New keyhole breast cancer surgery could offer better looks, same safety
NCT ID NCT07539545
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new type of breast-conserving surgery that uses a small camera inserted through a hidden armpit incision to remove tumors, compared to the standard open approach. About 1,366 women with early-stage breast cancer will be randomly assigned to one of the two surgeries. The goal is to see if the new method leads to fewer complications, better cosmetic results, and similar cancer control over five years.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Minimal accessory-incision-assisted endoscopic breast-conserving surgery
- What this could lead to
- If successful, this could offer a less invasive surgical option for breast cancer that improves cosmetic results while maintaining safety and cancer control.
- What could go wrong
- This is an early-stage trial comparing surgical techniques, not a new drug or cure. The procedure may not reduce recurrence risk or could have unforeseen complications. Results may not apply to all breast cancer patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 1,366 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2032
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * female patients aged 18-70 years (inclusive); * preoperative pathological examination confirmed it as invasive breast cancer or ductal carcinoma in situ; * both clinical and imaging examinations clearly indicated that the lesion was a single lesion confined within the gland, without invasion of the skin, subcutaneous tissue, pectoralis major muscle, or the nipple-areola complex; * tumors in the inner and outer quadrants (three classification method, as shown in Figure 2); * preoperative tumor size ≤3 cm (pre-neoadjuvant chemotherapy if applicable); * the tumor is more than 2 cm away from the nipple (the distance is based on physical examination, with MRI and ultrasound as supplementary methods); * the patient has a clear intention to preserve the breast and can receive standard radiotherapy after the operation; * voluntary provision of informed consent. . Exclusion Criteria: * clinically or radiologically evaluated as multifocal or multicentric breast cancer, with diffuse suspicious calcification, long spiculated masses, extensive local resection unable to obtain sufficient negative margins or ideal shape; * persistent positive tumor margins, and resection cannot ensure negative margins after resection; * inflammatory breast cancer; * pregnant and lactating women; * previous history of breast cancer surgery (including patients with recurrence after ipsilateral breast-conserving surgery); * breast cancer genetic gene mutations (such as BRCA1/2 gene mutations); * preoperative severe underlying diseases that cannot tolerate general anesthesia and surgical procedures. * other situations that the researchers consider unsuitable for participation
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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West China hospital of Sichuan University
Chengdu, Sichuan, 610000, China
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