Can a single injection stop scars? new trial aims to find out
NCT ID NCT07488988
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 2 trial tests whether verteporfin, a drug injected into the skin during tummy tuck surgery, can reduce scar formation. Twelve adults will receive different doses of verteporfin and a placebo in separate parts of their surgical wound. Researchers will compare scar appearance after 3 months using a standard rating scale.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- verteporfin
- What this could lead to
- If it works, this could point toward a simple injection to prevent or reduce scarring after surgery.
- What could go wrong
- This is a very small early-phase trial with only 12 people. The effect may be small or not work at all, and there could be side effects like injection reactions or delayed healing.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 12 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years old * Scheduled to undergo elective abdominoplasty amenable to primary closure * ASA class I-II * Fitzpatrick skin type I-IV * Ability to provide written and informed consent and willing to comply with study procedures Exclusion Criteria: * Pregnancy or planned pregnancy within the next 6 months at the time of inclusion * Breastfeeding * Smoking within the previous 6 months * Excessive alcohol intake (\>10 units/week for women, \>14 units/week for men) * Participants who are unable to read, understand and communicate in Danish sufficiently to provide informed consent and comply with study procedures * Known conditions of pathological scarring or other conditions affecting wound healing * Known hypersensitivity to verteporfin or any excipients * Porphyria or other photosensitivity disorders * Moderate hepatic dysfunction, defined as: 1. AST or ALT \>1.2 × ULN 2. Hypoalbuminemia or prolonged PT * Biliary obstruction, defined as: 1. ALP or GGT \>1.2 × ULN 2. Abnormal bilirubin * Autoimmune or fibrotic skin conditions including (but not limited to): 1\. Keloids or hypertrophic scars, scleroderma, lupus, GVD, morphea, lichen sclerosus, Ehlers-Danlos syndrome, cutis laxa, Marfan syndrome * Current use of photosensitizing medications (e.g. tetracyclines, thiazides, phenothiazines) * Any medical condition deemed by the investigator to pose a risk to safety or data integrity
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Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Odense University Hospital
Odense, 5000, Denmark
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Other studies related to the condition(s) this trial covers.