working copy of the NAGLU gene to help the body make an enzyme that is missing or faulty.…

This study tests whether bone marrow from deceased donors can be used to treat people with blood cancers like leukemia and lymphoma. Participants receive a transplant of cryopreserved marrow from a deceased donor or standard cells from a living donor. The goal is to see if the de…

This trial is testing an experimental treatment called CRT-402 for people with severe autoimmune diseases like lupus, scleroderma, and myositis that haven't improved with standard therapies. CRT-402 is a type of CAR-T cell therapy given by infusion that aims to deplete certain im…

This study tests whether a newer antifungal cream (luliconazole) works better than the standard treatment (ketoconazole) for pityriasis versicolor, a common fungal skin infection that causes light or dark patches. About 86 adults with the infection will use one of the two creams …

This trial is testing whether an experimental mRNA vaccine can safely reduce moderate-to-severe acne in adolescents aged 12 to 17. Participants receive either the vaccine at different dose levels or a placebo, and researchers monitor safety and changes in facial acne lesions. The…

This trial tests an inactivated EV71 vaccine in healthy children aged 6 to 71 months. The vaccine targets enterovirus 71, a major cause of severe hand, foot, and mouth disease in the Asia-Pacific region. Each child receives two doses, 30 days apart. Researchers measure whether th…

This study tests a new vaccine designed to prevent hand, foot, and mouth disease (HFMD) and herpangina in children aged 6 months to 5 years. About 6,000 healthy children will receive either the vaccine or a placebo to see if it safely protects against four common virus types that…

This phase 1 trial is testing an experimental drug called ATG-201 in adults with systemic lupus erythematosus, systemic sclerosis, or Sjögren's disease. ATG-201 is designed to bind to specific proteins on immune cells, potentially quieting the overactive immune response that driv…

This study tests whether a vitamin D-based cream (calcipotriol) works as well as steroid injections for regrowing hair in people with patchy alopecia areata. Sixty adults with less than half their scalp affected will use one of the two treatments for 12 weeks. The goal is to see …

Researchers are testing an experimental oral drug called VC005 in teenagers aged 12 to 17 who have non-segmental vitiligo, a condition where patches of skin lose their color. The study measures how the drug moves through the body and checks for safety over up to 24 weeks of treat…

Researchers test whether rituximab helps maintain lung function in adults with systemic sclerosis and interstitial lung disease whose disease has stabilized after initial rituximab treatment. Participants receive rituximab or placebo infusions at months 0, 6, and 12. The main mea…

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

This study tests whether a one-time infusion of specially engineered immune cells (CAR T cells) can improve lung function and skin hardening better than current treatments for people with active systemic sclerosis, a rare autoimmune disease. About 92 adults with lung involvement …

Researchers are testing an experimental topical gel called PP405 in men with androgenetic alopecia, the most common form of male pattern hair loss. The trial enrolls about 600 men aged 18 to 55 with moderate hair loss at the top of the scalp. Participants apply either the PP405 g…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

This phase III trial tests whether the oral drug nerandomilast can improve symptoms of idiopathic inflammatory myopathies, a group of rare autoimmune diseases that cause muscle weakness and inflammation. Adults with active myositis are randomly assigned to take nerandomilast or a…

Researchers are testing whether abrocitinib, an oral medicine taken once daily as a liquid, safely improves moderate-to-severe eczema in children aged 2 to under 6. About 90 children with a documented eczema diagnosis for at least a year will join. Two out of three will receive a…

Researchers are examining how well ritlecitinib works for people with alopecia areata when prescribed in everyday medical practice rather than in a controlled trial. The study draws on US electronic health records and insurance claims for about 7,500 patients aged 12 and older wh…

This trial tests an experimental drug called PF-08154225 in people with autoimmune diseases like lupus, rheumatoid arthritis, myositis, or scleroderma. The drug aims to calm the immune system, which mistakenly attacks healthy cells in these conditions. Participants receive the dr…

Researchers are testing whether trametinib, an FDA-approved cancer drug, can help infants with RASopathies who have a severe, life-threatening heart condition called hypertrophic cardiomyopathy. The trial enrolls about 25 babies with a confirmed genetic diagnosis. Participants re…

Researchers are testing whether adding an experimental DNA vaccine called iSCIB1+ to standard immunotherapy drugs nivolumab and ipilimumab helps people with advanced melanoma that cannot be removed by surgery. About 550 participants will be randomly assigned to receive either the…

This study tests whether giving two immunotherapy drugs (fianlimab and cemiplimab) before surgery can shrink melanoma tumors in people with stage IIIB to IV melanoma. About 35 adults will receive the drugs, then have surgery to remove any remaining cancer. The main goal is to see…

This trial tests a topical cream combining 5-fluorouracil and calcipotriene as a field treatment for actinic keratoses, which are rough, precancerous skin spots caused by sun damage. Researchers will compare how well the cream clears these spots in 32 people with normal immune fu…

Researchers are testing a treatment plan that uses two drugs, remibrutinib and omalizumab, in adults with chronic spontaneous urticaria whose hives and itching are not controlled by standard antihistamines. The study follows about 382 adults across multiple centers worldwide. The…

This phase 2 trial tests whether injecting botulinum toxin (Botox) into skin affected by hidradenitis suppurativa (HS) can reduce the number of painful abscesses, nodules, and draining tunnels, and ease pain. About 40 people with HS will receive either Botox or a saline placebo i…

Researchers are testing different doses of duvakitug, an injected drug, against placebo in adults with moderate to severe hidradenitis suppurativa. The trial enrolls about 156 people who have painful lumps and tunnels in at least two skin areas. Participants receive either duvaki…

Researchers are testing the drug cemiplimab, given alone or with other anti-cancer drugs, in people with locally advanced basal cell carcinoma that cannot be treated with surgery or radiation. The trial compares how well the combinations work against cemiplimab by itself and trac…

Researchers compare two common antibiotics, moxifloxacin and clindamycin, for adults with dental infections that have spread to the face or jaw. All participants first receive minor surgical drainage in a clinic. Then they are randomly assigned to take either moxifloxacin once da…

Researchers are testing a treatment for melanoma that has spread to the liver. They collect tumor-infiltrating lymphocytes, a type of immune cell, from the patient's own tumor and grow them in the lab. Before returning the cells, they use a technique called percutaneous hepatic p…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This trial tests two food supplements for hair health in men aged 35 to 65 with mild to moderate male pattern baldness. Participants take one capsule daily for 84 days, and researchers compare the supplements against a placebo. The study measures changes in hair density, hair los…

This phase II trial tests whether the chemotherapy drug temozolomide can shrink tumors in people with advanced or metastatic melanoma that has a mutation in the BAP1 gene. BAP1 normally helps repair damaged DNA, and when it is faulty, cancer cells may become more sensitive to cer…

This trial tests whether an oral medication called zasocitinib (TAK-279) can reduce the redness, thickening, scaling, and painful cracks of palmoplantar psoriasis, a type of psoriasis that affects the palms and soles. Adults with moderate-to-severe non-pustular palmoplantar psori…

This study tests whether the drug Bimzelx (bimekizumab) can improve skin symptoms in adults with pityriasis rubra pilaris, a rare condition causing red, scaly patches. Researchers will enroll 12 participants and measure how many achieve at least 75% improvement in skin severity a…

This early-phase trial tests a nebulized therapy called UC-EVs, derived from human umbilical cord cells, in adults with immune-mediated inflammatory diseases (such as IgG4-related disease or systemic sclerosis) that affect the lungs. Participants inhale the vesicles daily for 7 d…

This Phase 3 trial tests a new topical drug called APSMNF for male pattern baldness. About 336 men aged 18 to 60 will apply it twice daily for 24 weeks. Researchers will measure changes in hair density using a special camera and track any side effects.

This study explores whether giving people with mild-to-moderate eczema a straightforward treatment plan using only Opzelura cream helps them stick to their medication routine. Participants apply the cream twice daily until their skin clears, then as needed. Some participants also…

This trial gives deucravacitinib, an oral drug that calms the immune system, to adults with lupus or Sjögren's disease and to children with psoriasis or psoriatic arthritis. Participants join after finishing an earlier study of the same drug, and the goal is to see how safe and t…

This early-stage trial tests an experimental drug called HXN5003 in healthy volunteers and in people with moderate-to-severe atopic dermatitis, a common form of eczema. The study first gives a single dose to healthy participants to check safety, then gives multiple doses to eczem…

This Phase 1 trial tests a single oral dose of HRS-4139, an experimental drug for psoriasis, in healthy adults aged 18 to 55. Researchers measure how the body absorbs and processes the drug, and watch for any side effects. The goal is to establish a safe dose for future studies i…

This study tests whether combining two drugs—ASTX727 (a pill) and retifanlimab (given through a vein)—can shrink tumors and control advanced Merkel cell cancer in people whose disease has worsened after standard immunotherapy. About 31 adults with stage III or IV Merkel cell canc…

This trial is testing an experimental drug called FG-M131 in people with a type of blood cancer called peripheral T-cell lymphoma that has come back or not responded to prior treatment. FG-M131 is designed to target and destroy cancerous T cells that carry a marker called TRBC1, …

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This trial tests whether a device called CUSA can remove lipomas, which are common benign fatty lumps under the skin, using a minimally invasive approach. Researchers plan to enroll 30 adults with lipomas larger than 1 cm on the trunk, limbs, or neck. The goal is to see if CUSA c…

This early-stage trial will test whether injecting adalimumab (Humira) into the eye during Boston KPro surgery is safe for 8 patients with severe corneal damage. The study focuses on side effects and tolerability, not yet on how well it works. It is for people who have run out of…

This phase 2 trial tests whether an oral drug called EC-18 can reduce the severity of moderate to severe atopic dermatitis, a chronic inflammatory skin condition. About 150 adults aged 19 to under 80 will take either EC-18 or a placebo once daily for 16 weeks. Researchers will me…

This early-stage trial tests an experimental oral drug called HCXT-2001 in healthy adults to see if it is safe and how the body handles it. Researchers give a single dose of the drug or a placebo and monitor for side effects, vital signs, and lab results. The study also measures …

Pulse oximeters, which clip onto a finger to estimate blood oxygen levels, can be less accurate when blood flow to the fingers is poor, a common issue in critically ill patients. This trial tests whether warming the hand and lower forearm for 15 minutes improves the accuracy of t…

This Phase 2 trial tests a cream called delgocitinib in 30 adults with frontal fibrosing alopecia, a condition that causes hair loss at the front of the scalp. Everyone in the study will use the cream for 24 weeks. Researchers will measure changes in hairline and hair counts to s…

This study tests whether a cream called delgocitinib, already approved for chronic hand eczema, is safe and tolerable when applied to skin affected by early-stage cutaneous T-cell lymphoma (mycosis fungoides). Up to 15 adults with stable disease will apply the cream twice daily f…

This clinical trial is testing an oral medication called TLL-018 in adults with moderate-to-severe atopic dermatitis, a chronic skin condition causing itchy, inflamed skin. The study aims to see if TLL-018 can significantly improve skin symptoms compared to a placebo. Participant…

This study tests whether omega-3 supplements or a special anti-demodex eyelid cleanser can help treat and prevent chalazia (styes) in children aged 4 to 17. All 168 participants will use warm compresses, and they will be split into three groups: one adds omega-3 fish oil and stan…

This Phase 3 trial is testing whether an experimental biologic called tilrekimig can reduce the severity of moderate-to-severe atopic dermatitis (eczema) in people aged 12 and older. Participants will receive either tilrekimig, an existing treatment (dupilumab), or a placebo for …

This Phase 3 trial tests garetosmab, an antibody that blocks activin A, in 18 children and teens with fibrodysplasia ossificans progressiva (FOP), a rare disease where muscle and tissue turn into bone. The study will check safety, side effects, and whether the drug reduces new ab…

This phase II trial tests whether an experimental oral drug called TLL-018 can reduce itching and hives in adults with moderate-to-severe chronic spontaneous urticaria (CSU) that hasn't responded to standard antihistamines. Participants will take either a low or high dose of TLL-…

This early-stage trial is testing an experimental drug called HXN6005 in healthy volunteers and in people with moderate-to-severe atopic dermatitis, a common form of eczema. The study is divided into three parts: first, healthy participants receive a single dose to check safety; …

This trial is testing whether an experimental drug called TRIV-573 can improve symptoms of moderate to severe atopic dermatitis, a chronic inflammatory skin condition. Adults with active disease will receive either TRIV-573 or a placebo as multiple injections over several weeks. …

This phase 2 trial tests whether a topical cream containing ruxolitinib (OPZELURA) can completely heal painful ulcers in adults with pyoderma gangrenosum, a chronic inflammatory skin condition. About 12 participants will apply the cream twice daily for 24 weeks while continuing s…

This trial tests whether a once-daily foam containing roflumilast can treat seborrheic dermatitis, a common skin condition causing red, flaky patches on the scalp, face, and trunk. About 300 people ages 9 and older with moderate to severe disease will apply either the active foam…

This trial is investigating whether cryoablation, a technique that freezes and destroys breast tumors with extreme cold, can be an effective alternative to surgery for certain patients. The study will include adults with localized breast cancer who cannot or choose not to have su…

This trial compares two treatment approaches for moderate to severe pemphigus vulgaris, a rare autoimmune disease causing painful blisters on skin and mucous membranes. One group receives rituximab (a biologic that targets immune B-cells) plus corticosteroids, while the other get…

This study tests whether bimekizumab, a drug already approved for other skin conditions, can help heal wounds in people with pyoderma gangrenosum (PG), a rare and painful skin disorder. Adults with PG will receive injections of bimekizumab every few weeks for 24 weeks. The main g…

This Phase 3 trial is testing whether a microneedle pad delivering botulinum toxin A can improve symptoms of Raynaud's phenomenon and digital ulcers in people with systemic sclerosis. The study compares the microneedle treatment to a placebo, measuring changes in finger temperatu…

This trial is testing an experimental drug called 611 in children aged 2 to 12 with moderate-to-severe atopic dermatitis, a common skin condition that causes itchy, inflamed skin. The drug is designed to block a specific immune signal that drives the inflammation behind eczema. T…

This pilot study will test whether a daily gummy supplement called Xtressé can safely improve hair growth in 40 men with male pattern baldness. Participants take two gummies each day for six months, and researchers measure changes in hair density and thickness using special camer…

This trial is testing an experimental oral medication called THB335 in adults with chronic spontaneous urticaria (CSU), a condition marked by persistent hives and itching that standard antihistamines don't fully control. Participants will take THB335 or a placebo alongside their …

This phase 2 trial tests whether an investigational medicine called SPY072 can improve hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps and tunnels. About 150 adults with moderate-to-severe HS who are already receiving standard care will be randomly a…

This phase 2 trial is testing whether an experimental oral drug called HS-20118 can improve moderate to severe plaque psoriasis, a condition that causes thick, scaly patches on the skin. About 120 adults with the condition will receive either HS-20118 or a placebo once a week for…

This study compares how well pressure ulcers (bedsores) heal in older adults receiving care at home versus in a long-term care facility. It also looks at quality of life, patient satisfaction, and treatment costs. Eighty people aged 60 to 90 with stage II-IV pressure ulcers will …

This early-stage trial is testing an experimental oral medication called VC005 in adolescents aged 12 to 18 with severe alopecia areata, a condition that causes patchy or complete hair loss. The study aims to understand how the drug is processed by the body, whether it is safe, a…

This clinical trial is testing whether the drug nemolizumab can help treat moderate-to-severe atopic dermatitis (a common type of eczema) in Chinese patients aged 12 and older. Participants will receive either nemolizumab or a placebo (a look-alike with no active drug) every four…

This pilot trial tests whether tirzepatide, a weekly injection used for diabetes and weight loss, can treat active central centrifugal cicatricial alopecia (CCCA), a permanent scarring hair loss condition. Twenty adults with active CCCA will inject tirzepatide for 12 months and u…

This trial tests whether combining fractional carbon dioxide laser treatment with a topical metformin cream works better than laser alone for acanthosis nigricans—dark, velvety patches on the neck. About 34 adults with this condition will have one side of their neck treated with …

This study looks at whether Jingwanhong Ointment, a traditional Chinese medicine applied to the skin, can safely and effectively treat pressure injuries (bedsores) in people who are bedridden long-term. Researchers will follow about 500 participants to measure how quickly wounds …

This early study tests a new drug called HN2302, which aims to create CAR-T cells inside the body to target and control autoimmune diseases like lupus and scleroderma. The trial will enroll 12 adults to check safety and see if the treatment works. It is a first step, so results w…

This phase II trial is testing an investigational drug called SHR-1139 in adults with plaque psoriasis who have not responded well to at least one biologic treatment. Participants will receive either SHR-1139 or a placebo via subcutaneous injection over a 52-week treatment period…

This trial investigates whether combining microneedling with a standard 5% minoxidil solution can improve hair regrowth in men with androgenetic alopecia (male pattern baldness). It will enroll 190 men aged 18-55 with specific hair loss grades, who will receive different micronee…

This trial is testing whether adding a special wound matrix (OCM) to standard compression and routine care helps heal venous leg ulcers better than standard care alone. Adults with a venous leg ulcer will be randomly assigned to receive either the OCM plus standard care or standa…

This trial is testing whether an experimental biologic called IBI3027 works as well as the approved drug dupilumab for people with moderate-to-severe atopic dermatitis (eczema). About 520 adults will be randomly assigned to receive either IBI3027 or dupilumab as a subcutaneous in…

This first-in-human trial evaluates BYN-001, an antibody designed to block IL-25, a protein linked to atopic dermatitis (eczema). The study first tests the drug in healthy volunteers to assess safety and how it moves through the body, then in people with moderate to severe eczema…

This trial tests whether a topical gel called GM-XANTHO can reduce the severity of psoriasis, a chronic skin condition that causes red, scaly patches. About 65 adults with plaque psoriasis will apply the gel or a placebo daily for 28 days. Researchers will measure changes in skin…

This pilot trial tests whether giving the immunosuppressant drug mycophenolate mofetil (MMF) for six months after a stem cell transplant can prevent systemic sclerosis from relapsing. Six adults with scleroderma who are undergoing a stem cell transplant will take MMF starting 90 …

This trial evaluates a gene therapy skin graft called prademagene zamikeracel (pz-cel) for treating wounds in people with recessive dystrophic epidermolysis bullosa (RDEB), a severe genetic condition that causes fragile skin and chronic wounds. The study includes three parts: one…

This trial tests the drug mercaptopurine in people with hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a rare genetic condition that raises the risk of skin, uterine, and kidney tumors. The study aims to find the safest dose and see if the drug can shrink kidney canc…

This trial tests whether antiplatelet medications, specifically clopidogrel and aspirin, can reduce inflammation in the blood vessels of people with psoriasis or psoriatic arthritis. Participants take each drug or a placebo for four weeks, and researchers measure changes in infla…

This phase 2 trial is investigating whether giving immunotherapy before surgery for advanced melanoma (stage IIIB to IV M1a) can maintain survival while allowing patients to skip the usual adjuvant therapy after surgery. Participants are randomly assigned to receive either two in…

This study tests whether using ultrasound to push propolis (a natural bee product) into the skin can help heal diabetic foot ulcers faster. Eighty adults with diabetes and foot ulcers will either get propolis plus ultrasound or standard wound care for 4 weeks. The goal is to see …

This trial investigates whether a sensitive blood test (Signatera) can detect when it is safe to pause immunotherapy in people with advanced solid tumors like lung cancer, melanoma, and colorectal cancer. Participants are randomly assigned to either continuous standard immunother…

This phase II trial is testing an experimental tablet called TollB-001 in adults with systemic sclerosis, a rare autoimmune disease that causes skin thickening and can affect internal organs. The study aims to see whether the drug can improve skin symptoms and overall well-being …

This trial is testing whether giving two drugs—sintilimab and disitamab vedotin—before surgery can shrink tumors in people with a rare type of eyelid cancer called sebaceous gland carcinoma. Participants receive two cycles of the combination, then undergo surgery to remove the tu…

This study looks at how well upadacitinib, a daily pill, works compared to biologic injections for people with moderate-to-severe atopic dermatitis (eczema). The goal is to see if more patients can reach a state of minimal disease activity, meaning nearly clear skin and little to…

This early-stage trial is testing an experimental oral drug called HL40626S in healthy adults aged 18 to 55. The goal is to check the drug's safety, how the body processes it, and the best dose range. If it passes these initial safety checks, the drug could eventually be studied …

This trial compares three types of platelet-rich plasma (PRP) injections for androgenetic alopecia, the most common form of hair loss. Participants receive either standard PRP, PRP enhanced with red light, or PRP enhanced with blue light, and are blinded to which type they get. T…

This phase 1 trial tests an experimental cell therapy called LMY-922 (BAFF CAR-T cells) in people aged 16 to 75 with refractory autoimmune diseases, including rheumatoid arthritis, lupus, dermatomyositis, and systemic sclerosis. The therapy uses donor immune cells engineered to t…

This trial tests whether a daily application of roflumilast 0.3% cream can improve both chronic plaque psoriasis and moderate-to-severe nail psoriasis. People aged 12 and older with stable disease for at least 6 months apply the cream to affected nails and plaques daily for 24 we…

This trial tests whether a risk-based prevention bundle can lower the chance of pressure injuries in patients undergoing elective surgery lasting three hours or longer. Participants are assigned to receive either standard care or a bundle tailored to their individual risk level—l…

This phase II trial tests whether adding lisaftoclax to brentuximab vedotin improves outcomes for people with CD30-positive cutaneous T-cell lymphoma, including mycosis fungoides and primary cutaneous anaplastic large cell lymphoma. About 46 participants are randomly assigned to …

This trial tests whether adding a clinical pharmacist to dental care can improve how oral mucosal disorders — such as oral lichen planus, recurrent canker sores, burning mouth syndrome, oral thrush, and herpes infections — are managed. Dentists in some clinics will get pharmacist…

This trial tests whether different scaffolds—a blood clot or various platelet-rich fibrin preparations—can improve healing in teeth that need a second root canal treatment. Sixty participants will receive one of four scaffolds during the procedure and be followed for a year. The …

This phase 3 trial tests whether monitoring tumor DNA in the blood (ctDNA) can help doctors switch hormone therapy earlier in people with ER+/HER2- metastatic breast cancer. Participants whose ctDNA levels rise—before any symptoms or scans show progression—are randomly assigned t…

This early-phase trial tests a topical gel containing duvelisib, a drug that blocks certain immune signals, in people with early-stage mycosis fungoides — a type of skin lymphoma. The study enrolls about 30 participants with stage IA to IIA disease who have 3 to 5 accessible skin…

This trial investigates whether the immunotherapy drug cemiplimab can shrink advanced cutaneous squamous cell carcinoma in people who have received a kidney transplant. Because immunotherapy can trigger organ rejection, participants also receive the steroid prednisone to protect …

This trial investigates whether adding the antibiotic azithromycin to standard topical creams (betamethasone or tacrolimus) improves eczema symptoms in children aged 3 to 12 with mild to moderate atopic dermatitis. Researchers will measure changes in the Eczema Area and Severity …

This study compares two treatments for palmoplantar psoriasis, a form of psoriasis affecting the palms and soles. One group receives a topical steroid cream alone, while the other receives the same cream plus a fractional CO2 laser treatment every four weeks. The goal is to see i…

This study investigates whether two common vaccines—the shingles vaccine (RZV) and an RSV vaccine (RSVPreF3)—can slow the buildup of fatty plaque in the coronary arteries. The trial enrolls adults aged 50 and older who are at risk for cardiovascular events. Participants receive e…

This trial investigates whether fecal microbiota transplantation (FMT) can treat alopecia areata, an autoimmune condition causing patchy hair loss. Researchers will give adults with alopecia areata either FMT or a placebo for three days and track hair regrowth, immune changes, an…

This study tests whether a probiotic ointment (containing live, friendly bacteria) can improve eczema in children aged 6 months to 15 years. The ointment is compared to a basic lotion over 28 days. Researchers measure skin redness, itching, and skin barrier function to see if the…

This study tests whether a vaginal ovule device, used alongside standard antibiotics or antifungals, improves vaginal health in women with bacterial vaginosis or yeast infections. Eighty women aged 18 to 60 receive either the active device or a placebo ovule over three treatment …

This study tests whether blue LED light therapy can improve symptoms of common vaginal conditions like menopause-related dryness, bacterial vaginosis, and yeast infections. About 150 women aged 18 to 75 will receive the treatment either at home or in a clinic. Researchers will ch…

This study tests whether adding axelopran, a drug that blocks opioid side effects in the gut, to the immunotherapy nivolumab can help people with advanced melanoma that no longer responds to PD-1 inhibitors. The trial includes about 28 adults with unresectable or metastatic cutan…

This trial tests whether a new skin graft substitute (CAMP) plus standard wound care helps wounds heal faster after Mohs surgery for skin cancer compared to standard care alone. About 160 adults who have had Mohs surgery for a skin cancer will be randomly assigned to receive eith…

This trial tests whether a custom cream containing metformin (a diabetes drug), simvastatin (a cholesterol drug), and betamethasone (a steroid) can regrow hair in people with patchy alopecia areata, an autoimmune condition causing hair loss. Participants apply the cream twice dai…

This phase 2 trial tests a gel called EscharEx, made from pineapple enzymes, on people with venous leg ulcers that have stubborn dead tissue. The gel is applied to the wound to break down and remove non-viable tissue, potentially speeding up healing. The study involves 20 adults …

This early-phase trial tests two different drug combinations for people with T-cell lymphoma that has come back or not responded to prior treatment. One group receives belinostat plus azacitidine; the other receives belinostat plus pralatrexate. The goal is to find the safest dos…

This study tests a medicated foam called roflumilast applied daily to hidradenitis suppurativa (HS) lesions for 16 weeks. It includes adolescents and adults with mild to moderate HS (Hurley stage I or II) who have 4 to 10 painful lumps or abscesses but no draining tunnels. The ma…

This study offers continued access to anifrolumab (Saphnelo) for people with systemic lupus erythematosus, systemic sclerosis, or myopathies who completed a prior anifrolumab trial and are still benefiting from the drug. Participants receive the same treatment as before, while re…

This study looks at whether starting secukinumab early in people with moderate-to-severe hidradenitis suppurativa (a chronic skin condition causing painful lumps) can slow disease progression. Researchers will analyze data from existing medical records and registries across Europ…

This study tests whether a cream containing 10% cholesterol improves skin barrier function and quality of life more than a standard 10% urea cream in people with autosomal recessive congenital ichthyosis (ARCI), a rare genetic condition causing dry, scaly skin. Each participant a…

This Phase 2 trial tests whether small interfering RNA (siRNA) microneedle patches can improve the appearance of earlobe keloid scars after laser surgery. About 158 adults with earlobe keloids will receive either standard steroid injections alone or steroid injections plus the si…

This study compares two silicone gel formulations, Dermatix and Dermatix Ultra, to see if one is better at improving the appearance and symptoms of raised scars (keloids and hypertrophic scars). About 150 people with existing or new scars will use one of the gels twice daily for …

This pilot study tests an oral drug called golidocitinib in people with two rare blood cancers: mycosis fungoides/Sézary syndrome (a type of skin lymphoma) and T-cell large granular lymphocytic leukemia. The drug blocks a protein called JAK1, which is involved in cancer cell grow…

This study tests whether combining a fractional laser with a biostimulator (poly-L-lactic acid) can repair sun-damaged skin better than either treatment alone. The goal is to improve skin health and potentially lower the risk of skin cancer. Researchers will use AI-assisted imagi…

This study compares two treatments for actinic keratoses—rough, scaly spots that can turn into skin cancer—on the arms. One treatment uses a light-sensitizing gel followed by blue light (photodynamic therapy), while the other uses a two-step chemical peel. About 60 adults with sp…

This pilot study tests whether adding manual lymphatic drainage (a gentle massage technique) to standard wound care can help heal pressure injuries (bedsores) in patients hospitalized in intensive care. The trial randomly assigns 60 adults with a pressure injury on the sacrum (ta…

This study tests a new approach for treating keloids—thick, raised scars that can be painful and itchy. The treatment combines wide-band ultrasound with a traditional Chinese medicine preparation applied to the skin. The goal is to soften scar tissue, reduce symptoms, and prevent…

This study tests whether upadacitinib, a drug already approved for eczema, can help people who have both atopic dermatitis (a type of eczema) with moderate to severe itching and a hard-to-treat autoimmune liver disease called cholangitis. The drug works by blocking a pathway invo…

This study compares the standard antifungal drug itraconazole alone versus itraconazole combined with isotretinoin (an acne medication) in adults with tinea corporis or cruris (ringworm of the body or groin). The goal is to see if the combination shortens treatment time and impro…

This early-stage study is testing a new treatment called C-CAR168 for people with autoimmune diseases like multiple sclerosis, lupus, and myasthenia gravis that have not improved with standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab…

This study tests whether Maraviroc, a drug currently used for HIV, can reduce muscle inflammation and improve function in adults with myositis that hasn't responded to standard treatments. Ten participants will take a daily 300mg tablet for 12 weeks and undergo muscle biopsies an…

This early-phase trial tests a single infusion of universal CAR-T cells (RD06-05) in 30 children and adolescents with severe autoimmune diseases, including lupus, scleroderma, and kidney inflammation. The cells are designed to target and calm overactive immune cells. The main goa…

This study compares two topical medications—clascoterone cream and adapalene gel—for treating mild acne vulgaris. Researchers will enroll 60 people aged 12 to 35 with mild acne and randomly assign them to use one of the treatments for 12 weeks. The goal is to see which treatment …

This pilot study tests whether fecal microbiota transplantation (FMT) can improve moderate to severe hidradenitis suppurativa (HS), a painful skin condition. Researchers will give 24 adults a single FMT and track changes in their skin lesions over 12 weeks. The goal is to see if …

This phase 3 trial is testing a drug called trastuzumab rezetecan, alone or combined with bevacizumab, in 140 women with advanced triple-negative breast cancer that has a specific immune-suppressed pattern. The goal is to see if the combination can delay cancer growth better than…

This study tests two surgical techniques to treat stable white patches on the skin that are not caused by vitiligo. Both methods involve transplanting the patient's own skin cells, followed by laser therapy to boost color return. Twenty-two adults will each receive both treatment…

This study compares two standard steroid treatments for hypertrophic lichen planus, a chronic skin condition that causes thick, intensely itchy plaques. Fifty adults will be randomly assigned to apply a strong steroid cream twice daily for 12 weeks or receive steroid injections i…

This phase 2a trial tests whether a daily pill called ACT-777991 can help return color to the face of adults with non-segmental vitiligo. About 30 participants will take either the drug or a placebo for 24 weeks. Researchers will measure changes in skin color using a standard sco…

This study tests a cream called benvitimod (tapinarof) for people with cutaneous T-cell lymphoma, a rare skin cancer that causes red patches and itching. The cream is non-steroidal and works by targeting a specific receptor in skin cells. About 35 adults with the disease will app…

This study tests whether adding a fractional CO₂ laser to standard Glucantime injections helps heal skin sores from leishmaniasis faster and with less scarring. About 150 adults will be randomly assigned to get either the injection alone or the injection plus laser. Researchers w…

The SASHA trial is testing whether a single, high-dose radiation treatment delivered directly to the tumor site over one day is safe and effective for women with early-stage breast cancer. The study will enroll 134 women aged 40-85 who have already had a lumpectomy. Researchers w…

This study tests if a special wound dressing called MIRRAGEN® can help heal venous leg ulcers (open sores on the legs caused by poor blood flow) faster than standard care alone. About 110 adults with these ulcers will either get MIRRAGEN® plus standard care or standard care only.…

This study tests a new medicine called GR2301, given as shots under the skin, together with light therapy for people with vitiligo (a condition that causes white patches on the skin). The trial has two parts: first, finding the right dose, then testing how well it works. About 11…

This phase 2 trial will test whether combining two newer drugs (toripalimab and anlotinib) with standard chemotherapy can shrink tumors in people with a rare skin cancer called dermatofibrosarcoma protuberans (DFSP) that has stopped responding to the usual treatment. The study pl…

This first-in-human study tests the safety of a new drug called HBM7020. It will first be given to healthy volunteers at low doses, then to people with moderate to severe autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see …

This study tests whether a low daily dose of the acne drug isotretinoin can clear moderate to severe acne as effectively as the standard dose, but with fewer side effects. About 164 people aged 18-45 will be randomly assigned to one of two dose groups. Researchers will track acne…

This study will test whether a special electrical stimulation device (FREMS) plus the drug phenytoin can help heal chronic ulcers in people with diabetes. Twenty-six participants will be split into two groups: one gets the new combo, the other gets standard care. Researchers will…

This study looks at 120 adults with moderate-to-severe psoriasis who take secukinumab, a biologic drug. It compares two maintenance schedules: the standard every-4-week injection versus a non-standard schedule (longer intervals or lower dose). The goal is to see which schedule ke…

This study will test whether a newer cream called tapinarof works better than the standard betamethasone cream for mild-to-moderate plaque psoriasis. About 120 adults will use one of the two creams daily for up to 12 weeks. The main goal is to see how many people get at least a 7…

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets…

This study tests a drug called teclistamab in 24 adults with a severe, rapidly worsening lung disease linked to anti-MDA5 antibodies. The disease has a very poor outlook, with only about 25% of patients surviving 90 days without a lung transplant. Teclistamab aims to improve surv…

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard narrowband UVB light treatment can help restore skin color in people with vitiligo. Five adults with non-segmental vitiligo will receive UVB twice a week for 24 …

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This study tests if injecting polidocanol (a medicine that reduces blood flow) into keloids and hypertrophic scars can make them flatter and less noticeable. About 90 people with scars that are less than a year old will receive either polidocanol or a standard steroid injection. …

This pilot study will test a new type of radiation called FLASH radiotherapy for people with cutaneous lymphoma, a rare skin cancer. Ten participants will receive a single, ultra-fast dose of radiation to their skin lesions. The main goal is to see if the treatment is safe and to…

This early-phase trial tests whether a topical cream called squaric acid dibutyl ester (SADBE) can safely reduce pigment-producing cells in large congenital moles before they are surgically removed. Thirty adults with these birthmarks will apply the cream or a placebo for several…

This study tests whether freezing precancerous skin spots (cryotherapy) followed by a medicated ointment (tirbanibulin) works better than freezing alone for actinic keratosis on the scalp and forehead. About 59 adults with at least 8 spots will receive the combo treatment or a pl…

This study compares two types of compression bandages for treating venous leg ulcers, which are slow-healing wounds on the lower leg. About 386 adults will receive either the new Mepi Press 2 or the standard UrgoK2 bandage for up to 12 weeks. The goal is to see if the new bandage…

This early study will test whether a daily omega-3 cream and serum can change the balance of bacteria on eczema-affected skin. Ten adults with eczema will apply the treatment for 14 days, and researchers will measure four types of bacteria before and after. The study is explorato…

This Phase 2 trial tests whether adding benralizumab (a drug already used for asthma) to standard corticosteroid treatment can help people with DRESS syndrome recover faster and spend fewer days in the hospital. DRESS is a rare, severe allergic reaction to certain medications tha…

This study tests a new type of radiation called FLASH therapy, which delivers the entire dose in milliseconds instead of minutes. The goal is to see if it can treat skin cancers (squamous cell and basal cell carcinomas) just as well as standard radiation but with fewer side effec…

This study compares a new dressing called POLTX_Fiber to a standard one for chronic wounds like leg ulcers and pressure sores. Sixty adults with moderate-to-heavy wound drainage will be followed for 30 days. Researchers will track healing, infection, pain, and patient satisfactio…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study tests whether wearing compression stockings alone can prevent repeat episodes of erysipelas (a bacterial skin infection) as well as the usual approach of antibiotics plus stockings. About 200 adults who have had at least two infections in the same leg will be randomly …

This pilot study tests whether injecting dexpanthenol (a vitamin B5 derivative) under the skin around chronic wounds can help them heal faster. 40 adults with diabetic foot ulcers, venous leg ulcers, or arterial ulcers will receive either standard wound care alone or standard car…

This early-stage trial tests a stem cell injection (HS_SW01) in 21 adults with systemic sclerosis, a disease where the immune system attacks the body, causing skin hardening and organ damage. The main goal is to see if the treatment is safe and tolerable. Researchers will also ch…

This study tests a new type of breast-conserving surgery that uses a small camera inserted through a hidden armpit incision to remove tumors, compared to the standard open approach. About 1,366 women with early-stage breast cancer will be randomly assigned to one of the two surge…

This Phase II trial tests a new drug called VG712 against an existing drug, mogamulizumab, in about 386 people with advanced mycosis fungoides, a rare type of skin lymphoma. VG712 is designed to kill cancerous immune cells by blocking protein production. The study aims to see if …

This study tests whether a daily oral minoxidil pill (N1087) can help regrow hair in men with male pattern baldness. About 372 men aged 18 to 60 with moderate hair loss will take either the drug or a placebo for 24 weeks, with the dose slowly increased. The main goal is to see if…

This study tests whether exosomes from umbilical cord stem cells can safely help restore skin color in adults with vitiligo. 96 participants with active or stable vitiligo will receive either exosome infusions or injections alongside standard light therapy and ointment. The goal …

This study compares two prescription creams, tacrolimus and crisaborole, for treating mild to moderate eczema in children and teens aged 2 to 20. Both creams are steroid-free and aim to control inflammation without the side effects of long-term steroid use. Over 8 weeks, 72 parti…

This study tests whether adding a special cell secretion (called secretome) to standard light therapy helps restore skin color better in people with vitiligo. About 150 adults with stable vitiligo will receive either light therapy alone, or light therapy plus secretome applied th…

This study tests whether giving three drugs (pucotenlimab, lenvatinib, and temozolomide) before surgery can shrink tumors in people with a specific type of skin cancer called acral melanoma, which is stage IIB or III and can be removed. About 30 adults will receive the drug combi…

This study tests three different gels for mild-to-moderate acne: a standard clindamycin-retinoid combo, a clindamycin-retinoid-dexamethasone combo, and a gel made from stem-cell secretions (secretome). About 189 people will use one of the three gels for 8 weeks. Researchers will …

This phase 2 trial tests two drugs, cemiplimab and cetuximab, given before surgery to people with advanced skin cancer that is hard to remove. The goal is to shrink the tumor enough to make surgery easier or even unnecessary. The study will enroll 27 participants across three sit…

This study tests a daily pill called upadacitinib for people with severe forms of lichen planus, a skin disease causing painful mouth sores or hair loss. About 56 adults will receive either the drug or a placebo for 16 weeks to see if it reduces symptoms. The goal is to control t…

This early-stage study tests two forms of a hair loss drug (AD-303A topical and AD-3031 oral) in 30 men aged 19-55 with male pattern baldness. The goal is to see how the drug moves through the body, how well it works, and if it is safe. The study will help decide the right dose f…

This phase 3 study tests an injectable drug called MG-K10 for people aged 12 and older with moderate-to-severe atopic dermatitis (eczema) that hasn't improved with creams. About 498 participants will receive either MG-K10 or a placebo to see if it safely reduces skin redness, itc…

This study will test whether applying a special heat-reflecting coating to roofs can improve the health and well-being of 800 households in Colima, Mexico. The coating is designed to keep homes cooler indoors, which may help lower heart rate, improve blood sugar control, reduce d…

This study tests whether a gel containing methotrexate, an immune-suppressing drug, can regrow hair in people with localized alopecia areata better than minoxidil spray. About 268 adults with less than 25% scalp hair loss will apply one of the two treatments twice daily for 24 we…

This study tests whether special dressings made from donated human umbilical cord tissue, used along with standard wound care, can help close hard-to-heal leg ulcers faster than standard care alone. About 272 adults with venous leg ulcers that have not healed after 4 to 52 weeks …

This study tests whether two skin substitutes made from donated human umbilical cord tissue can help close hard-to-heal diabetic foot ulcers. About 272 adults with diabetes and a foot ulcer will receive either standard wound care alone or standard care plus weekly applications of…

This phase 3 trial tests an injection called ADSTEM for adults with moderate-to-severe atopic dermatitis (eczema) that hasn't responded well to standard treatments. About 286 people aged 19 to 70 will receive either the study drug or a placebo. The main goal is to see if the inje…

This study compares two oral medications—tofacitinib and methotrexate—for treating severe alopecia areata, an autoimmune condition causing hair loss. 78 adults aged 18-60 with severe scalp or total body hair loss will take one of the drugs for 12 weeks. The main goal is to see wh…

This study tests two prescription gels—metronidazole and clindamycin—to see which works better for moderate acne. Sixty adults aged 18 to 35 will apply the gel twice daily for 12 weeks. Doctors will check acne severity at the start and at weeks 4, 8, and 12 to measure improvement…

This study tests whether high intensity focused ultrasound (HIFU) works as well as standard cryotherapy (freezing) for treating low-risk basal cell carcinomas and Bowen's disease. About 294 adults with small skin cancers on their body (not face or hands) will be randomly assigned…

This study compares two treatments for generalized vitiligo: PUVA therapy (a light-based treatment) and the pill Tofacitinib. Researchers will enroll 64 adults with stable vitiligo covering more than 10% of their body. The goal is to see which treatment works better and is safer …

This Phase 3 trial tests whether an oral solution called N1087 can help women with female pattern hair loss regrow hair. About 372 women aged 18 to 60 will receive either N1087 or a placebo daily for 24 weeks. The study measures changes in hair density and thickness using scalp p…

This phase 3 trial is testing whether an oral (pill) form of arsenic trioxide works as well as the standard IV form for consolidation therapy in people with a low-risk type of acute promyelocytic leukemia (APL). About 120 adults and teens who have already completed initial treatm…

This early study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses modified immune cells to target and calm the overactive immune system. The main goals are to check safety and see i…

This study compares two forms of minoxidil—a topical spray and an oral pill—for treating androgenetic alopecia (common hair loss) in 200 men and women aged 18 to 50. Over 6 months, researchers will measure hair regrowth, shedding, and side effects. Participants will use either th…

This study tests biologic drugs for folliculitis decalvans, a rare scalp disease that causes painful pustules and permanent hair loss. Current antibiotics only work about half the time and the condition often returns. The trial will enroll 120 adults who have already tried at lea…

This study tests whether adding cold atmospheric plasma (CAP) to standard wound care helps diabetic foot and venous leg ulcers heal faster and stay healed longer. About 494 adults with these chronic wounds will receive either standard care alone or standard care plus CAP. The goa…

This study tests whether taking a short course of capecitabine pills before surgery can shrink tumors and improve outcomes for people with HPV-negative head and neck cancer. About 75 adults with stage III or IVa cancer will be randomly assigned to either standard care or capecita…

This study is testing whether people with certain non-invasive or early breast conditions (like ductal carcinoma in situ) can safely skip surgery and instead take hormone-blocking medication. The goal is to see if this approach keeps cancer from coming back over five years. The t…

This study compares three treatments for vulvar lichen sclerosus, a chronic skin condition causing itching and pain. 45 women aged 30-80 will receive either a steroid cream, an immune-modulating cream, or platelet-rich plasma (PRP) injections. The goal is to see which approach be…

This early-phase trial tests a new drug called DT-7012 for people with a rare type of skin lymphoma (CTCL) that has not responded to other treatments. The drug is an antibody designed to find and kill cancer cells in the skin and boost the immune system. About 30 adults with adva…

This phase 3 trial tests whether the drug brentuximab vedotin can prevent relapse in people with advanced cutaneous T-cell lymphoma (CTCL) who have recently had a stem cell transplant. About 84 adults with CD30-positive CTCL will receive either the drug or a placebo every three w…

This early study tests a gel made with the drug miltefosine for people with uncomplicated cutaneous leishmaniasis, a skin infection from a parasite. Fifteen adults will apply the gel to their sores daily for 28 days. The main goal is to see if the gel is safe and if it helps the …

This large study in Fiji tests whether a new combination of drugs (moxidectin plus two others) can safely treat three common parasitic infections: lymphatic filariasis, scabies, and strongyloidiasis. About 5,100 people will receive either the new combo or the standard treatment o…

Researchers are testing a noninvasive MRI technique that uses inhaled hyperpolarized xenon gas to measure lung function in adults with interstitial lung disease, pulmonary hypertension, and systemic sclerosis. The study includes about 51 participants, including healthy volunteers…

Researchers are testing a new way to measure how much sweat the body produces during controlled heat exposure. About 20 healthy volunteers and up to 10 people with ROSAH syndrome, a rare genetic condition that can cause reduced sweating, will sit in a temperature-controlled sauna…

This phase 3 trial tests whether a magnetic tracer (Magtrace) works as well as the standard radioactive dye plus blue dye for finding sentinel lymph nodes in people with melanoma. About 254 adults having surgery for melanoma will receive both tracers and be randomly assigned to h…

This study asks whether an artificial intelligence algorithm can diagnose mycosis fungoides, a rare type of skin lymphoma, from biopsy slides as accurately as certified dermatopathologists. Researchers will compare the AI's sensitivity and specificity against expert readings usin…

This study asks whether an artificial intelligence algorithm can accurately diagnose seborrheic keratosis—a common, non-cancerous skin growth—from tissue samples. Researchers will compare the AI's performance against certified dermatopathologists using 30 preserved slides. The go…

This pilot study is testing whether a rapid, point-of-care blood test can help identify early signs of infection and sepsis in preterm infants. Researchers will measure inflammatory markers like IL-6, PCT, CRP, and MxA in blood samples from about 40 to 80 premature babies, compar…

This study tests whether expired patch test allergens can still accurately diagnose allergic contact dermatitis, a common skin condition. Adults referred for patch testing will receive both expired and non-expired allergens on their skin at the same time. The researchers will com…

This trial tests whether a new ultra-rapid genetic test, using third-generation sequencing, can diagnose familial lymphohistiocytosis (FHL) in children within 5 days instead of the usual 6-8 weeks. FHL is a rare, life-threatening genetic condition where the immune system attacks …

This study tests whether AI-powered decision trees can help general practitioners better diagnose and manage allergies. About 600 patients with suspected allergies will be enrolled, and doctors will use an app that suggests next steps based on symptoms. The goal is to see if this…

This study looks at whether a blood gas measurement (the difference in carbon dioxide between central venous and arterial blood) can accurately diagnose low cardiac output in patients with septic shock from severe skin infections. About 74 adults will be monitored during hyperbar…

This study tests whether a mobile app using artificial intelligence can help frontline health workers in sub-Saharan Africa better diagnose skin-related neglected tropical diseases, like leprosy and scabies. Researchers will collect images from dermatologists to train the AI, the…

This study will test if a new type of MRI scanner, called Field-Cycling Imaging (FCI), can accurately measure the size of breast tumors in people with ductal carcinoma in situ (DCIS). Twelve participants will receive both a standard MRI and an FCI scan before surgery. The results…

This study tests a new type of PET scan using a tracer called 68Ga-FAPI-46 to find cancer that has spread in patients with lobular breast cancer. Standard scans often miss these metastases. The trial will enroll 45 adults whose standard PET scan was negative or unclear, and see i…

This study aims to develop an artificial intelligence system that can automatically detect potential melanomas using 3D whole-body skin images. Researchers will collect scans from 1,000 adults with many moles and compare the AI's findings to those of three skin specialists. The g…

This study compares a new DNA sequencing platform (MGI) against the current standard (Illumina) for diagnosing hereditary cancers like breast and ovarian cancer, Lynch syndrome, and intestinal polyposis. Researchers will analyze 248 patient samples using both platforms to see if …

This trial tests whether a nursing care bundle created with the help of artificial intelligence can prevent medical device-related pressure injuries in intensive care patients. These injuries, which can be painful and serious, affect about 1 in 5 ICU patients. The study will comp…

Researchers are testing whether removing a specific type of immune cell, called CD45RA-positive naive T cells, from donor stem cells can prevent graft-versus-host disease in older adults undergoing stem cell transplants for acute leukemia or myelodysplastic syndrome. The trial en…

People with multiple sclerosis or neuromyelitis optica spectrum disorder who take anti-CD20 drugs have a higher risk of shingles. The shingles vaccine is recommended for them, but the drug may weaken its effect. This trial compares two dosing schedules: one gives the second shot …

This trial tests whether a social media campaign can help young adults who tan reduce their tanning and avoid sunburns. Participants will create and share posts that encourage sun safety and challenge the media's tanned skin ideal. The study will compare their tanning and sun pro…

This trial tests a modified way to position patients during neurosurgery under general anesthesia. The new method uses an L-shaped arm board and a funnel-shaped adhesive film to better distribute pressure and reduce nerve strain. Researchers will compare this with standard positi…

This study tests whether leaving the white, creamy coating (vernix caseosa) on a newborn's skin for at least 24 hours after birth can prevent eczema (atopic dermatitis) during the first year of life. Over 1,300 mother-infant pairs in Chile will be randomly assigned to either keep…

This trial tests whether a short, purpose-built educational video can strengthen high-school students' belief in disaster preparedness and their perception of disaster risk. About 144 students from twelve classes at one school in West Kalimantan, Indonesia, will be randomly assig…

This Phase 3 trial tests whether a daily imiquimod cream applied to the face for 12 weeks can prevent new basal cell carcinomas (BCC) in 1,630 veterans at high risk. Participants apply either the active cream or a placebo and are followed for up to 3 years with skin exams. The go…

This trial tests whether a single dose of a live-attenuated shingles vaccine can effectively boost immunity in adults aged 50 and older who have already received the recombinant shingles vaccine. The study measures antibody and cellular immune responses after the booster. If it w…

This study tests an investigational vaccine that combines protection against measles, mumps, rubella, and chickenpox (varicella) in a single shot. It will be given as a second dose to healthy children aged 4 to 6 years who have already received a first dose of a similar vaccine. …

This study tests whether two skin treatments—microneedling and a chemical peel—can reduce the number of precancerous spots and skin cancers in older veterans. About 96 veterans aged 60 and older with fair skin and multiple precancerous spots will receive one treatment on one arm,…

This study tests whether a silicone foam dressing placed over the breathing tube, along with regularly moving the tube, can prevent pressure injuries inside the mouth. It will involve 75 adults in intensive care who need a breathing machine. The goal is to find a simple way to pr…

This study tests whether a gel made from aloe vera and peppermint can prevent pressure injuries (bedsores) in intensive care unit (ICU) patients. Forty adults who are at risk for bedsores will be randomly assigned to receive either the natural gel or standard hospital care. The m…

This study tests whether low doses of two hormone-blocking drugs, exemestane and tamoxifen, can help prevent breast cancer in postmenopausal women at high risk. About 140 women will take one of the two drugs for a year, and researchers will measure side effects and quality of lif…

This study tests a gel called TAR-0520 to see if it can prevent hand-foot syndrome, a painful skin reaction caused by the chemotherapy drug capecitabine. About 25 people with breast or colorectal cancer will apply the gel to their hands twice daily for 12 weeks. Their feet will n…

This study tests whether an extra dose of the shingles vaccine (Shingrix) can boost immunity in people who have had a solid-organ transplant, like a kidney or liver. About 30% of transplant patients still get shingles after the standard two-dose vaccine, likely due to immune-supp…

This study tests whether a gel containing polyhexanide and biguanide can prevent biofilm (a tough layer of bacteria) from forming in pressure ulcers (bedsores). About 140 adults over 65 with stage II or III bedsores will receive the gel alone or with a special dressing. The goal …

This study tests whether a genetic test can prevent rare but severe skin reactions caused by the common gout drug allopurinol. About 228 Vietnamese adults with gout will either get the test before treatment or receive standard care. Those with a high-risk gene will take a differe…

Researchers are testing an experimental drug called olatorepatide in adults with moderate to severe hidradenitis suppurativa who also live with overweight or obesity. Hidradenitis suppurativa causes painful lumps and tunnels under the skin. The trial compares olatorepatide with a…

Researchers are testing an experimental oral drug called soquelitinib in adults with moderate-to-severe hidradenitis suppurativa, a chronic skin condition that causes painful lumps and tunnels. The trial aims to see if the drug is safe and can reduce the number of inflammatory le…

Immune checkpoint inhibitors help treat cancer, but they often cause a skin rash that can make patients uncomfortable and disrupt their cancer care. This trial tests whether adding Wucao Anfu Formula, an external traditional Chinese herbal wet compress, to standard steroid treatm…

Researchers at the University of Miami compare three ways to control pain after nail unit procedures: suzetrigine, a combination of oxycodone and acetaminophen, and alternating acetaminophen and ibuprofen. The study enrolls 45 adults undergoing these procedures. Participants take…

Researchers are asking people with psoriasis to use Doublebase Once, a once-daily leave-on emollient, as their only moisturizer for about one month. Up to 100 adults across the UK join from home and answer online questionnaires about their skin and how the product feels to use. T…

Infantile hemangioma is a common birthmark that can grow quickly in a baby's first months. Researchers are testing a 5% simvastatin ointment applied directly to the skin of babies aged 3 to 6 months with newly diagnosed superficial hemangiomas. The study checks whether the ointme…

This trial tests whether adding a donor nerve graft during implant-based breast reconstruction helps women regain breast and nipple sensation after nipple-sparing mastectomy. Each participant has one breast randomly chosen to receive the graft, while the other breast serves as a …

Researchers are testing whether a topical gel containing sirolimus can flatten raised epidermal nevi and even out their color. The study enrolls people aged 6 and older who have had stable, non-inflammatory epidermal nevi for at least three years. Participants apply the gel twice…

Researchers are testing an experimental biologic drug called PRA-216 in adults with moderate to severe atopic dermatitis, a form of eczema. The trial compares PRA-216 with a placebo to see whether the drug is safe and can reduce eczema severity. Participants must have had eczema …

This Phase 3 study tests the safety of SD-101 cream (6% allantoin) in 80 people with epidermolysis bullosa, a condition that causes fragile, blistering skin. Participants must have completed a prior study (SD-007). The main goal is to track any side effects over time.

Researchers are testing a modified surgical technique for squamous cell carcinoma in situ on the scalp, an early form of skin cancer. Standard surgery can remove deep tissue that holds hair follicles, causing permanent bald spots. This pilot study uses partial thickness excision,…

This study asks whether a once-daily emollient called Doublebase Once can safely help manage ichthyosis, a condition causing dry, scaly skin. About 100 people with ichthyosis will replace their usual moisturizer with Doublebase Once for 28 days, applying it once daily. Participan…

This Phase 2 study tests lebrikizumab (Ebglyss) in 15 adults with moderate-to-severe prurigo nodularis, a skin condition causing intense itching and hard bumps. Participants receive injections every two weeks for 24 weeks. The main goals are to measure how much itching decreases …

This pilot study tests whether a 16-week Mediterranean-style diet program is practical and acceptable for adults with hidradenitis suppurativa, a chronic skin condition. All 30 participants receive the same program, which includes video counseling, cooking education, and food sup…

This study tests whether adding low-level red-light therapy to the standard hair-loss treatment minoxidil helps breast cancer patients regrow hair lost during chemotherapy. About 50 adults with stage I-IV breast cancer who lost at least half their scalp hair after chemo will be e…

This trial tests whether giving patients a prescription for haloperidol to use as needed at home can help control symptoms of cannabinoid hyperemesis syndrome — a condition marked by severe nausea, vomiting, and abdominal pain from heavy cannabis use. The goal is to see if having…

This trial tests whether a single injection of polynucleotides, a solution called PLINEST One, can improve scar quality after thyroid or parathyroid surgery. Adults aged 40 to 60 having neck surgery for the first time will receive either the polynucleotide injection or a saline p…

This trial investigates whether a dietary supplement can reduce hair loss in women who experience telogen effluvium—a type of temporary shedding—while taking GLP-1 medications like semaglutide or tirzepatide. Over 120 days, participants will take the supplement daily, and researc…

This study tests whether dexamethasone palmitate, a steroid, can better relieve shingles pain and prevent long-term nerve pain compared to standard care. About 954 adults with shingles rash and severe pain will receive the drug by injection or infusion. Researchers will track pai…

This trial is testing a soft silicone foam dressing called Mepilex Up on adults with leg or foot ulcers and skin tears. The goal is to see if the dressing helps wounds progress toward healing and is safe to use. About 70 participants will use the dressing for up to 6 weeks, and d…

This study tests whether a procedure called dermabrasion, which sands the skin, can improve the appearance of scars from free flap reconstruction in the head and neck. Forty adults who had flap surgery at least three months ago will have half their scar treated and half left alon…

This early-phase trial tests a new drug called TLL-018 in 36 adults with moderate-to-severe chronic spontaneous urticaria (hives) that standard antihistamines can't control. The goal is to see how quickly TLL-018 reduces itching and hives after the first dose. Participants will r…

This study explores whether a self-guided web program called 'Better Nights, Better Days for Youth' can improve sleep and reduce pain in teenagers with rheumatic diseases like arthritis and lupus. Teens aged 12-18 with sleep problems will track their sleep and pain daily, then us…

This pilot trial tests a topical cream containing patented microspicules that deliver Penghu seaweed extracts to the skin. The study will enroll healthy adults aged 40-65 with signs of facial aging or pigmentation, applying the cream to one side of the face for comparison. Resear…

This study tests if a special cooling cap can reduce hair loss in people with advanced solid tumors who are receiving a type of chemotherapy called antibody-drug conjugates (ADCs). About 102 women will be split into two groups: one gets the cooling cap during treatment, the other…

This trial tests whether a structured, supervised exercise program that activates the calf muscle pump can improve healing of venous leg ulcers compared to standard advice to walk at home. The study involves adults aged 20 to 60 with non-healing ulcers, and it measures changes in…

This trial tests whether a special laser, called UltraClear, can safely improve skin laxity and provide a lifting effect on the lower face, under the chin, and neck. Up to 50 adults aged 35 to 65 will receive two laser treatments about seven weeks apart. Researchers will check re…

This trial tests whether exercising in a pool or on land offers greater relief for women with lipedema, a condition causing painful fat buildup in the legs. Sixty women with moderate-to-severe lipedema will be split into three groups: supervised aquatic workouts, land-based train…

This pilot trial is testing whether a topical gel called Filsuvez, made from birch triterpenes, is safe and helpful for people aged 6 months and older with moderate-to-severe epidermolysis bullosa simplex (EBS), a condition causing fragile skin and blisters. Participants will app…

This trial tests whether a magnesium-based supplement taken before bed can improve sleep quality and speed up recovery after intense exercise. Healthy, recreationally active adults aged 18-40 will take the supplement or a placebo for two weeks each, then complete a leg exercise p…

This study tests an inhaled powder called LIQ861 (treprostinil) in adults with scleroderma who have frequent, painful Raynaud's attacks—episodes where fingers or toes turn color and become numb or tingly. About 75 participants will be randomly assigned to receive either a dose th…

This trial asks whether combining silicone sheets with standard pressure garments can improve the appearance and quality of limb scars better than pressure garments alone. About 60 adults aged 18-65 with scars from injury or surgery will receive either the combined treatment or p…

This trial tests whether warming lidocaine or adding sodium bicarbonate, hyaluronidase, or tranexamic acid can make the numbing injection less painful and reduce bleeding during upper eyelid surgery. About 80 adults having bilateral blepharoplasty will receive different mixtures …

This 28-day study is testing whether a lotion containing ubiquinol, pomegranate peel extract, ceramides, and salicylic acid can improve acne lesions and skin comfort in adults with mild-to-moderate acne. Forty participants aged 18 to 40 will use the lotion daily alongside their u…

This study tests whether adding a personalized anti-inflammatory diet to standard physical therapy (compression, massage, and exercise) reduces leg swelling and improves quality of life in women with lipedema. 75 women aged 18-65 with stage I-III lipedema will be randomly assigne…

This trial tests whether a device called SofWave, which delivers high-intensity ultrasound energy under the skin, can lift and tighten the lower face and upper neck. About 30 healthy adults aged 40 to 55 with mild to moderate skin laxity will receive one treatment. Doctors will r…

This study tests whether applying citric acid during a procedure to remove dark gum pigmentation leads to better-looking results and faster healing. Adults aged 18 to 50 with natural dark gums will receive either standard depigmentation or depigmentation plus acid. The researcher…

This trial tests whether a spray containing superoxide dismutase, an antioxidant enzyme, can reduce severe skin reactions caused by radiation therapy. Head and neck cancer patients scheduled for radiotherapy apply the spray five times daily to the treated skin area. The study com…

This study tests whether taking a high dose of whey protein after each workout helps breast cancer survivors gain more muscle and lose more fat compared to exercise alone. Participants are women aged 20 to 89 who have completed treatment for breast cancer and are prescribed exerc…

This phase 2 trial tests whether nemolizumab, an injectable biologic, can reduce severe itching in women with vulvar lichen sclerosus, a chronic inflammatory skin condition. Participants receive weight-based doses of the drug and track their itch scores daily. The study focuses o…

This early-phase trial investigates whether monthly injections of hyaluronidase into the fingers can improve stiffness and hand function in people with systemic sclerosis who have sclerodactyly (tight, thickened skin on the fingers). The study enrolls 10 adults aged 18 to 60 and …

This study tests a new barrier cream (Dermategrity "Anti-fecal" Barrier Cream) that contains zinc oxide and a natural plant extract to protect and heal skin damaged by incontinence. Sixty adults with incontinence-associated dermatitis will receive either the new cream or a standa…

This pilot study investigates whether injections of Poly-L-Lactic acid (PLLA), a collagen-stimulating substance, can safely improve skin laxity and wrinkles on the neck. Ten adults aged 30-60 with mild to severe neck skin looseness will receive a single treatment session. Researc…

Cellulitis is a painful bacterial skin infection. This study tests whether adding naproxen (an anti-inflammatory drug) to standard antibiotics helps reduce redness and pain faster than antibiotics alone. About 884 adults with cellulitis will take either naproxen or a placebo for …

This study investigates whether budesonide, an anti-inflammatory medication, can improve swallowing difficulties in people with dystrophic epidermolysis bullosa, a rare genetic condition that causes fragile skin and scarring. The researchers will review medical records of 15 pati…

This early-stage trial tests an experimental tablet called Alpha-0261 in people with chronic spontaneous urticaria (long-lasting hives) and in healthy volunteers. The study checks the drug's safety, how the body processes it, and whether it reduces hive activity and itching. Part…

This study tests whether a non-invasive treatment called extracorporeal shock wave therapy (ESWT) can reduce pain and improve quality of life in people with lipedema, a chronic condition causing painful fat buildup. Participants receive six sessions over two weeks, with pain, fun…

This study tests whether an artificial intelligence-powered digital education program can reduce the severity of radiodermatitis (skin irritation from radiation) and improve quality of life in women with breast cancer. 38 patients will be randomly assigned to either receive the A…

This phase 2 trial tests a medicated foam called roflumilast on skin rashes caused by checkpoint inhibitor cancer drugs. Twenty adults with mild to severe rash will apply the foam daily for 16 weeks. The goal is to see if it safely reduces rash severity and improves quality of li…

This study tests whether adding a pill called pentoxifylline to standard skin creams can improve mild-to-moderate psoriasis. About 140 adults will take either the study drug or a placebo twice daily for 12 weeks. Researchers will measure changes in skin severity, itch, and qualit…

This study tests whether isotretinoin or doxycycline works better for treating an acne-like rash that can appear in people taking certain cancer drugs. About 50 participants who already have a moderate to severe rash will receive one of the two medications. The goal is to see whi…

This study tests a new 'smart bandage' that checks wound moisture, temperature, and acidity, then sends updates to a nurse's app. About 110 adults with hard-to-heal leg ulcers will either get the smart bandage plus standard care or standard care alone. The goal is to see if the s…

This early-phase trial tests whether a home-based morning light therapy program can help people with advanced melanoma who are receiving tumor-infiltrating lymphocyte (TIL) therapy. The light therapy is delivered through an iPad app and aims to improve the body's natural sleep-wa…

This Phase 1 trial will test the safety and tolerability of multiple doses of PG-033 tablets in 30 healthy adults. Participants will be randomly assigned to receive either PG-033 or a placebo. The study aims to find out how the drug moves through the body and whether it causes an…

This Phase 2 trial tests whether the experimental drug HRS-3095 can reduce itching and wheals in adults with chronic spontaneous urticaria (hives) that isn't well controlled by antihistamines. About 190 participants will receive either the drug or a placebo daily for 4 weeks. The…

This study tests whether adding oral iron supplements to standard eczema treatment can reduce skin symptoms and improve quality of life in adolescents aged 12 to 16 with mild to moderate atopic dermatitis. Researchers will also check if iron levels in the blood affect how well th…

This study tests whether Changji'an capsules, a traditional Chinese medicine, can reduce diarrhea and stomach pain in people with irritable bowel syndrome (IBS) where diarrhea is the main symptom. About 636 adults aged 18 to 65 will take the capsule or a placebo for 8 weeks. The …

This study tests a new online program called TEAM-LEADS designed to help teens and young adults (ages 13-22) with lupus or dermatomyositis reduce stress and improve heart-healthy behaviors like diet, exercise, and sleep. The program is self-guided and completed online. The study …

This study compares three lying positions (on your back, side, or stomach) before a routine injection into the buttock muscle. Researchers will measure pain, comfort, and satisfaction in 111 adults. The goal is to find the best position to make injections less uncomfortable.

This study tests whether a topical eye drop called timolol can help surgical wounds on the scalp heal faster and look better after Mohs surgery. About 40 adults will either use timolol or standard wound care. Researchers will check healing and scar appearance at 4, 8, and 12 week…

This pilot study will test whether taking a high dose of oral hyaluronan (HA35) daily for 40 days can reduce facial fullness, double chin, skin redness, and improve skin vitality and body weight. Thirty adults seeking non-invasive aesthetic improvement will participate. The study…

This study tests a gel made from hyaluronan (HA35) to see if it can quickly relieve moderate-to-severe itching from conditions like eczema, insect bites, and hives. About 30 adults will apply the gel once, and researchers will check itch levels at several time points up to 24 hou…

This study tests a special gel applied to the skin to see if it can quickly reduce pain from shingles. Thirty adults with shingles-related pain will receive a single application of the gel. Researchers will measure pain levels before and after application, focusing on relief with…

This small pilot study will test a new type of light therapy for moderate-to-severe acne. A special gel is applied to the face, then activated with red light to kill bacteria and reduce inflammation. Ten people aged 16 and older will receive treatments twice a week. The goal is t…

This study tests a new surgical approach for women with early breast cancer who need a nipple-sparing mastectomy. If cancer is found in the nipple during surgery, doctors will remove the nipple but try to save the pigmented skin around it (the areola) and rebuild a new nipple rig…

This study tests whether taking oral probiotics for 12 weeks can reduce acne lesions and lower inflammation in people with moderate acne. Researchers will compare probiotics to a placebo in 64 Pakistani participants aged 15-35. The goal is to find a safe, antibiotic-free way to m…

This study compares three types of CPAP masks (binasal prong, nasal cannula, and nasal mask) to see which causes fewer nasal pressure injuries in preterm infants. 75 babies in the NICU will be randomly assigned to one mask type and monitored for 4 days. The goal is to find the ge…

This study tests a special scanner that lets surgeons check, in real time during breast cancer surgery, whether all cancer has been removed. The goal is to reduce the need for a second operation. About 228 women with certain high-risk breast cancer types will take part. The scann…

This study tests whether a probiotic called Lactiplantibacillus plantarum Dad-13, originally from buffalo milk curd, can improve gut health and physical performance in 30 adolescent athletes. Participants will take the probiotic and have their gut bacteria, inflammation markers, …

This phase 2 trial tests whether verteporfin, a drug injected into the skin during tummy tuck surgery, can reduce scar formation. Twelve adults will receive different doses of verteporfin and a placebo in separate parts of their surgical wound. Researchers will compare scar appea…

This study tests whether daily red light therapy can prevent or reduce skin and mouth side effects in children aged 0-16 receiving radiation for cancer. About 248 kids will get a daily LED light treatment on the radiated area. Researchers will compare their side effects to those …

This study tests a special care plan to help Chinese patients with advanced EGFR-mutated lung cancer who are taking the drug amivantamab. The plan focuses on preventing common side effects like blood clots, skin rashes, and infusion reactions. About 122 adults will join to see if…

This study tests whether an oral collagen supplement (Collagendep) can reduce vulvar dryness in 40 women with genital lichen sclerosus who are also receiving fat grafting. Participants take the supplement daily for 4 months. The main goal is to see if dryness improves, with secon…

This study tests whether a medicated cream called crisaborole works better than a placebo cream for people with mild to moderate eczema. About 270 people aged 12 to 50 will apply the cream twice daily for four weeks. The goal is to see if the cream can clear or nearly clear the e…

This pilot study tests whether giving dexamethasone (a steroid) to children hospitalized with orbital cellulitis (a serious eye infection) is worth studying further. Thirty children will receive either dexamethasone or a placebo by IV. The main goal is to see if a larger trial is…

This study tests if a cream made from diacerein can safely reduce psoriasis symptoms like redness and scaling. About 60 adults with mild psoriasis will apply the cream or a placebo twice a day for two months. Doctors will check their skin at several visits to see if the cream lea…

This study compares two skin-protective strategies—a fragrance-free emollient plus foam dressing versus a silicone-based barrier film—in 104 head and neck cancer patients receiving TomoTherapy. The goal is to see which approach better prevents or reduces painful radiation dermati…

This study tests a cosmetic cream made with postbiotics (natural bacteria extracts) to see if it safely reduces wrinkles and age spots. About 45 women aged 35-60 with mild to moderate skin aging will apply the cream twice daily for 3 months. Researchers will measure changes in sk…

This study tests whether injections of stem cells from donated fat tissue can help loosen mouth fibrosis in people with systemic scleroderma. Fifty adults with limited mouth opening will receive either stem cell or placebo injections around the mouth and be followed for 24 weeks.…

This study tests whether taking a daily saffron extract capsule can improve skin health by reducing wrinkles, fine lines, and dark spots. Fifty healthy adults aged 30 to 55 will take either the saffron supplement or a placebo for a set period. Researchers will use special skin sc…

This study tests whether adding URGO FilmoCream Eczema to standard steroid cream works better than steroid cream alone for treating atopic dermatitis. Researchers will compare two similar eczema lesions on each of 44 adults—one treated with steroids only, the other with steroids …

This study tests a laser device called Epilady, used with or without a special cream, to lighten dark age spots on the hands and forearms of healthy women aged 35 to 70. Over 84 days, doctors will check how much the spots fade and how well the treatment is tolerated. The goal is …

This study tests whether adding shockwave therapy to standard care (like compression and massage) can reduce pain and swelling in women with lipedema. Fifty women aged 18-65 with early-stage lipedema will be randomly assigned to receive either standard care alone or standard care…

This study compares two types of nipple-sparing mastectomy: one done with a robotic arm through a small side incision, and the standard open surgery. Researchers want to see if the robotic method improves women's satisfaction, body image, and recovery over 12 months. The trial wi…

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This study follows 34 adults with moderate-to-severe hidradenitis suppurativa (HS) who are taking secukinumab as part of their routine care. Researchers will use a special CT scan to check if the drug affects the buildup of plaque in the heart arteries over 12 months. The goal is…

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

This study creates a UK-wide registry for people with vitiligo, a skin condition causing white patches. It will track the safety and effectiveness of current treatments in up to 30 patients. The goal is to improve long-term care by collecting real-world data from dermatologists.

Researchers are studying where the bacteria that infect skin sores come from in people with scabies or atopic dermatitis. They will compare bacteria grown from infected skin lesions with bacteria from nasal swabs to see if the same species appear in both places. A group of health…

Researchers at Al-Azhar University are studying whether type 2 diabetes is linked to changes in women's hair and scalp. The study compares 130 women aged 20 to 60, half with diabetes for at least a year and half healthy controls matched by age. Participants undergo clinical hair …

Researchers are studying whether the mix of bacteria in a person's gut can predict how well they respond to immunotherapy drugs called immune checkpoint inhibitors. The trial enrolls about 360 adults with advanced non-small cell lung cancer, melanoma, endometrial cancer, or cervi…

Researchers at the University of Edinburgh are interviewing people in Blantyre, Malawi, to learn how they recognize and manage common skin problems. The study includes adults with skin conditions and traditional healers. Participants share their experiences in 30-minute interview…

This observational study aims to collect and analyze data from up to two million patients with dermatologic conditions like vitiligo, atopic dermatitis, alopecia areata, and hidradenitis suppurativa, as well as their healthcare providers. By reviewing treatment patterns, outcomes…

Some people with inflammatory bowel disease who take anti-TNF drugs develop painful rashes in skin folds and around the mouth, a condition called SPIDER. Researchers at a French hospital are studying whether levels of Staphylococcus aureus bacteria in these rashes change over six…

Pressure ulcers, also known as bedsores, are a serious risk for patients in intensive care. This study tests whether a standard severity score called SAPS 2 can predict which patients will develop these painful wounds. Researchers will follow 500 ICU patients, comparing the SAPS …

This study builds a long-term research cohort for people with psoriasis, eczema, or hidradenitis suppurativa. Participants use a certified app to answer symptom questions and take standardized photos of their skin once a month, with longer questionnaires twice a year. Trained ass…

This registry study collects real-world data from about 300 adults treated with urinary bladder matrix (UBM) products for various wounds, including pressure ulcers, surgical incisions, and infections like Fournier's gangrene. Researchers track patient characteristics, treatment p…

Researchers are testing whether blood levels of a protein called asprosin are higher or lower in people with Behçet disease, and whether those levels match how active the disease is. The study will enroll 44 adults who meet the international criteria for Behçet disease. No treatm…

This study examines children aged 1 to 18 with tinea capitis, a common fungal infection of the scalp. Researchers will use clinical exams, dermoscopy, and laboratory tests to describe the infection's patterns and identify the specific fungi causing it. The goal is to improve unde…

This study asks whether women with lipodystrophy syndromes or Turner syndrome experience lower sexual quality of life than women in the general population. Researchers will compare survey responses from affected women with those from a large French cohort. The goal is to understa…

This study looks at adults with ringworm infections that resist standard antifungal treatment. Researchers will scrape the edge of the skin lesions and examine the samples under a microscope and in the lab to identify the fungus and test which antifungals might work. The goal is …

This trial tests whether teaching pressure ulcer prevention with the Pecha Kucha technique, a fast-paced presentation style with 20 slides shown for 20 seconds each, helps nursing students identify ulcer stages and retain knowledge better than a standard PowerPoint lecture. Resea…

This study looks at whether women with lipedema, a condition that causes abnormal fat buildup in the legs and arms, are more likely to have osteoporosis, a condition that weakens bones. Researchers will measure bone density in the spine and hip of 120 postmenopausal women with li…

This study looks at whether magnesium levels in the blood are related to sleep quality, pain, and quality of life in women with lipedema, a condition that causes abnormal fat buildup in the legs. Researchers will compare women with good sleep versus poor sleep to see if magnesium…

This study investigates whether adults with plaque psoriasis are more likely to have fibromyalgia and central sensitization—a condition where the nervous system becomes overly sensitive to pain—compared to healthy people. Researchers will compare 55 psoriasis patients with 55 mat…

This observational study aims to map the immune and molecular profiles of people with inflammatory skin conditions, including genetic forms like epidermolysis bullosa. By comparing these profiles to those of healthy individuals, researchers hope to identify unique signatures that…

This observational study looks at whether time spent driving is linked to differences in skin hydration between the left and right cheeks in female drivers in Florida. In left-hand-drive cars, the left cheek gets more sun exposure through the side window. Researchers will measure…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study looks at whether the 2-Minute Step Test—a quick, equipment-free exercise test—can reliably measure functional capacity in women with lipedema, a chronic fat tissue disorder that affects the legs and can limit mobility. Researchers will compare the step test results wit…

This study looks at how a special program, called the Geriatric Surgery Verification Program, works at the James Cancer Hospital. The program helps doctors and nurses better care for patients aged 65 and older who need cancer surgery. It includes checking for age-related issues l…

This study looks at whether a routine blood test measuring D-dimer levels can predict if the immunotherapy drug cemiplimab will control advanced cutaneous squamous cell carcinoma. Researchers will follow 116 patients starting cemiplimab in regular care, comparing disease control …

This study looks at how tiny particles called extracellular vesicles travel through the bloodstream in people with systemic sclerosis, an autoimmune disease that affects blood vessels and organs. Researchers will take blood samples from different points in the circulation to see …

This study compares two types of hamstring training—eccentric exercises like the Romanian deadlift and Nordic hamstring exercise versus sprint-specific drills—in healthy collegiate athletes. Over 10 weeks, researchers measure changes in muscle size, strength, power, and sprint pe…

This study investigates whether the bacteria living in the gut and on the scalp differ between men with androgenetic alopecia (common hair loss) and those without. Researchers will also look at how these bacterial communities change after treatment with oral minoxidil, a standard…

This study will measure a protein called IL-41 in the blood of 90 people with ankylosing spondylitis or psoriatic arthritis, plus healthy volunteers. Researchers want to see if higher levels of this protein are linked to more active disease. The goal is to find a simple blood tes…

This study measures how often depression occurs in adults with alopecia areata, a condition that causes patchy hair loss. Researchers will use a questionnaire to assess depressive symptoms in 100 patients at a dermatology clinic. No treatments or interventions are involved — the …

This observational study looks at whether children aged 3 months to 16 years are more likely to complete their full course of antibiotics when prescribed at a primary care clinic versus a hospital emergency department. Researchers surveyed parents by phone after treatment ended t…

This study follows 5,000 people with common inflammatory skin conditions—like eczema, psoriasis, and hidradenitis suppurativa—over up to 17 years to see how their disease severity changes. Researchers will collect medical history, treatments, and symptom scores to identify factor…

This study explores a new way to diagnose Lyme disease by measuring immune cell responses to the bacteria. Researchers use a technique called flow cytometry to analyze T-cells from patients with a late-stage form of Lyme disease. The goal is to see if this method can tell active …

This pilot study looks at how different resistance training routines change levels of myokines—molecules released by muscles during exercise—in women who have finished breast cancer treatment. Participants will be assigned to one of three exercise regimens (conditioning, strength…

This early-stage study tests the safety and tolerability of an experimental oral drug called HRS-8797 in healthy volunteers aged 18 to 55. Researchers will also measure how the drug behaves in the body and whether food affects its absorption. The goal is to gather essential safet…

This study will collect information from medical records and routine clinic visits of 100 people in Egypt with hereditary angioedema (HAE) type I or II. The goal is to understand how the condition is diagnosed and managed in current medical practice. No new treatments are being t…

This study tests a paper-based decision aid designed to help people with intermediate-risk melanoma decide whether to have a sentinel lymph node biopsy. The tool provides clear information about the procedure, its risks and benefits, and helps patients think about their personal …

This study looks at how muscle tiredness changes the way female volleyball players move their legs when landing on one foot. Researchers will use smartphone videos to measure hip, knee, and ankle motion in 35 athletes. The goal is to understand injury risks better, not to test a …

This study investigates whether a natural molecule called Maresin-1, which helps reduce inflammation, is linked to lipedema—a chronic condition causing painful fat buildup in women. Researchers will measure Maresin-1 levels in the blood of women with lipedema, women with obesity …

This study aims to create stem cell lines from blood samples of 16 people: 4 with severe scleroderma, 4 with mild scleroderma, and 8 of their healthy relatives. These stem cells will be turned into various tissue types (like heart, skin, and immune cells) in the lab to study how …

This study will test if blocking a protein called TL1A can reverse skin scarring in systemic sclerosis, a rare autoimmune disease. Researchers will take blood and skin samples from 10 patients with early diffuse scleroderma and 10 healthy people. They will treat the samples in th…

This study looks at how environmental factors like heat, cold, and pollution affect wounds, mental health, and drug use in homeless people in Augsburg. Researchers will compare wound care from a mobile unit to a hospital clinic, and use saliva tests to check drug use. The goal is…

This study looks at how people with skin conditions (like eczema, psoriasis, or skin cancer) manage stress, feel lonely, and bounce back from challenges. Researchers will compare 375 adults with and without skin disease across 15 European countries using questionnaires. The goal …

This study will test whether whole-body MRI scans and blood tests for tumor DNA can better detect cancer progression in a type of breast cancer that is often missed by standard scans. Researchers will follow 43 people with metastatic invasive lobular carcinoma for up to 30 months…

This study will test an artificial intelligence system that analyzes smartphone photos of hard-to-heal wounds to see if they are getting better, staying the same, or getting worse. Researchers will enroll 1,000 people with wounds that have not healed for over a month. The goal is…

This study looks at 199 children with type 1 diabetes who have been using insulin for at least 6 months. Researchers will check for skin problems like lumps under the skin (lipohypertrophy) caused by injections. They will also measure fat thickness with ultrasound and ask caregiv…

This study looks at whether people with oral lichen planus (a chronic mouth condition) have more gum disease than those without it. Researchers will compare 88 patients with oral lichen planus to 88 healthy people, all getting standard dental exams. The goal is to understand shar…

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This study aims to create a new questionnaire that measures how well nurses can prevent pressure injuries (also known as bedsores). Pressure injuries are a common problem in hospitals that can cause pain and longer stays. Researchers will test the questionnaire with 300 nurses in…

This study in Côte d'Ivoire tests whether giving mothers a cash reward for breastfeeding until their child is 24 months old increases breastfeeding rates and improves child and maternal health. About 1,040 mothers will either receive the cash incentive or just educational materia…

This study looks at how the skin barrier changes in intensive care patients who are at risk for pressure injuries (bedsores). Researchers will use non-invasive biosensors to measure things like skin moisture, acidity, and temperature in areas prone to bedsores. The goal is to und…

This study looks at women with a very early form of breast cancer called DCIS. It uses a special test to find those at low risk of the cancer coming back. The goal is to see if these low-risk women can skip radiation therapy after their lump-removal surgery without a meaningful i…

This study tests a new imaging technique called full-field OCT to see if it can spot muscle inflammation faster than the usual method, which takes weeks. Researchers will compare both methods on muscle samples from 20 healthy adults and people with suspected myositis. The goal is…

This study looks at whether the placement of hand sanitizer in a doctor's office affects how much psoriasis patients trust their doctor and feel stigmatized. Researchers will observe doctors' hand hygiene habits and ask 250 patients to fill out questionnaires. The goal is to find…

This study looks at how two common psoriasis drugs, cyclosporine and methotrexate, affect a protein called IL-33 in the blood. Researchers will measure IL-33 levels and track psoriasis severity in 118 adults with moderate to severe psoriasis. The goal is to understand how these d…

This study looks at how body composition (like fat and muscle) and metabolism (how the body uses energy) are connected in adult and older Filipino athletes. Researchers will measure things like body fat, muscle mass, resting energy use, and fitness levels in 120 athletes and non-…

This early-stage study tests a single dose of an experimental drug called BW-20805-2 in 24 healthy adults aged 18 to 60. The main goal is to check for side effects and see how the drug moves through the body. Participants receive one injection under the skin and are monitored for…

This study looks at whether operating room nurses who know more about pressure injuries caused by medical devices make better decisions in the operating room. About 165 nurses from three hospitals in Turkey will take a knowledge test and answer questions based on real-life scenar…

This study tests whether using a smartphone app to monitor chronic wounds at home can reduce the number of in-person doctor visits. One hundred adults with a single chronic wound (like a diabetic foot ulcer or pressure sore) will be split into two groups: one using the app with a…

This early-stage study tests a drug called DA-020 in 60 healthy women aged 18-55. The goal is to measure how much of the drug enters the blood after one application to the scalp and to check for side effects like blood pressure changes. This research helps understand the drug's s…

This study tests whether injecting two dyes around the tumor and into cancerous lymph nodes can help surgeons spot hidden cancer spread in head and neck cancer. Twenty adults with oral cavity or head and neck skin cancer will receive the dyes before surgery. The goal is to see if…

This study tests a non-invasive imaging technique called LC-OCT for diagnosing basal cell carcinoma, the most common skin cancer. Researchers will review medical records of about 300 patients to see if LC-OCT can accurately detect cancer and guide treatment without needing a biop…

This study will test a specially trained AI model (like ChatGPT) to see if it can help doctors correctly diagnose and recommend treatments for lymphedema, lipedema, and venous insufficiency. Researchers will compare the AI's suggestions to current medical guidelines. The goal is …

This study looks at the blood immune cells of 10 adults with a rare inherited skin condition called NIPAL4 ichthyosis. Researchers want to understand why three patients with this skin disease also developed a very rare lymphoma (Sezary syndrome). By describing the normal immune c…

This study tests whether taking statins (a common cholesterol drug) can protect the heart and brain from the harmful effects of breathing bushfire smoke. Healthy adults aged 18-64 will be exposed to simulated smoke in a controlled setting, with some taking statins short-term (2 d…

This study will test whether a facial cream containing postbiotics (beneficial bacteria byproducts) can improve the skin microbiome and appearance in 45 women aged 40-60 with sensitive skin. Participants will use a placebo cream for 6 weeks, then the active cream for 8 weeks. Res…

This study looks at how the antibiotic delafloxacin spreads through the body in 20 adults with serious skin, soft tissue, bone, or joint infections. Researchers will measure drug levels in blood and in tissues collected during surgery. The goal is to understand if the drug reache…

This study will compare two different tissue expanders used in breast reconstruction after mastectomy in 80 women. Some participants will also receive radiation therapy, which is not typically recommended with these devices. Researchers will evaluate aesthetic outcomes, patient s…

This study will look at 200 people aged 18 to 25 with mild, moderate, or severe acne, plus healthy volunteers, to understand how acne develops in Singapore's tropical climate. Researchers will analyze skin bacteria, immune responses, and use AI to grade acne from photos. The goal…

This study will see if using virtual care technologies in hospital units can reduce problems like patient falls, infections, and readmissions, while also improving patient satisfaction. About 10,000 adults admitted to six hospital units will take part, with three units using the …

This study tests whether training intensive care nurses in evidence-based practices can lower rates of ventilator-associated pneumonia, pressure ulcers, and central line bloodstream infections. Researchers will train nurses and use advanced equipment, then compare infection rates…

This study looks at a blood protein called FAP, which is linked to tissue scarring and inflammation. Researchers will measure FAP levels in people with rheumatoid arthritis and systemic sclerosis, as well as healthy volunteers, and compare them with standard tests and lung functi…

This study looks at how certain immune cells, called MAIT cells, behave in people with hidradenitis suppurativa (HS), a painful skin condition. Researchers will take skin and blood samples from 45 adults with HS and compare them to samples from people with other skin diseases. Th…

This study looks back at 238 patients with a common skin cancer called squamous cell carcinoma. Researchers will compare special skin photos (dermoscopic images) with lab results from removed tumors. The goal is to see if certain features in the photos can tell how deep the cance…

This study looks at whether using a high-frequency ultrasound before surgery for common skin cancers on the head and neck can help surgeons remove the entire tumor the first time. About 400 adults with basal or squamous cell skin cancer will be in the study. Some will get the sta…

This study will collect existing medical records from about 20,000 people aged 12 and older in Italy who have one of five inflammatory skin conditions: psoriasis, atopic dermatitis, vitiligo, alopecia areata, or hidradenitis suppurativa. Researchers want to describe who gets thes…

This study looks at whether people with oral lichen planus, a chronic mouth condition, have higher risks for heart problems or blood clots. Researchers will check blood samples from 55 adults for natural anticoagulant deficiencies and antiphospholipid antibodies. The goal is to b…

This study looks at how sex hormones, especially during pregnancy, change the immune cells in the skin. Researchers will compare pregnant women, non-pregnant women, and men, both with and without a skin condition called hidradenitis suppurativa. The goal is to understand how horm…

This study will develop and test a digital twin-haptic mixed reality simulation to teach nursing students how to manage pressure injuries (bedsores). About 130 second-year nursing students will be randomly assigned to either the mixed reality simulation or a standard high-fidelit…

This study will measure three types of fats (ceramides and S1P) in the blood of 40 people with acne and 40 healthy volunteers. The goal is to see if these fats are different in acne patients and if they relate to acne severity. No treatment is given—just a blood draw. The results…

This study will collect health information, samples, and data from 100 people in Luxembourg (800 total across Europe) who have rheumatoid diseases and are starting or changing treatment. Researchers hope to find patterns that can predict which treatments work best for each person…