Can a laser and diabetes drug erase dark skin patches?
NCT ID NCT07760181
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial tests whether combining fractional carbon dioxide laser treatment with a topical metformin cream works better than laser alone for acanthosis nigricans—dark, velvety patches on the neck. About 34 adults with this condition will have one side of their neck treated with the combination and the other side with laser only, to compare results. The study measures changes in the severity of the patches using a standard scoring system and a doctor's overall assessment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Fractional carbon dioxide laser plus topical metformin
- What this could lead to
- If effective, this combination could offer a more effective treatment for acanthosis nigricans, a skin condition often linked to insulin resistance.
- What could go wrong
- This is a small early-phase study, so results may not be conclusive. Risks include skin irritation, scarring, or no added benefit from the metformin.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 34 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * \- male or female patients aged 18-50 years * clinically \& dermoscopy diagnosed acanthosis nigricans involving the neck * skin types iii-v * stable systemic condition for at least 3 months * willingness to comply with study protocol and follow-up Exclusion Criteria: * \- pregnancy or lactation * malignancy-associated acanthosis nigricans * active skin infection or inflammatory dermatosis at the treatment site * history of keloid or hypertrophic scar formation * photosensitivity disorders * use of topical or systemic treatment for acanthosis nigricans within the last 4 weeks * previous laser treatment to the neck within the last 6 months
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.